This volume gives an overview on the currently debated ethical issues regarding advance directives from an international perspective. It focuses on a wider understanding of the known and widely accepted concept of patient self-determination for future situations. Although advance directives have been widely discussed since the 1980s, the ethical bases of advance directives still remain a matter of heated debates. The book aims to contribute to these controversial debates by integrating fundamental ethical issues on advance directives with practical matters of their implementation. Cultural, national and professional differences in how advance directives are understood by health care professions and by patients, as well as in laws and regulations, are pinpointed.

Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician's fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual's susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain-machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.

Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.

The Baltic Sea is an area extensively explored by the oceanographers. Hence it is one of the most often described marine areas in the scientific literature. However, there are still several fields which are poorly investigated and reported by scientists. One of them is the carbon cycle of the Baltic Sea. Although it is believed the shelf seas are responsible for about 20% of all marine carbon dioxide uptake, while they constitute only 7% of the whole sea surface, still a scientific debate exists on the role of the Baltic Sea in the global carbon cycle. "Carbon cycle of the Baltic Sea" is intended to be a comprehensive presentation and discussion of state of the art research by biogeochemists involved in the Baltic Sea carbon cycle research. This work presents both qualitative and quantitative descriptions of the main carbon flows in the Baltic Sea as well as their possible shifts induced by climatic and global change.

This completely updated fifth edition of Bacterial Fish Pathogens is a comprehensive discussion of the biological aspects of the bacteria which cause disease in farmed and wild fish. Since the 4th edition was published in 2007, there has been an upturn in the application of molecular approaches to taxonomy, diagnosis and vaccine development. New pathogens, e.g. Aeromonas schubertii, have been described. Also, there has been the emergence of diseases caused by bacteria which have not been cultured, and which have been equated with new taxa, i.e. Candidatus . Consideration is given to all the bacterial fish pathogens, including primary pathogens and opportunists."

1. 1 Nautilus and Allonautilus: Two Decades of Progress W. Bruce Saunders Department of Geology Bryn Mawr College Bryn Mawr PA 19010 wsaunder@brynmawr. edu Neil H. Landman Division of Paleontology American Museum of Natural History New York, New York 10024 landman@amnh. org When Nautilus: Biology and Paleobiology of a Living Fossil was published in 1987, it marked a milestone in cross-disciplinary collaboration. More than half of the contributing authors (36/65) were paleontologists, many of whom were collaborating with neontological counterparts. Their interest in studying this reclusive, poorly known animal was being driven by a search for clues to the mode of life and natural history of the once dominant shelled cephalopods, through study of the sole surviving genus. At the same time, Nautilus offered an opportunity for neontologists to look at a fundamentally different, phylogenetically basal member of the extant Cephalopoda. It was a w- win situation, combining paleontological deep-time perspectives, old fashioned expeditionary zeal, traditional biological approaches and new techniques. The results were cross-fertilized investigations in such disparate fields as ecology, functional morphology, taphonomy, genetics, phylogeny, locomotive dynamics, etc. As one reviewer of the xxxvi Introduction xxxvii book noted, Nautilus had gone from being one of the least known to one of the best understood of living cephalopods.

Advance in barley sciences presents the latest developments in barley sciences. It collects 39 papers submitted to the 11th International Barley Genetics Symposium, and covers all presentation sessions of the conference, i.e., barley development and economy, utilization of germplasm, genetic resources and genetic stocks, end-uses, biotic stress tolerance, abiotic stresses, new and renewed breeding methodology, barley physiology, breeding success stories, barley genomics and all other '-omics.' Th e information will be useful for barley breeders, brewers, biochemists, molecular geneticists and biotechnologists. Th is book may also serve as reference text for students and scientists engaged in barley research. Dr. Guoping Zhang is a barley breeder and crop physiologist at the Department of Agronomy, Zhejiang University, China. Dr. Chengdao Li is a senior molecular geneticist and barley breeder at the Department of Agriculture and Food, Western Australia, Australia. He is also an adjunct professor at Murdoch University of Australia and Zhejiang University. Dr. Xu Liu, a member of the China Academy of Engineering, is a plant resources researcher at the Chinese Academy of Agricultural Sciences.

