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This comprehensive, superbly illustrated reference is designed to provide practical diagnostic assistance for hematopathologists when dealing with common and uncommon lesions in bone marrow trephine biopsies (BMTBs). At the heart of the book is a systematic analysis of neoplastic hematological and non-hematological disease entities, with concise identification of the key features of myeloproliferative neoplasms, myelodysplastic syndromes, acute and chronic leukemias, eosinophilia-associated myeloid/lymphoid neoplasms, lymphoproliferative disorders, and selected non-hematopoietic malignancies. Relevant examples of BMTBs are presented, with microscopic description, high-quality photomicrographs, and clinical data. The book also explains how to assess hematopoietic and stromal components of normal BMTBs, identifies the heterogeneous patterns that may be observed in healthy individuals, and analyzes reactive conditions, with particular attention to diagnostic problems and pitfalls.
The new and fully updated edition of the definitive haematology textbook for undergraduate and postgraduate students and trainees Hoffbrand's Essential Haematology is widely regarded as the most authoritative introduction to the subject available, helping medical students and trainee doctors understand the essential principles of modern clinical and laboratory haematology for nearly four decades. Now in its eighth edition, this market-leading textbook introduces the formation and function of blood cells and the diseases that arise from dysfunction and disruption of these processes. Beautifully presented with over 300 stunning colour illustrations, the new edition has been thoroughly updated to reflect recent advances in knowledge of the pathogenesis of blood diseases and their diagnosis and treatment. This new text: Describes disorders and diseases of the blood such as the various anaemias and white cell disorders, leukaemias, lymphomas and myeloma, as well as bleeding and thrombotic disorders Incorporates the latest World Health Organization (WHO) classification of haematological neoplastic diseases Reviews contemporary application of multiparameter flow cytometry, DNA sequencing and other technologies in evaluating patients with suspected haematological disease Discusses the therapeutic use of chimeric antigen T-cells, mono- and bi-specific monoclonal antibodies, inhibitors of intracellular signalling pathways and direct orally acting anticoagulants Includes sections on blood transfusion and the haematological aspects of systemic diseases, pregnancy and the neonate Hoffbrand's Essential Haematology is a vital resource for all students and trainees, and a valuable reference for practicing specialists wishing to update their knowledge.
Describes the immunological aspects of blood transfusion medicine, examining the immuno-chemistry of blood group antigens, the immune destruction of cells, correlations between blood groups and disease, and the effect transfusion-induced retroviral infection has on immune response.
* Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure * Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts * Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected *400 high quality photographs to aid with blood cell identification * Highlights the purpose and clinical relevance of haematology laboratory tests throughout
Powerfully involving narrative and incisive detail, clarity and inherent drama: Blood offers in abundance the qualities that define the best popular science writing. Here is the sweeping story of a substance that has been feared, revered, mythologized, and used in magic and medicine from earliest times--a substance that has become the center of a huge, secretive, and often dangerous worldwide commerce.
Winner of the Los Angeles Times Book Prize, Blood was described by judges as "a gripping page-turner, a significant contribution to the history of medicine and technology and a cautionary tale. Meticulously reported and exhaustively documented."
Are you constantly exhausted? Does sleep not refresh you? Is your balance not what it was? Do you have tingling or even burning in your fingers and toes? Then your problem may be vitamin B12 deficiency. Your doctor may test you for this but your blood levels look OK so what should you do then? Or you may receive treatment but not feel any better? This book is a guide to the complexities of this deceptively simple problem - how it can be diagnosed, how it can be treated, and how those who have it can cope with the lifelong repercussions. Incorporating the latest research, and the input of the thousands of members of the Pernicious Anaemia Society, this book is both practical and engaging, illustrated with many personal stories that will resonate with sufferers and their friends and families.
Highly Commended at the British Medical Association Book Awards 2016 Postgraduate Haematology provides up-to-date knowledge of the pathogenesis, clinical and laboratory features, management and treatment of a wide range of blood and bone marrow disorders in a concise and user friendly style. * Up-to-date knowledge of the pathogenesis, clinical and laboratory features and management of all blood disorders * New sections reflect advances in the specialty, including knowledge gained from new generation sequencing, latest anticoagulant drugs, diagnostic laboratory tools, and treatment strategies * Superb four-color illustrations and photomicrographs of blood cells and tissues throughout * Includes algorithms to aid with decision-making for treatment * Companion website includes figures and tables for download
The past decade has witnessed tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma as well as in understanding of the underlying molecular pathogenesis. Optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors. Even more importantly, molecular targeted approaches have been shown to be effective in the treatment of distinct lymphoma subtypes. Against this background, clinical management of especially the rare lymphomas remains a challenge for the general oncologist. This book provides a comprehensive overview of current treatment strategies in these rare lymphoma subtypes. Experts in the field from around the world describe the histomorphology in a clinically relevant manner, consider the role of risk factors in detail, and discuss the spectrum of therapeutic approaches. Special emphasis is placed on the translation of molecular science into clinical care, and a disease-specific algorithm is proposed for each entity. This book will prove an excellent resource for both experienced and inexperienced practitioners.
Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day. Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format Includes and illustrates the WHO Classification of Hematologic Malignancies Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology. "Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing" "There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date"
The Oxford Handbook of Clinical Haematology provides core and concise information on the entire spectrum of blood disorders affecting both adults and children. Updated for its fourth edition, it includes all major advances in the specialty, including malignant haematology, haemato-oncology, coagulation, transfusion medicine, and red cell disorders, with a brand new chapter on rare diseases. Practically focused, and specifically designed for ease-of-use, and rapid access to the information you need, this handbook is an indispensable resource on all aspects of haematology for all trainee doctors, nurses, technicians, and research professionals. The handbook is divided into clinical approach and disease-specific areas. The clinical approach section outlines various symptoms and signs in patients with blood disease to enable the reader to formulate a sensible differential diagnosis beofre embarking on investigation and treatment. The disease-specific section is written by four authors whose expertise covers the whole breadth of diseases included in the book. All authors have contributed to national guidelines (e.g. British Committee for Standards in Haematology, BCSH) and are experts in the evidence base that exists for each topic. The Oxford Handbook of Clinical Haematology offers a concise and logical approach to caring for patients with diseases of the blood.
Thoroughly revised and updated, ABC of Clinical Haematology is an essential guide and introduction to clinical haematology and to the treatment and management of common blood related disorders. The fourth edition contains new chapters that reflect the most recent developments whilst other chapters have been extensively revised to include the new tests and treatments that are now available for certain conditions such as chronic leukaemia, multiple myeloma and bleeding disorders. With contributions from leading experts in their respective fields, this text provides an ideal reference for primary care practitioners and other healthcare professionals working with patients who have blood related problems.
The third edition of this popular pocket book, A Beginner s Guide to Blood Cells written by Professor Barbara Bain, provides a concise introduction to normal and abnormal blood cells and blood counts for trainees in haematology. * Includes a brand new chapter on emergency morphology, designed to make the clinical significance and urgency of certain laboratory findings clear for biomedical scientists and to assist trainee haematologists in the recognition of major clinically important abnormalities * Contains exceptional full colour images throughout * Introduces important basic concepts of hematology, setting haematological findings in a clinical context * Provides a fully updated self-assessment section * An essential resource for trainee haematologists, biomedical scientists, and biomedical science and medical students
The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant--molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins. Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others. Demonstrates the clinical relevance of molecular biology in hematology Provides overviews of recent advances in cancer-cell biology, with an emphasis on leukemia and lymphoma Offers new and updated chapters written by an international team of experts in the field Presents new full-color charts, graphs, and illustrations Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.
This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
Following the familiar, easy-to-use at a Glance format, Haematology at a Glance, Fourth Edition is a broad and accessible introduction to the study of blood. Fully revised and updated to reflect advances in the field and in clinical practice, this new edition covers essential knowledge, from basic hematological physiology to blood disorders and their diagnosis and treatment. This new edition of Haematology at a Glance: * Features expanded sections on the underlying mechanisms, diagnostic techniques and management of the malignant haematological diseases. Also incorporates recent advances in knowledge of thrombosis and the newer oral anticoagulants * Contains the very latest clinical treatments * Includes updated illustrations and clinical photographs to illustrate concepts and aid understanding * Features extensive online self-assessment at www.ataglanceseries.com/haematology This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.
Ensure you are accurately identifying cells at the microscope with Clinical Hematology Atlas, 5th Edition. An excellent companion to Rodak's Hematology: Clinical Principles & Applications, this award-winning atlas offers complete coverage of the basics of hematologic morphology, including examination of the peripheral blood smear, basic maturation of the blood cell lines, and information on a variety of clinical disorders. Nearly 500 photomicrographs, schematic diagrams, and electron micrographs vividly illustrate hematology from normal cell maturation to the development of various pathologies so you can be sure you're making accurate conclusions in the lab. Schematic diagrams, photomicrographs, and electron micrographs are found in every chapter to visually enhance understanding of hematologic cellular morphology. Smaller trim size, concise text, and spiral binding make it easy to reference the atlas in the laboratory. Chapter on normal newborn peripheral blood morphology covers the normal cells found in neonatal blood. Chapter on body fluids illustrates the other fluids found in the body besides blood, using images from cytocentrifuged specimens. The most common cytochemical stains, along with a summary chart for interpretation, are featured in the leukemia chapters to help classify both malignant and benign leukoproliferative disorders. Chapter featuring morphologic changes after myeloid hematopoietic growth factors is included in the text. Morphologic abnormalities are covered in the chapters on erythrocytes and leukocytes, along with a description of each cell, in a schematic fashion. User resources on the Evolve companion site feature review questions and summary tables to further enhance their learning experience. NEW! Appendix with comparison tables of commonly confused cells includes lymphocytes versus neutrophilic myelocytes and monocytes versus reactive lymphoctyes to help users see the subtle differences between them. NEW! Glossary of hematologic terms at the end of the book provides a quick reference to easily look up definitions.
Thalassemia is one of the most common genetic disorders worldwide and presents major public health and social challenges in areas of high incidence. The frequency of this disorder varies considerably with geographic locations and racial groups. Thalassemia refers to a group of inherited hemolytic anemia disorders that involve defects in the synthesis of hemoglobin - or -polypeptide chains. It leads to decreased hemoglobin production and hypochromic microcytic anemia associated with erythrocyte dysplasia and destruction. Homozygous -thalassemia (also known as thalassemia major, Cooley's anemia, or Mediterranean anemia) is associated with the most severe signs and symptoms. Thalassemia major (TM) is a life-threatening condition that commonly manifests during early infancy, after which progressive pallor, severe anemia, and failure to thrive are common. Children with TM often develop feeding problems, recurrent fever, bleeding tendencies (especially epistaxis), susceptibility to infection, pathologic fractures of long bones and vertebrae, endocrine abnormalities, splenomegaly, lack of sexual maturation, and growth retardation. This book discusses cures and treatments available for thalassemia, as well as the causes and the type of long-term health outcomes it may cause.
From ASCP Press comes the BOC Study Guide for Phlebotomy Second Edition, a comprehensive tool designed to prepare phlebotomy students and professionals for their BOC Certification Exams, and assist instructors in developing written competency assessments. Improved and expanded from the first edition with over 1,300 study questions Questions and images appear as they do on the latest BOC Phlebotomy certification exam Updated for all curriculum areas required by the BOC Content recently evaluated by BOC-selected reviewers Information on the BOC Exam, plus sample study workflows and exam preparation tips
Crash Course - your effective every-day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have the essential information you need in one place to excel on your course and achieve exam success. A winning formula now for over 20 years, each series volume has been fine-tuned and fully updated - with an improved full-colour layout tailored to make your life easier. Especially written by senior students or junior doctors - those who understand what is essential for exam success - with all information thoroughly checked and quality assured by expert Faculty Advisers, the result are books which exactly meet your needs and you know you can trust. Each chapter guides you succinctly through the full range of curriculum topics, integrating clinical considerations with the relevant basic science and avoiding unnecessary or confusing detail. A range of text boxes help you get to the hints, tips and key points you need fast! A fully revised self-assessment section matching the latest exam formats is included to check your understanding and aid exam preparation. The accompanying enhanced, downloadable eBook completes this invaluable learning package. Series volumes have been honed to meet the requirements of today's medical students, although the range of other health students and professionals who need rapid access to the essentials of haematology and immunology will also love the unique approach of Crash Course. Whether you need to get out of a fix or aim for a distinction Crash Course is for you! Provides the exam syllabus in one place - saves valuable revision time Written by senior students and recent graduates - those closest to what is essential for exam success Quality assured by leading Faculty Advisors - ensures complete accuracy of information Features the ever popular 'Hints and Tips' boxes and other useful aide-memoires - distilled wisdom from those in the know Updated self-assessment section matching the latest exam formats - confirm your understanding and improve exam technique fast
Morphology of Blood Disorders, 2nd edition is an outstanding atlas with over 800 high-quality digital images, covering the whole spectrum of blood and bone marrow morphology, with particular emphasis on malignant haematology. Originally written in the Italian language by two world leaders in the field, the book has been expertly translated by the renowned haematologist and teacher, Barbara Bain. This book explores the major topics of haematological pathology, blending classical teaching with up-to-date WHO classification and terminology. Each image in this book is derived from material obtained for diagnostic purposes from patients with serious haematological conditions. Morphological details are supplemented by detailed descriptions of the output and role of automated instruments in disorders of the blood. Morphology of Blood Disorders, 2nd edition is an essential reference source for diagnosis in the haematology laboratory, designed to be the go-to guide for anyone with an interest in blood cell morphology.
This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine.
Drawing on an extensive series of cases, this book describes and illustrates in detail the FDG-PET/CT appearances of the most common lymphomas in both adults and children, covering presentations at various anatomic sites. In addition, all other aspects of the current application of FDG-PET/CT in the evaluation and management of patients with malignant lymphomas are described. Full explanations are provided of the potential benefits and limitations of advanced PET/CT techniques and technologies that support novel chemotherapy and radiotherapy approaches in the treatment of lymphoma, and particular attention is paid to the major challenge of incorporating progress in quantitative imaging technology into radiotherapy treatment planning, guidance, and monitoring. This clinical case-based atlas will be an invaluable tool for radiologists, hematologists, and clinical oncologists.
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