Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable" RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

Occupational Neurotoxicology, Volume Seven covers neurotoxicants and exposures to a variety of hazards in the workplace and how they can affect nervous functions in different ways. Metals and organic compounds, both at high level acute exposure and long-term low-level exposure can affect motor functions, cognition, behavior and neurosensory functions. Sections cover Oil leakage in aircraft, aerotoxic syndrome, Organic solvents, WTC neurotoxicities, Environmental intolerance, Pesticides, Carbon monoxide, Mercury Neurotoxicity in Gold Miners, and the Current evolution of neurobehavioral methods.

Advances in Agronomy, Volume 170, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Advances in Botanical Research: Past, Current and Future Topics, Volume 100 in the Advances in Botanical Research series, celebrates a remarkable achievement as 100 volumes have now been published, with several others being prepared. New chapters in this monumental release include Editorial activities for Advances in Botanical Research, Revisiting ABR editing in the period 2006-2012: An exciting experience with Jean-Claude Kader, A tribute to the scientific contributions of Pierre Gadal and his laboratory, Evolution of Bacterial Phototrophy, Algae for Global Sustainability, Genomics of cyanobacteria: New insights and lessons for shaping our future, An overview of the root-knot-nematode compatible interaction, and more.

Bioinspiration is recognized by the World Health Organization as having great promise in transforming and democratizing health systems while improving the quality, safety, and efficiency of standard healthcare in order to offer patients the tremendous opportunity to take charge of their own health. This phenomenon can enable great medical breakthroughs by helping healthcare providers improve patient care, make accurate diagnoses, optimize treatment protocols, and more. Unfortunately, the consequences can be serious if those who finance, design, regulate, or use artificial intelligence (AI) technologies for health do not prioritize ethical principles and obligations in terms of human rights and preservation of the private life. Advanced Bioinspiration Methods for Healthcare Standards, Policies, and Reform is the fruit of the fusion of AI and medicine, which brings together the latest empirical research findings in the areas of AI, bioinspiration, law, ethics, and medicine. It assists professionals in optimizing the potential benefits of AI models and bioinspired algorithms in health issues while mitigating potential dangers by examining the complex issues and innovative solutions that are linked to healthcare standards, policies, and reform. Covering topics such as genetic algorithms, health surveillance cameras, and hybrid classification algorithms, this premier reference source is an excellent resource for AI specialists, hospital administrators, health professionals, healthcare scientists, students and educators of higher education, government officials, researchers, and academicians.

Tremors, Volume 163 in the International Review in Neurobiology serial highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

The fastest growing realization everywhere is that humanity can't go on the way it is going. Indeed, the great fear is we're entering endgame where we appear to have lost the race between self-destruction and self-discovery-the race to find the psychologically relieving understanding of our `good and evil'-afflicted human condition. Well, astonishing as it is, this book by Australian biologist Jeremy Griffith presents the 11th hour breakthrough biological explanation of the human condition necessary for the psychological rehabilitation and transformation of our species! The culmination of 40 years of studying and writing about our species' psychosis, FREEDOM delivers nothing less than the holy grail of insight we have needed to free ourselves from the human condition. It is, in short, as Professor Harry Prosen, a former president of the Canadian Psychiatric Association, asserts in his Introduction, "The book that saves the world!". Griffith has been able to venture right to the bottom of the dark depths of what it is to be human and return with the fully accountable, true explanation of our seemingly imperfect lives. At long last we have the redeeming and thus transforming understanding of human behaviour! And with that explanation found all the other great outstanding scientific mysteries about our existence are now also able to be truthfully explained-of the meaning of our existence, of the origin of our unconditionally selfless moral instincts, and of why we humans became conscious when other animals haven't. Yes, the full story of life on Earth can finally be told-and all of these incredible breakthroughs and insights are presented here in this `greatest of all books'.

Advances in Agronomy, Volume 169, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Executive functions develop during the first years of life and determine future learning and personal development. Executive dysfunction is related to various neurodevelopmental disorders, so its study is of great interest for intervention in children with neurotypical development and in those who have suffered a neurodevelopmental disorder. The Handbook of Research on Neurocognitive Development of Executive Functions and Implications for Intervention offers updated research on executive functions and their implication in psychoeducational intervention. It establishes a multidisciplinary context to discuss both intervention experience and research results in different areas of knowledge. Covering topics such as childhood inhibitory processing, mindfulness interventions, and language development, this major reference work is an excellent resource for psychologists, medical professionals, researchers, academicians, educators, and students.

