Brucella is a genus of Gram-negative, facultative, intracellular bacteria that are highly pathogenic for a variety of mammals, including humans. Recently the WHO cited brucellosis to be the world's most widespread zoonosis. An important feature of the pathogenicity of these organisms is their ability to survive and replicate within the host macrophages. However the mechanism for this is unclear. In addition, none of the classical bacterial virulence factors found in other bacterial pathogens have been found in the genomes of the forty Brucella species and biovars analysed to date. Nevertheless the application of systems biology approaches in recent years has transformed research, permitting fascinating new insights into Brucella molecular biology and genomics. Written by highly acclaimed Brucella scientists, this book comprehensively reviews the most important advances in the field. Opening chapters focus on genetic diversity within Brucella, covering both classical and new species. Pa

The rapid urbanization and industrialization of developing countries across the globe have necessitated for substantial resource utilization and development in the areas of Healthcare, Environment, and Renewable energy. In this context ,this resourceful book serves as a definitive source of information for the recent developments in application of microbial enzymes in various sectors. It covers applications in fermentation processes and their products, extraction and utilisation of enzymes from various sources and their application in health and biomass conversion for production of value added products. Different chapters discuss various areas of bioprospecting in enzyme technology, and describe why these are the mainstays for industrial production of value added products. The rich compilation of the cutting-edge advances and applications of the modern industrial based techniques hold feasible solutions for a range of current issues in enzyme technology. This book will be of particular interest for scientists, academicians, technical resource persons, engineers and members of industry. Undergraduate and graduate students pursuing courses in the area of industrial biotechnology will find the information in the book valuable. General readers having interest towards biofuels, enzyme technology, fermented food and value added products, phytochemicals and phytopharmaceutical products will also find the book appealing. Readers will discover modern concepts of enzymatic bioprocess technology for production of therapeutics and industrial value added products.

Two new volumes of Methods in Enzymology continue the legacy of this premier serial with quality chapters authored by leaders in the field. Circadian Rhythms and Biological Clocks Part A and Part B is an exceptional resource for anybody interested in the general area of circadian rhythms. As key elements of timekeeping are conserved in organisms across the phylogenetic tree, and our understanding of circadian biology has benefited tremendously from work done in many species, the volume provides a wide range of assays for different biological systems. Protocols are provided to assess clock function, entrainment of the clock to stimuli such as light and food, and output rhythms of behavior and physiology. This volume also delves into the impact of circadian disruption on human health. Contributions are from leaders in the field who have made major discoveries using the methods presented here.

This book integrates findings from across domains in performance psychology to focus on core research on what influences peak and non-peak performance. The book explores basic and applied research identifying cognition-action interactions, perception-cognition interactions, emotion-cognition interactions, and perception-action interactions. The book explores performance in sports, music, and the arts both for individuals and teams/groups, looking at the influence of cognition, perception, personality, motivation and drive, attention, stress, coaching, and age. This comprehensive work includes contributions from the US, UK, Canada, Germany, and Australia.

This volume constitutes the most recent and most comprehensive consideration of the largest family of bony fishes, the Cichlidae. This book offers an integrated perspective of cichlid fishes ranging from conservation of threatened species to management of cichlids as invasive species themselves. Long-standing models of taxonomy and systematics are subjected to the most recent applications and interpretations of molecular evidence and multivariate analyses; and cichlid adaptive radiations at different scales are elucidated. The incredible diversity of endemic cichlid species in African lakes is revisited as possible examples of sympatric speciation and as serious cases for management in complex anthropogenic environments. Extreme hydrology and bathymetry as driver of micro-allopatric speciation is explored in the African riverine hotspot of diversity of the lower Congo River. Dramatic new molecular evidence draws attention to the complex taxonomy and systematics of Neotropical cichlids including the crater lakes of Central America. Molecular genetics, genomics, imaging tools and field study techniques assess the roles of natural, sexual and kin selection in shaping cichlid traits and beyond. The complex behavioral adaptations of cichlids are considered from a number of sub-disciplines including sensory biology, neurobiology, development, and evolutionary ecology. Most importantly, this volume puts forth a wealth of new interpretations, explanatory hypotheses and proposals for practical management and applications that will shape the future for these remarkable fishes in nature as well as their use as models for the study of biology.

This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.

How do desires and fears motivate human sociability? What effect do these motivators have on reproductive, social and political behaviour? And, crucially, how might we understand them separate from preconceived notions of design or higher morality? Taking these questions as a focus, this book examines human evolution with the emphasis on sexual selection and the evolution of a number of human psychological processes. Exploring evolutionary, sexual and maturational processes, along with primate, fossil and geological evidence, Vannelli argues that human nature can be conceptualised as species-typical desires and fears, derived from sexual selection during human evolution, and that these are major motivators of behaviour. Presenting additional evidence from the anthropology of band societies, along with material from group behaviour, Vannelli highlights the importance of pair-bonding, friendship, alliance behaviour, vengeance seeking and interpersonal politics in social behaviour, providing a unique interdisciplinary framework for understanding human nature and the evolution of human sociability.

