Two new volumes of Methods in Enzymology continue the legacy of this premier serial with quality chapters authored by leaders in the field. Circadian Rhythms and Biological Clocks Part A and Part B is an exceptional resource for anybody interested in the general area of circadian rhythms. As key elements of timekeeping are conserved in organisms across the phylogenetic tree, and our understanding of circadian biology has benefited tremendously from work done in many species, the volume provides a wide range of assays for different biological systems. Protocols are provided to assess clock function, entrainment of the clock to stimuli such as light and food, and output rhythms of behavior and physiology. This volume also delves into the impact of circadian disruption on human health. Contributions are from leaders in the field who have made major discoveries using the methods presented here.

We grow up thinking there are five senses, but we forget about the ten neglected senses of the body that both enable and limit our experience. Embodied explores the psychology of physical sensation in ten chapters: balance, movement, pressure (acting in gravity), breathing, fatigue, pain, itch, temperature, appetite, and expulsion (the senses of physical matter leaving the body). For each sense, two people are interviewed who live with extreme experiences of the sense being investigated; their stories bring to life how far physical sensations matter to us and how much they define what is possible in our life. How physical sensation shapes behavior and how behavior is shaped by sensation are examined. A final chapter presents a theory of what is common across the ten senses: of how we deal with being urged to act, and what happens when extreme sensation is inescapable.

The scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths.

The terrestrial organisms of the Galapagos Islands live under conditions unlike those anywhere else. At the edge of a uniquely rich mid-ocean upwelling, their world is also free of mammalian predators and competitors, allowing them to live unbothered, exuberant lives. With its giant tortoises, marine iguanas, flightless cormorants, and forests of giant daisies, there's no question that this is a magnificent place. Long before people traversed the Earth, evolution endowed native species with adaptations to these special conditions and to perturbations like El Nino events and periodic droughts. As the islands have grown ever-more connected with humanity, those same adaptations now make its species vulnerable. Today, the islands are best viewed as one big social-ecological system where the ability of each native organism to survive and reproduce is a product of human activity in addition to ecological circumstances. In this book, William H. Durham takes readers on a tour of Galapagos and the organisms that inhabit these isolated volcanic islands. Exuberant Life offers a contemporary synthesis of what we know about the evolution of its curiously wonderful organisms, how they are faring in the tumultuous changing world around them, and how evolution can guide our efforts today for their conservation. The book highlights the ancestry of a dozen specific organisms in these islands, when and how they made it to the Galapagos, as well as how they have changed in the meantime. Durham traces the strengths and weaknesses of each species, arguing that the mismatch between natural challenges of their habitats and the challenges humans have recently added is the main task facing conservation efforts today. Such analysis often provides surprises and suggestions not yet considered, like the potential benefits to joint conservation efforts between tree finches and tree daisies, or ways in which the peculiar evolved behaviors of Nazca and blue-footed boobies can be used to benefit both species today. In each chapter, a social-ecological systems framework is used to highlight links between human impact, including climate change, and species status today, Historically, the Galapagos have played a central role in our understanding of evolution; what these islands now offer to teach us about conservation may well prove indispensable for the future of the planet.

The Management of Scientific Integrity within Academic Medical Centers discusses the impact scientific misconduct has in eight complex case studies. Authors look at multifaceted mixtures of improper behavior, poor communication, cultural issues, adverse medical/health issues, interpersonal problems and misunderstandings to illustrate the challenge of identifying and managing what went wrong and how current policies have led to the establishment of quasi legal processes within academic institutions. The book reviews the current global regulations and concludes with a section authored by a US federal court judge who provides his perspective on the adequacy of current regulations and policies.

Perioperative Neurosciences: Translational Research examines current clinical research focused on complications and the improvement of patient outcomes in neuroanesthesia and neurocritical care. The book addresses important translational topics including neuroanesthetics, pharmacogenomics, neuroprotection and neurotoxicity. In addition, it covers special considerations for topics such as stroke, traumatic brain injury and pain, as well as for specific patient populations like geriatric and pediatric.

