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Books > Medicine > Clinical & internal medicine > Haematology
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Angiogenesis and Anti-Angiogenesis in Hematological Malignancies (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R3,104
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Angiogenesis and Anti-Angiogenesis in Hematological Malignancies (Paperback, Softcover reprint of the original 1st ed. 2014)
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It has been generally accepted that angiogenesis is involved in the
pathogenesis of hematological malignancies, like acute and chronic
leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative
neoplasms and multiple myeloma. The extent of angiogenesis in the
bone marrow has been correlated with disease burden, prognosis and
treatment outcome. Reciprocal positive and negative interactions
between tumor cells and bone marrow stromal cells, namely
hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts,
endothelial cells, endothelial progenitor cells, T cells,
macrophages and mast cells, mediated by an array of cytokines,
receptors and adhesion molecules, modulate the angiogenic response
in hematological tumors. More recently, it has been emphasized the
pro-angiogenic role of the so called “vascular niche”,
indicating a site rich in blood vessels where endothelial cells and
mural cells such as pericytes and smooth muscle cells create a
microenvironment that affects the behavior of several stem and
progenitor cells, in hematological malignancies.
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