Proceedings of the Tenth Annual Symposium on Blood Transfusion, Groningen 1985, organized by the Red Cross Blood Bank Groningen-Drenthe

Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.

This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.

Welcome to the City of Groningen, the center of the North of the Netherlands. Groningen is proud of the long lasting tradition of scientific symposia organised by the Sanquin Blood Bank. These Sanquin International Symposia on Blood Transfusion have become a true traditional event in Groningen, marking the early academic year and have contributed to the specific reputation of Groningen and its University in the scientific field of Transfusion Medicine. The growing tradition has also contributed to initiatives of both University, Province and the City of Groningen to bring science and industry together - BioMedCity Groningen. Such repu- tion does not just happen, but is the result of creative and scientific leadership, of vision and an open mind, to explore in a team spirit horizons. Groningen is particularly proud of this reputation thanks to its leadership, the Sanquin Blood Bank North-East. This year in particular the theme chosen some two years ago is extremely timely as it illustrates the activities and scientific interest of an integrated team which includes our regional Sanquin Blood Bank North-East and fits in the City initiatives within the concept of BioMedCity, Groningen.

Hemostatis and Desmopressin: Molecular Mechanisms of Cellular Responses to DDAVP; S. Hashemi, et al. Pharmacology and Pharmacodynamics of Desmopressin: Toxicity of Desmopressin and Related Peptides; L.B. Kinter, et al. Desmopressin in Renal Disease: Control of Bleeding in Uremic Patients; Y. Sultan. Desmopressin and Platelets: Desmopressin in the Treatment of Congenital and Acquired Defects of Platelet Function; M. Cattaneo, P.M. Mannucci. Desmopressin and Surgery: Desmopressin, von Willenbrand Factor, and Surgery; M. Weinstein. Desmopressin and Blood Donation: Effects of Desmopressin on Normal Donors in Plasma Exchange Donations; R.J. Sassetti, B.C. McLeod. Clinical Applications of Desmopressin in Hemophilia and von Willenbrand's Disease: Intravenous and Subcutaneous Desmopressin; M. Kohler, G. Mariani. SideEffects and Adverse Reactions of Desmopressin: DDAVP and Tachyphylaxis in Healthy Subjects; V. Vicente, et al. Recapitulation: General Recapitulation and Search for a Consensus; P.M. Mannucci, et al. 33 additional articles. Index.

For both volumes:
A comprehensive collection of cutting-edge methods for the molecular and cellular analysis of platelets and megakaryocytes. Volume 1 details basic and advanced techniques for analyzing platelet and megakaryocyte function. The approaches presented for platelet analysis include aggregometry, secretion, arachidonic acid metabolism, procoagulent response, platelet adhesion under static and flow conditions, flow cytometry, and production of microparticles. The techniques for study of megakaryocyte function allow the measurement of specialized structures for platelet production, the appearance of platelet-specific surface receptors, and the increase in ploidy. Volume 2 offers techniques for studying many aspects of signaling in platelets and megakaryocytes, as well as state-of-the-art commentaries on our understanding of these cells. The methods include ligand-binding assays, the study of protein and lipid kinases and phosphatases, the analysis of lipid rafts, and the measurement of intracellular calcium levels. There are also techniques for study of electrophysiological events, nitric oxide signaling, venom proteins, and for the internalization of proteins into platelets through permeabilization. This volume also describes the application of molecular and post-genomic methods are to the study of platelets and megakaryocytes. All protocols follow the successful Methods in Molecular Biologya"[ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. The two volumes offer novice and experienced cellbiologists, hematologists, and clinicians not only a benchmark survey of the field, but also a comprehensive library of proven techniques essential for productive research on platelets and megakaryocytes today.

