It is widely acknowledged that life has adapted to its environment, but the precise mechanism remains unknown since Natural Selection, Descent with Modification and Survival of the Fittest are metaphors that cannot be scientifically tested. In this unique text, invertebrate and vertebrate biologists illuminate the effects of physiologic stress on epigenetic responses in the process of evolutionary adaptation from unicellular organisms to invertebrates and vertebrates, respectively. This book offers a novel perspective on the mechanisms underlying evolution. Capacities for morphologic alterations and epigenetic adaptations subject to environmental stresses are demonstrated in both unicellular and multicellular organisms. Furthermore, the underlying cellular-molecular mechanisms that mediate stress for adaptation will be elucidated wherever possible. These include examples of 'reverse evolution' by Professor Guex for Ammonites and for mammals by Professor Torday and Dr. Miller. This provides empiric evidence that the conventional way of thinking about evolution as unidirectional is incorrect, leaving open the possibility that it is determined by cell-cell interactions, not sexual selection and reproductive strategy. Rather, the process of evolution can be productively traced through the conservation of an identifiable set of First Principles of Physiology that began with the unicellular form and have been consistently maintained, as reflected by the return to the unicellular state over the course of the life cycle.

This book provides a broad overview how extremophiles can be used in biotechnology, including for the production and degradation of compounds. It reviews various recent discoveries and applications related to a large variety of extremophiles, considering both prokaryotes as well as eukaryotes.

This book provides a comprehensive and authoritative review of the chemical analysis of UV filters in coastal waters and their impact on the marine environment. The sun care is today the most important sector within the cosmetics industry, with annual increases in sales. The main components of sunscreens, organic and inorganic UV filters, have been detected in many coastal regions, with the highest concentrations in coastal areas under high anthropogenic pressure. Moreover, these compounds have been found to be bioaccumulated in aquatic biota causing biological and toxicological responses; some organic UV filters act as endocrine disruptors in aquatic biota, affecting survival, behavior, growth, development and reproduction. On the other hand, inorganic UV filters, mainly based on nanoparticles, have been demonstrated to have various impacts on marine organisms, such as inducing oxidative stress in abalones, accumulating in microalgae, affecting the immune response in mussels, bleaching corals, and genotoxicity in fish, among others. All these effects of sunscreens on the marine environment highlight the need for more stringent and environmentally friendly regulations. This book covers the latest analytical methodologies used in assessing the impact of UV filters impact on marine waters, especially on marine biota, and also critiques the global regulation of UV filters and the environmental risk of using sunscreens. Featuring specific case studies of the environmental effects of sunscreens in the Mediterranean Sea and Hawaii, which highlight the importance of balancing human health with environmental health of coastal ecosystems, it will appeal not only to scientists and students from various disciplines (environmental chemistry, biology, ecology, biogeochemistry, fisheries and climate change among others), but also to environmental managers wanting to promote new restrictive regulations on the use of UV filters, and to professionals from the cosmetic industry interested in the development of eco-friendly sunscreens.

A unique chronology with entries describing the key events in the 3,000-year conflict between religion and science over the explanation and definition of life on Earth. Exhaustively researched and authoritative, Chronology of the Evolution-Creationism Controversy does what no other work does: it examines the conflict between the religious and scientific views of life on Earth in its full 3,000-year historical context, showing readers how this roiling debate has played out over the centuries. With hundreds of entries, Chronology of the Evolution-Creationism Controversy describes specific cultural, religious, and scientific events relevant to the evolution-creationism controversy from the first notions of creationism in ancient Egypt to the present. Within this historical approach, it identifies a number of recurring themes that have shaped the debate through the ages, including famous court cases, the recurrence of the "intelligent design" argument, disagreements over the age of the Earth, and the impact of technological advances on both the scientific and faith-based viewpoints. While approaching the subject globally throughout, the book's second half focuses on tensions between science and religious thought in the United States since the early 1900s. Comprises over 1,400 chronologically arranged entries on important political, legal, and social events in the ongoing controversy between science- and faith-based views of the Earth and life Offers a thorough bibliography spanning historical aspects of the controversy, creationist literature, and resources from evolutionary biology Includes a one-of-a-kind glossary for easy access to definitions of relevant terms used by both anti-evolutionists and scientists Provides an extensive index serving as a reference tool and as a way to explore recurring themes Presents detailed appendices on estimating Earth's age, the geologic timescale, major species of known Hominines, and key legal decisions involving the teaching of evolution and creationism

This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.

