Genetic science is about to radically alter our lives. Sooner than you can imagine, human beings will be capable of diagnosing their own illnesses, designating the sex of their children, even designing the food they eat -- all as easily as using a cell phone. Now is the time for every one of us to take control of our DNA, and one man is uniquely qualified to show us how: Glenn McGee, bioethicist at the University of Pennsylvania, pioneer in the study of "home genetics," and the acknowledged wunderkind of the exciting world found at the nexus of life science and computer technology.

One of the most respected authorities in the field of genomics -- the study of the genetic "software" inside plants, animals, and us -- McGee takes us on an eye-opening journey behind the headlines and into the heart of this formidable cutting-edge science. Probing the far-ranging ethical and legal implications of genomic research, McGee tackles its most controversial and hotly debated aspects -- from patenting your DNA to genetic engineering at the supermarket -- and explodes unnecessary fears about this wondrous new knowledge.

We live in a brave new world. Beyond Genetics provides us with the knowledge we need to take the right steps forward into tomorrow ... and beyond.

Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties. The benefits of medical image synthesis have sparked growing interest in a number of advanced clinical applications, such as magnetic resonance imaging (MRI)-only radiation therapy treatment planning and positron emission tomography (PET)/MRI scanning. This book will be a comprehensive and exciting resource for undergraduates, graduates, researchers, and practitioners.

Shortlisted for the Royal Society Science Book Prize 2021 'To compare any book to a Sacks is unfair, but this one lives up to it . . . I finished it feeling thrillingly unsettled, and wishing there was more.' - James McConnachie, Sunday Times In Sweden, refugee children fall asleep for months and years at a time. In upstate New York, high school students develop contagious seizures. In the US Embassy in Cuba, employees complain of headaches and memory loss after hearing strange noises in the night. These disparate cases are some of the most remarkable diagnostic mysteries of the twenty-first century, as both doctors and scientists have struggled to explain them within the boundaries of medical science and - more crucially - to treat them. What unites them is that they are all examples of a particular type of psychosomatic illness: medical disorders that are influenced as much by the idiosyncratic aspects of individual cultures as they are by human biology. Inspired by a poignant encounter with the sleeping refugee children of Sweden, Wellcome Prize-winning neurologist Suzanne O'Sullivan travels the world to visit other communities who have also been subject to outbreaks of so-called 'mystery' illnesses. From a derelict post-Soviet mining town in Kazakhstan, to the Mosquito Coast of Nicaragua via an oil town in Texas, to the heart of the Maria Mountains in Colombia, O'Sullivan hears remarkable stories from a fascinating array of people, and attempts to unravel their complex meaning while asking the question: who gets to define what is and what isn't an illness? Reminiscent of the work of Oliver Sacks, Stephen Grosz and Henry Marsh, The Sleeping Beauties is a moving and unforgettable scientific investigation with a very human face. 'A study of diseases that we sometimes say are 'all in the mind', and an explanation of how unfair that characterisation is.' - Tom Whipple, The Times Books of the Year

As a neurosurgeon, I lived in a world filled with fear and suffering, death and cancer. But rarely, if ever, did I think about what it would be like if what I witnessed at work every day happened to me. This book is the story of how I became a patient myself. As a retired brain surgeon, Henry Marsh thought he understood illness, but he was unprepared for the impact of his diagnosis of advanced cancer. And Finally explores what happens when someone who has spent a lifetime on the frontline of life and death finds himself contemplating what might be his own death sentence. As he navigates the bewildering transition from doctor to patient, he is haunted by past failures and projects yet to be completed, and frustrated by the inconveniences of illness and old age. But he is also more entranced than ever by the mysteries of science and the brain, the beauty of the natural world and his love for his family. Elegiac, candid, luminous and poignant, And Finally is ultimately not so much a book about death, but a book about life and what matters in the end.

A TIMES ENVIRONMENT AND SCIENCE BOOK OF THE YEAR 2022 'The ideal guide to what is not just a fiendishly complex area of science but also an ethical minefield' Mail on Sunday A new gene editing technology, invented just seven years ago, has turned humanity into gods. Enabling us to manipulate the genes in virtually any organism with exquisite precision, CRISPR has given scientists a degree of control that was undreamt of even in science fiction. But CRISPR is just the latest, giant leap in a long journey to master genetics. The Genetic Age shows the astonishing, world-changing potential of the new genetics and the possible threats it poses, sifting between fantasy and the reality when it comes to both benefits and dangers. By placing each phase of discovery, anticipation and fear in the context of over fifty years of attempts to master the natural world, Matthew Cobb, the Baillie-Gifford-shortlisted author of The Idea of the Brain, weaves the stories of science, history and culture to shed new light on our future. With the powers now at our disposal, it is a future that is almost impossible to imagine - but it is one we will create ourselves.

