Your cart is empty
A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people.
It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”
This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger.
Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
The question of why an individual would actively kill itself has long been an evolutionary mystery. Pierre M. Durand's ambitious book answers this question through close inspection of life and death in the earliest cellular life. As Durand shows us, cell death is a fascinating lens through which to examine the interconnectedness, in evolutionary terms, of life and death. It is a truism to note that one does not exist without the other, but just how does this play out in evolutionary history? These two processes have been studied from philosophical, theoretical, experimental, and genomic angles, but no one has yet integrated the information from these various disciplines. In this work, Durand synthesizes cellular studies of life and death looking at the origin of life and the evolutionary significance of programmed cellular death. The exciting and unexpected outcome of Durand's analysis is the realization that life and death exhibit features of coevolution. The evolution of more complex cellular life depended on the coadaptation between traits that promote life and those that promote death. In an ironic twist, it becomes clear that, in many circumstances, programmed cell death is essential for sustaining life.
Widespread across open lands and cities of Europe, Africa, and Asia, the common kestrel (Falco tinnunculus) is one of the most abundant and studied birds of prey. This book brings together and synthesises the results of research on kestrels for professional ornithologists and scientists that seek to consolidate a vast body of literature. It is also a reference for those readers who may not have the depth of scientific knowledge to navigate new fields of scientific enquiry. It examines many aspects of the species' biology, from the reproductive strategies to the behavioural and demographic adaptations to changes of environmental conditions. It also discusses the roles of physiology and immunology in mediating the adaptability of kestrels to the ongoing environmental changes with a particular focus on contaminants. This volume presents new and exciting avenues of research on the ecology and behaviour of the common kestrel.
From penguins to dinosaurs, trilobites and humans, an acclaimed paleontologist and ichnologist reveals the subterranean secret of survival.
Voted one of Christianity Today's 1998 Books of the Year For decades, Christians have felt voiceless in the critical debate over evolution. Until now. Finally, ordinary Christians have the opportunity and the resources to defeat the false claims of Darwinism. With all of the complicated scientific debate swirling around the topic of evolution, Christians need an easy way to understand the basic issues without oversimplifying. Phillip Johnson has the answer: the key to defeating the false claims of Darwinism is to open our minds to good thinking habits. Here is first-rate advice on avoiding common mistakes in discussions about evolution, understanding the legacy of the Scopes trial, spotting deceptive arguments, and grasping the basic scientific issues without getting bogged down in unnecessary details. In the bestselling and critically acclaimed Darwin on Trial and Reason in the Balance, Phillip Johnson took on the academic elites and exposed the misleading claims of evolutionary naturalism.Defeating Darwinism by Opening Minds provides a new and powerful treatment of these issues for high-school students, parents, teachers, pastors, youth advisors and ordinary readers. Johnson aims not just to defeat a bad theory, but to defeat it in the right way-by opening minds to the truth.
This unique visual reference presents more than 750 brilliant, four-color images of bacterial isolates commonly encountered in diagnostic microbiology and the methods used to identify them, including microscopic and phenotypic characteristics, colony morphology, and biochemical properties. Chapters cover the most important bacterial pathogens and related organisms, including updated taxonomy, epidemiology, pathogenicity, laboratory and antibiotic susceptibility testing, and molecular biology methodology Tables summarize and compare key biochemical reactions and other significant characteristics New to this edition is a separate chapter covering the latest developments in total laboratory automation The comprehensive chapter on stains, media, and reagents is now augmented with histopathology images A new Fast Facts chapter presents tables that summarize and illustrate the most significant details for some of the more commonly encountered organisms For the first time, this easy-to-use atlas is available digitally for enhanced searching. Color Atlas of Medical Bacteriology remains the most valuable illustrative supplement for lectures and laboratory presentations, as well as for laboratorians, clinicians, students, and anyone interested in diagnostic medical bacteriology.
