Powerfully involving narrative and incisive detail, clarity and inherent drama: Blood offers in abundance the qualities that define the best popular science writing. Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.

Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."

Alex Dowsett’s pulsating autobiography lifts the lid on a decade of life in the world’s greatest pelotons and tells how he succeeded despite being the world’s only top sportsperson with haemophilia A. For over a decade Alex Dowsett had been one of Britain’s best cyclists. He has ridden Grand Tours and Classics for elite teams including Sky and Movistar and broke the iconic World Hour Record – the ultimate time trial challenge. With humour, insight and brutal honesty, Alex tells of the challenges he has faced in his struggle to reach the top and his years as a pro-cyclist. Alex has achieved all this despite being the only top sportsperson in the world with haemophilia A. He describes how the condition – in which falls can be fatal – blighted his young sporting life, and his determination to succeed in cycling. Amazingly, he went on to excel in a sport in which cuts, grazes and bruises are a given. Every professional cyclist requires courage, but Alex takes fearlessness to another level. With an allstar cycling cast, including Bradley Wiggins, Chris Froome, Lance Armstrong and Mark Cavendish, this pulsating book lifts the lid on life in the peloton at the world’s top level. Open and frank in his views, Alex recalls his highs – including his coming of age time trial victory, a famous Giro d’Italia stage victory riding solo for 18 kilometres and famously breaking the World Hour record in 2015 – as well as his frustrations at the injustices he faced in the sport. Alex announced his forthcoming retirement at the end of the 2022 season and this memoir perfectly chronicles a career in which he was driven equally by love and rage. His compelling personal story combines with his take on being part of the golden age of British cycling and his sometimes outspoken views to produce an inspirational story of sporting endeavour.

This fourth edition presents an updated and expanded text and illustrations to reflect continued morphologic, immunophenotypic, and especially molecular advances in the field of neoplastic hematology, mostly due to the rapidly expanding application of next-generation sequencing. Those advances not only allow a more reliable diagnosis of the majority of tumors and identification of early changes such as monoclonal B-cell lymphocytosis or clonal hematopoiesis of indeterminate potential (CHIP), but also in many cases identify mutations or phenotypic changes in tumors that can be targeted by mutation-specific or antigen-specific drugs. This edition incorporates the updated WHO classification of hematopoietic tumors and new immunophenotypic and molecular markers to provide a thorough pathologic overview of hematologic neoplasms while focusing on flow cytometric features. Special emphasis has been put on hematological neoplasms with crucial clinical significance such as acute promyelocytic leukemia, other acute leukemias, and difficult areas in flow cytometry. Flow cytometric features in AML, MDS, CMML, CLL and measurable residual disease were significantly expanded. There are many new comparative tables, illustrations, and diagrams of algorithmic approaches.

Sickle cell and thalassaemia are among the world's most common genetic conditions. They are especially common in Africa, Brazil, the Caribbean, the Middle East and Asia. They affect all ethnic groups but they particularly impact on minority ethnic groups in North America, Europe and Australasia. Much research has focused on clinical, laboratory and genetic studies of these conditions. Through a wide-ranging selection of readings based on social scientific research into sickle cell and thalassaemia, this book seeks to redress this imbalance. This is important as, through an examination of the different social, economic and cultural contexts of the lives of people living with sickle cell or thalassaemia, the contributors demonstrate that people are more than the sum of their genes and that their life experiences are rarely derived solely from the clinical severity of their condition but depend on the social context of their lives. Genetics and Global Public Health presents a new concluding chapter which highlights the critical nature of social science research for sickle cell and thalassaemia communities, providing key insights into the social contexts of human behaviour and analysing how societal arrangements could change to assist people living with either condition. It will be of great interest to postgraduate and research students as well as professionals working in the field of public health. This book was originally published as a special issue of the journal Ethnicity and Health.

This comprehensive atlas is unique in being devoted to the MRI appearances of bone marrow in the axial and appendicular skeleton of adults and children. Normal MRI findings, including common variants and degenerative changes, are first documented. MRI appearances in the entire spectrum of neoplastic and non-neoplastic infiltrative marrow disorders are then presented, with accompanying explanatory text. Among the conditions considered are multiple myeloma, the acute and chronic leukemias, diffuse metastases, diffuse lymphomas, the anemias, polycythemia vera, myelofibrosis, storage disorders, and infections. Characteristic changes to bone marrow following various forms of treatment are also displayed and discussed. The selected images reflect the use of a variety of sequences and techniques, such as fat suppression, chemical shift imaging, and contrast-enhanced imaging.