THE PHILOSOPHY OF QUALITY ASSURANCE IN THE BLOOD BANK H. F. Taswell One year before this symposium, Cees Smit Sibinga and I began to discuss an approach to quality assurance in the blood bank which we felt would be both important and practical and could serve as the basis for the choice of subjects to be presented in the symposium. As an introduction to this book, I would like to outline our approach, the subjects chosen and the rationale behind our choice. What is the fundamental purpose of a blood bank and trans fusion service? Simply stated, the purpose of a blood bank and transfusion service and of a quality assurance program in blood banking is, for the one to provide and, the other to assure safe and effective transfusion therapy. This objective is in contrast to that of other clinical laboratories. The objective in a clinical chemistry laboratory is to produce accurate test results which will be meaningful to the clinician taking care of his patient. In most clinical laboratories, therefore, the goals of a quality assurance program are largely quantitative, that is, to assure accurate numerical test results. In contrast, in the blood bank, the goals of quality assurance are primarily qualitative, that is, to assure safe and effective transfusion. As a result, two somewhat different approaches to quality assurance are necessary."

The practice of transfusing blood started at the bedside but over the last few decades blood transfusion has become more and more a laboratory directed discipline. The emphasis on serology and laboratory controlled measures has made blood transfusion safer and more effective, but laboratory and clinical aspects of the discipline have tended to become increasingly separated. As a result of this separation clinical developments in blood transfusion may not have derived full benefit from the knowledge accrued in blood transfusion services. Over the last five years the Red Cross Blood Bank Groningen-Drenthe has organised yearly symposia with a clinical theme in order to bring blood banks and clinicians closer together. Many of the recent major advances in clinical medicine have been based on developments in blood transfusion practice. This is certainly true for paediatric medicine. For instance, in paediatric oncology, including leukemia, cell separator programmes have made available new forms of support. Further, blood component therapy has provided an effective means of control in some of the bleeding disorders of children. Some of these topics are discussed in this symposium dealing with intensive care. Haemolytic disease of the newborn and exchange transfusion are other aspec.ts of intensive care. Our purpose in dealing with them was twofold.

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.

This book deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. It offers a series of international contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease, and has a special focus on diseases and targets of therapeutical intervention. The book will interest researchers and clinicians from inflammation research.

Blood Science is a relatively new discipline which merges biochemistry, haematology, immunology, transfusion science and genetics. This bringing together of traditional disciplines requires a corresponding change in education and training for healthcare scientists and Blood Science: Principles and Pathology is written in response to this emerging need. An introduction to the subject and an overview of the techniques used in blood science are followed by a series of chapters based on groups of analytes investigated in blood - red blood cells, white blood cells and platelets, followed by the constituents of plasma, including waste products, electrolytes, glucose, lipids, enzymes, hormones, nutrients, drugs, poisons and others. Each chapter is supported by learning objectives, summaries and further information, and a focus is given to chapter specific case studies with interpretation to demonstrate how laboratory data in conjunction with clinical details is utilised when investigating patients with actual or suspected disease. Finally, a separate chapter offers more detailed case reports that integrate the different aspects of blood science. Undergraduate students taking blood science modules as part of their BSc programmes in Biomedical and Healthcare Sciences will appreciate the level of integration between clinical biochemistry and haematology. In addition, this book will provide suitable initial reading for those students embarking on blood science modules on MSc programmes and will be of value to new graduates entering the profession and starting their career in blood science departments by supplementing practice-based training with the required theoretical underpinning. This book is approved by the Institute of Biomedical Science and written by its expert writers, many of whom work on the Institute s advisory panels.

The first International Meeting on Apheresis was held in Dyon in 1984. At the congress it became clear that both the technical and therapeutic sides developed very rapidly and it appeared fruitful to bring together the investigators of the different countries working in the areas. At that time immunology had come to pervade many clinical specialities, and hemapheresis, especially plasmapheresis was considered a therapeutic tool in many immunological diseases which hitherto had proved to be fatal. New methods to identify certain antibodies and circulating immune complexes in the serum and the possibilities to remove them from the blood by several techniques (filtration, centrifugation, immunoabsorp tion) led to an almost uncontrolled use of plasma exchange in a variety of diseases. Since then the technical possibilities of this technique were further recognized, as was the impact of immunology on many diseases, and the possibilities to collect specific components for therapeutic pur poses. But also we became aware of the limited contributions of anec dotal data on successes or failures of apheresis as adjuvant treatment. Therefore international prospective studies were initiated to make critical assessment possible of apheresis in various diseases."