Using "the sharing paradigm" as a guiding concept, this book demonstrates that "sharing" has much greater potential to make rural society resilient, sustainable and inclusive through enriching all four sharing dimensions: informal, mediated, communal and commercial sharing. The chapters are divided into two parts, one that focuses on case studies of the sharing ecosystem services in Japan, the other on case studies from around the world including in the regions of Africa, Asia-Pacific, South America and Europe. Reflecting the recent growing attention to sharing concept and its application to economic and urban context, this publication explores opportunities and challenges to build more resilient and sustainable society in harmony with nature by critical examination of sharing practices in rural landscapes and seascapes around the world. This book introduces not only traditional communal and non-market sharing practices in different rural areas, but also new forms of sharing through integration of traditional practices and modern science and technologies.
This book introduces new and provocative neuroscience research that advances our understanding of intelligence and the brain. Compelling evidence shows that genetics plays a more important role than environment as intelligence develops from childhood, and that intelligence test scores correspond strongly to specific features of the brain assessed with neuroimaging. In understandable language, Richard J. Haier explains cutting-edge techniques based on genetics, DNA, and imaging of brain connectivity and function. He dispels common misconceptions, such as the belief that IQ tests are biased or meaningless, and debunks simple interventions alleged to increase intelligence. Readers will learn about the real possibility of dramatically enhancing intelligence based on neuroscience findings and the positive implications this could have for education and social policy. The text also explores potential controversies surrounding neuro-poverty, neuro-socioeconomic status, and the morality of enhancing intelligence for everyone. Online resources, including additional visuals, animations, questions and links, reinforce the material.
An original, authoritative guide to the impact of grief on the brain, the heart, and the body of the bereaved Grief happens to everyone. Universal and enveloping, grief cannot be ignored or denied. This original new book by psychologist Dorothy P. Holinger uses humanistic and physiological approaches to describe grief's impact on the bereaved. Taking examples from literature, music, poetry, paleoarchaeology, personal experience, memoirs, and patient narratives, Holinger describes what happens in the brain, the heart, and the body of the bereaved. Readers will learn what grief is like after a loved one dies: how language and clarity of thought become elusive, why life feels empty, why grief surges and ebbs so persistently, and why the bereaved cry. Resting on a scientific foundation, this literary book shows the bereaved how to move through the grieving process and how understanding grief in deeper, more multidimensional ways can help quell this sorrow and allow life to be lived again with joy. Visit the author's companion website for The Anatomy of Grief: dorothypholinger.com/
Chronic diseases have rapidly become the leading global cause of morbidity and mortality, yet there is poor understanding of this transition, or why particular social and ethnic groups are especially susceptible. In this book, Wells adopts a multidisciplinary approach to human nutrition, emphasising how power relations shape the physiological pathways to obesity, diabetes, hypertension and cardiovascular disease. Part I reviews the physiological basis of chronic diseases, presenting a 'capacity-load' model that integrates the nutritional contributions of developmental experience and adult lifestyle. Part II presents an evolutionary perspective on the sensitivity of human metabolism to ecological stresses, highlighting how social hierarchy impacts metabolism on an intergenerational timescale. Part III reviews how nutrition has changed over time, as societies evolved and coalesced towards a single global economic system. Part IV integrates these physiological, evolutionary and politico-economic perspectives in a unifying framework, to deepen our understanding of the societal basis of metabolic ill-health.
This book offers a comprehensive account of India's four biodiversity hotspots: the Himalaya, Indo-Burma, Western Ghats and Sri Lanka and Andaman and Nicobar Islands. With a focus on tropical rainforests, it includes more than 30 chapters covering different vertebrate fauna e.g. fishes, amphibians, reptiles, birds, and mammals, as well as topics such as conservation and management aspects. Written by experts in the field of biodiversity conservation and management, it offers ample new insights into a number of subjects related to the faunal communities of tropical forest ecosystems, providing a valuable resource for conservationists and researchers in the field of flora and fauna diversity.
What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.
