This volume is part of the definitive edition of letters written by and to Charles Darwin, the most celebrated naturalist of the nineteenth century. Notes and appendixes put these fascinating and wide-ranging letters in context, making the letters accessible to both scholars and general readers. Darwin depended on correspondence to collect data from all over the world, and to discuss his emerging ideas with scientific colleagues, many of whom he never met in person. The letters are published chronologically: volume 27 includes letters from 1879, the year in which Darwin completed his manuscript on movement in plants. He also researched and published a biography of his grandfather Erasmus. The Darwins spent most of August on holiday in the Lake District. In October, Darwin's youngest son, Horace, became officially engaged to Ida Farrer, after some initial resistance from her father, who, although an admirer of Charles Darwin, thought Horace a poor prospect for his daughter.

Evolutionary biomechanics is the study of evolution through the analysis of biomechanical systems. Its unique advantage is the precision with which physical constraints and performance can be predicted from first principles. Instead of reviewing the entire breadth of the biomechanical literature, a few key examples are explored in depth as vehicles for discussing fundamental concepts, analytical techniques, and evolutionary theory. Each chapter develops a conceptual theme, developing the underlying theory and techniques required for analyses in evolutionary biomechanics. Examples from terrestrial biomechanics, metabolic scaling, and bird flight are used to analyse how physics constrains the design space that natural selection is free to explore, and how adaptive evolution finds solutions to the trade-offs between multiple complex conflicting performance objectives. Evolutionary Biomechanics is suitable for graduate level students and professional researchers in the fields of biomechanics, physiology, evolutionary biology and palaeontology. It will also be of relevance and use to researchers in the physical sciences and engineering.

Over millions of years in the fossil record, hominin teeth preserve a high-fidelity record of their own growth, development, wear, chemistry and pathology. They yield insights into human evolution that are difficult, if not impossible, to achieve through other sources of fossil or archaeological data. Integrating dental findings with current debates and issues in palaeoanthropology, this book shows how fossil hominin teeth shed light on the origins and evolution of our dietary diversity, extended childhoods, long lifespans, and other fundamental features of human biology. It assesses methods to interpret different lines of dental evidence, providing a critical, practical approach that will appeal to students and researchers in biological anthropology and related fields such as dental science, oral biology, evolutionary biology, and palaeontology.

This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1-3), DNA Replication; Part 2 (Chapters 4-6), DNA Recombination; Part 3 (Chapters 7-9), DNA Repair; Part 4 (Chapters 10-13), Genome Instability and Mutagenesis; Part 5 (Chapters 14-15), Chromosome Dynamics and Functions; Part 6 (Chapters 16-18), Cell Cycle and Checkpoints; Part 7 (Chapters 19-21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.

The book is an indispensable companion to all students of biology, but particularly those enrolled in courses concerning experimental design, data analysis, hypothesis testing, research methods, or any practical project work.

'Insight' is not a very popular word in psychology or biology. Popular terms-like "intelligence", "planning", "complexity" or "cognitive"- have a habit of sprawling out to include everyone's favourite interpretation, and end up with such vague meanings that each new writer has to redefine them for use. Insight remains in everyday usage: as a down-to-earth, lay term for a deep, shrewd or discerning kind of understanding. Insight is a good thing to have, so it's important to find out how it evolved, and that's what this book is about. Coming 20 years after publication of Richard Byrne's seminal book The Thinking Ape, Evolving Insight develops a new theory of the evolutionary origins of human abilities to understand the world of objects and other people. Defining mental representation and computation as 'insight', it reviews the evidence for insight in the cognition of animals. The book proposes that the understanding of causality and intentionality evolved twice in human ancestry: the "pretty good" understanding given by behaviour parsing, shared with other apes and related to cerebellar expansion; and the deeper understanding which requires language to model and is unique to humans. However, Ape-type insight may underlie non-verbal tests of intentionality and causal understanding, and much everyday human action. Accessible to those with little background in the topic, Evolving Insight is an important new work for anyone with an interest in psychology and the biological sciences.

