This book looks at where stem cell technology is presently and how
it is instrumental in advancing the field of disease modeling and
cell transplantation. By focusing on major human disorders such as
Alzheimer's disease, cancer, and heart disorders, the book
summarizes the major findings in the field of human stem cells and
dissect the current limitations on our understanding of stem cells
biology. The chapters focus on the genetics, genomics, epigenetics
and physiology of stem cells models, together with technological
advances on molecular biology such as CRISPR/Cas9 or epigenetic
editing, that will be instrumental in the future of human disease
modeling and treatment. In base of the limitations of current
disease models and in front of the unmet necessity of finding
therapeutical interventions for human disorders, the availability
of stem cell technology has opened new doors for several fields.
The unlimited self-renewal capacity and more extensive
differentiation potential of stem cells offers a theoretically
inexhaustible and replenishable source of any cell subtype. Since
Professor Shinya Yamanaka described it, 10 years ago in his seminal
paper, that somatic cells could be reprogrammed to inducible stem
cells (iPSC) just by expressing four transcription factors, the
field of has exploded, especially its applications in biomedical
research.
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