'A dazzling, beguiling story . . . told at an exhilarating pace' Literary Review 'Henry Gee makes the kaleidoscopically changing canvas of life understandable and exciting. Who will enjoy reading this book? - Everybody!' Jared Diamond, author of Guns, Germs, and Steel For billions of years, Earth was an inhospitably alien place - covered with churning seas, slowly crafting its landscape by way of incessant volcanic eruptions, the atmosphere in a constant state of chemical flux. And yet, despite facing literally every conceivable setback that living organisms could encounter, life has been extinguished and picked itself up to evolve again. Life has learned and adapted and continued through the billions of years that followed. It has weathered fire and ice. Slimes begat sponges, who through billions of years of complex evolution and adaptation grew a backbone, braved the unknown of pitiless shores, and sought an existence beyond the sea. From that first foray to the spread of early hominids who later became Homo sapiens, life has persisted, undaunted. A (Very) Short History of Life is an enlightening story of survival, of persistence, illuminating the delicate balance within which life has always existed, and continues to exist today. It is our planet like you've never seen it before. Life teems through Henry Gee's lyrical prose - colossal supercontinents drift, collide, and coalesce, fashioning the face of the planet as we know it today. Creatures are engagingly personified, from 'gregarious' bacteria populating the seas to duelling dinosaurs in the Triassic period to magnificent mammals with the future in their (newly evolved) grasp. Those long extinct, almost alien early life forms are resurrected in evocative detail. Life's evolutionary steps - from the development of a digestive system to the awe of creatures taking to the skies in flight - are conveyed with an alluring, up-close intimacy.

This textbook provides an accessible introduction to physics for undergraduate students in the life sciences, including those majoring in all branches of biology, biochemistry, and psychology and students working on pre-professional programs such as pre-medical, pre-dental, and physical therapy. The text is geared for the algebra-based physics course, often named College Physics in the United States. The order of topics studied are such that most of the problems in the text can be solved with the methods of Statics or Dynamics. That is, they require a free body diagram, the application of Newton’s Laws, and any necessary kinematics. Constructing the text with a standardized problem-solving methodology, simplifies this aspect of the course and allows students to focus on the application of physics to the study of biological systems. Along the way, students apply these techniques to find the tension in a tendon, the sedimentation rate of red blood cells in haemoglobin, the torques and forces on a bacterium employing a flagellum to propel itself through a viscous fluid, and the terminal velocity of a protein moving in a Gel Electrophoresis device. This is part one of a two-volume set; volume 2 introduces students to the conserved-quantities and applies these problem-solving techniques to topics in Thermodynamics, Electrical Circuits, Optics, and Atomic and Nuclear Physics always with continued focus on biological applications.

In a book that is both groundbreaking and accessible, Daniel C. Dennett, whom Chet Raymo of The Boston Globe calls "one of the most provocative thinkers on the planet," focuses his unerringly logical mind on the theory of natural selection, showing how Darwin's great idea transforms and illuminates our traditional view of humanity's place in the universe. Dennett vividly describes the theory itself and then extends Darwin's vision with impeccable arguments to their often surprising conclusions, challenging the views of some of the most famous scientists of our day.

This Handbook provides an overview of neuroscience-driven research methodologies and how those methodologies might be applied to theory-based research in the nascent field of neuroentrepreneurship. A key challenge of this field is that few neuroscientists are trained as entrepreneurship scholars and few entrepreneurship scholars are trained as neuroscientists, but this book skillfully bridges that gap. Expert contributors include concrete examples of new ways to conduct research in their contributions, which have the potential to shed light onto areas such as decision making and opportunity recognition and allow neuroentrepreneurs to ask different, perhaps better, questions than ever before. This Handbook also presents current thinking and examples of pioneering work, serves as a reference for those wishing to incorporate these methods into their own research, and provides several helpful discussions on the nature of answerable questions using neuroscience techniques. Neuroentrepreneurship is an important, emerging field for neuroscientists and entrepreneurship scholars alike. For the former audience, this book presents concrete research questions and entrepreneurship applications; for the latter, it serves as a primer and introduction to neuroscientific methods. Graduate students studying entrepreneurship, and practitioners who are keen to promote innovation and entrepreneurial skills in their leadership, will also find this Handbook to be of interest. Contributors include: W. Becker, C. Bellavitis, M.C. Boardman, M. Colosio, C. Couffe, M. Day, P.M. de Holan, A.A. Gorin, S. Guillory, N. Krueger, A. Passarelli, V. Perez-Centeno, C. Reeck, L. Schjoedt, K.G. Shaver, A. Sud, T. Treffers, M.K. Ward

