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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Chromatin Signaling and Diseases (Hardcover)
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Chromatin Signaling and Diseases (Hardcover)
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Chromatin Signaling and Diseases covers the molecular mechanisms
that regulate gene expression, which govern everything from
embryonic development, growth, and human pathologies associated
with aging, such as cancer. This book helps researchers learn about
or keep up with the quickly expanding field of chromatin signaling.
After reading this book, clinicians will be more capable of
explaining the mechanisms of gene expression regulation to their
patients to reassure them about new drug developments that target
chromatin signaling mechanisms. For example, several epigenetic
drugs that act on chromatin signaling factors are in clinical
trials or even approved for usage in cancer treatments,
Alzheimer's, and Huntington's diseases. Other epigenetic drugs are
in development to regulate various class of chromatin signaling
factors. To keep up with this changing landscape, clinicians and
doctors will need to stay familiar with genetic advances that
translate to clinical practice, such as chromatin signaling.
Although sequencing of the human genome was completed over a decade
ago and its structure investigated for nearly half a century,
molecular mechanisms that regulate gene expression remain largely
misunderstood. An emerging concept called chromatin signaling
proposes that small protein domains recognize chemical
modifications on the genome scaffolding histone proteins,
facilitating the nucleation of enzymatic complexes at specific loci
that then open up or shut down the access to genetic information,
thereby regulating gene expression. The addition and removal of
chemical modifications on histones, as well as the proteins that
specifically recognize these, is reviewed in Chromatin Signaling
and Diseases. Finally, the impact of gene expression defects
associated with malfunctioning chromatin signaling is also
explored.
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