Air pollution is an alarming problem, not only in terms of air quality, but also in relation to health issues. Toxic air pollutant concentrations produce harmful impacts on plant health and human health. Further, though there are various sources of air pollution, anthropogenic and biogenic sources are becoming increasingly problematic. A number of control methods have been applied to reduce the air pollutant concentrations so that their global environmental burden on plants as well as humans can be mitigated. However, as confirmed in numerous reports and studies, their concentrations continue to be very high and everyday cases related to air pollution have become exponentially high not only in developing countries but also in developed countries. In plants, toxic air quality has various adverse effects, including biochemical and physiological disorders, chronic diseases and/or lower yields. In humans, air pollutants affect the body's metabolism and immune system, lungs and central nervous system. This book provides an essential overview of air pollution, its impacts on plant and human health, and potential control strategies. The respective chapters cover general monitoring and characterization techniques for air pollutants, air quality modelling applications, plant and human health effects, risk assessment, and air pollution control policy. Given its scope, the book offers a valuable and unique resource for students of Environmental Science, Biological Science, Medical Science and Agriculture; and for environmental consultants, researchers and other professionals whose work involves air quality, plant and human related research.

This book provides hands-on conceptual, theoretical, and case study discussions on vulnerability and resilience in the global south. This book covers the core of adaptation strategies in developing countries context in an easy-to-follow theoretical and empirical examples. This book shares contemporary approaches on vulnerability, adaptation strategies, and resilience, which aim to assist its targeted audience (academics, policymakers, and practitioners) to understand and make informed decisions in a wide variety of real-world resilience situations.

The book discusses the complex interactions between plants and their associated microbial communities. It also elucidates the ways in which these microbiomes are connected with the plant system, and how they affect plant health. The different chapters describe how microbiomes affect plants with regard to immunity, disease conditions, stress management and productivity. In addition, the book describes how an 'additional plant genome' functions as a whole organ system of the host, and how it presents both challenges and opportunities for the plant system. Moreover, the book includes a dedicated section on using omics tools to understand these interactions, and on exploiting them to their full potential.

Fritz Muller (1821-1897), though not as well known as his colleague Charles Darwin, belongs in the cohort of great nineteenthcentury naturalists. In Darwin's Man in Brazil, David A. West recovers Muller's legacy. He describes the close intellectual kinship between Muller and Darwin, detailing a lively correspondence spanning seventeen years, in which the two men often discussed new research topics and exchanged ideas. Darwin frequently praised Muller's powers of observation and interpretation, counting him among those scientists whose opinions he valued most. A free thinker who refused to sign the Christian oaths required of teachers in Prussia, Muller emigrated to Brazil in 1852 to become a pioneer farmer researching tropical biology. In the 1860s he reorganized his biological research in order to test Darwin's theory of evolution. Conducting field studies to answer questions generated from a Darwinian perspective, Muller was unique among naturalists testing Darwin's theory of natural selection because he investigated an enormous diversity of plants and animals rather than a relatively narrow range of taxa. Despite the importance and scope of his work, however, Muller is known for relatively few of his discoveries. West remedies this oversight, chronicling the life and work of this remarkable and overlooked man of science.

This book examines what seems to be the basic challenge in neuroscience today: understanding how experience generated by the human brain is related to the physical world we live in. The 25 short chapters present the argument and evidence that brains address this problem on a wholly trial and error basis. The goal is to encourage neuroscientists, computer scientists, philosophers, and other interested readers to consider this concept of neural function and its implications, not least of which is the conclusion that brains don't "compute."

Darwin takes a look at the life of this incredible man, from his birth, his ground-breaking publications and far-flung travels, Darwinism and his theories on evolution, all the way to his final days. Over 160 stunning images and illustrations are included within Darwin, ranging from personal diary entries (such as those he made when deciding whether to marry or not), letters and handwritten notes, as well as sketches from Darwin's famous works. Revealing the famous scientist's life in compelling detail, Darwin covers not only his scientific career and On the Origin of Species but his personal struggles also, allowing us to see what truly made the man.