The new and fully updated edition of the definitive haematology textbook for undergraduate and postgraduate students and trainees Hoffbrand's Essential Haematology is widely regarded as the most authoritative introduction to the subject available, helping medical students and trainee doctors understand the essential principles of modern clinical and laboratory haematology for nearly four decades. Now in its eighth edition, this market-leading textbook introduces the formation and function of blood cells and the diseases that arise from dysfunction and disruption of these processes. Beautifully presented with over 300 stunning colour illustrations, the new edition has been thoroughly updated to reflect recent advances in knowledge of the pathogenesis of blood diseases and their diagnosis and treatment. This new text: Describes disorders and diseases of the blood such as the various anaemias and white cell disorders, leukaemias, lymphomas and myeloma, as well as bleeding and thrombotic disorders Incorporates the latest World Health Organization (WHO) classification of haematological neoplastic diseases Reviews contemporary application of multiparameter flow cytometry, DNA sequencing and other technologies in evaluating patients with suspected haematological disease Discusses the therapeutic use of chimeric antigen T-cells, mono- and bi-specific monoclonal antibodies, inhibitors of intracellular signalling pathways and direct orally acting anticoagulants Includes sections on blood transfusion and the haematological aspects of systemic diseases, pregnancy and the neonate Hoffbrand's Essential Haematology is a vital resource for all students and trainees, and a valuable reference for practicing specialists wishing to update their knowledge.

Sales HandleConcise and condensed content referenced to the classic main text of Williams Hematology, 10th edition. This book is perfect for use when time is tight on rounds or in the clinic. Excellent resource for the hematologist and non-hematologist. Everything you need to know about the fundamental principles and practice of non-malignant and malignanthematology. --Coversall topics covered on the hematology-oncology board review ----Includesall of the most current classifications of hematology diseases --Greatresource for the non-hematologist with in-depth explanations --Includescoverage of COVID-19 and abnormal clotting written by leading experts About the Book Although it's a handbook it is deceptively comprehensive. --Hematologists diagnose and treat blood diseases, including clots,sickle cell disease and other hemoglobinopathies, leukemias,and lymphomas, ---Concise and condensed content referenced to the classic maintextbook. --It is the perfect book to be used on rounds and in the clinic. --Authoritative quick and practical reference that can be used as acompanion or stand-alone tool for point-of-care facts and board preparation. --Succinct focus on diagnosis and management. --Includes numerous tables that contain diagnostic and therapeuticinformation relevant to the diseases discussed. --Coverage of COVID-19 infections because of the frequent manifestationof associated coagulation abnormalities that are associated withrespiratory deterioration and death. Some patients with COVID-19 tend to develop thromboembolic complications. Market/Audience Oncology fellows: 1500 Hematology/oncology: 20,000 Internal Medicine: 100,000 IM Residents: 9000 Medical Genetics: 2500 Genetic Counselors: 1000 Pediatric hematologists: 2000 3rd year medical students: 17,000 2nd yearmedical students: 17,000 Advancedpractice professionals: 50,000 Pharmaceuticalcompanies Pharma Benefit to the CustomerThe fastest way to access and use the authority of Williams Hematology. Must have condensed version for hematology and internal medicine residents. --Perfect for students, residents, and fellows needing quick but credible guidance on diagnosis and treatmentof common nonmalignant and malignant blood diseases. --Carefully edited to deliver only the most clinical point-of-care facts, making differential diagnosis faster, easier, and more efficient. --Edited by the leading global experts in malignant and nonmalignant hematology. Author Profile---The Williams' editorial team truly represents the cream of the crop of research and clinical hematology. The editors are all known worldwide for their contributions to the field. Most of the editors are previous Presidents of the American Society of Hematology. --The lead editor for the 10th edition of the Williams Manual, Marshall Lichtman, is former Dean of the Rochester University School of Medicine, and a former President of the American Society of Hematology. Author's Other TitlesKaushansky/Williams Hematology, 9/e (0071833005), 2015, McGraw Hill. Reviews* 5 Star Doody's Review for the 9th edition

"Autologous Stem Cell Transplantation" integrates basic research and clinical aspects underlying the most recent results in those malignant diseases where progress is most effective.
Recent evidence shows that higher doses are better in inducing higher cure rates in hematological neoplasias, although myeloblation related to dose intensity can be a limiting factor. The toxicity can now be controlled with autologous marrow and peripheral blood progenitor cell transplantation, used with or without growth factors. The combination of high dose chemoradiotherapy followed by re-infusion of autologous stem cells constitute a dramatic advance in the treatment of refactory and relapse hematological neoplasias.