This book outlines the evolution of our political nature over two million years and explores many of the rituals, plays, films, and other performances that gave voice and legitimacy to various political regimes in our species' history. Our genetic and cultural evolution during the Pleistocene Epoch bestowed a wide range of predispositions on our species that continue to shape the politics we support and the performances we enjoy. The book's case studies range from an initiation ritual in the Mbendjela tribe in the Congo to a 1947 drama by Bertolt Brecht and include a popular puppet play in Tokugawa Japan. A final section examines the gradual disintegration of social cohesion underlying the rise of polarized politics in the USA after 1965, as such films as The Godfather, Independence Day, The Dark Knight Rises, and Joker accelerated the nation's slide toward authoritarian Trumpism.

This book offers a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various disorders. This book presents biomedical and anthropological data on the use of ayahuasca and provides critiques on how it is used for treating depression, PTSD, anxiety, substance dependence, and eating disorders. The volume also explores ayahuasca's role in the psychological well-being and quality of life of humans, and discusses possibilities of it enhancing cognition and coping with grief. The book examines ayahuasca's association with psychotherapy and also highlights the challenges of integrating plant medicines into psychiatry. Further, the book expands on some preliminary research with animals, suggesting that ayahuasca acts at multiple levels of neural complexity. The study on the neurogenic effects of ayahuasca alkaloids opens a new avenue of research with potential applications ranging from psychiatric disorders to brain damage and dementia. Psychologists, psychiatrists, and other mental health professionals will find this book relevant to their work regarding substance abuse and alternative medicine.

New Therapeutic Strategies for Brain Edema and Cell Injury, Volume 145, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this volume presenting interesting chapters on the Blood-brain barrier breakdown and brain edema formation in Alzheimer’s disease, Blast brain Injury induced edema formation and therapeutic measures, Brain edema in Parkinson’s disease. Novel therapeutic strategies, Brain edema and blood-brain barrier breakdown in sleep deprivation. Therapeutic potential of cerebrolysin, Differential cell injury induced by NMDA antagonist MK 801 in early age, Anesthetics influence Brain edema in concussive head injury, and more.

Every year nine million people are diagnosed with tuberculosis, every day over 13,400 people are infected with AIDs, and every thirty seconds malaria kills a child. For most of the world, critical medications that treat these deadly diseases are scarce, costly, and growing obsolete, as access to first-line drugs remains out of reach and resistance rates rise. Rather than focusing research and development on creating affordable medicines for these deadly global diseases, pharmaceutical companies instead invest in commercially lucrative products for more affluent customers. Nicole Hassoun argues that everyone has a human right to health and to access to essential medicines, and she proposes the Global Health Impact (global-health-impact.org/new) system as a means to guarantee those rights. Her proposal directly addresses the pharmaceutical industry's role: it rates pharmaceutical companies based on their medicines' impact on improving global health, rewarding highly-rated medicines with a Global Health Impact label. Global Health Impact has three parts. The first makes the case for a human right to health and specifically access to essential medicines. Hassoun defends the argument against recent criticism of these proposed rights. The second section develops the Global Health Impact proposal in detail. The final section explores the proposal's potential applications and effects, considering the empirical evidence that supports it and comparing it to similar ethical labels. Through a thoughtful and interdisciplinary approach to creating new labeling, investment, and licensing strategies, Global Health Impact demands an unwavering commitment to global justice and corporate responsibility.

Volume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of The Enzyme series was on Natural Products and Cancer Signaling Targets: Isoprenoids, Polyphenols and Flavonoids), will highlight the significant advance made in the field in elucidating mechanisms of anticancer effect of the major phytochemicals.

This book comprises the proceedings of the 12th International Conference on Asia-Pacific Microscopy Conference (APMC12) focusing on emerging opportunities and challenges in the field of materials sciences, life sciences and microscopy techniques. The contents of this volume include papers on aberration corrected TEM & STEM, SEM - FIB, ion beam microscopy, electron diffraction & crystallography, microscopy and imaging associated with bio-nanotechnology, medical applications, host-pathogen interaction, etc. This book will be beneficial to researchers, educators, and practitioners alike.

Brian Skyrms presents eighteen essays which apply adaptive dynamics (of cultural evolution and individual learning) to social theory. Altruism, spite, fairness, trust, division of labor, and signaling are treated from this perspective. Correlation is seen to be of fundamental importance. Interactions with neighbors in space, on static networks, and on co-evolving dynamics networks are investigated. Spontaneous emergence of social structure and of signaling systems are examined in the context of learning dynamics.