This book offers focused and concise coverage of all issues relating to malnutrition in the field of neurology, and in particular addresses practical aspects of nutritional support from a neurology perspective. In addition to providing basic knowledge on important nutritional concepts (body metabolism, assessment and diagnosis of malnutrition, epidemiology, enteral/parenteral nutrition), detailed information is presented on nutritional support for various neurologic disorders handled in a variety of settings, including the neurointensive care unit. Much consideration is also given to the diagnosis and management of dysphagia, which is a common and highly critical cause of malnutrition in these patients. Finally, the newly developing concept of neuronutrition (or brain foods) - the use of certain nutrients for treatment of neurologic disorders - is discussed. By providing practical solutions to commonly encountered challenges in the nutritional management of neurologic patients, this book will prove a valuable resource for practicing neurologists in a wide variety of fields. It will also be very useful for medical personnel from other specialties such as clinical nutrition, critical care, and geriatric medicine.
Machine learning and big data is hot. It is, however, virtually unused in clinical trials. This is so, because randomization is applied to even out multiple variables Modern medical computer files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required This is the first publication of clinical trials that have been systematically analyzed with machine learning. In addition, all of the machine learning analyses were tested against traditional analyses. Step by step statistics for self-assessments are included The authors conclude, that machine learning is often more informative, and provides better sensitivities of testing than traditional analytic methods do
The book addresses current public concern about the adverse effect of agrochemicals and their effect on the agro-ecosystem. This book also aims to satisfy and contribute to the increasing interest in understanding the co-operative activities among microbial populations and their interaction with plants. It contains chapters on a variety of interrelated aspects of plant-microbe interactions with a single theme of stress management and sustainable agriculture. The book will be very useful for students, academicians, researcher working on plant-microbe interaction and also for policy makers involved in food security and sustainable agriculture.
Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.
This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases. The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses. The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.
Sir Joseph Banks was one of the great figures of Georgian England, best known for participating as naturalist in Cook's Endeavour voyage (1768-71), as a patron of science and as the longest-serving President of the Royal Society (1778-1820). This volume brings together all Banks's papers concerning Iceland and the North Atlantic, scattered in repositories in Britain, the United States, Australia and Denmark, and most published here for the first time. A detailed introduction places them in historical context.
We live in a complex and dynamic world. Understanding how to monitor, manage and conserve species and habitats - the goal of applied ecology - is of ever-increasing importance. Applied Ecology shows students how an understanding of ecological theory can be used to address the most important issues facing ecologists today. Its explicitly problem-solving approach reflects the reality of using ecological tools and approaches in applied contexts, while also highlighting the key ecological theories that underpin those applications to make the link between theory and practice clear. With an emphasis throughout on the realities of applying ecological theory, the book features interviews with a range of leading applied ecologists, and over 30 case studies to give students a clear sense of contemporary applied ecology in action. In addition, over 20 Hot Topic panels capture issues and approaches at the forefront of current practice. Online Resource Centre: The Online Resource Centre to accompany Applied Ecology features: For students: - Twelve bonus case studies to augment those featured in the book - Extended versions of the Interviews with Applied Ecologists that appear in the book For lecturers: - Problem-solving activities for use in a workshop, seminar, or tutorial setting - Figures from the book in digital format, for use in lecture presentations