This book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essentially organized into transverse neural segments or neuromeres and longitudinal zones which follow the curved axis of the brain. (2) The FMUs initially represent thin neuroepithelial fields; in the course of further development they are transformed into three-dimensional radial units, extending from the ventricular surface to the meningeal surface of the brain. (3) The principal histogenetic processes, including cellular proliferation, cell migration and differentiation, essentially take place within the confines of these radial units, controlled by characteristic sets of developmental regulatory genes. (4) Although most developing neurons migrate radially and settle within their own FMU, at many locations neuroblasts leave the FMU where they were produced and migrate tangentially to other nearby or remote territories, colonizing parts of foreign FMUs. (5) Many structural complexes in the adult brain, including the cerebral and cerebellar cortices, are the products of radial and tangential intermingling of migrated cell contingents. (6) By using appropriate molecular markers, all neuron types in the adult CNS can be traced back to a specific progenitor zone within a specific FMU, and the progeny of any FMU can be traced to their final positions with the help of selective labeling approaches. (7) Early outgrowing axons form bundles, which tend to pass close to the border zones of the radial units. By means of their molecularly diversely tuned growth cones, these extending axons decide how to behave at each boundary they encounter, sometimes even reorienting at right angles. Collectively these early axonal bundles form a checkerboard-like scaffold, which accentuates the molecular regionalization of the CNS and leads to the formation of topographically ordered synaptic fields. The book covers all of these aspects in detail, providing a morphologic model (blueprint) that highlights the natural coordinates of CNS structure resulting from the conserved molecularly controlled shaping phenomena within morphogenetic fields.

CCTV for Wildlife Monitoring is a handbook on the use of CCTV in nature watching, conservation and ecological research. CCTV offers a unique ability to monitor wildlife in real time, stream video to the web, capture imagery of fast-moving species or cold animals such as wet otters or fish and maintain monitoring over long periods of time in a diverse array of habitats. Wildlife watchers can take advantage of a huge range of CCTV cameras, recording devices and accessories developed for use in non-wildlife applications. CCTV allows intimate study of animal behaviour not possible with other technologies. With expert experience in engineering, photography and wildlife, Susan Young describes CCTV equipment and techniques, giving readers the confidence to tackle what initially may seem technically challenging. The book enables the reader to navigate the technical aspects of recording: basic analogue, high definition HD-TVI and IP cameras, portable CCTV, digital video recorders (DVR) and video processing by focusing on practical applications. No prior knowledge of CCTV is required - step-by-step information is provided to get anyone started recording wildlife. In-depth methods for recording foxes, badger, deer, otters, small mammals and fish are also included, and the book makes comparisons with trail cameras where appropriate. Examples of recorded footage illustrate the book along with detailed diagrams on camera set-ups and links to accompanying videos on YouTube. Case-studies show real projects, both the equipment used and the results. This book will be of interest to amateur naturalists wishing to have a window into the private world of wildlife, ecological consultants monitoring protected species and research scientists studying animal behaviour.

Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.

This book includes invited contributions presenting the latest research on the oceanography and environment of the Red Sea. In addition to covering topics relevant to research in the region and providing insights into marine science for non-experts, it is also of interest to those involved in the management of coastal zones and encourages further research on the Red Sea

Albert Hofmann, who died in 2008 aged 102, first synthesized lysergic acid diethylamide (LSD) in 1938, but the results of animal tests were so unremarkable that the chemical was abandoned. Driven by intuition, he synthesized it again in 1943, and serendipitously noticed its profound effects on himself. Although his work produced other important drugs, including methergine, hydergine and dihydroergotamine, it was LSD that shaped his career. After his discovery of LSD's properties, Hofmann spent years researching sacred plants. He succeeded in isolating and synthesizing the active compounds in the Psilocybe mexicana mushroom, which he named psilocybin and psilocin. During the 60s, Hofmann struck up friendships with personalities such as Aldous Huxley, Gordon Wasson, and Timothy Leary. He continued to work at Sandoz until 1971 when he retired as Director of Research for the Department of Natural Products. He subsequently served as a member of the Nobel Prize Committee, and was nominated by Time magazine as one of the most influential figures of the 20th century. In 2007, Albert Hofmann asked Amanda Feilding if she could publish his Problem Child, and shortly before his death he approved a new and updated translation of his autobiography (first published by McGraw Hill in 1979). It appears here for the first time in print.