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross- tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Arguing that human evolution has come to a stand-still, this book sets out to explore the evolutionary steps that have defined life on this planet. It describes the stages from cosmic to chemical and biological evolution and to the development of civilization and culture. From this scientific approach, the author concludes that new rules of ethics are required in order to maintain and improve the civilization and culture of humanity. Matare argues for corrective genetic interference and explores the moral implications.

This book introduces readers to classical population genetics and the ways in which it can be applied to practical problems, including testing for natural selection, genetic drift, genetic differentiation, population structuring, gene flow and linkage disequilibrium. It provides a comprehensive monograph on the topic, addressing the theory, applications and evolutionary deductions, which are clearly explained using experimental results. It also offers separate chapters on origin, establishment and spread of chromosomal aberrations in populations along with details of culturing, maintaining and using Drosophila ananassae (genetically unique and the most commonly used species along with D. melanogaster) for genetic research. Encompassing topics like genetics, evolution, Drosophila genetics, population genetics, population structuring, natural selection and genetic drift in considerable detail, it provides a valuable resource to undergraduate and postgraduate students, as well as researchers at all level. This book explores some fundamental questions concerning the role of natural selection and genetic drift on the degree of inversion polymorphism. India, with its wide diversity in geo-climatic conditions, provides an excellent platform to conduct such studies. The book showcases sampling records of inversion frequencies in natural Indian populations of D. ananassae that cover more than two decades. It highlights case studies in which sampling data on inversion frequencies was combined with that from earlier surveys, generating a time series that allows the evolutionary dynamics of inversion polymorphism to be explored. Such long time series are rare but nonetheless crucial for studying the evolutionary dynamics of inversion polymorphism. The population-genetic analysis discussed is unprecedented in terms of its temporal (two decades) and spatial (most regions of India covered) scale and investigates the patterns of polymorphic system in D. ananassae to see if there is any temporal divergence. It endeavors to present a holistic picture of inversion polymorphism across the country (India). Chromosomal aberrations, particularly paracentric inversions, are used as a tool for discussing population genetic studies, helping human geneticists, gynecologists and other medical professionals understand why some aberrations are fatal in humans, with affected embryos often not surviving the first trimester of pregnancy, while similar aberrations in Drosophila flies aid in their adaptation to the environmental heterogeneity across the globe.

This volume critically reviews all previously published work of parasites that interact with krill (order Euphausiacea) updating misconceptions and summarizing the diversity of epibionts, ectoparasites, mesoparasites and endoparasites that interact with these crustaceans. As far as we know, there is a lack of books about parasites of marine crustaceans not targeted to fisheries and aquaculture. Thus, this would be the most complete and integrative monograph of parasites of marine zooplankton and micro nektonic organisms worldwide. Krill form immense aggregations and serve as food for multiple planktonic and nektonic predators playing a crucial role in pelagic food web. Besides, several species are also used for human consumption. For these reasons there is a growing concern about the health issues that krill parasites may impose on other species, including us. This book provides a comprehensive review of parasites of a crustacean order that can extrapolate to potential parasites in other crustacean taxa worldwide.

The biological and genetic bases of behavioral diversity have long been topics of study within many disciplines, including evolutionary biology, genetics, ethology, sociobiology, and comparative psychology, but only relatively recently have attempts been made to bring these different approaches together. This volume covers a wide range of interdisciplinary research which uses some of the newest and most promising methods and technologies. Presented here is an overview of findings in the ongoing search for the ultimate causes of behavior in several different species, including primates, dogs, rodents, birds, and fish. Divided into five parts, the work describes research on sexual and kin selection, personality and temperament, molecular genetics of personality, color vision and body coloration, and the neurological underpinnings of complex behaviors. Valuable for researchers as well as graduate students in a wide range of fields from neuroscience to ecology, the book is also useful to those seeking to move beyond the boundaries of their own discipline and to expand their knowledge.

Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer s, Parkinson s, and Huntington 's diseases.

r ed Algae in Genome Age book most people reading this book have childhood memories about being enthralled at the beach with those rare and mysterious living forms we knew as seaweeds. We were fascinated at that time by their range of red hues and textures, and most of all, their exotic beauty. t o a scientist, red algae represent much more than apparent features. t heir complex forms have attracted morphologists for centuries; their intricate life cycles have brought more than one surprise to plant biologists familiar only with ferns and fowering plants; their unusual tastes have been appreciated for mill- nia, and their valuable chemical constituents have been exploited for nearly as long, most recently by biotech companies; their diversity in marine, freshwater, and t- restrial environments has offered centuries of engaging entertainment for botanists eager to arrange them in orderly classifcation systems; still, the red algae continue to teach us how many more challenges need to be overcome in order to understand their biodiversity, biological functions, and evolutionary histories.

Drawing together interview material, medical publications, and first-hand accounts, this book shows that what is being remade in the burgeoning medical field of face transplantation is not only the lives of patients, but also the very ways that state institutions, surgeons, and families make sense of rights, claims for inclusion, and life itself.

This book focuses on neuro-engineering and neural computing, a multi-disciplinary field of research attracting considerable attention from engineers, neuroscientists, microbiologists and material scientists. It explores a range of topics concerning the design and development of innovative neural and brain interfacing technologies, as well as novel information acquisition and processing algorithms to make sense of the acquired data. The book also highlights emerging trends and advances regarding the applications of neuro-engineering in real-world scenarios, such as neural prostheses, diagnosis of neural degenerative diseases, deep brain stimulation, biosensors, real neural network-inspired artificial neural networks (ANNs) and the predictive modeling of information flows in neuronal networks. The book is broadly divided into three main sections including: current trends in technological developments, neural computation techniques to make sense of the neural behavioral data, and application of these technologies/techniques in the medical domain in the treatment of neural disorders.

Lakes across the globe require help. The Lake Restoration Handbook: A New Zealand Perspective addresses this need through a series of chapters that draw on recent advances in modelling and monitoring tools, citizen science and First Peoples' roles, catchment and lake-focused restoration techniques, and policy implementation. New Zealand lakes, like lakes across the globe, are subject to multiple pressures that have increased in severity and scale as land use has intensified, invasive species have spread and global climate change becomes manifest. This books builds on the popular Lake Managers Handbook (1987), which provided guidance on undertaking investigations into, and understanding lake ecosystems in New Zealand. The Lake Restoration Handbook: A New Zealand Perspective synthesises contemporary issues related to lake restoration and rehabilitation, integrated with social science and cultural viewpoints, and complemented by authoritative topic-area summaries by renowned scientists and practitioners from across the globe. The book examines the progress of lake restoration and the new and emerging tools available to managers for predicting and effecting change. The book will be a valuable resource for natural and social scientists, policy writers, lake managers, and anyone interested in the health of lake ecosystems.

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

Enabling Environment is as real as it gets. The global commons are jointly owned and their inhabitants are jointly obligated to ensure their preservation. In the face of protracted negotiations, convoluted documentation, discord, and incessant bickering among scientists, activists, pressure groups of various hues, politicians and negotiators, very often the people on the ground are ignored or taken for granted. In the meantime, life meanders along. It is these 'everyday individuals' who make consumption-related choices on their lifestyles, travel or on preferring certain products or services over others. Enabling Environment puts the individual front and center.

Ecosystem services need to be recognized, appropriately priced and the costs allocated to the agents concerned. Enabling Environment is about defining economic and non-economic incentive structures and utilizing them to arrive at pro-environmental outcomes. This collection of articles illustrates the use of existing social, economic and regulatory structures, and the financial architecture and instruments, suitably modified or extended, to help internalize the environmental externality.