This volume offers a much-needed compilation of essential reviews on diverse aspects of plant biology, written by eminent botanists. These reviews effectively cover a wide range of aspects of plant biology that have contemporary relevance. At the same time they integrate classical morphology with molecular biology, physiology with pattern formation, growth with genomics, development with morphogenesis, and classical crop-improvement techniques with modern breeding methodologies. Classical botany has been transformed into cutting-edge plant biology, thus providing the theoretical basis for plant biotechnology. It goes without saying that biotechnology has emerged as a powerful discipline of Biology in the last three decades. Biotechnological tools, techniques and information, used in combination with appropriate planning and execution, have already contributed significantly to economic growth and development. It is estimated that in the next decade or two, products and processes made possible by biotechnology will account for over 60% of worldwide commerce and output. There is, therefore, a need to arrive at a general understanding and common approach to issues related to the nature, possession, conservation and use of biodiversity, as it provides the raw material for biotechnology. More than 90% of the total requirements for the biotechnology industry are contributed by plants and microbes, in terms of goods and services. There are however substantial plant and microbial resources that are waiting for biotechnological exploitation in the near future through effective bioprospection. In order to exploit plants and microbes for their useful products and processes, we need to first understand their basic structure, organization, growth and development, cellular process and overall biology. We also need to identify and develop strategies to improve the productivity of plants. In view of the above, in this two-volume book on plant biology and biotechnology, the first volume is devoted to various aspects of plant biology and crop improvement. It includes 33 chapters contributed by 50 researchers, each of which is an expert in his/her own field of research. The book begins with an introductory chapter that gives a lucid account on the past, present and future of plant biology, thereby providing a perfect historical foundation for the chapters that follow. Four chapters are devoted to details on the structural and developmental aspects of the structures of plants and their principal organs. These chapters provide the molecular biological basis for the regulation of morphogenesis of the form of plants and their organs, involving control at the cellular and tissue levels. Details on biodiversity, the basic raw material for biotechnology, are discussed in a separate chapter, in which emphasis is placed on the genetic, species and ecosystem diversities and their conservation. Since fungi and other microbes form an important component of the overall biodiversity, special attention is paid to the treatment of fungi and other microbes in this volume. Four chapters respectively deal with an overview of fungi, arbuscularmycorrhizae and their relation to the sustenance of plant wealth, diversity and practical applications of mushrooms, and lichens (associated with a photobiont). Microbial endosymbionts associated with plants and phosphate solubilizing microbes in the rhizosphere of plants are exhaustively treated in two separate chapters. The reproductive strategies of bryophytes and an overview on Cycads form the subject matter of another two chapters, thus fulfilling the need to deal with the non-flowering Embryophyte group of plants. Angiosperms, the most important group of plants from a biotechnological perspective, are examined exhaustively in this volume. The chapters on angiosperms provide an overview and cover the genetic basis of flowers development, pre-and post-fertilization reproductive growth and development, seed biology and technology, plant secondary metabolism, photosynthesis, and plant volatile chemicals. A special effort has been made to include important topics on crop improvement in this volume. The importance of pollination services, apomixes, male sterility, induced mutations, polyploidy and climate changes is discussed, each in a separate chapter. Microalgalnutra-pharmaceuticals, vegetable-oil-based nutraceuticals and the importance of alien crop resources and underutilized crops for food and nutritional security form the topics of three other chapters in this volume. There is also a special chapter on the applications of remote sensing in the plant sciences, which also provides information on biodiversity distribution. The editors of this volume believe the wide range of basic topics on plant biology that have great relevance in biotechnology covered will be of great interest to students, researchers and teachers of botany and plant biotechnology alike.
You may like...
Analyzing Network Data in Biology and…
Natasa Przulj Paperback
Decoding the World - A Roadmap for the…
Po Bronson, Arvind Gupta Hardcover
Snyder and Champness Molecular Genetics…
Tina M. Henkin, Joseph E. Peters Hardcover R2,781 Discovery Miles 27 810
Grasp - The Science Transforming How We…
Sanjay Sarma, Luke Yoquinto Hardcover
The Power Of Suffering
David Roland Paperback
The Biological Universe - Life in the…
Wallace Arthur Hardcover R510 Discovery Miles 5 100
Inferior - The True Power of Women and…
Angela Saini Paperback (1)
Social - Why our brains are wired to…
Matthew D. Lieberman Paperback (1)
The Circadian Code - Lose Weight…
Satchin Panda Hardcover (2)
Ecology - From Individuals to Ecosystems
Michael Begon, Colin R. Townsend, … Paperback R1,236 Discovery Miles 12 360