Progress in Genomic Medicine: From Research to Clinical Application provides a careful synthesis of the foundations, current trends and translational challenges in genomic medicine, clarifying pathways forward and enabling genomic medicine research and implementation across clinical settings and treatment development. Sections address the history and growth of genetic medicine, with a discussion of key studies in syndrome delineations, inherited diseases, biochemical genetics, and chromosome abnormalities, overview clinical applications made possible through genomic advances, with chapters on DNA sequencing for clinical genetic diagnosis, genotype-phenotype correlations in individuals and across populations, new-born screening for treatable genetic disorders, and more. In addition, social, ethical and public health aspects of applying genomic technologies are included throughout. Here, Dr. Smith applies her experience and participation in the field, across its major milestones, to put current research, clinical advances, and ongoing questions in context.

Emerging Plant Growth Regulators in Agriculture: Roles in Stress Tolerance presents current PGR discoveries and advances for agricultural applications, providing a comprehensive reference for those seeking to apply these tools for improved plant health and crop yield. As demand for agricultural crops and improved nutritional requirement continue to escalate in response to increasing population, plant researchers have focused on identifying scientific approaches to minimize the negative impacts of climate change on agriculture crops. Among the various applied approaches, the application of plant growth regulators (PGRs) have gained significant attention for their ability to enhance stress tolerance mechanisms. This book was developed to provide foundational and emerging information to advance the discovery of novel, cost-competitive, specific and effective PGRs for applications in agriculture.

Modelling: The Oculomotor Systems, Volume 269 in the Progress in Brain Research serial highlights new advances in the field with this new volume presenting interesting chapters on topics including The function and phylogeny of eye movements, The behavior of motoneurons, Statics of plant mechanics, Dynamics of plant mechanics, The functional operation of the vestibulo-ocular reflex, Basic framework of the vestibulo-ocular reflex, Oculomotor signals, Signal processing in the vestibulo-ocular reflex, Plasticity and repair of the vestibulo-ocular reflex, The behavior of the optokinetic system, Models of the optokinetic system, Neurophysiology of the optokinetic system, and much more.

Recent Advances and Controversies in Gamma Knife Neurosurgery, Volume 268, the latest release in the Progress in Brain Research series, highlights new advances in the field with this new volume presenting interesting chapters on the latest in Dosimetry, Radiobiology, Evolving Gamma Knife Technology, Imaging, Arteriovenous Malformations, Dural A-V Fistulae, Cavernous Malformations, Vestibular Schwannoma, Other Schwannoma, Meningiomas, Pituitary Adenomas, Craniopharyngiomas, Metastases, Glioma Low Grade, Glioma High Grade, Glomus Tumors, Less Common Tumors, Orbital Indications, Trigeminal Neuralgia, Epilepsy, Movement, Psychosurgery, and Future Trends.

Advances in Genetics, Volume 108 provides the latest information on genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Clinical applications of cancer genetics and genomics, Epigenetic mutations in childhood tumors- the paradigm of Wilms tumor, Preventive population genomics-the model of BRCA related cancers, Recent advances of PARP inhibitors in medical oncology, Role of single cell and liquid biopsy in cancer research and clinical applications. Other chapters cover Recent advances and clinical utility of prostate cancer genomics, Recent advances in lung cancer genomics- applications in targeted therapy, and more.

Deep Learning in Bioinformatics: Techniques and Applications in Practice introduces the topic in an easy-to-understand way, exploring how it can be utilized for addressing important problems in bioinformatics, including drug discovery, de novo molecular design, sequence analysis, protein structure prediction, gene expression regulation, protein classification, biomedical image processing and diagnosis, biomolecule interaction prediction, and in systems biology. The book also presents theoretical and practical successes of deep learning in bioinformatics, pointing out problems and suggesting future research directions. Dr. Izadkhah provides valuable insights and will help researchers use deep learning techniques in their biological and bioinformatics studies.

Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Volume 161 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Cannabis Exposure During Adolescence: A Uniquely Sensitive Period for Neurobiological Effects, The Stoned-Age: A Systematic Review of the Neurobiological Effects of Adolescent Cannabinoid Exposure on Preclinical Animal Models, Genetic Influences Impacting Nicotine Use and Abuse During Adolescence: Insights from Human and Animal Studies, the Impact of Adolescent Nicotine Exposure on Adulthood Alcohol Consumption: The Role of Neuropeptides, and much more. Additional chapters cover The Role of Sex in the Persistent Effects of Adolescent Alcohol Exposure on Behavior and Neurobiology in Rodents, The Effects of Peri-Adolescent Alcohol Use on the Developing Hippocampus, Regulation of Glutamate Signaling in the Extended Amygdala by Adolescent Alcohol Exposure, Peri-Adolescent Binge Drinking Effects on Hippocampal Neurogenesis, Neuroepigenetic Consequences of Adolescent Ethanol Exposure, Adolescent Neuroimmunity and Its Interaction with Alcohol, and much more.

Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.

The Volume Regulating Neuroethics: Transnational Legal challenges will focus on the new and fascinating ethical and legal challenges posed by neurotechnology and its global regulation. The Volume will address topics ranging from the foundations of neuroethics, free will and human liberty to their impact in criminal and civil liability, the legal regulation of biotechnological developments and its challenges for health, privacy and other fundamental human rights.

