|
Books > Medicine > Clinical & internal medicine > Haematology
This book illustrates applications of mathematics to various
processes (physiological or artificial) involving flowing blood,
including hemorheology, microcirculation, coagulation, kidney
filtration and dialysis, offering a historical overview of each
topic. Mathematical models are used to simulate processes normally
occurring in flowing blood and to predict the effects of
dysfunctions (e.g. bleeding disorders, renal failure), as well as
the effects of therapies with an eye to improving treatments. Most
of the models have a completely new approach that makes
patient-specific simulations possible. The book is mainly intended
for mathematicians interested in medical applications, but it is
also useful for clinicians such as hematologists, nephrologists,
cardio-surgeons, and bioengineers. Some parts require no specific
knowledge of mathematics. The book is a valuable addition to
mathematics, medical, biology, and bioengineering libraries.
This is the 13th edition of a book written for students and
specialists who are interested in developing a fundamental
understanding of pathology and treatment of hematologic diseases.
The amount of knowledge required by hematologists to identify the
best course of treatment for a patient in this field is changing
rapidly and has fueled an explosion of new drugs that target
pathways virtually unknown a decade ago. We are now also entering
an era of effective immunotherapy for a variety of hematologic
malignancies, but the long term outcomes and toxicities of these
treatment approaches are still unknown. This first edition in
English is a significant novelty in the history of this work. Its
underlying goals, however, remain the same of the first Italian
edition: to help students and specialists understand the basis,
treatment and management of hematologic diseases.
Soft tissue tumors are a large and heterogeneous group of tumors
and pseudotumors with a spectrum of behavior from benign to frankly
malignant. This Atlas of Soft Tissue Tumor Pathology provides an
overview of reactive, pseudoneoplastic, benign and intermediate
neoplasms, sarcomas and related conditions arising in subcutaneous
and deep soft tissues. Emphasis is placed on microscopic
appearances with correlation with gross diagnostic findings where
relevant. In addition, the immunohistochemical and molecular
genetic features of the major soft tissue tumor subtypes are
presented. This compendium of soft tissue tumors illustrates the
vast majority of diseases you are likely to encounter in surgical
pathology.
This book discusses the aspects of haploidentical transplants and
will shed light on the debates and questions on this burgeoning
field and timely topic. Donor selection, graft failure, minimal
CD34+ cell requirement, and conditioning regimens used for
haploidentical transplants will be written by expert authors
dealing with this type of transplants. Approximately one third of
the books' chapters cover logic and basic aspects; the remaining
two thirds of the book discuss clinical aspects, outcomes, and
future perspectives, thus providing a comphrensive discussion of
the topic. Haploidentical transplantation is extremely timely,
rapidly-changing area and increasing its use will decrease the need
for time-consuming, expensive, unrelated donor search. Moreover,
Haploidentical Stem Cell Transplantation brings a set of clear
answers to questions of feasibility, advantages over unrelated
transplants, cost effectivity and outcome..
This book represents a major contribution to the emerging science
of regenerative medicine using non-fetal sources of stem cells. The
Editors, Dr Niranjan Bhattacharya and Professor Phillip
Stubblefield, have brought together some of the most pre-eminent
scientists working on regenerative medicine to share information on
currently ongoing work in this area alongside unpublished
observations that will help to shape the contours of future
therapies. Regenerative Medicine: Using Non-Fetal Sources of Stem
Cells discusses the potential clinical and therapeutic applications
using non-fetal stem cells as well as providing instruction on the
collection, isolation and characterization of stem cells from
various non-fetal sources, such as menstrual blood, adipose tissue,
breast milk and uprooted decidual teeth. This book will be an
invaluable resource for both active researches and those entering
the field. The Editors truly hope that the text will act as a
stimulant to professionals and clinical scientists, who may be
inspired to further the work of the pioneering scientists who have
contributed to this volume.
The risk of cancer increases with age, and the number of older
adults seeking treatment is increasing dramatically in line with
the aging population. The care of older patients differs from that
of younger adults because of differences in the biology of the
tumor, age-related differences in host physiology, co-morbidity
burden and psychosocial issues, which might impact the efficacy and
side effects of cancer therapy. This book focuses on the management
of hematological cancer and provides guidance on the management
issues specific to older patients, spanning background and
epidemiology, special considerations in the management of older
people, therapeutics and psychosocial considerations.
This book provides a review of imaging techniques and applications
in stem cell transplantation and other cell-based therapies. The
basis of different molecular imaging techniques is explained in
detail, as is the current state of interventional radiology
techniques. While the whole is a comprehensive discussion, each
chapter is self-sufficient enough so that each can be reviewed
independently. The contributors represent years of international
and cross-disciplinary expertise and perspective and are all well
known in their fields. comprehensive information on the role of
clinical and molecular imaging in stem cell therapy from this book
reviewed in detail. Essential reading for radiologists and
physicians who are interested in developing a basic understanding
of stem cell imaging and applications of stem cells and cell based
therapies. However, it will also be of interest to clinical
scientists and researchers alike, including those involved in stem
cell labeling, tracking & imaging, cancer therapy, angiogenesis
and cardiac regeneration.
This book will provide an overview of how to manage patients with
lymphoma in the format of a series of engaging case studies.
Lymphomas are cancers that originate in the lymphatic system. There
are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin
lymphoma. These lymphomas comprise various subtypes with prognosis
and treatment depending on the stage and type of the cancer.
Lymphoma is a major global health problem; non-Hodgkin lymphoma in
particular is the tenth most common type of cancer worldwide. In
response to this there have been a number of significant advances
in the available treatment options for lymphoma with new
breakthrough drugs being approved or registered for approval. In
light of this, this case study book will be an extremely timely
guide for all hematologists, oncologists, and healthcare
professionals wishing to keep up-to-date with these recent
developments. The format of this book is also particularly
appealing as it offer readers a practical approach to the clinical
management of patients with these conditions as suggested by
leading physicians from the City of Hope National Medical Center in
California, USA in an era of vast therapeutic development.