History has always mattered to Scots, and rarely more so than now at the outset of a new century, with a new census appearing in 2011 and after more than ten years of a new parliament. An almost limitless archive of our history lies hidden inside our bodies and we carry the ancient story of Scotland around with us. The mushrooming of genetic studies, of DNA analysis, is rewriting our history in spectacular fashion. In The Scots: A Genetic Journey, Alistair Moffat explores the history that is printed on our genes, and in a remarkable new approach, uncovers the detail of where we are from, who we are and in so doing colour vividly a DNA map of Scotland.

In this ground-breaking work, philosopher and cognitive scientist Andy Clark turns a common view of the human mind upside down. In stark opposition to familiar models of human cognition, Surfing Uncertainty explores exciting new theories in neuroscience, psychology, and artificial intelligence that reveal minds like ours to be prediction machines-devices that have evolved to anticipate the incoming streams of sensory stimulation before they arrive. This keeps minds like ours a few steps ahead of the game, poised to respond rapidly and apparently effortlessly to threats and opportunities as (and sometimes even before) they arise. Creatures thus equipped are more than simple response machines. They are knowing agents deep in the business of understanding their worlds. Such agents cope with changing and uncertain worlds by combining sensory evidence with informed prediction. Remarkably, the learning that makes neural prediction possible can itself be accomplished by the ceaseless effort to make better and better predictions. A single fundamental trick (the trick of trying to predict your own sensory inputs) thus enables learning, empowers moment-by-moment perception, and installs a rich understanding of the surrounding world. Action itself now appears in a new and revealing light. For action is not so much a 'response to an input' as a neat and efficient way of selecting the next 'input'. As mobile embodied agents we are forever intervening, actively bringing about the very streams of sensory information that our brains are simultaneously trying to predict. This binds perception and action in a delicate dance, a virtuous circle in which neural circuits animate, and are animated by, the movements of our own bodies. Some of our actions, in turn, structure the physical, social, and technological worlds around us. This moves the goalposts by altering the very things we need to engage and predict. Surfing Uncertainty brings work on the predictive brain into full and satisfying contact with work on the embodied and culturally situated mind. What emerges is a bold new vision of what brains do that places circular causal flows and the active structuring of the environment, center-stage. In place of cognitive couch potatoes idly awaiting the next sensory inputs, Clark's journey reveals us as proactive predictavores, skilfully surfing the waves of sensory stimulation.

AS WE TAKE CHARGE OF OUR INDIVIDUAL POWER TO CREATE, WE HAVE THE POTENTIAL, AS A SPECIES, TO CHANGE OUR WORLD. Every creation begins as a thought. Our thoughts travel as electrical impulses along neural pathways; neurons wire together, creating electromagnetic fields. These fields are invisible energy, yet they influence the molecules of matter around us the way a magnet organizes iron filings. In Mind to Matter, award-winning researcher Dawson Church explains how our minds create matter. We can now trace the science behind each link in the chain from thought to thing, showing the surprising ways in which our intentions create the material world. The science in the book is illustrated by many authentic case histories of people who harnessed the extraordinary power of the mind to create. Neuroscientists have measured a specific brain-wave formula that is linked to manifestation. This 'flow state' can be learned and applied by anyone. New discoveries in epigenetics, neuroscience, electromagnetism, psychology, cymatics and quantum physics connect each step in the process. They show that the whole universe is self-organizing, and when our minds are in flow, they coordinate with nature's emergent intelligence to produce synchronous outcomes. 'I love this book. It constantly fascinated me with delicious facts and so many captivating stories. And it is wonderful to see science catching up with what the shamans and sages have always known!' - Donna Eden, author of Energy Medicine 'As The Secret meets the scientist in Dawson's work, the boundaries of what you've believed possible will be stretched far beyond your existing picture of reality.' - Jack Canfield, co-author of the #1 New York Times bestselling Chicken Soup (R) series and featured teacher in The Secret

A complete background to concepts and principles of behavioral genetics, Neurobehavioral Genetics: Methods and Applications, Second Edition features a broad spectrum of the most current techniques in neurobehavioral genetics in a single source. International researchers incorporate several new developments in the field, including: -Developmental neurobehavioral genetics -Gene-gene interaction -New approaches in bioinformatics -Gene expression -Single gene techniques Based on various studies of living organisms ranging from primates to rodents to invertebrates, this edition offers a contemporary approach to examining the relationship between the genetic mechanisms in the brain and behavior. The authors examine how past and recent advances in methods and knowledge come together in the comparative genetics of behavior. They introduce the reader to experimental approaches available for the genetic study of emotionality, focusing on the use of animal models. This edition explores studies in neurogenetic disorders, including schizophrenia and bipolar disorders, examines genetic traits in personality such as altruism, and evaluates aggression in mice and humans. It also discusses the applications of quantitative methods and molecular genetics in basic and clinical research. Neurobehavioral Genetics: Methods and Applications, Second Edition brings together new techniques and methods to promote a better understanding of genetics and their effects on behavior. The book is an excellent resource for investigators who want to incorporate genetic methods into neurobehavioral and psychiatric research.