Climate Change and Crop Stress: Molecules to Ecosystems expounds on the transitional period where science has progressed to 'post-genomics' and the gene editing era, putting field performance of crops to the forefront and challenging the production of practical applicability vs. theoretical possibility. Researchers have concentrated efforts on the effects of environmental stress conditions such as drought, heat, salinity, cold, or pathogen infection which can have a devastating impact on plant growth and yield. Designed to deliver information to combat stress both in isolation and through simultaneous crop stresses, this edited compilation provides a comprehensive view on the challenges and impacts of simultaneous stresses.

Advances in Agronomy, Volume 170, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Radiation-Processed Polysaccharides: Emerging Roles in Agriculture is the first book to focus exclusively on this emerging and important option for reducing the overuse and negative impact of agrochemicals in agriculture. Among practices being developed for effective and eco-friendly plant growth regulators in crop production, using radiation-processed polysaccharides (RPPs) is a promising technique. Comprised of chapters from diverse areas of plant science, including agriculture, agronomy, biotechnology, nanotechnology, molecular biology, and radiation agriculture, this book provides insights into the practical application of RPPs and inspires further research toward sustainable and efficient agricultural production. Polysaccharides (sodium alginate, carrageenan, chitosan and others) in their depolymerized state are increasingly important to agriculture based on their unique biological properties, biocompatibility, biodegradability and non-toxicity. Understanding the impact of RPPs on the plant phenotype, translocation of nutrients from source to sink, signal processing, and crosstalk helps improve the applicability of RPPs and sustainable agricultural yield.

Nearly 44 million people have Alzheimer's or related dementia worldwide, according to the Alzheimer's Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer's and other forms of dementia. First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer's disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer's disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer's diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer's disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer's disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.

Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice.

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.

Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS: Part II, Volume 161, in the International Review on Neurobiology serial highlights new advances, with this volume presenting chapters on topics including Introduction to Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Peri-adolescent Exposure to (Meth)amphetamine in Animal Models, The Impact of Adolescent Nicotine Exposure on Alcohol Use During Adulthood: The Role of Neuropeptides, Cannabis Exposure During Adolescence: A uniquely Sensitive Period for Neurobiological Effects, The Stoned Age: Sex Differences in the Effects of Adolescent Cannabinoid Exposure on Prefrontal Cortex Structure and Function in Animal Models, and more.

The Rise of Chance in Evolutionary Theory: A Pompous Parade of Arithmetic explores a pivotal conceptual moment in the history of evolutionary theory: the development of its extensive reliance on a wide array of concepts of chance. It tells the history of a methodological and conceptual development that reshaped our approach to natural selection over a century, ranging from Darwin's earliest notebooks in the 1830s to the early years of the Modern Synthesis in the 1930s. Far from being a "pompous parade of arithmetic," as one early critic argued, evolution transformed during this period to make these conceptual and technical tools indispensable. This book charts the role of chance in evolutionary theory from its beginnings to the earliest days of modern evolutionary theory, making it an ideal resource for evolutionary biologists, historians, philosophers, and researchers in science studies or biological statistics.

MRI with hyperpolarized carbon-13 agents is a powerful emerging imaging modality that can measure real-time metabolism in cells, animals, and humans. It uses endogenous, non-toxic contrast agents that a hyperpolarized, resulting in up to 100,000-fold increases in sensitivity. This technique uses no ionizing radiation, and is being applied in a range of human trials. It's primary use is for metabolic imaging, but it can also measure perfusion, pH, and necrosis. Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy is designed to be a one stop shop for understanding hyperpolarized 13C MRI. This book explains the principles of this imaging modality, the requirements for performing studies, shows how to interpret the results, and gives an overview of current biomedical applications. It is suitable for engineers, scientists and clinicians in radiology and biomedical imaging who want to understand this technology.

Nitrogen Assessment: Pakistan as a Case-Study provides a detailed overview of issues and challenges related to nitrogen use and overuse, thus serving as a reference for researchers in Pakistan and providing important insights for other geographic regions. Excess and inefficient nitrogen use in crops and livestock sectors is polluting our rivers, seas, atmosphere, and ecosystems, contributing to climate change, hampering biodiversity, and contributing to stratospheric ozone depletion. This book covers the importance of nitrogen in relation to food security, human health, and economic stability in South Asia. It also discusses nitrogen status, sources, sinks, and drivers of nitrogen use in Pakistan, focusing on current nitrogen measures and policies. Nitrogen pollution is one of the biggest challenges of 21st Century, and the international scientific community is beginning to recognize the significance of nitrogen pollution and to explore how to combat it. The editors' institution, University of Agriculture, Faisalabad, partners with South Asia Nitrogen Hub, which includes about 30 organizations from South Asia and UK working on nitrogen assessment, budgeting, awareness, and policy guidance, as well as possible measures to reduce nitrogen pollution. Nitrogen Assessment: Pakistan as a Case-Study provides an important guide to this work and is written in a way that is accessible to an audience with a wide range of experience from advanced students to seasoned researchers.

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

International Review of Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.