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

Darwin takes a look at the life of this incredible man, from his birth, his ground-breaking publications and far-flung travels, Darwinism and his theories on evolution, all the way to his final days. Over 160 stunning images and illustrations are included within Darwin, ranging from personal diary entries (such as those he made when deciding whether to marry or not), letters and handwritten notes, as well as sketches from Darwin's famous works. Revealing the famous scientist's life in compelling detail, Darwin covers not only his scientific career and On the Origin of Species but his personal struggles also, allowing us to see what truly made the man.

An immersive blend of chicken-keeping memoir and animal welfare reporting by a journalist who accidentally became obsessed with her flock. Since first domesticating the chicken thousands of years ago, humans have become exceptionally adept at raising them for food. Yet most people rarely interact with chickens or know much about them. In Under the Henfluence, Tove Danovich explores the lives of these quirky, mysterious birds who stole her heart the moment her first box of chicks arrived at the post office. From a hatchery in Iowa to a chicken show in Ohio to a rooster rescue in Minnesota, Danovich interviews the people breeding, training, healing and, most importantly, adoring chickens. With more than 60 billion chickens living on industrial farms around the world, they're easy to dismiss as just another dinner ingredient. Yet Danovich's reporting reveals the hidden cleverness, quiet sweetness and irresistible personalities of these birds, as well as the complex human-chicken relationship that has evolved over centuries. This glimpse into the lives of backyard chickens doesn't just help us to understand chickens better - it also casts light back on ourselves and what we've ignored throughout the explosive growth of industrial agriculture. Woven with delightful and sometimes heartbreaking anecdotes from Danovich's own henhouse, Under the Henfluence proves that chickens are so much more than what they bring to the table.

Good and effective treatment in radiotherapy requires careful consideration of the complex variables involved as well as critical assessment of the techniques. This new edition of an established classic takes into account advances in imaging and treatment delivery and reflects the current state of the art in the practice of radiotherapy, emphasizing the underlying principles of treatment that can be applied for conventional, conformal, and novel treatments.

- The book discusses the recent techniques in NGS data analysis which is the most needed material by biologists (students and researchers) in the wake of numerous genomic projects and the trend toward genomic research. - The book includes both theory and practice for the NGS data analysis. So, readers will understand the concept and learn how to do the analysis using the most recent programs. - The steps of application workflows are written in a manner that can be followed for related projects. - Each chapter includes worked examples with real data available on the NCBI databases. Programming codes and outputs are accompanied with explanation. - The book content is suitable as teaching material for biology and bioinformatics students. Meets the requirements of a complete semester course on Sequencing Data Analysis Covers the latest applications for Next Generation Sequencing Covers data reprocessing, genome assembly, variant discovery, gene profiling, epigenetics, and metagenomics

This unique textbook explores core cognitive psychology topics from an innovative new perspective, focusing on key real-world issues to show how we understand and experience the world. The book examines compelling topics such as creativity, problem-solving, reasoning, rationality and language, all within the context of modern 21st century life. Each chapter demonstrates how this vibrant and constantly evolving discipline is at the heart of some of the biggest issues facing us all today. The last chapter discusses the future of cognitive psychology, which includes guidance on conducting rigorous, replicable research and how to use skills from cognitive psychology to be an effective student. Packed with pedagogical features, each chapter includes boxed examples of cognitive psychology in the real world and engaging ‘try it yourself’ features. Each chapter also includes objectives, a range of illustrative figures, chapter summaries, key readings and a glossary for ease of use. The book is fully supported by original online resources for students and instructors. Offering a new model for the study of cognitive psychology that brings the subject alive, the book is essential reading for all students studying psychology and related disciplines.

The physical world is infinitely complex, yet most of us are able to find our way around it. We can walk through unfamiliar streets while maintaining a sense of direction, take shortcuts along paths we have never used and remember for many years places we have visited only once. These are remarkable achievements.

In Wayfinding, Michael Bond explores how we do it: how our brains make the ‘cognitive maps’ that keep us orientated, even in places that we don’t know. He considers how we relate to places, and asks how our understanding of the world around us affects our psychology and behaviour.