Anemia in the elderly has been properly defined as the silent epidemic, representing 3 million people in the United States aged 65 years and older. Incidence and prevalence of this condition increase with age. It differs in its etiology, pathogenesis and treatment from anemia in children and younger adults. Anemia is associated with reduced survival, increased risk of functional dependence and hospitalization, increased risk of congestive heart failure and stage renal disease and cognitive disorders. Approximately 70% of anemia in older individuals is reversible.

'The test cases are particularly variable, including pertinent management tips in the answers. The book also contains a set of useful self-assessment questions. Being pedantic, this could now benefit from an increase in the proportion of 'Single Best Answer Questions', now ubiquitous in undergraduate assessment. This will continue to be on my local recommended reading list, particularly for those students wanting a thorough understanding of Haematology, from the laboratory through to basic management. It would also be a good text for those starting a career in Haematology, such as Physician Associates and doctors early in their training.'British Journal of HaematologyThis second edition of Haematology: A Core Curriculum is written by a haematologist with more than forty-five years of experience in teaching haematology to medical students and whose pedagogical and writing skills are widely admired within the field.The textbook takes a useful, practical approach, incorporating self-evaluation questions and learning objectives that give students the information needed to understand the topic and clear indications of the core knowledge required to progress within the field of haematology. Themes covered include clinical haematology and the scientific basis of the discipline and the causes and pathogenesis of haematological disorders as well as how conditions are diagnosed and treated.Haematology closely follows the Imperial College London curriculum but medical students, trainee nurses and biomedical science students from other institutions will find the textbook equally suitable, since it includes the core student haematology curriculum as recommended by the Royal College of Pathologists.Related Link(s)

There is no field of medicine in which advances in therapy have been so closely linked to a better understanding of molecular medicine than in the area of hematologic malignancies. For example, recent insights into the understanding of Epstein-Barr virus have led to new treatment options for patients with posttransplant lymphoproliferative disorders, as discussed in the chapter by Dr. Richard Ambinder et al. Similarly, Drs. Slack and Gallagher discuss the explosion of recent information regarding the molecular pathogenesis of acute promyelocytic leukemia. This particular morphologic subtype of acute my- eloid leukemia warrants separate discussion because of our increased under- standing of the pathogenesis of leukemia, as well as the dramatic advances in outcome that have occurred with differentiation therapy provided by the vitamin A derivative aW-trans retinoic acid, as discussed in the chapter by Drs. Frankel and Powell. New approaches in the therapy of diffuse aggressive lymphomas in relationship to prognostic factors are discussed by Drs. Koc and Schenkein. Novel approaches to cutaneous T-cell lymphomas are discussed by Drs. Foss and Kuzel. Drs. Fonseca and Greipp discuss prognostic factors in myeloma, which are potentially important since they may serve to identify patients who may benefit from aggressive therapy such as bone marrow trans- plantation, which is discussed in the chapter by Dr. David Vesole. State-of-the-art reviews are provided in the chapters on AIDS-related non- Hodgkin's lymphoma by Drs. Volm and Von Roenn, adult acute lympho- blastic leukemia by Drs.