Describes the immunological aspects of blood transfusion medicine, examining the immuno-chemistry of blood group antigens, the immune destruction of cells, correlations between blood groups and disease, and the effect transfusion-induced retroviral infection has on immune response.

Blood Science is a relatively new discipline which merges biochemistry, haematology, immunology, transfusion science and genetics. This bringing together of traditional disciplines requires a corresponding change in education and training for healthcare scientists and Blood Science: Principles and Pathology is written in response to this emerging need. An introduction to the subject and an overview of the techniques used in blood science are followed by a series of chapters based on groups of analytes investigated in blood - red blood cells, white blood cells and platelets, followed by the constituents of plasma, including waste products, electrolytes, glucose, lipids, enzymes, hormones, nutrients, drugs, poisons and others. Each chapter is supported by learning objectives, summaries and further information, and a focus is given to chapter specific case studies with interpretation to demonstrate how laboratory data in conjunction with clinical details is utilised when investigating patients with actual or suspected disease. Finally, a separate chapter offers more detailed case reports that integrate the different aspects of blood science. Undergraduate students taking blood science modules as part of their BSc programmes in Biomedical and Healthcare Sciences will appreciate the level of integration between clinical biochemistry and haematology. In addition, this book will provide suitable initial reading for those students embarking on blood science modules on MSc programmes and will be of value to new graduates entering the profession and starting their career in blood science departments by supplementing practice-based training with the required theoretical underpinning. This book is approved by the Institute of Biomedical Science and written by its expert writers, many of whom work on the Institute s advisory panels.

This text provides a comprehensive overview of the essential concepts and malignancies of hematology. Now in its second edition, the book reviews every major hematologic disorder and disease entity in thorough detail, from incidence and prevalence to patient and treatment-related issues. Formatted in an organized and easy-to-read outline style to facilitate rapid learning and information processing, the book allows readers to easily locate topics of immediate interest without wading through entire sections to obtain the desired data. Written by a diverse range of experts in the field, Concise Guide to Hematology, Second Edition is a valuable resource for clinicians, residents, trainees, and entry-level fellows who work in or are just entering the field of hematology.

Haemophilia in Aotearoa New Zealand provides a richly detailed analysis of the experience of the bleeding disorder of haemophilia based on longterm ethnographic research. The chapters consider experiences of diagnosis; how parents, children, and adults care and integrate medical routines into family life; the creation of a gendered haemophilia; the use and ethical dilemmas of new technologies for treatment, testing and reproduction; and how individuals and the haemophilia community experienced the infected blood tragedy and its aftermath, which included extended and ultimately successful political struggles with the neoliberalising state. The authors reveal a complex interplay of cultural values and present a close-up view of the effects of health system reforms on lives and communities. While the book focuses on the local biology of haemophilia in Aotearoa New Zealand, the analysis allows for comparison with haemophilia elsewhere and with other chronic and genetic conditions.

As an essential guide to paediatric haematology, this concise text offers a quick and reliable source of practical information for clinicians. Covering all blood disorders in children, the contents are structured to include all the major disease groups and include introductory chapters on normal haemopoiesis, normal coagulation, infections and transfusion. Whilst the text focuses on practical management, sufficient background information is given to enable trainees to care effectively for patients. Essential Paediatric Haematology is an ideal text for haematologists and paediatricians in training and a valuable source of reference for other health care professionals.

For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug, and how the core team-denied their share of the profits-went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time. In the multibillion-dollar business of biotech, where pharmaceutical companies, the government, hedge funds, and venture capitalists have spent billions on funding, experimentation, and treatments, a single molecule can stop cancer in its tracks-and make the people who find that rare molecule astonishingly rich. For Blood and Money follows a small team at a biotech start-up in California, who have found one of these rare molecules. Their compound, known as a BTK inhibitor, seems to work on a vicious type of leukemia. When patients start rising from their hospice beds, the team knows they're onto something big. What follows is a story of genius, pathos, and drama, in which vivid characters navigate a world of corporate intrigue and ambiguous morality. Vardi's narrative immerses readers in the recent explosion of biotech start-ups. He describes the scientists, doctors, and investors who are risking everything to develop new, life-saving treatments, and introduces suffering patients for whom the stakes are life-or-death. A gripping nonfiction read, For Blood and Money illustrates why it's so hard to bring new drugs to market, explains why they are so expensive, and examines how profit-driven venture capitalists are shaping the future of medicine.

