This volume is the second part of the thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists, brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

Dramatic advances in computing power enable simulation of DNA sequences generated by complex microevolutionary scenarios that include mutation, population structure, natural selection, meiotic recombination, demographic change, and explicit spatial geographies. Although retrospective, coalescent simulation is computationally efficient-and covered here-the primary focus of this book is forward-in-time simulation, which frees us to simulate a wider variety of realistic microevolutionary models. The book walks the reader through the development of a forward-in-time evolutionary simulator dubbed FORward Time simUlatioN Application (FORTUNA). The capacity of FORTUNA grows with each chapter through the addition of a new evolutionary factor to its code. Each chapter also reviews the relevant theory and links simulation results to key evolutionary insights. The book addresses visualization of results through development of R code and reference to more than 100 figures. All code discussed in the book is freely available, which the reader may use directly or modify to better suit his or her own research needs. Advanced undergraduate students, graduate students, and professional researchers will all benefit from this introduction to the increasingly important skill of population genetic simulation.

This volume of Progress in Molecular Biology and Translational Science introduces emerging strategies of studying RNA structure and function using nanotechnological tools. The volume aims to provide the readers with a novel view and give them opportunities to think about how to incorporate the new technologies into their own research.

Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

Ending hunger, achieving food security and promoting sustainable development are at the top of the list of United Nations (UN) sustainable global development priorities. In the times of high population growth and increasing pressure of agricultural systems, efficiency in use of natural resources has been at the epicenter of sustainable agricultural. The concept of 'Input efficiency' implies production of high quantity and quality of food, from using only finite natural resources as inputs, in the form of mainly land, water, nutrients, energy, or biological diversity. In this book, editors provide a roadmap to the food, nutritional, and environmental security in the agricultural systems. They share insight into the approaches that can be put in practice for increasing the input use efficiency in the cropping systems and achieve stability and sustainability of agricultural production systems. This book is of interest to teachers, researchers, climate change scientists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, agroforestry, agroecology, and environmental sciences. National and international agricultural scientists, policymakers will also find this to be a useful read.

Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

This volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action. Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds.

Consequences of Intracellular Amyloid in Alzheimer's Disease addresses one of the more currently unresolved aspects confounding Alzheimer's research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D'Andrea's first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer's Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in neuronal cells, and includes sections on such topics as actin transport in axons and neurofilament transport.

Perception of Pixelated Images covers the increasing use of these images in everyday life as communication, socialization, and commerce increasingly rely on technology. The literature in this book is dispersed across a wide group of disciplines, from perception and psychology to neuroscience, computer science, engineering, and consumer science. The book summarizes the research to date, answering such questions as, What are the spatial and temporal limits of perceptual discrimination of pixelated images?, What are the optimal conditions for maximizing information extracted from pixelated images?, and How does the method of pixelation compromise or assist perception?

This book offers a new theoretical framework within which to understand "the mind-body problem". The crux of this problem is phenomenal experience, which Thomas Nagel famously described as "what it is like" to be a certain living creature. David Chalmers refers to the problem of "what-it-is-like" as "the hard problem" of consciousness and claims that this problem is so "hard" that investigators have either just ignored the issue completely, investigated a similar (but distinct) problem, or claimed that there is literally nothing to investigate - that phenomenal experience is illusory. This book contends that phenomenal experience is both very real and very important. Two specific "biological naturalist" views are considered in depth. One of these two views, in particular, seems to be free from problems; adopting something along the lines of this view might finally allow us to make sense of the mind-body problem. An essential read for anyone who believes that no satisfactory solution to "the mind-body problem" has yet been discovered.

The most comprehensive and practical guide available for caregivers of children who have seizures and epilepsy, now completely updated. For more than 30 years, parents, caregivers, and health care providers have trusted Seizures and Epilepsy in Children to provide comprehensive, science-based information and practical answers to the most common questions about these conditions. In this new edition, completely revised and updated, a team of experts from Johns Hopkins Medicine offers guidance on: * diagnostic testing and the latest treatments * recommendations for the best devices, apps, and websites * driving, health insurance, and playing sports * navigating school and other environments * mental health issues and counseling * coping with disability * side effects from medications This new edition also features dedicated chapters on diet, complementary and alternative medicine, and rescue medicines. Seizures and Epilepsy in Children is the go-to resource for caregivers and families with children who have epilepsy and seizures.

Antimicrobial Food Packaging takes an interdisciplinary approach to provide a complete and robust understanding of packaging from some of the most well-known international experts. This practical reference provides basic information and practical applications for the potential uses of various films in food packaging, describes the different types of microbial targets (fungal, bacteria, etc.), and focuses on the applicability of techniques to industry. Tactics on the monitoring of microbial activity that use antimicrobial packaging detection of food borne pathogens, the use of biosensors, and testing antimicrobial susceptibility are also included, along with food safety and good manufacturing practices. The book aims to curtail the development of microbiological contamination of food through anti-microbial packaging to improve the safety in the food supply chain.

Endocannabinoids, the latest volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into the neurobiology of migraines. It reviews the current knowledge and understanding in the field, and provides a starting point for researchers and practitioners entering the field.

Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD.

This book is an inclusive coverage of advances in aquaculture health management. It offers latest updates as well as explains the novel concepts and issues related to aquatic animal health management. To support the understanding of the concepts, there is extensive use of illustrations. Chapters emphasize on the state of art techniques and hold great promise for the sustainable development of aquaculture. This book is of interest to teachers, researchers, aquatic biologists, capacity builders and policymakers. Also the book serves as additional reading material for undergraduate and graduate students of aquatic sciences, marine sciences, biotechnology, ecology, and environmental sciences. National and international aquatic scientists, policy makers will also find this to be a useful read.