Comprises four parts, the first of which provides an overview of the topics that are developed from fundamental principles to more advanced levels in the other parts. Presents in the second part an in-depth introduction to the relevant background in molecular and cellular biology and in physical chemistry, which should be particularly useful for students without a formal background in these subjects. Provides in the third part a detailed treatment of microscopy techniques and optics, again starting from basic principles. Introduces in the fourth part modern statistical approaches to the determination of parameters of interest from microscopy data, in particular data generated by single molecule microscopy experiments. Uses two topics related to protein trafficking (transferrin trafficking and FcRn-mediated antibody trafficking) throughout the text to motivate and illustrate microscopy techniques

The only book to take a really broad look at literature and emotion from a variety of perspectives including neuroscience Section on theory introduces the more complex areas of affect theory and cognitive science so people can understand throughout the book Looks at a wide variety of literature but also features commonly studied writers such as Shakespeare, Chaucer, Austen and Woolf

Encyclopedia of Cancer, Third Edition, Three Volume Set provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented.

Designed primarily as an introduction to realistic modeling methods, Computational Neuroscience: Realistic Modeling for Experimentalists focuses on methodological approaches, selecting appropriate methods, and identifying potential pitfalls. The author addresses varying levels of complexity, from molecular interactions within single neurons to the processing of information by neural networks. He avoids theoretical mathematics and provides just enough of the basic math used by experimentalists.

What makes this resource unique is the inclusion of a CD-ROM that furnishes interactive modeling examples. It contains tutorials and demos, movies and images, and the simulation scripts necessary to run the full simulation described in the chapter examples. Each chapter covers: the theoretical foundation; parameters needed; appropriate software descriptions; evaluation of the model; future directions expected; examples in text boxes linked to the CD-ROM; and references.

The first book to bring you cutting-edge developments in neuronal modeling. It provides an introduction to realistic modeling methods at levels of complexity varying from molecular interactions to neural networks. The book and CD-ROM combine to make Computational Neuroscience: Realistic Modeling for Experimentalists the complete package for understanding modeling techniques.

This book introduces acoustic wave theories using a reader-friendly matrix-based linear algebra approach. It will enable the reader to take advantage of software tools such as MATLAB (commercial codes) and OCTAVE (open-source codes) to gain better and deeper understanding of the underlying physics quickly. In this aspect, this text can be regarded as a practical introduction of the acoustic wave theories in an easy-to-follow linear algebra format using matrix manipulations instead of an abstract approach relying on tensor manipulations. The book also uses case studies to demonstrate how the fundamentals on acoustic waves discussed throughout the book are applied in device designs and analyses such that the connections and interdependences between the underlying sciences and the observed behavior and performances can be better appreciated by the reader. To achieve this, all problems for illustrations, examples, case studies, and device analyses are developed and solved based on the mathematical foundations laid out in the book.

This book considers the natural history and cultural symbolism of a most unusual woodpecker - a species that neither excavates nest holes in trees, nor bores into wood to find insect prey. The Wryneck is best renowned for performing a twisting, writhing head and neck display when threatened, but this ground-breaking work reveals many more secrets of its behaviour and evolution. Detailed information is presented on the species' origins, taxonomy, anatomy, appearance, moult, calls, distribution, conservation status, habitats, movements, breeding, diet and relationships, along with a chapter on its closest relative, the Red-throated Wryneck. The text is richly illustrated throughout with high quality photographs as well as sound spectrograms. The author augments his many hours watching Wrynecks with comprehensive literature research, creating what is surely the definitive volume on the species. This all-encompassing and engaging account has been written for a wide audience, whether professional ornithologist, citizen scientist, amateur birder, woodpecker aficionado or simply someone who wishes to learn more about this curious and remarkable bird.

Learning and Memory provides a balanced review of the core methods and the latest research on animal learning and human memory. Topical coverage ranges from the basic and central processes of learning, including classical and instrumental conditioning and encoding and storage in long-term memory, to topics not traditionally covered, such as spatial learning, motor skills, and implicit memory. The general rules of learning are reviewed along with the exceptions, limitations, and best applications of these rules. Alternative approaches to learning and memory, including cognitive, neuroscientific, functional, and behavioral, are also discussed. Individual differences in age, gender, learning abilities, and social and cultural background are explored throughout the text and presented in a dedicated chapter. The relevance of basic principles is highlighted throughout the text with everyday examples that ignite reader interest in addition to more traditional examples from human and animal laboratory studies. Research examples are drawn from education, neuropsychology, psychiatry, nursing, and ecological (or everyday) memory. Each chapter begins with an outline and concludes with a detailed summary. Applications and extensions are showcased in text boxes as well as in distinct applications sections in every chapter, and review and recapitulation sections are interspersed throughout the chapters.

