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Books > Medicine > Clinical & internal medicine > Haematology
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Protein Structural Biology in Biomedical Research, Part A, Volume 22 (Hardcover)
Loot Price: R2,959
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Protein Structural Biology in Biomedical Research, Part A, Volume 22 (Hardcover)
Series: Advances in Molecular & Cell Biology
Expected to ship within 10 - 15 working days
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Recent advances in protein structural biology, coupled with new
developments in human genetics, have opened the door to
understanding the molecular basis of many metabolic, physiological,
and developmental processes in human biology. Medical pathologies,
and their chemical therapies, are increasingly being described at
the molecular level. For single-gene diseases, and some multi-gene
conditions, identification of highly correlated genes immediately
leads to identification of covalent structures of the actual
chemical agents of the disease, namely the protein gene products.
Once the primary sequence of a protein is ascertained, structural
biologists work to determine its three-dimensional, biologically
active structure, or to predict its probable fold and/or function
by comparison to the data base of known protein structures.
Similarly, three-dimensional structures of proteins produced by
microbiological pathogens are the subject of intense study, for
example, the proteins necessary for maturation of the human HIV
virus. Once the three-dimensional structure of a protein is known
or predicted, its function, as well as potential binding sites for
drugs that inhibit its function, become tractable questions. The
medical ramifications of the burgeoning results of protein
structural biology, from gene replacement therapy to "rational"
drug design, are well recognized by researchers in biomedical
areas, and by a significant proportion of the general population.
The purpose of this book is to introduce biomedical scientists to
important areas of protein structural biology, and to provide an
insightful orientation to the primary literature that shapes the
field in each subject.
The chapters in this volume cover aspects of protein structural
biology which have led to the recognition of fundamental
relationships between protein structure and function.
General
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