This book offers an essential introduction to the latest advances in delayed genetic regulatory networks (GRNs) and presents cutting-edge work on the analysis and design of delayed GRNs in which the system parameters are subject to uncertain, stochastic and/or parameter-varying changes. Specifically, the types examined include delayed switching GRNs, delayed stochastic GRNs, delayed reaction-diffusion GRNs, delayed discrete-time GRNs, etc. In addition, the solvability of stability analysis, control and estimation problems involving delayed GRNs are addressed in terms of linear matrix inequality or M-matrix tests. The book offers a comprehensive reference guide for researchers and practitioners working in system sciences and applied mathematics, and a valuable source of information for senior undergraduates and graduates in these areas. Further, it addresses a gap in the literature by providing a unified and concise framework for the analysis and design of delayed GRNs.

This book shows how to decompose high-dimensional microarrays into small subspaces (Small Matryoshkas, SMs), statistically analyze them, and perform cancer gene diagnosis. The information is useful for genetic experts, anyone who analyzes genetic data, and students to use as practical textbooks.Discriminant analysis is the best approach for microarray consisting of normal and cancer classes. Microarrays are linearly separable data (LSD, Fact 3). However, because most linear discriminant function (LDF) cannot discriminate LSD theoretically and error rates are high, no one had discovered Fact 3 until now. Hard-margin SVM (H-SVM) and Revised IP-OLDF (RIP) can find Fact3 easily. LSD has the Matryoshka structure and is easily decomposed into many SMs (Fact 4). Because all SMs are small samples and LSD, statistical methods analyze SMs easily. However, useful results cannot be obtained. On the other hand, H-SVM and RIP can discriminate two classes in SM entirely. RatioSV is the ratio of SV distance and discriminant range. The maximum RatioSVs of six microarrays is over 11.67%. This fact shows that SV separates two classes by window width (11.67%). Such easy discrimination has been unresolved since 1970. The reason is revealed by facts presented here, so this book can be read and enjoyed like a mystery novel. Many studies point out that it is difficult to separate signal and noise in a high-dimensional gene space. However, the definition of the signal is not clear. Convincing evidence is presented that LSD is a signal. Statistical analysis of the genes contained in the SM cannot provide useful information, but it shows that the discriminant score (DS) discriminated by RIP or H-SVM is easily LSD. For example, the Alon microarray has 2,000 genes which can be divided into 66 SMs. If 66 DSs are used as variables, the result is a 66-dimensional data. These signal data can be analyzed to find malignancy indicators by principal component analysis and cluster analysis.

Rock surfaces provide a challenging habitat for a broad diversity of micro- or small-sized organisms. They interact with each other forming complex communities as well with their substrate causing biodeterioration of rock. Extreme fluctuation in light, temperature and hydration are the main factors that determine the rock surface habitats. The habitat includes epilithic organisms which thrive on the surface without penetrating the rock, endolithic organisms which live just beneath the surface using a thin layer of the rock surface for protection against adverse conditions of the environment (e.g. light protection, storage of water) and chasmo-endolithic organisms which use fractures of the rock surface for a more habitable environment. The book will provide an overview of the various organismal groups, from prokaryotes to vascular plants and arthropods, as well as survey organism-mediated interactions with the rock surface. The latter include biogenic weathering (biogeochemistry, state-of-the art imaging methods), photosynthesis and nitrogen fixation at and inside the rock surface.

This volume presents the first collection of essays dedicated to the science fiction of microbiologist Joan Slonczewski. Posthuman Biopolitics consolidates the scholarly literature on Slonczewski's fiction and demonstrates fruitful lines of engagement for the critical, cultural, and theoretical treatment of her characters, plots, and storyworlds. Her novels treat feminism in relation to scientific practice, resistance to domination, pacifism versus militarism, the extension of human rights to nonhuman and posthuman actors, biopolitics and posthuman ethics, and symbiosis and communication across planetary scales. Posthuman Biopolitics explores the breadth and depth of Joan Slonczewski's vision, uncovering the reflective ethical practice that informs her science fiction.

This book reviews the globally important freshwater resource of the Great Lakes, which is currently threatened by contaminants that compromise water quality and impact its ecological and economic health. Divided into four parts, this volume covers historic, current and emerging sources of contamination from heavy metals and persistent organic pollutants to microplastics; and identifies their ecological impacts. Due to factors ranging from rapidly changing land use practices, climate change and our emerging understanding of their impact on biological, chemical and physical interactions, the effectiveness of management strategies has proven highly variable. Continued enhancements in the rate of lake recovery are required to sustain the health of the Great Lakes. Accordingly, the book also explores recent advances in contaminant detection, along with future steps forward in lake management approaches. Revealing our current knowledge gaps and providing a roadmap towards sustainable solutions, the book offers a valuable asset for scientists, managers and the public alike.

This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.