This volume of"International Review of Neurobiology" concentrates on modern concepts of focal epileptic networks. The volume addresses specific topics such as seizures (including transition and termination), limbic networks, alteration of metabolism, and neocortical focus and malformation of cortical development, among others.

Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews, and thematic volumes that focus on recent progress in a specific area of neurobiology research.

Our knowledge about the mechanisms involved in pathophysiology of epilepsy has rapidly expanded during last decade
This special volume brings overview about modern concepts of epileptic focus organization and about the altered neural network dynamics which results in propensity of the brain tissue to generate spontaneous and repeated seizures
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This is a fascinating encyclopedia comparing the most important adaptations and evolutions in the natural world with the most important discoveries and inventions of human history. Welcome to the amazing world of adaptations, where species-including humans-develop fascinating new capabilities to ensure a competitive edge in their environment, or in some cases, survival itself. Encyclopedia of Adaptations in the Natural World is a wide-ranging catalog of the most important of those adaptations-from photosynthesis to the the peculiar "vampire"-like behavior of the tiny life form called the prion. The seven chapters in the Encyclopedia cover the key survival challenges all organisms face. Entries within those chapters cover specific adaptations from all forms of life, including animals, plants, bacteria, algae, fungi, and viruses. For each adaptation, the book also describes a related technological breakthrough in the human world, showing how engineers today study natural processes to help them develop new inventions. Provides diagrams of the process of photosynthesis, the functional areas of the human brain, and the bluefin tuna Includes 58 photographs and electron microscope images illustrating the adaptations in the book Presents bibliographic listings of key reference books, internet resources, and academic papers for further reading

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.

Rewire the brain processes that cause obsessions and compulsions-and take back your life! If you've ever wondered why you seem to get trapped in an endless cycle of obsessive, compulsive thoughts, you don't have to wonder anymore. Grounded in cutting-edge neuroscience and evidence-based cognitive behavioral therapy (CBT), Rewire Your OCD Brain will show you how and why your brain gets stuck in a loop of obsessive thinking, uncertainty, and worry; and offers the tools you need to short-circuit this response and get your symptoms under control-for good. Written by clinical psychologist Catherine Pittman and clinical neuropsychologist William Youngs, this groundbreaking book will show how neurological functions in your brain lead to obsessions, compulsions, and anxiety. You'll also find tons of proven-effective coping strategies to help you manage your worst symptoms-including relaxation, exercise, healthy sleep habits, cognitive restructuring, cognitive defusion, distraction, and mindfulness. The brain is powerful, and the more you work to change the way you respond to obsessive thoughts, the more resilient you'll become. If you're ready to rewire the brain processes that lie at the root of your obsessive thoughts, this book has everything you need to get started today.

The first IVF baby was born in the 1970s. Less than 20 years later, we had cloning and GM food, and information and communication technologies had transformed everyday life. In 2000, the human genome was sequenced. More recently, there has been much discussion of the economic and social benefits of nanotechnology, and synthetic biology has also been generating controversy.
This important volume is a timely contribution to increasing calls for regulation - or better regulation - of these and other new technologies. Drawing on an international team of legal scholars, it reviews and develops the role of human rights in the regulation of new technologies. Three controversies at the intersection between human rights and new technology are given particular attention. First, how the expansive application of human rights could contribute to the creation of a brave new world of choice, where human dignity is fundamentally compromised; second, how new technologies, and our regulatory responses to them, could be a threat to human rights; and, third, how human rights could be used to create better regulation of these technologies.

The book focuses on four broad topics related to trapping of agriculturally important tephritid fruit flies, namely i) lures and traps, ii) invasion biology and detection of infestations, iii) attract and kill systems, and iv) trade regulations and risk assessment. This comprehensive structure progresses from the biological interaction between insect and lures/traps to the area-wide use of trapping systems to the utilization and impact of trapping data on international trade. The chapters include accounts of earlier research but are not simply compendia and instead evaluate past and current work as a tool for critical analysis and proposal of productive avenues for future work. At present there is no book available that deals with fruit fly trapping in such a broad context. Our book fills this gap and serves as a global reference for both those interested in fruit flies specifically as well as anyone dealing with the threat of invasive agricultural insects in general.