MXenes offer single step processing, excellent electrical conductivity, easy heat dissipation behavior, and capacitor-like properties and are used in photodetectors, lithium-ion batteries, solar cells, photocatalysis, electrochemiluminescence sensors, and supercapacitors. Because of their superior electrical and thermal conductivities, these composites are an ideal choice in electromagnetic interference (EMI) shielding. MXene Nanocomposites: Design, Fabrication, and Shielding Applications presents a comprehensive overview of these emerging materials, including their underlying chemistry, fabrication strategies, and cutting-edge applications in EMI shielding. * Covers modern fabrication technologies, processing, properties, nanostructure formation, and mechanisms of reinforcement. * Discuss biocompatibility, suitability, and toxic effects. * Details innovations, applications, opportunities, and future directions in EMI shielding applications. This book is aimed at researchers and advanced students in materials science and engineering and is unique in its detailed coverage of MXene-based polymer composites for EMI shielding.

Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Food Packaging: Advanced Materials, Technologies, and Innovations is a one-stop reference for packaging materials researchers working across various industries. With chapters written by leading international researchers from industry, academia, government, and private research institutions, this book offers a broad view of important developments in food packaging. Presents an extensive survey of food packaging materials and modern technologies Demonstrates the potential of various materials for use in demanding applications Discusses the use of polymers, composites, nanotechnology, hybrid materials, coatings, wood-based, and other materials in packaging Describes biodegradable packaging, antimicrobial studies, and environmental issues related to packaging materials Offers current status, trends, opportunities, and future directions Aimed at advanced students, research scholars, and professionals in food packaging development, this application-oriented book will help expand the reader's knowledge of advanced materials and their use of innovation in food packaging.

Biological Psychology is the study of psychological processes in terms of biological functions. A major obstacle to understanding dialogue in the field has always been its terminology which is drawn from a variety of non-psychological sources such as clinical medicine, psychiatry and neuroscience, as well as specialist areas of psychology such as ethology, learning theory and psychophysics. For the first time, a distinguished international team of contributors has now drawn these terms together and defined them both in terms of their physical properties and their behavioural significance.
The Dictionary of Biological Psychology will prove an invaluable source of reference for undergraduates in psychology wrestling with the fundamentals of brain physiology, anatomy and chemistry, as well as researchers and practitioners in the neurosciences, psychiatry and the professions allied to medicine. It is an essential resource both for teaching and for independent study, reliable for fact-checking and a solid starting point for wider exploration.

eBook available with sample pages: 0203298845

We are in the midst of what is being called the 'psychedelic renaissance' with growing interest into how psychedelics alter consciousness, brain function and brain connectivity. The acute, often profound, effects of the psychedelic experience can induce lasting improvements in mental health demonstrating that chemistry forms the basis of mystical experience, consciousness and mental wellbeing.

Software Simulation and Modeling in Psychology: MATLAB, SPSS, Excel and E-Prime describes all the stages of psychology experimentation, from the manipulation of factors, to statistical analysis, data modeling, and automated stimuli creation. The book shows how software can help automate various stages of the experiment for which operations may quickly become repetitive. For example, it shows how to compile data files (instead of opening files one by one to copy and paste), generate stimuli (instead of drawing one by one in a drawing software), and transform and recode tables of data. This type of modeling in psychology helps determine if a model fits the data, and also demonstrates that the algorithmic is not only useful, but essential for modeling data.

Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more.

Imaging in Movement Disorders: Imaging in Atypical Parkinsonism and Familial Movement Disorders, Volume 142, addresses the use of imaging modalities across the spectrum of movement disorders and dementias. Over the last decades, advances in neuroimaging tools have played a pivotal role in expanding our understanding of disease aetiology and pathophysiology, identifying biomarkers to monitor disease progression, aiding differential diagnosis and in the identification of novel targets for therapeutic intervention. This updated volume covers PET Molecular Imaging in Atypical Parkinsonism, SPECT Molecular Imaging in Atypical Parkinsonism, Structural MRI in Atypical Parkinsonism, Functional MRI in Atypical Parkinsonism, and more.

