Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics.

Stress: Neuroendocrinology and Neurobiology: Handbook of Stress Series, Volume 2, focuses on neuroendocrinology, the discipline that deals with the way that the brain controls hormonal secretion, and in turn, the way that hormones control the brain. There have been significant advances in our understanding of neuroendocrine molecular and epigenetic mechanisms, especially in the way in which stress-induced hormonal and neurochemical changes affect brain plasticity, neuronal connectivity, and synaptic function. The book features the topic of epigenetics, and how it enables stress and other external factors to affect genetic transmission and expression without changes in DNA sequence. Integrated closely with new behavioral findings and relevance to human disorders, the concepts and data in this volume offer the reader cutting-edge information on the neuroendocrinology of stress. Volume 2 is of prime interest to neuroscientists, clinicians, researchers, academics, and graduate students in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry, and in some areas of the social sciences, including stress and its management in the workplace.

Environmental heat stress is associated with a marked decrease in orthostatic tolerance (OT), which is defined as the ability to stand or sit upright without symptoms of dizziness, lightheadedness, presyncope, or fainting. In most healthy humans, the autonomic nervous system makes rapid and balanced adjustments to heart rate and peripheral blood flow, such that most people are able to stand up "successfully" most of the time, in most environments. The goal of this book is to discuss various aspects of the sympathetic neural response to heat stress, how the sympathetic nervous system coordinates the successful integrative physiological response to orthostasis, and what happens when it encounters both challenges simultaneously. We include overviews of mechanisms of thermoregulation and blood pressure regulation in humans, with particular focus on control of cardiac output and neurovascular control mechanisms during heat stress. We discuss the implications that these changes have for distribution of peripheral blood flow and, in particular, for blood flow to the cerebral circulation. The added stressor of dehydration is also discussed, as it so often goes hand in hand with heat stress. We end with a brief presentation of countermeasures against the decreases in OT with heat stress.

Mathematics for Neuroscientists, Second Edition, presents a comprehensive introduction to mathematical and computational methods used in neuroscience to describe and model neural components of the brain from ion channels to single neurons, neural networks and their relation to behavior. The book contains more than 200 figures generated using Matlab code available to the student and scholar. Mathematical concepts are introduced hand in hand with neuroscience, emphasizing the connection between experimental results and theory.

This book discusses the management of individuals on the autistic spectrum as well as other developmental challenges. It provides an excellent resource guide for parents, caregivers, educators, healthcare workers, psychologists, and everyone involved in the care of differently abled and autistic persons. The approach is practical, and the aim is to try to gain deeper understanding into these conditions. Based on the experience of the staff and parents of the Rainbow Centre, the management is a person-centred, multidisciplinary and quality-of-life focused approach to helping these persons. The book also covers the history and future directions across one's lifespan in the care of these individuals.

This book discusses the management of individuals on the autistic spectrum as well as other developmental challenges. It provides an excellent resource guide for parents, caregivers, educators, healthcare workers, psychologists, and everyone involved in the care of differently abled and autistic persons. The approach is practical, and the aim is to try to gain deeper understanding into these conditions. Based on the experience of the staff and parents of the Rainbow Centre, the management is a person-centred, multidisciplinary and quality-of-life focused approach to helping these persons. The book also covers the history and future directions across one's lifespan in the care of these individuals.

The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of 1-adrenoceptors and increase renin secretion rate by activation of 1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Under normal conditions, the renal mechanosensory nerves activated by stretch of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension.

Obesity and Esophageal Disorders is a comprehensive review on the impact of obesity on esophageal disorders and how to approach, recognize and treat those disorders. Covering the critical gap in awareness on the impact of obesity on esophageal disorders, this reference presents the newest diagnostic technologies, including high resolution manometry, EndoFLIP, wireless pH monitoring, and mucosal integrity devices. The book shows treatment options like bariatric surgery and endo-bariatrics that decrease the latency period for diagnosis and management of patients. Finally, the understanding of the potential effects of different bariatric surgeries on esophageal motility is explored. This importance reference serves researchers looking to determine future projects by providing novel pathophysiologic mechanisms about how obesity affects GERD and esophageal motility. It serves clinicians, surgeons and trainees with guidance on diagnostic approaches, management options, and how to recognize/treat post-surgical esophageal complications of patients with obesity.

Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more.

One of Britain's foremost astrobiologists offers an accessible and game-changing account of life on Earth. __________________ Why is all life based on carbon rather than silicon? And beyond Earth, would life - if it exists - look like our own? __________________ The puzzles of life astound and confuse us like no other mystery. But in this groundbreaking book, Professor Charles Cockell reveals how nature is far more understandable and predictable than we would think. Breathing new life into Darwin's theory of natural selection, The Equations of Life puts forward an elegant account of why evolution has taken the paths it has. In a captivating journey into the forces that shape living things on Earth, Cockell explains that the fundamental laws of physics constrain nature at every turn. Fusing the latest in scientific research with fascinating accounts of the creatures that surround us, this is a compelling argument about what life can - and can't - be.

Concepts and techniques in genomics and proteomics covers the important concepts of high-throughput modern techniques used in the genomics and proteomics field. Each technique is explained with its underlying concepts, and simple line diagrams and flow charts are included to aid understanding and memory. A summary of key points precedes each chapter within the book, followed by detailed description in the subsections. Each subsection concludes with suggested relevant original references.

A derivative of the Encyclopedia of Inland Waters, Biogeochemistry of Inland Waters examines the transformation, flux and cycling of chemical compounds in aquatic and terrestrial ecosystems, combining aspects of biology, ecology, geology, and chemistry. Because the articles are drawn from an encyclopedia, they are easily accessible to interested members of the public, such as conservationists and environmental decision makers.

Key Concepts in Environmental Chemistry provides a modern and concise introduction to environmental chemistry principles and the dynamic nature of environmental systems. It offers an intense, one-semester examination of selected concepts encountered in this field of study and provides integrated tools in explaining complex chemical problems of environmental importance. Principles typically covered in more comprehensive textbooks are well integrated into general chapter topics and application areas. The goal of this textbook is to provide students with a valuable resource for learning the basic concepts of environmental chemistry from an easy to follow, condensed, application and inquiry-based perspective. Additional statistical, sampling, modeling and data analysis concepts and exercises will be introduced for greater understanding of the underlying processes of complex environmental systems and fundamental chemical principles. Each chapter will have problem-oriented exercises (with examples throughout the body of the chapter) that stress the important concepts covered and research applications/case studies from experts in the field. Research applications will be directly tied to theoretical concepts covered in the chapter. Overall, this text provides a condensed and integrated tool for student learning and covers key concepts in the rapidly developing field of environmental chemistry.

Global Ecology focuses on the perception of the biosphere or the ecosphere as a unified cooperative system with numerous synergistic effects, which describe the distinctive properties of this sphere. This book is subdivided into five parts dealing with diverse aspects in global ecology. The first part of the book provides comprehensive description of the biosphere, including its unique characteristics and evolution. This part also describes various spheres in the biosphere, such as the hydrosphere, noosphere, and pedosphere as well as their composition. The next part focuses on the global cycles, including calcium, carbon, iron, microbial nitrogen, oxygen, phosphorus, sulfur, and water cycles. In addition, global balances and flows are explained. Presented in the third part are the results of the global cycles and flows as well as the patterns of the climatic factors and marine currents. There is also a part discussing the climate interactions, climatic changes, and its effect on the living organisms. The book concludes by covering the application of stoichiometry in the biosphere and in ecosystems. The book offers a comprehensive view of global ecology and ecological stoichiometry, which will aid in the processes of global ecology.

Insect-Plant Interactions, the latest edition in the Advances in Botanical Research series, which publishes in-depth and up-to-date reviews on a wide range of topics in the plant sciences, features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology.

Tissue Engineering, Third Edition provides a completely revised release with sections focusing on Fundamentals of Tissue Engineering and Tissue Engineering of Selected Organs and Tissues. Key chapters are updated with the latest discoveries, including coverage of new areas (skeletal TE, ophthalmology TE, immunomodulatory biomaterials and immune systems engineering). The book is written in a scientific language that is easily understood by undergraduate and graduate students in basic biological sciences, bioengineering and basic medical sciences, and researchers interested in learning about this fast-growing field.

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective.

Chromatin Remodelling and Immunity, Volume 106, the latest release in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.