Sex, Gender, and Epigenetics: From Molecule to Bedside explores the complex interplay of sex and gender-based influences on gene expression via epigenetic mechanisms. The book provides an overview of the field and evidence gathered to-date that is followed by a discussion of epigenetic pathways by which biological sex and the impact of the environment collaborate to regulate genetic function. The book also analyzes the impact of ancestors' environmental experience on subsequent generations and describes the nature of sex-specific transmission of environmentally induced epigenetic modifications. Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics.

Statistics for Applied Behavior Analysis Practitioners and Researchers provides practical and useful content for individuals who work directly with, or supervise those who work directly with, individuals with ASD. This book introduces core concepts and principles of modern statistical analysis that practitioners will need to deliver ABA services. The organization of the book works through the flow of behavior analytic service provision, aiming to help practitioners read through research, evaluate intervention options, incorporate statistics in their analysis of time-series intervention and assessment data, and effectively communicate assessment and intervention effects using statistics. As professionals who provide applied behavior analysis (ABA) services are required to use evidence-based practices and make data-based decisions regarding assessments and interventions, this book will help them take a modern, scientific approach to derive knowledge and make decisions based on statistical literacy.

Self-organizing Neural Maps: From Retina to Tectum describes the underlying processes that determine how retinal fibers self-organize into an orderly visual map. The formation of neural maps is a fundamental organizing concept in neurodevelopment that can shed light on developmental mechanisms and the functions of genes elsewhere. The book presents a summary of research in the retinotectal field with an ultimate goal of synthesizing how underlying mechanisms in neural development harmoniously come together to create life. A broad spectrum of neuroscientists and biomedical scientists with differing backgrounds and varied expertise will find this book useful.

Exercise on Brain Health, Volume 147 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on Exercise on bipolar disorder in humans, Exercise on Parkinson's disease in humans, Exercise on spinal cord injury in animals, Exercise on spinal cord injury in humans, Exercise promotes synaptic plasticity, Exercise promotes neural connectivity, Exercise on spinogenesis, Peripheral-central crosstalk of exercise on brain health, Exercise and Parkinson's, Exercise on binge alcohol consumption, Exercise on depression, and Exercise on chronic fatigue syndrome, and more.

DNA Repair, Volume 45 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on DNA polymerase beta and other gap-filling enzymes in mammalian base excision repair, Translesion polymerases, mechanism and function, The Rev1-Pol? Mutasome: Structure and Interactions in Translesion Synthesis, Challenges for base excision repair enzymes: acquiring access to damaged DNA in chromatin Nucleotide excision repair, DNA damage recognition mechanisms in mammalian nucleotide excision repair, Advances in understanding DNA mismatch repair, and more.

The nematode C. elegans is one of the most important model organisms for understanding neurobiology. Its completely mapped neural connectome of 302 neurons and fully characterized and stereotyped development have made it a prototype for understanding nervous system structure, development, and function. Fifty-six out of C. elegans' total of 959 somatic cells are classified as neuroglia. Although research on worm glia has lagged behind studies focused on neurons, there has been a steep upswing in interest during the past decade. Information arising from the recent burst of research on worm glia supports the idea that C. elegans will continue to be an important animal model for understanding glial cell biology. Since the developmental lineage of all cells was mapped, each glial cell in C. elegans is known by a specific name and has research associated with it. We list and describe the glia of the hermaphrodite form of C. elegans and summarize research findings relating to each glial cell. We hope this lecture provides an informative overview of worm glia to accompany the excellent and freely available online resources available to the worm research community.

Nonheme Iron Enzymes: Structures and Mechanisms, Volume 117, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors.

Advances in Agronomy, Volume 158, continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied, and exemplary of the abundant subject matter addressed by this long-running serial.

Effective use of Social Media in Public Health offers a well-organized and comprehensive review of social media and its impact on people’s lives and the public health sector. Divided into sections, the book addresses the growing use (and importance) of social media in conducting and disseminating research findings and covers an array of issues from cyberbullying to diversity and inclusion. Written by health educators and practitioners for health educators and practitioners, this book is a timely resource on the topics discussed.

Microbial Endophytes: Prospects for Sustainable Agriculture discusses the practical and theoretical aspects regarding the use of endophytic microorganisms in agriculture, providing insights on the biotechnological applications associated with long-term crop production. Chapters deal with the various aspects of endophytic microorganisms, including isolation, enumeration, characterization procedures, diversity analysis, and their role as biofertilizer, biocontrol agent and microbial inoculants. Framed to discuss the present and future potential of microbial endophytes in biotic and abiotic stress management, bioremediation, bioactive compounds production, and in nanotechnology, this book provides a single-volume resource that will be valuable to academics and researchers interested in microbiology, agricultural sciences and biotechnology.

The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer's, Parkinson's, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

Theory of Endobiogeny, Volume 3: Advanced Concepts for Treatment of Complex Clinical Conditions explains complex and multi-factorial disorders and diseases using the theory of endobiogeny. It provides detailed applications of biological modeling, in-depth assessment into common disorders, an endobiogenic analysis, guidance on using biological modeling tools, and suggestions for treatment using standard of care treatments that also take into account diet, lifestyle and medicinal plants. This approach is an evolution in thinking from reductionism to holism, offering advice for symptomatic treatments that can be used in conjunction with a new way of thinking about diseases and disease management.

Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies. In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering. Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence.

New Therapeutic Strategies for Brain Edema and Cell Injury, Volume 145, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this volume presenting interesting chapters on the Blood-brain barrier breakdown and brain edema formation in Alzheimer’s disease, Blast brain Injury induced edema formation and therapeutic measures, Brain edema in Parkinson’s disease. Novel therapeutic strategies, Brain edema and blood-brain barrier breakdown in sleep deprivation. Therapeutic potential of cerebrolysin, Differential cell injury induced by NMDA antagonist MK 801 in early age, Anesthetics influence Brain edema in concussive head injury, and more.

The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation has played in adaptive evolution, as well as in developmental biology and susceptibility to disease. Here, Moyra Smith, a celebrated researcher in the field, sheds light on common themes in gene regulation across evolutionary timelines, illuminating new areas of focus and pathways for future research. Early chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time and in response to environmental and local conditions, and the role of epigenetics in adaptive evolution, with later chapters considering the role of adaptive gene regulation in healthy processes and developmental biology, as well as in disease biology. Throughout the book, a comparative approach is adopted across organisms, to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.

This book explores how predictive processing, which argues that our brains are constantly generating and updating hypotheses about our external conditions, sheds new light on the nature of the mind. It shows how it is similar to and expands other theoretical approaches that emphasize the active role of the mind and its dynamic function. Offering a complete guide to the philosophical and empirical implications of predictive processing, contributors bring perspectives from philosophy, neuroscience, and psychology. Together, they explore the many philosophical applications of predictive processing and its exciting potential across mental health, cognitive science, neuroscience, and robotics. Presenting an extensive and balanced overview of the subject, The Philosophy and Science of Predictive Processing is a landmark volume within philosophy of mind.

The Theory of Endobiogeny Volume 2: Foundational Concepts for Treatments of Common Clinical Conditions addresses the core elements of the adaptation response to stressors: autonomic nervous system (ANS), corticotropic axis, immunity and digestive tract function. The volume is oriented for clinical practice, offering clear discussions on treating the root cause of numerous common disorders, and symptomatically addressing the destabilizing factor in a vast number of disorders ranging from depression to irritable bowel, and from migraines to insomnia called spasmophilia.

Immunotherapy of Cancer, Volume 143, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Contributions from leading experts in the field make this a must have update on the topic.

Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation.