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Hemoglobin Disorders - Molecular Methods and Protocols (Hardcover, 2003 ed.)
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Hemoglobin Disorders - Molecular Methods and Protocols (Hardcover, 2003 ed.)
Series: Methods in Molecular Medicine, 82
Expected to ship within 10 - 15 working days
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Hemoglobin and Hemoglobinologists This volume, Hemoglobin
Disorders: Molecular Methods and Protocols, will be introduced with
a review of the great milestones in the field, and the scientists
responsible for those achievements. The history of hemoglobin can
be divided into three periods: the Classical period, the Modern
period, and the Post-Modern period. I am inclined to include as the
four major members of the classical period Francis Roughton,
Quentin Gibson, Jeffries Wyman, and Linus Pauling, not only because
of their achievements, but also because of the superb scientists
they trained and/or influenced. Francis John Worsely Roughton
(1899-1972) (Fig. 1), in his laboratory at Trinity College in
Cambridge, England, made the first measurements of the rapid
reaction of oxygen with hemoglobin at the millisecond scale, at
first by flow-mixing methods and later by flash photolysis. He not
only opened an era of molecular research of hemoglobin, but also
invented the methodology for fast reactions through the use of
laser technology, which was later improved by others so that even
faster reactions could be detected. Another contribution of
Roughton was the education of Quentin H. Gibson (Fig. 2), his
favorite s- dent, who, in his laboratory in Sheffield, continued to
expand the horizon of ligand binding to hemoglobin, defining the
oxygen binding constants for each of the hemes of hemoglobin.
Though this did not, as expected, solve the und- lying mechanism of
ligand cooperativity as discussed below, it was nonet- less an
important milestone.
General
Imprint: |
HumanaPress
|
Country of origin: |
United States |
Series: |
Methods in Molecular Medicine, 82 |
Release date: |
March 2003 |
First published: |
2003 |
Editors: |
Ronald L. Nagel
|
Dimensions: |
235 x 155 x 19mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
300 |
Edition: |
2003 ed. |
ISBN-13: |
978-0-89603-962-9 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Haematology
|
LSN: |
0-89603-962-5 |
Barcode: |
9780896039629 |
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