This book is about politics and planning outside of cities, where urban political economy and planning theories do not account for the resilience of places that are no longer rural and where local communities work hard to keep from ever becoming urban. By examining exurbia as a type of place that is no longer simply rural or only tied to the economies of global resources (e.g., mining, forestry, and agriculture), we explore how changing landscapes are planned and designed not to be urban, that is, to look, function, and feel different from cities and suburbs in spite of new home development and real estate speculation. The book's authors contend that exurbia is defined by the persistence of rural economies, the conservation of rural character, and protection of natural ecological systems, all of which are critical components of the contentious local politics that seek to limit growth. Comparative political ecology is used as an organizing concept throughout the book to describe the nature of exurban areas in the U.S. and Australia, although exurbs are common to many countries. The essays each describe distinctive case studies, with each chapter using the key concepts of competing rural capitalisms and uneven environmental management to describe the politics of exurban change. This systematic analysis makes the processes of exurban change easier to see and understand. Based on these case studies, seven characteristics of exurban places are identified: rural character, access, local economic change, ideologies of nature, changes in land management, coalition-building, and land-use planning. This book will be of interest to those who study planning, conservation, and land development issues, especially in areas of high natural amenity or environmental value. There is no political ecology book quite like this-neither one solely focused on cases from the developed world (in this case the United States and Australia), nor one that specifically harnesses different case studies from multiple areas to develop a central organizing perspective of landscape change.

The book is the proceedings of the 2nd International Conference on NeuroRehabilitation (ICNR 2014), held 24th-26th June 2014 in Aalborg, Denmark. The conference featured the latest highlights in the emerging and interdisciplinary field of neural rehabilitation engineering and identified important healthcare challenges the scientific community will be faced with in the coming years. Edited and written by leading experts in the field, the book includes keynote papers, regular conference papers, and contributions to special and innovation sessions, covering the following main topics: neuro-rehabilitation applications and solutions for restoring impaired neurological functions; cutting-edge technologies and methods in neuro-rehabilitation; and translational challenges in neuro-rehabilitation. Thanks to its highly interdisciplinary approach, the book will not only be a highly relevant reference guide for academic researchers, engineers, neurophysiologists, neuroscientists, physicians and physiotherapists working at the forefront of their field, but will also help to act as bridge between the scientific, engineering and medical communities.

This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.

This volume integrates the latest findings on earliest life forms, identified and characterised in some of the oldest rocks on Earth. New material from prominent researchers in the field is presented and evaluated in the context of previous work. Emphasis is placed on the integration of analytical methods with observational techniques and experimental simulations. The opening section focuses on submarine hot springs that the majority of researchers postulates served as the cradle of life on Earth. In subsequent sections, evidence for life in strongly metamorphosed rocks such as those in Greenland is evaluated and early ecosystems identified in the well preserved Barberton and Pilbara successions in Southern Africa and Western Australia. The final section includes a number of contributions from authors with alternate perspectives on the evidence and record of early life on Earth. Audience This volume will be valuable to researchers and graduate students in biogeosciences, geochemistry, paleontology and geology interested in the origin of life on earth.

Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of "sigma receptors" to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives.

This book compiles and presents new developments in statistical causal inference. The accompanying data and computer programs are publicly available so readers may replicate the model development and data analysis presented in each chapter. In this way, methodology is taught so that readers may implement it directly. The book brings together experts engaged in causal inference research to present and discuss recent issues in causal inference methodological development. This is also a timely look at causal inference applied to scenarios that range from clinical trials to mediation and public health research more broadly. In an academic setting, this book will serve as a reference and guide to a course in causal inference at the graduate level (Master's or Doctorate). It is particularly relevant for students pursuing degrees in statistics, biostatistics, and computational biology. Researchers and data analysts in public health and biomedical research will also find this book to be an important reference.