The definitive overview of haematology and its recent developments Haematology has advanced considerably in recent decades. As new developments emerge, there is a continuous need for an accessible and up-to-date survey for medical students, discussing the major haematological disorders, their clinical presentations, their treatments, and more. Written by specialists with an interest in medical education, Lecture Notes: Haematology is a succinct, highly illustrated student guide to the essentials of this important field. It integrates the physiological, pathological, and clinical dimensions of haematology in a single comprehensive guide, and provides medical students and early-career clinicians with the core knowledge required to succeed in the subject. The 11th edition of this guide includes updated sections and expanded chapters detailing the newest advances in the field. In this 11th edition of Lecture Notes: Haematology, readers will also find: Discussion of both pathogenesis and management of all major haematological disorders Online clinical cases with >150 multiple choice questions to allow you to test and apply your knowledge Lecture Notes: Haematology, 11th edition is a valuable resource for medical students and junior doctors looking to increase their expertise in this medical specialty.

Aktualisiertes Referenzwerk fur die laborgestutzte Diagnose von Hamoglobinstoerungen Die uberarbeitete und aktualisierte 2. Auflage von Haemoglobinopathy Diagnosis bietet umfassende praxisorientierte Informationen zur fundierten laborgestutzten Diagnose von Hamoglobinstoerungen. Dieses pragnante Fachbuch zeigt die klinischen Eigenschaften der Erkrankung und liefert wertvolle Hilfestellung fur Laborwissenschaftler. Der Autor legt den Schwerpunkt auf die Auswahl, Leistungsfahigkeit und Interpretation von Testverfahren, die in den meisten Labors zum Einsatz kommen. Das Fachbuch erlautert, wann spezielle Tests erforderlich sind und welche Leistungen von spezialisierten Referenzzentren angeboten werden. Informationen zur Diagnostik werden in einen klinischen Kontext gestellt. Die 3. Auflage wurde von einem fuhrenden Hamatologen mit Erfahrung im Lehrbetrieb geschrieben. Das Praktikerbuch enthalt anschauliche Beispiele und Fragen zur Selbstuberprufung des Lehrstoffes. Hinzu kommen Informationen zu den jungsten Entwicklungen in dem Fachgebiet. - Praxisorientiertes Fachbuch mit einer Fulle von Illustrationen zur laborgestutzten Diagnose von Hamoglobinstoerungen. - Enthalt Fragen zur Selbstuberprufung des Gelernten. Auch fur Dozenten sind die Fragen ein gutes didaktisches Hilfsmittel. - Prasentiert neue Inhalte zu pranatalen Screenings und zur pranatalen Diagnostik. - Bietet eine Fulle von Fallstudien, ideal fur den angehenden Facharzt. Dieses Fachbuch richtet sich angehende Facharzte in der Hamatologie, Hamatologen und Laborwissenschaftler. Haemoglobinopathy Diagnosis ist Referenzwerk und Lehrbuch zugleich, das alle Facetten der Diagnose von Hamoglubinstoerungen abdeckt.

Are you constantly exhausted? Does sleep not refresh you? Is your balance not what it was? Do you have tingling or even burning in your fingers and toes? Then your problem may be vitamin B12 deficiency. Your doctor may test you for this but your blood levels look OK so what should you do then? Or you may receive treatment but not feel any better? This book is a guide to the complexities of this deceptively simple problem - how it can be diagnosed, how it can be treated, and how those who have it can cope with the lifelong repercussions. Incorporating the latest research, and the input of the thousands of members of the Pernicious Anaemia Society, this book is both practical and engaging, illustrated with many personal stories that will resonate with sufferers and their friends and families.

Haemophilia in Aotearoa New Zealand provides a richly detailed analysis of the experience of the bleeding disorder of haemophilia based on longterm ethnographic research. The chapters consider experiences of diagnosis; how parents, children, and adults care and integrate medical routines into family life; the creation of a gendered haemophilia; the use and ethical dilemmas of new technologies for treatment, testing and reproduction; and how individuals and the haemophilia community experienced the infected blood tragedy and its aftermath, which included extended and ultimately successful political struggles with the neoliberalising state. The authors reveal a complex interplay of cultural values and present a close-up view of the effects of health system reforms on lives and communities. While the book focuses on the local biology of haemophilia in Aotearoa New Zealand, the analysis allows for comparison with haemophilia elsewhere and with other chronic and genetic conditions.