This book provides a compact introduction to the bootstrap method. In addition to classical results on point estimation and test theory, multivariate linear regression models and generalized linear models are covered in detail. Special attention is given to the use of bootstrap procedures to perform goodness-of-fit tests to validate model or distributional assumptions. In some cases, new methods are presented here for the first time. The text is motivated by practical examples and the implementations of the corresponding algorithms are always given directly in R in a comprehensible form. Overall, R is given great importance throughout. Each chapter includes a section of exercises and, for the more mathematically inclined readers, concludes with rigorous proofs. The intended audience is graduate students who already have a prior knowledge of probability theory and mathematical statistics.

This highly interdisciplinary book discusses the phenomenon of life, including its origin and evolution, against the background of thermodynamics, statistical mechanics, and information theory. Among the central themes is the seeming contradiction between the second law of thermodynamics and the high degree of order and complexity produced by living systems. As the author shows, this paradox has its resolution in the information content of the Gibbs free energy that enters the biosphere from outside sources. Another focus of the book is the role of information in human cultural evolution, which is also discussed with the origin of human linguistic abilities. One of the final chapters addresses the merging of information technology and biotechnology into a new discipline - bioinformation technology.This third edition has been updated to reflect the latest scientific and technological advances. Professor Avery makes use of the perspectives of famous scholars such as Professor Noam Chomsky and Nobel Laureates John O'Keefe, May-Britt Moser and Edward Moser to cast light on the evolution of human languages. The mechanism of cell differentiation, and the rapid acceleration of information technology in the 21st century are also discussed.With various research disciplines becoming increasingly interrelated today, Information Theory and Evolution provides nuance to the conversation between bioinformatics, information technology, and pertinent social-political issues. This book is a welcome voice in working on the future challenges that humanity will face as a result of scientific and technological progress.

"As a sex writer, Jesse Bering is fearless--and peerless." --Dan Savage
"You are a sexual deviant. A pervert, through and through." We may not want to admit it, but as the award-winning columnist and psychologist Jesse Bering reveals in "Perv," there is a spectrum of perversion along which we all sit. Whether it's voyeurism, exhibitionism, or your run-of-the-mill foot fetish, we "all" possess a suite of sexual tastes as unique as our fingerprints--and as secret as the rest of the skeletons we've hidden in our closets.
Combining cutting-edge studies and critiques of landmark research and conclusions drawn by Sigmund Freud, Alfred Kinsey, and the "DSM-5," Bering pulls the curtain back on paraphilias, arguing that sexual deviance is commonplace. He explores the countless fetishists of the world, including people who wear a respectable suit during the day and handcuff a willing sexual partner at night. But he also takes us into the lives of "erotic outliers," such as a woman who falls madly in love with the Eiffel Tower; a pair of "deeply "affectionate identical twins; those with a particular penchant for statues; and others who are enamored of crevices "not "found on the human body.
Moving from science to politics, psychology, history, and his own reflections on growing up gay in America, Bering confronts hypocrisy, prejudice, and harm as they relate to sexuality on a global scale. Humanizing so-called deviants while at the same time asking serious questions about the differences between thought and action, he presents us with a challenge: to understand that our best hope of solving some of the most troubling problems of our age hinges entirely on the "amoral "study of sex.
As kinky as it is compassionate, illuminating, and engrossing, "Perv "is an irresistible and deeply personal book. "I can't promise you an orgasm at the end of our adventure," Bering writes, "but I "can" promise you a better understanding of why you get the ones you do."

Stroke Rehabilitation: Insights from Neuroscience and Imaging informs and challenges neurologists, rehabilitation therapists, imagers, and stroke specialists to adopt more restorative and scientific approaches to stroke rehabilitation based on new evidence from neuroscience and neuroimaging literatures. The fields of cognitive neuroscience and neuroimaging are advancing rapidly and providing new insights into human behavior and learning. Similarly, improved knowledge of how the brain processes information after injury and recovers over time is providing new perspectives on what can be achieved through rehabilitation.
Stroke Rehabilitation explores the potential to shape and maximize neural plastic changes in the brain after stroke from a multimodal perspective. Active skill based learning is identified as a central element of a restorative approach to rehabilitation. The evidence behind core learning principles as well as specific learning strategies that have been applied to retrain lost functions of movement, sensation, cognition and language are also discussed. Current interventions are evaluated relative to this knowledge base and examples are given of how active learning principles have been successfully applied in specific interventions. The benefits and evidence behind enriched environments is reviewed with examples of potential application in stroke rehabilitation. The capacity of adjunctive therapies, such as transcranial magnetic stimulation, to modulate receptivity of the damaged brain to benefit from behavioral interventions is also discussed in the context of this multimodal approach. Focusing on new insights from neuroscience and imaging, the book explores the potential to tailor interventions to the individual based on viable brain networks.
This book is intended for clinicians, rehabilitation specialists and neurologists who are interested in using these new discoveries to achieve more optimal outcomes. Equally as important, it is intended for neuroscientists, clinical researchers, and imaging specialists to help frame important clinical questions and to better understand the context in which their discoveries may be used.