Most brain related activity has focussed on specialized interests within individual disciplines. Recent multidisciplinary activity has provided the impetus to break down these boundaries and encourage a freer exchange of information across disciplines. This text reflects these developments. It spans the landscape of brain science to provide core information from 12 disciplines (including evolution, philosophy, anatomy, chemistry, computer science, brain dynamics, psychology, neurology, psychiatry, psychotherapy and brain imaging).
In outlining how and why it is now possible to realistically model aspects of the brain's dynamics from such a wide range of intellectual endeavors, this book will prove itself useful to undergraduates, postgraduates and all those seeking a contemporary perspective and evaluation of the current status and future directions in the brain sciences.

Recent work in cognitive science, much of it placed in opposition to a computational view of the mind, has argued that the concept of representation and theories based on that concept are not sufficient to explain the details of cognitive processing. These attacks on representation have focused on the importance of context sensitivity in cognitive processing, on the range of individual differences in performance, and on the relationship between minds and the bodies and environments in which they exist. In each case, models based on traditional assumptions about representation have been assumed to be too rigid to account for the effects of these factors on cognitive processing. In place of a representational view of mind, other formalisms and methodologies, such as nonlinear differential equations (or dynamical systems) and situated robotics, have been proposed as better explanatory tools for understanding cognition.
This book is based on the notion that, while new tools and approaches for understanding cognition are valuable, representational approaches do not need to be abandoned in the course of constructing new models and explanations. Rather, models that incorporate representation are quite compatible with the kinds of complex situations being modeled with the new methods. This volume illustrates the power of this explicitly representational approach--labeled "cognitive dynamics"--in original essays by prominent researchers in cognitive science. Each chapter explores some aspect of the dynamics of cognitive processing while still retaining representations as the centerpiece of the explanations of the key phenomena. These chapters serve as an existence proof that representation is not incompatible with the dynamics of cognitive processing. The book is divided into sections on foundational issues about the use of representation in cognitive science, the dynamics of low level cognitive processes (such as visual and auditory perception and simple lexical priming), and the dynamics of higher cognitive processes (including categorization, analogy, and decision making).

A complete restructuring and updating of the classic 1982 Handbook of Chemical Property Estimation Methods (commonly known as "Lyman's Handbook"), the Handbook of Property Estimation Methods for Chemicals: Environmental and Health Sciences reviews and recommends practical methods for estimating environmentally important properties of organic chemicals. One of the most eagerly anticipated revisions in scientific publishing, the new Handbook includes both a foreword and a chapter by Dr. Lyman.
Written for convenient and frequent use, each chapter integrates recent developments while retaining the elements that made the first version a classic. As a reference tool, the New Edition is indispensable. It comprehensively reviews recent developments in chemical property estimation methods and focuses on the properties most critical to environmental fate assessment.

Advances in Petrochemical Engineering and Green Development is a compilation of selected papers from the 3rd International Conference on Petrochemical Engineering and Green Development (ICPEGD 2022) and focuses on the research of petrochemical engineering. The proceedings features the most cutting-edge research directions and achievements related to geology and green development. Subjects in this proceedings include: Petroleum and Petrochemical Engineering Fossil Technologies Oil & Gas Production Renewable Energy Sources and Technology Green Synergy Innovation Urban Crisis Management The collection of papers in this proceedings will promote the development of petrochemical industry and energy, resource sharing, flexibility and high efficiency. Thereby, it will promote scientific information interchange between scholars from top universities, research centers and high-tech enterprises working all around the world.

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume I, Part 1 covers fundamental topics such as the basic principles of ion permeation and selectivity, voltage-dependent, ligand-dependent and mechano-dependent ion channel activation mechanisms, the mechanisms for ion channel desensitization and inactivation and basic ion channel pharmacology and inhibition. Volume I, Part 2 aims to offer a practical guide of cardinal methods for researching ion channels, including heterologous expression and voltage-clamp and patch-clamp electrophysiology, isolation of native currents using patch-clamp, modelling ion channel gating, structures and its dynamics, crystallography and cryo- electron microscopy, fluorescence and paramagnetic resonance spectroscopy methods and genetics approaches in model organisms. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