This book provides insights into dynamic and complex interrelationships between professionalism and medical practice. It does so by looking into the most relevant and recent theoretical and practical frameworks and by systematizing and integrating extensive and growing literature on medical professionalism. Through honest and prudent contributions from very diverse backgrounds and contexts, this book provides an understanding of medical professionalism derived from a broader historical and cultural context in order to contribute to everyday professional life and practice - the very place of its existence. The book presents the conflicting and sometimes irreconcilable demands and challenges physicians face in everyday practice. A better understanding of these fundamental issues is the only way for medicine to maintain and preserve its unique morality, the same one that enabled its existence in the first place. The book is relevant for everyone immersed and interested in the subject of medical professionalism as a resource, which may ease or guide them through the complexities of issues at hand. It will also contribute to the ongoing debate on medical professionalism, medical ethics, bioethics, and professionalism and ethics in general.

This book integrates current advances in biology, economics of information and linguistics research through applications using agent-based modeling and social network analysis to develop scenarios of communication and language emergence in the social aspects of biological communications. The book presents a model of communication emergence that can be applied both to human and non-human living organism networks. The model is based on economic concepts and individual behavior fundamental for the study of trust and reputation networks in social science, particularly in economics; it is also based on the theory of the emergence of norms and historical path dependence that has been influential in institutional economics. Also included are mathematical models and code for agent-based models to explore various scenarios of language evolution, as well as a computer application that explores language and communication in biological versus social organisms, and the emergence of various meanings and grammars in human networks. Emergence of Communication in Socio-Biological Networks offers both a completely novel approach to communication emergence and language evolution and provides a path for the reader to explore various scenarios of language and communication that are not constrained to the human networks alone. By illustrating how computational social science and the complex systems approach can incorporate multiple disciplines and offer an integrated theory-model approach to the evolution of language, the book will be of interest to researchers working with computational linguistics, mathematical linguistics, and complex systems.

This book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The clinical section covers everything from epidemiological features to epigenetic regulation to behavioral therapies and much in between. The basic science section presents the latest knowledge on the underlying causes of the disorder including the role of various neurotransmitters, neurexins and neuroligins, reelin, and other proteins. Chapters also explore the cognition and motor control in autism and the connection between oxidative stress and mitochondrial dysfunction and autism. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.

Quantum Mechanics I: The Fundamentals provides a graduate-level account of the behavior of matter and energy at the molecular, atomic, nuclear, and sub-nuclear levels. It covers basic concepts, mathematical formalism, and applications to physically important systems. This fully updated new edition addresses many topics not typically found in books at this level, including: Bound state solutions of quantum pendulum Morse oscillator Solutions of classical counterpart of quantum mechanical systems A criterion for bound state Scattering from a locally periodic potential and reflection-less potential Modified Heisenberg relation Wave packet revival and its dynamics An asymptotic method for slowly varying potentials Klein paradox, Einstein-Podolsky-Rosen (EPR) paradox, and Bell's theorem Delayed-choice experiments Fractional quantum mechanics Numerical methods for quantum systems A collection of problems at the end of each chapter develops students' understanding of both basic concepts and the application of theory to various physically important systems. This book, along with the authors' follow-up Quantum Mechanics II: Advanced Topics, provides students with a broad, up-to-date introduction to quantum mechanics. Quantum Mechanics II: Advanced Topics offers a comprehensive exploration of the state-of-the-art in various advanced topics of current research interest. A follow-up to the authors' introductory book Quantum Mechanics I: The Fundamentals, this book expounds basic principles, theoretical treatment, case studies, worked-out examples and applications of advanced topics including quantum technologies. A thoroughly revised and updated this unique volume presents an in-depth and up-to-date progress on the growing topics including latest achievements on quantum technology. In the second edition six new chapters are included and the other ten chapters are extensively revised. Features Covers classical and quantum field theories, path integral formalism and supersymmetric quantum mechanics. Highlights coherent and squeezed states, Berry's phase, Aharonov-Bohm effect and Wigner function. Explores salient features of quantum entanglement and quantum cryptography. Presents basic concepts of quantum computers and the features of no-cloning theorem and quantum cloning machines. Describes the theory and techniques of quantum tomography, quantum simulation and quantum error correction. Introduces other novel topics including quantum versions of theory of gravity, cosmology, Zeno effect, teleportation, games, chaos and steering. Outlines the quantum technologies of ghost imaging, detection of weak amplitudes and displacements, lithography, metrology, teleportation of optical images, sensors, batteries and internet. Contains several worked-out problems and exercises in each chapter. Quantum Mechanics II: Advanced Topics addresses various currently emerging exciting topics of quantum mechanics. It emphasizes the fundamentals behind the latest cutting-edge developments to help explain the motivation for deeper exploration. The book is a valuable resource for graduate students in physics and engineering wishing to pursue research in quantum mechanics.

Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume presents an up to date presentation of current knowledge and problems in the field of thermal receptors. This is a rapidly evolving research area and the book contains important contributions from some of the leaders in the field.

How do we become aware of things and events in the outside world, and how does the brain control the muscular system and behavior? This book examines the history of Western attempts to explain how messages might be sent from the sense organs to the brain and from the brain to the muscles. It focuses on a construct called animal spirit, which would permeate philosophy and guide physiology and medicine for over two millennia.
The authors' story opens along the Eastern Mediterranean, where they examine how Pre-Socratic philosophers related the soul to air-wind or pneuma. They then trace what Hippocrates, Plato and Aristotle wrote about this pneuma, and how Stoic and Epicurean philosophers approached it. They also visit Alexandria, where Hellenistic anatomists provided new thoughts about the nerves and the ventricles. Thereafter, the authors return to the Greek mainland, where they show how Galen's pneuma psychikon or spiritus animae would provide an explanation for sensations and movements.
Galen's writings would guide science and medicine for well over a thousand years, albeit with some modifications. One change, found in early Christian writers Nemesius and Augustine, involved assigning perception, cognition, and memory to different spirit-filled ventricles. After examining how pious Scholastics later dealt with the nerve spirit, the authors turn to how questions began to be raised about it in the 1500s and 1600s. Here they examine the rise of modern science with its revealing experiments, microscopic observations, and attempts to break with the past. Descartes, Swammerdam, Borelli, Glisson, Willis, Newton, Hartley, Boerhaave and Haller are among the featured players in this part of the story.
Nevertheless, the animal spirit doctrine continued to survive (although modified), because no adequate replacement for it was immediately forthcoming. The replacement theory stemmed from experiments on electric fishes started in the 1750s. Additional research on these fishes and then on frogs eventually led scientists to abandon their time-honored ideas. The authors trace some of the developments leading to modern electrophysiology and end with an epilogue centered on what this history teaches us about paradigmatic changes in the life sciences.

This stimulating analysis reviews the broad potential of animal models to foster a deeper understanding of human pathology, strengthen connections between genetic and behavioral studies, and develop more effective treatments for mental disorders. Widely-studied and lesser-used species are examined in models that capture features along the continuum of normative and pathological behavior. The models highlight genetic causes of core features, or endophenotypes, of developmental, internalizing, and externalizing disorders, as well as dementia. Expert contributors address questions ranging from how suitable species are chosen for study to the costs and benefits of using inbred versus outbred strains, and the effects of housing environment on subject animals. Larger issues addressed include how to evaluate the applicability of animal behavioral models to the human condition and how these models can harness emerging molecular technologies to further our understanding of the genetic basis of mental illness. Included in the coverage: Mating and fighting in Drosophila. Attachment and social bonding. Impulsivity in rodents and humans. Animal models of cognitive decline. Animal models of social cognition. Future directions for animal models in behavioral genetics. A detailed map of where this evolving field is headed, Animal Models of Behavior Genetics shows geneticists, molecular biologists, and cognitive neuroscientists paths beyond established concepts toward a more knowledgeable and collaborative future.