The way we think about physical space has been crucial to our evolution: the ability to navigate over large distances in prehistoric times gave Homo sapiens an advantage over the rest of the human family. Children are instinctive explorers, developing a spatial understanding as they roam. And yet today few of us make use of the wayfaring skills that we inherited from our nomadic ancestors. Most of us have little idea what we may be losing.

Bond seeks an answer to the question of why some of us are so much better at finding our way than others. He also tackles the controversial subject of sex differences in navigation, and finally tries to understand why being lost can be such a devastating psychological experience.

For readers of writers as different as Robert Macfarlane and Oliver Sacks, Wayfinding is a book that can change our sense of ourselves.

What are genes? What do genes do? These questions are not simple and straightforward to answer; at the same time, simplistic answers are quite prevalent and are taken for granted. This book aims to explain the origin of the gene concept, its various meanings both within and outside science, as well as to debunk the intuitive view of the existence of 'genes for' characteristics and disease. Drawing on contemporary research in genetics and genomics, as well as on ideas from history of science, philosophy of science, psychology and science education, it explains what genes are and what they can and cannot do. By presenting complex concepts and research in a comprehensible and rigorous manner, it examines the potential impact of research in genetics and genomics and how important genes actually are for our lives. Understanding Genes is an accessible and engaging introduction to genes for any interested reader.

Introducing the Collins Modern Classics, a series featuring some of the most significant books of recent times, books that shed light on the human experience - classics which will endure for generations to come. What if intelligent life on earth not only evolved on land, but also in the sea? Other Minds is a bold new story of how nature became aware of itself - a story that largely occurs in the ocean, where animals first appeared. Tracking the mind's fitful development over millennia, Other Minds explores the incredible evolutionary journey of the cephalopods. What kind of intelligence do they possess? And how did the octopus, a solitary creature with little social life, become so smart? Heralded as the 'scuba-diving philosopher' when Other Minds first published, Peter Godfrey-Smith explores the underwater world and the concept of sentience to trace the question of inner life back to its roots. By comparing human beings with our most remarkable animal relatives, Other Minds casts crucial new light on the octopus mind - and on our own.

Are you a human? Do you have a mind? Then this book is for you. 'The story of the human mind as told by psychology's best storyteller' DANIEL GILBERT Nothing is more familiar and yet less understood than the human mind. It defines the experience of being human, and yet its workings contain some of the deepest mysteries ever encountered. Written by one of the world's greatest teachers of psychology, The Human Mind provides a masterful and riveting guide to all that we have learned since modern science began probing those mysteries. How does a three-pound lump of grey-ish meat give rise to conscious experience? What is the function of emotions such as disgust, gratitude and shame? How do our biases affect us and how can we overcome them? How does the mind of a child differ from that of an adult? How does memory work? What causes mental illness? Are we rational? Are we all a little bit racist? What makes us kind? What makes us cruel? What makes us happy? Many of these questions now have answers; many others don't yet; many widely accepted theories are probably wrong. This book takes us to the very limits of what is known. It shines new light on all that you take most for granted: everything you think and feel, everything you say and do, everything that makes you you. 'An extraordinary book that absolutely delivers on its sweeping ambitions ... like having the mind's complexities untangled by a witty, eloquent and deeply knowledgeable friend' OLIVER BURKEMAN

When faced with new challenges, it's easy to feel our solutions need to be equally unprecedented. We think we need a revolution. But what if this is a big mistake? In Evolutionary Ideas, Sam Tatam shows how behavioural science and evolutionary psychology can help us solve tomorrow's challenges, not by divining something the world has never seen, but by borrowing from yesterday's solutions - often in the most unexpected ways. Just as millions of years of evolution have helped craft the wing and dorsal fin, thousands of engineers, designers, marketers and advertisers have toiled to solve many of the problems you face today. Over time, through intent, design, social learning and sheer luck, we have found what works. Armed with an enhanced ability to see these patterns in human innovation, we can now systematically approach the creative process to develop more effective ideas more readily and rapidly. Just as Japanese engineers reduced bullet train noise by studying the evolved biology of the owl and kingfisher, today we can see how Disney improved the queueing experience in the same way Houston airport made arrivals feel faster (while making people walk further). We'll learn how the chocolate at the bottom of a Cornetto ice cream can improve an Error 404 message, and what a bowl of M&Ms has in common with a canary in a coal mine. These are Evolutionary Ideas. Exploring five of the most critical challenges we face today, we learn how to 'breed' more effective solutions from those that have survived. The result is a dynamic and exciting way of solving problems and supercharging creativity - for anyone in any endeavour.