Many experts now consider genetic evaluation to be pivotal for the optimal diagnosis, classification, risk stratification, and therapeutic decision-making for persons diagnosed with blood cancer. This new text specifically focuses on the genetic alterations essential for establishing diagnosis and assesses how they might impact the precision oncology standard of care. Providing an authoritative review of the state of the art, this is essential reading for physicians, hematologists, and oncologists for optimal management of individual patients.

This fully illustrated text is an essential guide for trainees in Haematology and Medicine studying for higher examinations, as well as for professionals wishing to expand their knowledge or revalidate. The book contains over 100 illustrated cases covering the whole field of malignant and non-malignant haematology, including coagulation problems and infectious diseases. Each case contains a set of questions written by two Royal College examiners, with answers on the reverse page. Readers can make differential diagnoses and devise treatment plans and prognoses, before turning the page to read the experts' detailed answers. The cases are presented in random order - just as they would be in real life - and are of varying lengths and degrees of difficulty, accompanied by hundreds of colour photomicrographs, photographs, and x-rays. This new edition is revised and updated, with new cases, images, and tables.

The third edition of this popular pocket book, A Beginner s Guide to Blood Cells written by Professor Barbara Bain, provides a concise introduction to normal and abnormal blood cells and blood counts for trainees in haematology. * Includes a brand new chapter on emergency morphology, designed to make the clinical significance and urgency of certain laboratory findings clear for biomedical scientists and to assist trainee haematologists in the recognition of major clinically important abnormalities * Contains exceptional full colour images throughout * Introduces important basic concepts of hematology, setting haematological findings in a clinical context * Provides a fully updated self-assessment section * An essential resource for trainee haematologists, biomedical scientists, and biomedical science and medical students

ASCP requirement. "To pass the ASCP and become a licensed medical lab tech, this text is the ultimate blood bank source for the required classes." - Amazon Reviewer "Great resource for anyone in a Medical Technology or Medical Laboratory Science Program! I would highly recommend this book!" - Mary L., Amazon Reviewer "Amazing legendary book in the field. Helpful for practicing Transfusion Medicine and Hematology." - Zubair S., Amazon Reviewer Join the generations of students who have embarked on successful careers with a firm foundation in the theory and practice of blood banking and transfusion practices. Denise Harmening's classic text teaches you not only how to perform must-know tests and tasks, but to understand the scientific principles behind them. You'll begin with a review of the basic concepts of red blood cell and platelet preservation, genetics, immunology, and molecular biology. Then you'll move to the hows and whys of clinical practice. And, you'll be prepared for new advances in the field.

Red blood cells in humans-and most other mammals-have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses-the bridging model and the depletion model-that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate stu

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation summarizes current understanding and development of clinical allogeneic HSC transplantation discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors details detection of bone marrow contamination by tumor cells and removal procedures focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors explores the effects of growth factor administration and leukapheresis on PB stem cell donors shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study,

Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. Th is knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory.

This volume places medical understanding in an evolutionary framework. Using published data on the frequencies of abnormal hemoglobins in the world's populations, Livingston analyzes and interprets these frequencies in the light of world distribution of diff erent forms of diseases such as malaria. He further develops the genetic theory of the evolutionary homeostasis.

Livingston discusses the relation of abnormal hemoglobins to endemic malaria and, shows how natural selection pressures explain the known distribution of these traits. Where non-coinciding distributions arise, the book presents other genetic, anthropological, evolutionary, and epidemiological evidence to explain these discrepancies. This classic work remains a useful sourcebook for professors and graduate students of anthropology, genetics, epidemiology, and hematology.

Frank B. Livingstone was professor emeritus of biological anthropology at the University of Michigan. He recieved the Martin Luther King Award from the Southern Christian Leadership Conference for his groundbreaking research on sickle cell anemia and is the author of Data on the Abnormal Hemoglobin's and Glucose-Six-Phosphate Deficiency in Human Populations.

Jonathan Marks is a professor of anthropology, at the University of North Carolina, Charlotte.