This volume presents the current state of laser-assisted bioprinting, a cutting edge tissue engineering technology. Nineteen chapters discuss the most recent developments in using this technology for engineering different types of tissue. Beginning with an overview, the discussion covers bioprinting in cell viability and pattern viability, tissue microfabrication to study cell proliferation, microenvironment for controlling stem cell fate, cell differentiation, zigzag cellular tubes, cartilage tissue engineering, osteogenesis, vessel substitutes, skin tissue and much more. Because bioprinting is on its way to becoming a dominant technology in tissue-engineering, Bioprinting in Regenerative Medicine is essential reading for those researching or working in regenerative medicine, tissue engineering or translational research. Those studying or working with stem cells who are interested in the development of the field will also find the information invaluable.

This book provides a snapshot of representative modeling analyses of coastal hypoxia and its effects. Hypoxia refers to conditions in the water column where dissolved oxygen falls below levels that can support most metazoan marine life (i.e., 2 mg O2 l-1). The number of hypoxic zones has been increasing at an exponential rate since the 1960s; there are currently more than 600 documented hypoxic zones in the estuarine and coastal waters worldwide. Hypoxia develops as a synergistic product of many physical and biological factors that affect the balance of dissolved oxygen in seawater, including temperature, solar radiation, wind, freshwater discharge, nutrient supply, and the production and decay of organic matter. A number of modeling approaches have been increasingly used in hypoxia research, along with the more traditional observational and experimental studies. Modeling is necessary because of rapidly changing coastal circulation and stratification patterns that affect hypoxia, the large spatial extent over which hypoxia develops, and limitations on our capabilities to directly measure hypoxia over large spatial and temporal scales. This book consists of 15 chapters that are broadly organized around three main topics: (1) Modeling of the physical controls on hypoxia, (2) Modeling of biogeochemical controls and feedbacks, and, (3) Modeling of the ecological effects of hypoxia. The final chapter is a synthesis chapter that draws generalities from the earlier chapters, highlights strengths and weaknesses of the current state-of-the-art modeling, and offers recommendations on future directions.

The science of cannabinoids is 50 years old. These past years provided a remarkable and constant number of breakthroughs, showing that the signaling mediated by endocannabinoids and lipid mediators impacts almost every function of the body. Indeed, this represents a special field of research, which allows tackling the complexity of biological functions, and provides potential therapeutic frameworks for a plethora of diseases. The number of exciting discoveries brought up to the scientific community almost on a daily basis highlights the importance of an updated volume on this topic. Particularly, given that potential therapeutic benefits of cannabis and cannabinoids are currently under heavy analysis in many Countries worldwide. Hence, the main objective of this book is to explore not only some of the many functions of endocannabinoids (and lipid mediators) in physiological control of networks at a cellular and molecular level, but also to extend this knowledge for potential use of cannabinoids and/or drugs regulating endocannabinoid levels in vivo as therapeutic target(s) in neurological and neuropsychiatric disorders. In this book new findings and ideas about the endocannabinoid system and its roles as neuronal circuit modulator related to human brain pathologies characterized by alterations in neuroplasticity will be highlighted. Endocannabinoid roles in key systems controlling appetite, pain, learning and memory, as well as sleep and stress responses will be presented. In addition, pathological processes associated with changes in endocannabinoid signaling will be discussed in the context of anxiety, autism, depression and addiction. This book will provide an excellent background to researchers looking for extending their areas of interest, and to newcomers in the field.

This volume details widely used and newer lab protocols for studying hypoxic responses in physiology and diseases. Chapters guide the reader through the application of hypoxic conditions, to the techniques of molecular biology, biochemical, cell biology, genomic,bioinformatic, metabolic, and animal studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Hypoxia: Methods and Protocols aims to provide a valuable set of tools that can be used to study hypoxia and beyond.