Reflecting the expertise and perspective of five leading mammalogists, the fourth edition of Mammalogy: Adaptation, Diversity, Ecology significantly updates taxonomy, includes a new chapter on mammalian molecular phylogenetics, and highlights several recently described species. There are close to 5,500 species in the class Mammalia, including the blue whale-the largest animal that has ever lived-and the pygmy shrew, which weighs little more than a penny. The functional diversity of mammals has allowed them to play critical roles in every ecosystem, whether marine, freshwater, alpine, tundra, forest, or desert. Many mammal species are critically endangered and present complex conservation and management challenges. This book touches on those challenges, which are often precipitated by overharvesting and habitat loss, as well as emerging threats, such as the impact of wind turbines and white nose syndrome on bats and chronic wasting disease on deer. Among the updates and additions to the fourth edition of Mammalogy are numerous new photos, figures, and cladograms, over 4,200 references, as well as: a completely new chapter on mammalian phylogeny and genomics; current taxonomy - including major changes to orders, suborders, and superfamilies of bats and rodents; an explanation of the recent inclusion of whales with terrestrial even-toed ungulates; updates on mammalian structural, functional adaptations, and fossil history; and, recent advances in our understanding of phylogeny, biogeography, social behavior, and ecology; a discussion of two new orders and thirteen newly recognized extant families It also includes: reflections on the implications of climate change for mammals; thorough examinations of several recently described species, including Durrell's vontsira ( Salanoia durrelli) and the Laotian rock rat ( Laonastes aenigmamus); an explanation of mammalian biomechanics, such as that seen in lunge feeding of baleen whales; Breakout boxes on unique aspects of mammals, including the syntax of bat songs, singing mice, and why there are no green mammals (unless we count algae-covered sloths). Maintaining the accessible, readable style for which Feldhamer and his coauthors are well known, this new edition of Mammalogy is the authoritative textbook on this amazingly diverse class of vertebrates.

This is the most up-to-date guide to the management of coastal waters.Some of the world's most important bodies of water, from the Black Sea to the Bay of Bengal, are classified as 'semi-enclosed marine systems' (SEMS). Separated from the open seas by a strait, island archipelago, or physical process, SEMS are particularly vulnerable to environmental damage and particularly difficult to fully understand and manage."Watersheds, Bays, and Bounded Seas" provides state-of-the-science information about these complex systems and identifies best management practices to preserve them. With contributions by natural and social scientists, the book examines both the political and biophysical forces affecting semi-enclosed marine systems.SEMS comprise a substantial portion of the coasts - areas with high population density - and we rely on them for often-competing services such as navigation and transport, disposal of waste, provision of food, extraction of minerals, and leisure. The book describes how human activities could irrevocably alter these fragile ecosystems, exploring threats from runoff to climate change. It also addresses the unique challenges of managing SEMS, including cooperation between multiple nations.

Learn about the most important discoveries and theories of this science in The Biology Book. Part of the fascinating Big Ideas series, this book tackles tricky topics and themes in a simple and easy to follow format. Learn about Biology in this overview guide to the subject, brilliant for novices looking to find out more and experts wishing to refresh their knowledge alike! The Biology Book brings a fresh and vibrant take on the topic through eye-catching graphics and diagrams to immerse yourself in. This captivating book will broaden your understanding of Biology, with: - More than 95 ideas and events key to the development of biology and the life sciences - Packed with facts, charts, timelines and graphs to help explain core concepts - A visual approach to big subjects with striking illustrations and graphics throughout - Easy to follow text makes topics accessible for people at any level of understanding The Biology Book is a captivating introduction to understanding the living world and explaining how its organisms work and interact - whether microbes, mushrooms, or mammals. Here you'll discover key areas of the life sciences, including ecology, zoology, and biotechnology, through exciting text and bold graphics. Your Biology Questions, Simply Explained This book will outline big biological ideas, like the mysteries of DNA and genetic inheritance; and how we learnt to develop vaccines that control diseases. If you thought it was difficult to learn about the living world, The Biology Book presents key information in a clear layout. Here you'll learn about cloning, neuroscience, human evolution, and gene editing, and be introduced to the scientists who shaped these subjects, such as Carl Linnaeus, Jean-Baptiste Lamarck, Charles Darwin, and Gregor Mendel. The Big Ideas Series With millions of copies sold worldwide, The Biology Book is part of the award-winning Big Ideas series from DK. The series uses striking graphics along with engaging writing, making big topics easy to understand.