Advances in Agronomy, Volume 168, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Sexual Dysfunction in Parkinson's Disease, Volume 182, the latest release in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of trending and important topics, including Prevalence, clinical presentations and impact on relationship, Pathophysiology, Scales for assessing sexual dysfunction in Parkinson's disease, Diagnostic work up: Laboratory and biomarkers, Management strategies, ICD DDS and sex dysfunction, Non-motor fluctuations and sex dysfunction, Exploring Sexual Dysfunction in Care Homes, and The impact of non-motor symptoms burden on sexual functions.

Defence from Invertebrates to Mammals: Focus on Tonic Immobility, Volume 273 in the Progress in Brain Research series, highlights new advances in the field. Chapters in this new release include Defensive responses in invertebrates, Introduction to defensive behavior in vertebrates, Neural circuits of fear and defensive behavior, Fear-associated factors modulating TI, Environmental, ecological and methodological factors of TI Modulation, The neuroethological approach to defense in rabbits, Neurophysiological mechanisms of TI, Neuromediators, brain areas and circuits involved in defense responses, Autonomic correlates of defense responses, Neuroendocrine correlates of stress and TI, Pain control during TI and other immobility models, and more.

Machine Learning in Bioinformatics of Protein Sequences guides readers around the rapidly advancing world of cutting-edge machine learning applications in the protein bioinformatics field. Edited by bioinformatics expert, Dr Lukasz Kurgan, and with contributions by a dozen of accomplished researchers, this book provides a holistic view of the structural bioinformatics by covering a broad spectrum of algorithms, databases and software resources for the efficient and accurate prediction and characterization of functional and structural aspects of proteins. It spotlights key advances which include deep neural networks, natural language processing-based sequence embedding and covers a wide range of predictions which comprise of tertiary structure, secondary structure, residue contacts, intrinsic disorder, protein, peptide and nucleic acids-binding sites, hotspots, post-translational modification sites, and protein function. This volume is loaded with practical information that identifies and describes leading predictive tools, useful databases, webservers, and modern software platforms for the development of novel predictive tools.

Advances in Agronomy, Volume 167, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Neurosurgical Management of Psychiatric Disorders, Part B, Volume 267 in the Progress in Brain Research serial highlights new advances in the field with this new volume presenting interesting chapters on topics such as the Neurosurgical Management of Tourette Syndrome, Stereotactic Surgeries for Opioid Addiction: Patient Selection and Results, Psychiatric Disorders as Indication for Surgical Management of Drug-Resistant Temporal Epilepsy, Surgery of Autism: Is it Possible?, Psychogenic Pain: Diagnosis and Management, Stereotactic Cingulotomy and Capsulotomy for Obsessive-Compulsive Disorders: Indications and Comparative Results, and much more.

Many people have written biographies of Charles Darwin, but the story of his family and roots in Shrewsbury is little known. This book, containing original research, fills that gap. The key player is Charles' father, Dr Robert Darwin, a larger-than-life character whose financial acumen enabled Charles to spend his whole life on research unencumbered by money worries. Through Susannah, Charles' mother, we are introduced to the Wedgwood family, whose history was so closely interwoven with the Darwins. The stories of Charles' five siblings are detailed, and there is a wealth of local material, such as information on Shrewsbury School and its illustrious headmaster, Samuel Butler. The book is fully illustrated with contemporary and modern pictures, and will be of interest to anyone wanting to discover more about the development of Shrewsbury's most famous son.

The 2021 IPCC report made one thing crystal clear - global climate change is here to stay. Time is up. We need to act or climate change will lead to inconceivable suffering by billions of people. Buying Time for Climate Action is the combined narrative of world class experts, all committed to help humanity survive its largely self-induced destructive course. Changing that course requires urgent action. Determining which actions will lead to helpful change requires insights into the stumbling blocks that always emerge when actions aimed at change are planned, resulting in lost time. The experts who contributed to this volume, through their expertise, networks, wisdom and creativity, have largely concluded that the way to cope with the stumbling blocks is to avoid them by focusing on grassroots initiatives. Their narratives and discussions, presented in this book, highlight such thinking.The book is essential reading for anyone committed to help avoid an existential disaster for humanity, and ready to move plans into effective action.