This issue of Hematology/Oncology Clinics will feature articles
such as: Anaplastic large cell lymphomaj; New agents; Transplant,
Uncommon variants; ATLL, CD30+ LPD of skin; NK/T, MF/SS; and many
more!
This volume describes up-to-date techniques used in understanding
the molecular biology of acute myeloid leukemia (AML) and
addressing advances in diagnosis, classification, prognostication,
and therapeutic strategies to potentially impact overall patient
survival. The chapters in this book cover topics such as:
cytochemical staining, single-cell mass cytometry of AML and
Leukemia stem/progenitor cells, microsphere-based assessment of DNA
methylation for AML prognosis, a zebrafish model for evaluating the
function of human leukemic gene IDH1 and its mutation, and the
isolation of biologically active exosomes from plasma of patients
with cancer. Written in the highly successful Methods in Molecular
Biology series format, chapters include introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and tips
on troubleshooting and avoiding known pitfalls. Cutting-edge and
practical, Acute Myeloid Leukemia: Methods and Protocols is a
valuable resource for scientists and researchers to further their
studies and advancements in the field of AML.
Master implementation of the techniques of flow cytometry in
diagnosing complex haematological diseases and malignancies in
patients, worldwide. Featuring World Health Organization
recommendations on pre-analytical steps, instrument settings and
panel construction, this invaluable manual offers invaluable
support for those researching, practising and analyzing the cause
of hematological malignancies. Authored by leading experts, this
book puts flow-cytometry into everyday context. With a focus on
multicolour panels, the manual provides readers an experienced
understanding of effective, implementation techniques.
Practitioners of all levels are offered a background in a variety
of diseases presented alongside the most current methodology.
Wide-ranging and comprehensive; detailed images of healthy blood,
bone marrow and lymph-nodes are illustrated throughout, allowing
for effective diagnosis. Through engaging with differential
diagnoses, the manual offers an understanding of similar symptoms
and mimicking malignancies, avoiding inaccurate results. Featuring
in-depth descriptions of chronic diseases; users can reach accurate
diagnosis, first time.
This book illustrates applications of mathematics to various
processes (physiological or artificial) involving flowing blood,
including hemorheology, microcirculation, coagulation, kidney
filtration and dialysis, offering a historical overview of each
topic. Mathematical models are used to simulate processes normally
occurring in flowing blood and to predict the effects of
dysfunctions (e.g. bleeding disorders, renal failure), as well as
the effects of therapies with an eye to improving treatments. Most
of the models have a completely new approach that makes
patient-specific simulations possible. The book is mainly intended
for mathematicians interested in medical applications, but it is
also useful for clinicians such as hematologists, nephrologists,
cardio-surgeons, and bioengineers. Some parts require no specific
knowledge of mathematics. The book is a valuable addition to
mathematics, medical, biology, and bioengineering libraries.
Natural killer (NK) cells are important effector cells of innate
immune system implicated in many physiological processes including
elimination of cancer cells and virus infected cells. NK cells
comprise a majority of large granular lymphocytes circulating in
peripheral blood with a minority derived from T cell lineage. Even
though NK cells were first described more than 40 years ago, it was
not until the 1980s and 1990s when immunophenotyping was
incorporated into clinical diagnostic methods and resulted in
discovery of distinct disorders of large granular lymphocytes and
NK cells. Since then, significant progress was made in our better
understanding of immunophenotypic and genotypic characteristics,
biology, functions as well as disorders of these cells. Most
recently, clinical studies using NK-cell based immunotherapy have
shown promising results in treatment of some of malignant diseases.
Disorders of large granular lymphocytes and NK cells are rare
comprising only about 1% of all lymphoid malignancies in western
countries. The rarity of these conditions was a main reason that
the progress in our understanding of pathogenesis and development
of novel therapeutic approaches has been delayed compared to
development in more common B cell lymphoid malignancies. The low
incidence of these diseases and scarcity of prospective clinical
trials also limit the availability of evidence based research
literature as well as comprehensive reviews about NK cell
disorders. Thus, the editors decided to take on the challenging
task and summarize our current knowledge about malignant and benign
diseases of large granular lymphocytes in this book based on the
best available evidence. The editors selected topics most relevant
to clinical practice in order to provide a useful guide for
practicing physicians. Chapters describing four disorders (T-cell
large granular lymphocytic leukemia, chronic lymphoproliferative
disorder of NK cells, extranodal NK cell lymphoma and aggressive NK
cell leukemia) incorporated into most recent 2016 revision of
classification of lymphoid malignancies are separated into
experimental, diagnositc and clinical parts for easier
understanding and reading. We are aware of challenges and inherited
limitations of any larger project like this one due to a rapid
progress especially in the field of genomics, which may not be
incorporated in this book before it is published. The editors and
contributing authors would like to thank the publisher NOVA for
their support.
This issue of Clinics in Laboratory Medicine entitled "Risk, Error
and Uncertainty: Laboratory Quality Management in the Age of
Metrology" will be guest edited by Sten Westgard, James Westgard,
and David Armbruster. The issue will cover a broad range of topics
related to management in the laboratory including but not limited
to: Metrology Perspectives; Biologic Variation Approach to Daily
Laboratory; Clinical Outcome Approach to Goal Setting; Six Sigma
Quality Management System; Traceability and Comparability; MU,
Risk, and Sigma-metrics at Sunway; and Quality Indicators for the
Total Testing Process, among others.
|
|