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in RNA folding and dynamics, RNA-protein interactions and large RNPs.

Digestive System Malignancies provides an up-to-date overview on the most relevant diagnostic techniques, staging of malignancies, and current therapeutic modalities for digestive system malignancies. With coverage from esophageal, gastric and pancreatic cancers, to colon, anal and peritoneal surface, this reference offers a wide-ranging guide to malignancies throughout the digestive system. The use of engaging infographics provides an "at-a-glace" perspective on the subject, allowing users to retain a large amount of information without scrolling through large text or complex algorithms. This is an important reference for clinicians, surgeons, medical students and scientists that need a quick reference on digestive system malignancies.

Virology is in a sense both one of the most important precursors and one of the most significant beneficiaries of structural and cellular molecular biology. Numerous breakthroughs in our understanding of the molecular interactions of viruses with host cells are ready for translation into medically important applications such as the prevention and treatment of viral infections. This book collects a wide variety of examples of frontline research into molecular aspects of viral infections from virological, immunological, cell- and molecular-biological, structural, and theoretical perspectives.

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not - as we once believed - unique to a few receptor subfamilies.

Antimicrobial Food Packaging, Second Edition continues to be an essential resource covering all aspects in the development and application of novel antimicrobial films to all types of packaged foods. The book is organized in six parts to include the main backgrounds and frameworks of the topic, types of packaging materials and packaging systems and the migration of packaging elements into food, the most relevant established and emerging technologies for microbial detection in food systems, the development and application of antimicrobial packaging strategies to specific food sectors, and the most promising combinational approaches, also including combinational edible antimicrobial coatings. Useful to a wide audience of researchers, scientists and students, the new edition brings six new chapters that include the latest information on smart packaging, algae biofilms for antimicrobial packaging applications, polylactic acid-tea polyphenol nanofibers, use in antimicrobial packaging, chitosan and proanthocyanidins, chitosan and e-polylysine bionanocomposite films, citrus essential oils, and also includes dairy products.

This monograph is a summary of the conference on Eurytemora, gathering renowned researchers from all over the world to discuss new advances in Phylogeny, Biogeography, Taxonomy, and Ecology of this important group of estuarine crustaceans, held the 13-17 May 2019 in St. Petersburg, Russia. The present volume includes 17 selected papers, in which you will discover new aspects of the modern theory on the history and recent geographical distribution (biogeography) of an important group of estuarine crustaceans, revealing coincidences with a modern model of continental drift. The researchers suggest a new hypothesis on time and place of origin of continental calanoid copepods. The specialists show that studying external morphology in detail helps to increase identification and differentiation between closely related sibling species within the Eurytemora group. Several ecological questions on invasive and pseudocryptic copepod species are debated. Finally, the last chapter of this monography is devoted to taxa related to the Eurytemora group, Epischura, Temora, Temoropia, and Pseudodiaptomus. First published as a Special Issue of Crustaceana 93(3-5): 241-547.

Neuroscience has made considerable progress in figuring out how the brain works. We know much about the molecular-genetic and biochemical underpinnings of sensory and motor functions. Recent neuroimaging work has opened the door to investigating the neural underpinnings of higher-order cognitive functions, such as memory, attention, and even free will. In these types of investigations, researchers apply specific stimuli to induce neural activity in the brain and look for the function in question. However, there may be more to the brain and its neuronal states than the changes in activity we induce by applying particular external stimuli. In Volume 2 of Unlocking the Brain, Georg Northoff addresses consciousness by hypothesizing about the relationship between particular neuronal mechanisms and the various phenomenal features of consciousness. Northoff puts consciousness in the context of the resting state of the brain thereby delivering a new point of view to the debate that permits very interesting insights into the nature of consciousness. Moreover, he describes and discusses detailed findings from different branches of neuroscience including single cell data, animal data, human imaging data, and psychiatric findings. This yields a unique and novel picture of the brain, and will have a major and lasting impact on neuroscientists working in neuroscience, psychiatry, and related fields.