The theme of this 14th International Symposium on Blood Transfusion is closely related to the work and scientific contributions of the Dutch cryobiology pioneer Dr. Herman W. Krijnen of the Dutch Red Cross Central Laboratory. Dr. Krijnen was known and respected in the national and interna tional blood transfusion community as an extremely competent scientist and a beloved and admired colleague. Dr. Krijnen was intentionally honoured with the invitation to open this symposium on cryopreservation and low temperature biology in blood transfusion and be the guest of honour at this event. Unfortunately, Dr. Krijnen suddenly died on the first of June 1989. In honour and mem ory of Dr. Krijnen this symposium will therefore be dedicated to him. Since the lOth International Symposium on Blood Transfusion in 1985 highlighted the theme of "Future developments in blood banking," major changes have occurred in the blood banking world. Most of these changes were forced upon the Blood Banks by the fear of spreading AIDS through contaminated donations. This not only led to the wide spread testing of blood, but also to a more appropriate counselling of the community and the blood donors in specific. Additionally, virus inacti vation techniques were introduced for those components derived from multiple donations and intended for a regular transfusion in haemophi lia patients and others."

Structured to be a companion to the recently published Handbook of Transfusion Medicine, the Handbook of Pediatric Transfusion Medicine is dedicated to pediatric hematology-oncology and transfusion medicine, a field which remains ambiguous and which has generated few comprehensive texts. This book stands alone as one of the few texts that addresses transfusion issues specific to pediatric medicine. Written in an eminently readable style, this authoritative handbook is a requirement for any pediatric physician or caregiver.
* Neonatal and fetal immune response and in utero development issues
* Blood compatability and pre-transfusion testing issues specific to pediatric and neonatal transfusion
* Therapeutic apheresis including red blood cell exchange and prophylactic chronic erythrocytapheresis for sickle cell patients
* Also includes a section that concentrates on the consent, quality and legal issues of blood transfusion and donation

Blood Tests Made Easy is a quick reference guide designed to bring medical students up to speed when interpreting blood tests on their clinical placements. Small enough to be carried and quickly referenced on the go, this book covers everything you need to know when interpreting bloods, including the main abnormalities you are likely to encounter. Rather than focusing on theory or physiology, it is designed to provide an easy-to-follow guide to support clinical decision making. This latest addition to the Made Easy series will fill knowledge gaps on blood test interpretation, becoming a valuable asset both for medical students and, later, as a reference guide to increase junior doctors' confidence on the wards. Relevant to real life - material laid out like real hospital laboratory tests Easy to use - information presented in a clear and accessible format Case studies and multiple-choice questions to aid revision Portable for easy access on the wards

This book provides clear instruction on the surgical treatment of joint problems in adult hemophilia patients. The procedures applicable to specific joints, including the shoulder, elbow, hip, knee and ankle, are carefully reviewed with the aid of high-quality illustrations. The surgical treatment of articular hemophilic pseudotumors and bone cysts is also considered. In addition, clinically relevant information is provided on a range of topics, such as the treatment of hemophilic hemarthrosis, the imaging of hemophilic joints, hematological perioperative management, anesthesia, rehabilitation and pharmacoeconomics. Finally, the controversial issues of postoperative thromboembolic prophylaxis and the role of COX-2 inhibitors in hemophiliacs are reviewed. The guidance provided draws on both the authors' extensive personal experience and an in-depth review of the pertinent literature. The book offers an excellent, up-to-date account of knowledge on musculoskeletal problems and approaches to joint surgery in adults with hemophilia. It will be of value to orthopedic surgeons, rehabilitation physicians, hematologists, radiologists and pharmacy researchers.

This new edition of an essential text for all those working within transfusion and blood banking is now even more biologically and clinically relevant, incorporating the latest information on the genes for various blood groups and including greater content on the functional significance of blood groups. The book covers techniques used in blood grouping, troubleshooting and quality assurance and integrates serology with molecular biology, marrying the basic understanding at the genetic level with a cellular understanding of the red blood cell membrane. Now in full colour throughout.

This book describes the latest methods of oncological and hematological diagnostics such as immunological, molecular genetic and histological essays. All methods are described in principle in their different variations and compared in their effectiveness and cost. At the end of each chapter a detailed description of the "how-to-do" is given. The book is written for scientists, clinicians and personnel from research laboratories, specialised laboratories and routine diagnostic laboratories in hospitals. It satisfies the increased demand for information on new methods in hematology and oncology.