This fascinating reference book delves into the origins of the vernacular and scientific names of sharks, rays, skates and chimeras. Each entry offers a concise biography, revealing the hidden stories and facts behind each species' name. Full of interesting facts and humorous titbits, the authors' extensive research and detective work has made this book a comprehensive source of knowledge on everyone associated with the naming of a species. A fascinating resource for anyone with an interest in sharks, from curious naturalist to professional ichthyologist, it is an essential addition to the library of anyone wishing to satisfy those tickling questions on the mysteries behind the names. Sometimes a name refers not to a person but to a fictional character or mythological figure. Eptatretus eos is named after the Greek goddess of the dawn in reference to the pink colouring of the hagfish. The Chilean Roundray Urotrygon cimar, named after Centro de Investigacion en Ciencias del Mar y Limnologia in honour of its 20th anniversary, and the Angular Angelshark Squatina Guggenheim, named after the John Simon Guggenheim Memorial Foundation, are both named after institutions. The Whiteleg Skate Amblyraja taaf is just a shorthand way of describing a toponym - Territoire des Terres australes et antarctiques francaises. There are also entries which are light-hearted such as the one for a lady who told us "that decoration of her cakes have included roughtail skate Bathyraja trachura, red abalone Haliotis rufescens, and chinook salmon Oncorhynchus tshawytscha." Following the success of their previous Eponym Dictionaries, the authors have joined forces to give the Elasmobranch group of fishes a similar treatment but they have also included the describers and authors of the original descriptions of the fishes involved, in addition to those names that are, or appear to be, eponyms. They have tracked down some 850 names of living as well as dead people. Of these half are eponyms after people who have fish named after them and may also have described a fish or fishes. The other half are ichthyologists, marine biologists and other scientists who have become involved in the description and naming of sharks, rays, skates and chimeras. For each person mentioned there is brief, pithy biography. Additionally there are some 50 entries for what sound like eponyms but turned out not to have any connection to a person, such as the Alexandrine Torpedo is named after the city in Egypt and not Alexander the Great. In some cases these are a reminder of the courage of scientists whose dedicated research in remote locations exposed them to disease and even violent death. The eponym ensures that their memory will survive, aided by reference works such as this highly readable dictionary. Altogether 1,577 fishes are listed.

"Evolution: Components and Mechanisms" introduces the many recent discoveries and insights that have added to the discipline of organic evolution, and combines them with the key topics needed to gain a fundamental understanding of the mechanisms of evolution. Each chapter covers an important topic or factor pertinent to a modern understanding of evolutionary theory, allowing easy access to particular topics for either study or review. Many chapters are cross-referenced.

Modern evolutionary theory has expanded significantly within only the past two to three decades. In recent times the definition of a gene has evolved, the definition of organic evolution itself is in need of some modification, the number of known mechanisms of evolutionary change has increased dramatically, and the emphasis placed on opportunity and contingency has increased. This book synthesizes these changes and presents many of the novel topics in evolutionary theory in an accessible and thorough format.

This book is an ideal, up-to-date resource for biologists, geneticists, evolutionary biologists, developmental biologists, and researchers in, as well as students and academics in these areas and professional scientists in many subfields of biology.
Discusses many of the mechanisms responsible for evolutionary change Includes an appendix that provides a brief synopsis of these mechanisms with most discussed in greater detail in respective chaptersAids readers in their organization and understanding of the material by addressing the basic concepts and topics surrounding organic evolution Covers some topics not typically addressed, such as opportunity, contingency, symbiosis, and progress

This ambitious compendium provides an extensive overview on the "supporting cells" of the vertebrate central nervous system, these being glial cells which far outnumber neurons but are much less understood. Covering multiple aspects of this family of transporters-- from structural properties, to their involvement in signaling and gene expression regulation, this volume presents the most recent research on the roles of glial amino acid transporters as key molecules of brain metabolism and signaling.

With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

This special volume of "Progress in Molecular Biology and Translational Science" provides a current overview of how memory is processed in the brain.A broad range of topics are presented by leaders in the field, ranging from brain circuitry to synaptic plasticity to the molecular machinery that contributes to the brain's ability to maintain information across time. Memory systems in the prefrontal cortex, hippocampus and amygdala are considered as well. In addition, the volume covers recent contributions to our understanding of memory from in vivo imaging, optogenetic, electrophysiological, biochemical and molecular biological studies.
Articles from world renowned experts in memoryCovering topics from signaling, epigenetic, RNA translation to plasticityMethodological approaches includemolecular and cellular, behavioral, electrophysiological, optogenetic and functional imaging"