This book provides an introduction to the significant role of physics in evolution, based on the ideas of matter and energy resource flow, organism self-copying, and ecological change. The text employs these ideas to create quantitative models for important evolutionary processes. Many fields of science and engineering have come up against the problem of complex design-when details become so numerous that computer power alone cannot make progress. Nature solved the complex-design problem using evolution, yet how it did so has been a mystery. Both laboratory experiments and computer-simulation attempts eventually stopped evolving. Something more than Darwin's ideas of heredity, variation, and selection was needed. The solution is that there is a fourth element to evolution: ecological change. When a new variation is selected, this can change the ecology, and the new ecology can create new opportunities for even more new variations to be selected. Through this endless cycle, complexity can grow automatically. This book uses the physics of resource flow to describe this process in detail, developing quantitative models for many evolutionary processes, including selection, multicellularity, coevolution, sexual reproduction, and the Serengeti Rules. The text demonstrates that these models are in conceptual agreement with numerous examples of biological phenomena, and reveals, through physics, how complex design can arise naturally. This will serve as a key text on the part physics plays in evolution, and will be of great interest to students at the university level and above studying biophysics, physics, systems biology, and related fields.

The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain's cognitive system, the Brain's motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

Evolutionary Psychiatry challenges a medical model which has supplied few effective answers to long-standing conundrums. A comprehensive introduction to the new science of Darwinian Psychiatry, this second edition includes important fresh material on a number of disorders, along with an entirely new chapter on research.
Anthony Stevens and John Price argue that psychiatric symptoms are manifestations of ancient adaptive strategies which are no longer necessarily appropriate but which can best be understood and treated in an evolutionary and developmental context. Particularly important are the Stevens and Price propose to account for the worldwide existence of mood disorders and schizophrenia, as well as offering solutions for such puzzles as paedophilia, sado masochism and the function of dreams.
Readily accessible to both the specialist and non-specialist reader, Evolutionary Psychiatry describes in detail the disorders and conditions commonly encountered in psychiatric practice and shows how evolutionary theory can account for their biological origins and functional nature.

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In this eye-opening chronicle of scientific research on the brain in the early Cold War era, the acclaimed historian Andreas Killen traces the complex circumstances surrounding the genesis of our present-day fascination with this organ. The 1950s were a transformative, even revolutionary decade in the history of brain science. Using new techniques for probing brain activity and function, researchers in neurosurgery, psychiatry, and psychology achieved dramatic breakthroughs in the treatment of illnesses like epilepsy and schizophrenia, as well as the understanding of such faculties as memory and perception. Memory was the site of particularly startling discoveries. As one researcher wrote to another in the middle of that decade, “Memory was the sleeping beauty of the brain—and now she is awake.” Collectively, these advances prefigured the emergence of the field of neuroscience at the end of the twentieth century. But the 1950s also marked the beginning of the Cold War and a period of transformative social change across Western society. These developments resulted in unease and paranoia. Mysterious new afflictions—none more mystifying than “brainwashing”—also appeared at this time. Faced with the discovery that, as one leading psychiatrist put it, “the human personality is not as stable as we often assume,” many researchers in the sciences of brain and behavior joined the effort to understand these conditions. They devised ingenious and sometimes transgressive experimental methods for studying and proposing countermeasures to the problem of Communist mind control. Some of these procedures took on a strange life of their own, escaping the confines of the research lab to become part of 1960s counterculture. Much later, in the early 2000s, they resurfaced in the War on Terror. These stories, often told separately, are brought together by the historian Andreas Killen in this chronicle of the brain’s mid-twentieth-century emergence as both a new research frontier and an organ whose integrity and capacities—especially that of memory—were imagined as uniquely imperiled in the 1950s. Nervous Systems explores the anxious context in which the mid-century sciences of the brain took shape and reveals the deeply ambivalent history that lies behind our contemporary understanding of this organ.

While most books contain some information on related sensors topics, they are limited in their scope on biomedical sensors. Sensors in Biomedical Applications: Fundamentals, Design, Technology and Applications is the first systematized book to concentrate on all available and potential sensor devices of biomedical applications! Sensors in Biomedical Applications presents information on sensor types in a comprehensive and easy to understand format. The first four chapters concentrate on the basics, lending an understanding to operation and design principles of sensor elements. Introduced are sections on: basic terms, sensor technologies, sensor structure and sensing effects. The next three chapters describe application possibilities: physical sensors, sensors for measuring chemical qualities and biosensors. Finally, a chapter covers biocompatability, in addition to an appendix and glossary. Sensors in Biomedical Applications is the definitive reference book for a broad audience. All physicists, chemists and biologists interested in the chemical basis and effects of sensors will find this work invaluable. Biomedical engineers and sensor specialists will find the text useful in its pointed analysis of special design, processing and application problems. Physicians practicing with diagnostic tools will want to see the possibilities and limits of biomedical sensors. Finally, students of all of the above areas who wish to learn more about the basics of biomedical sensors need to have this book.