This volume looks at a collection of stem cell and regenerative techniques used by both novice and expert scientists. Chapters cover topics such as tissue repaired by expansion and reprogramming; induced pluripotent stem cells driven in neuronal or vascular differentiation; using mesenchymal stem cells to derive skeletal muscle, osteoblasts, and spermatogonial cells; and the technique of monitoring the development of sub-organ microenvironments in the developing pancreas. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Stem Cells and Tissue Repair: Methods and Protocols, Second Edition is a valuable resource that provides readers with the latest descriptions and references for exploring this vast field in regenerative medicine.

Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development.

This volume provides a collection of protocols for the study of DNA-DNA contact maps, replication profiles, transcription rates, RNA secondary structures, protein-RNA interactions, ribosome profiling and quantitative proteomes and metabolomes. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Yeast Functional Genomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.

To understand modern principles of sustainable management and the conservation of wildlife species requires intimate knowledge about demography, animal behavior, and ecosystem dynamics. With emphasis on practical application and quantitative skill development, this book weaves together these disparate elements in a singlecoherent textbook for senior undergraduate and graduate students. It reviews analytical techniques, explaining the mathematical and statistical principles behind them, and shows how these can be used to formulaterealistic objectives within an ecological framework.

This third edition is comprehensive and up-to-date, and includes: Brand new chapters that disseminate rapidly developing topics in the field: habitat use and selection; habitat fragmentation, movement, and corridors; population viability. analysis, the consequences of climate change; and evolutionary responses to disturbanceA thorough updating of all chapters to present important areas of wildlife research and management with recent developments and examples.A new online study aid - a wide variety of downloadable computer programs in the freeware packages R and Mathcad, available through a companion website. Worked examples enable readers to practice calculations explained in the text and to develop a solid understanding of key statistical procedures and population models commonly used in wildlife ecology and management.The first half of the book provides a solid background in key ecological concepts. The second half uses these concepts to develop a deeper understanding of the principles underlying wildlife management and conservation. Global examples of real-life management situations provide a broad perspective on the international problems of conservation, and detailed case histories demonstrate concepts and quantitative analyses. This third edition isalso valuable to professional wildlife managers, park rangers, biological resource managers, and thoseworking in ecotourism.

'A new approach to mental disorder. Randolph Nesse's insightful book suggests that conditions such as anxiety and depression have a clear evolutionary purpose ... This intriguing book turns some age-old questions about the human condition upside down' Tim Adams, Observer One of the world's most respected psychiatrists provides a much-needed new evolutionary framework for making sense of mental illness With his classic book Why We Get Sick, Randolph Nesse established the field of evolutionary medicine. Now he returns with a book that transforms our understanding of mental disorders by exploring a fundamentally new question. Instead of asking why certain people suffer from mental illness, Nesse asks why natural selection has left us with fragile minds at all. Drawing on revealing stories from his own clinical practice and insights from evolutionary biology, Nesse shows how negative emotions are useful in certain situations, yet can become excessive. Anxiety protects us from harm in the face of danger, but false alarms are inevitable. Low mood prevents us from wasting effort in pursuit of unreachable goals, but it often escalates into pathological depression. Other mental disorders, such as addiction and anorexia, result from the mismatch between modern environments and our ancient human past. Taken together, these insights and many more help to explain the pervasiveness of human suffering, and show us new paths for relieving it. Good Reasons for Bad Feelings will fascinate anyone who wonders how our minds can be so powerful, yet so fragile, and how love and goodness came to exist in organisms shaped to maximize Darwinian fitness.

Shakespeare and Cognition examines the essential relationship between vision, knowledge, and memory in Renaissance models of cognition as seen in Shakespeare's plays. Drawing on both Aristotle's Metaphysics and contemporary cognitive literary theory, Arthur F. Kinney explores five key objects/images in Shakespeare's plays a " crowns, bells, rings, graves and ghosts a " that are not actually seen (or, in the case of the latter, not meant to be seen), but are central to the imagination of both the playwright and the playgoers.

The contemporary crisis of emerging disease has been a century and a half in the making. Human, veterinary, and crop health practitioners convinced themselves that disease could be controlled by medicating the sick, vaccinating those at risk, and eradicating the parts of the biosphere responsible for disease transmission. Evolutionary biologists assured themselves that coevolution between pathogens and hosts provided a firewall against disease emergence in new hosts. Most climate scientists made no connection between climate changes and disease. None of these traditional perspectives anticipated the onslaught of emerging infectious diseases confronting humanity today. As this book reveals, a new understanding of the evolution of pathogen-host systems, called the Stockholm Paradigm, explains what is happening. The planet is a minefield of pathogens with preexisting capacities to infect susceptible but unexposed hosts, needing only the opportunity for contact. Climate change has always been the major catalyst for such new opportunities, because it disrupts local ecosystem structure and allows pathogens and hosts to move. Once pathogens expand to new hosts, novel variants may emerge, each with new infection capacities. Mathematical models and real-world examples uniformly support these ideas. Emerging disease is thus one of the greatest climate change-related threats confronting humanity. While time is short, the danger is great, and we are largely unprepared, The Stockholm Paradigm offers hope for managing the crisis. By using the DAMA (document, assess, monitor, act) protocol, we can "anticipate to mitigate" emerging disease, buying time and saving money while we search for more effective ways to cope with this challenge.

As humans evolved, we developed technologies to modify our environment, yet these innovations are increasingly affecting our behavior, biology, and society. Now we must figure out how to function in the world we've created. Over thousands of years, humans have invented ingenious ways to gain mastery over our environment. The ability to communicate, accumulate knowledge collectively, and build on previous innovations has enabled us to change nature. Innovation has allowed us to thrive. The trouble with innovation is that we can seldom go back and undo it. We invent, embrace, and exploit new technologies to modify our environment. Then we modify those technologies to cope with the resulting impacts. Gluckman and Hanson explore what happens when we innovate in a way that leads nature to bite back. To provide nourishment for a growing population, humans developed methods to process and preserve food; but easy access to these energy-dense foods results in obesity. To protect ourselves from dangerous pathogens we embraced cleanliness and invented antibiotics, which has led to rising rates of autoimmune diseases and antibiotic-resistant bacteria. More recently, our growing dependence on the internet and social media has been linked to mental health concerns and declining social cohesion. And we are only at the beginning of the digital transformation that will influence every part of our existence. Our ingenuity has not only changed our world-it has changed us. Focusing on immediate benefits, we rarely pause to consider the longer-term costs of innovation. Yet we are now starting to see how our choices affect the way our brains develop and our bodies function. The implications are profound. Ingenious opens our eyes to the dangers we face and offers solutions we cannot ignore.

As the science of selection develops in the context of human reproduction, features such as the genetic improvement of health, athletic prowess or intelligence may become accepted grounds for choosing future children. Thus, the biological enhancement of the human race, so central to the discredited eugenic regimes of the twentieth century, may now be resurfacing under a new guise. Unnerving similarities between earlier eugenic selection programmes and those now being proposed in the context of twenty-first century human reproduction, with the development of procedures such as gene editing, suggest that a more 'sanitised' era of a new eugenics has dawned. There is, therefore, an urgent need to consider and evaluate both current and future selection practices from a Christian perspective based on Scripture. Calum MacKellar offers an accessible, inter-disciplinary analysis, blending science, history and Christian theology, enabling readers to develop an informed opinion about the topics encountered. To some degree, all members of society are affected by these new scientific developments in human reproduction, regardless of background, and will thus benefit from such a survey.

This book presents the proceedings of the Gmunden Retreat on NeuroIS 2016, reporting on topics at the intersection of Information Systems (IS) research, neurophysiology and the brain sciences. Readers will discover the latest findings from top scholars in the field of NeuroIS, which offer detailed insights on the neurobiology underlying IS behavior, essential methods and tools and their applications for IS, as well as the application of neuroscience and neurophysiological theories to advance IS theory.