Native Fibrin Gel Networks and Factors Influencing their Formation in Health and Disease.- The Structure and Evolution of Vertebrate Fibrinogen: A Comparison of the Lamprey and Mammalian Proteins.- Nucleotide Sequences of the Three Genes Coding for Human Fibrinogen.- On the Identity of Fibrin(ogen) Oligomers Appearing During Fibrin Polymerization.- Immunochemical Studies of A? Chain Crosslinking.- Abnormal Fibrinogens with Two Structural Defects.- Electrophoretic Characterizations of Cross-Linked Fibrinogen Derivatives in Blood and Vascular Tissue by Zonal Immobilization on Glyoxyl Agarose.- Studies on the Localization and Accessibility of Sites in Fibrin which Are Involved in the Acceleration of the Activation of Plasminogen by Tissue-Type Plasminogen Activator.- Prothrombinase: Recognition and Developments.- The Initiation of the Tissue Factor Dependent Pathway of Blood Coagulation.- Interactions Between the Contact System, Neutrophils and Fibrinogen.- A New Trisaccharide Sugar Chain Linked to a Serine Residue in the First EGF-Like Domain of Clotting Factors VII and IX and Protein Z.- Multiple Epitope Specificity of Monoclonal Antibodies to a Single Synthetic Peptide: Use in the Characterization of the GP lIb-IIIa Binding Domain of von Willebrand Factor.- Factor VII and Dietary Fat Intake.- Characterization of Snake Venom Principles Affecting Blood Coagulation and Platelet Aggregation.- Thrombin-Like Venom Enzymes: Structure and Function.- Thrombin Inhibition by Synthetic Hirudin Peptides.- Effects of Structural Modifications on the Properties of Tissue Plasminogen Activator (tPA).- Molecular Genetics of Alpha 2 Plasmin Inhibitor.- Biological Properties of Hybrid Plasminogen Activators.- The Regulation of the Activaton of the Fibrinolysis System.- The Mechanisms of the Activation of Plasminogen by Streptokinase and Urokinase.- Protein C and Fibrinolysis: A Link Between Coagulation and Fibrinolysis.- Transformation of Prostacyclin (PGI2) to a Biologically Active Metabolite: 5(6)-Oxido-PGI1 by Cytochrome P450-Dependent Epoxygenase.- Studies on the Localization of Fibrinogen Binding Sites on Platelet Glycoprotein IIIa.- Affinity Labeling of Nucleotide Binding Sites of Enzymes and Platelets.- The Effect of Ganodermic Acid S on Human Platelets.- Role of Insulin Receptors in the Expression of Prostaglandin E1 Binding Activity in Platelets.- Platelet-Fibrin Interaction in the Suspension and Under Flow Conditions.- An Independent Haemostatic Mechanism: Shear Induced Platelet Aggregation.- Regulation of Eicosanoid Biosynthesis in Endothelial Cells: Critical Role of De Novo Synthesis of Prostaglandin Endoperoxide Synthase.- Modulation of Endothelial Function by Hypoxia: Perturbation of Barrier and Anticoagulant Function, and Induction of a Novel Factor X Activator.- Fibrin and the Vessel Wall.- Interactions between Fibrin, Collagen and Endothelial Cells in Angiogenesis.- New Developments in Thrombolytic Therapy.- Coronary Thrombosis: Pathogenesis and Prevention.- Implications of the TIMI Trials.- Thrombotic Microangiopathy.- Clinical Trials with Alteplase (RT-pa) in Acute Myocardial Infarction.- The Effects of Streptokinase and Tissue Plasminogen Activator on Left Ventricular Function.- Modern Strategies for Treatment of Acute Myocardial Infarction: Significance of Haemostaseological and Rheological Findings.- Clinical Application of Tissue Plasminogen Activator Therapy in Acute Myocardial Infarction.- Fibrinogen Proteolysis and Coagulation System Activation During Thrombolytic Therapy.- Altered Rheological Properties of Blood Following Administrations of Tissue Plasminogen Activator and Streptokinase in Patients with Acute Myocardial Infarction.- Monoclonal Antibodies for the Detection of Thrombosis.- The Pharmacology and Clinical Pharmacology of Defibrotide: A New Profibrinolytic, Antithrombotic, and Anti-Platelet Substance.- Author Index.

All subjects have their canon of literature that should be studied before serious students can advance in their chosen fields. Containing papers carefully compiled not merely for their historical importance but also for their contemporary relevance, Classic Papers in Breast Disease is that resource. A team of experts shares their experience in researching, diagnosing, and treating breast disease.
Each chapter contains not just a compilation of papers, but a critical commentary on the papers, their strengths and weaknesses, and their relevance to current practice and research. The commentary, always insightful and straightforward, ranges from theory to practice, from physical to psychological. Each chapter also has a brief introduction to set the scene as the author sees it. All the papers share in common their place as building blocks, as judged by the refraction of history, in the current knowledge base or in current research.

During the last decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes and to gain information about gene expression. Microarray is in its early stage but already there have been pattern descriptions that may have prognostic implications. The impact of chromosomal abnormalities is now clearer than before, and the complicated interaction between the stroma cells, the myeloma cells, and numerous cytokines and their receptors has been better explained. Attempts have been made to utilize this new knowledge to develop targeted therapy and although results are still modest, improvements have been obtained with thalidomide and analogues, as well as with proteasome inhibitors. It is therefore highly appropriate that this new comprehensive reference should appear at this time. The book covers the whole field of multiple myeloma, and also related diseases such as Waldemstrom's macroglobulinaemia, and incorporates both the basic science underlying the diseases and their clinical management. Each chapter has been written to "stand alone," allowing the reader to dip into particular subject and find information quickly without the need to browse through multiple chapters. In addition to the developments described above, all of which are considered here, many other approaches to targeted therapy are reviewed.

As an essential guide to paediatric haematology, this concise text offers a quick and reliable source of practical information for clinicians. Covering all blood disorders in children, the contents are structured to include all the major disease groups and include introductory chapters on normal haemopoiesis, normal coagulation, infections and transfusion. Whilst the text focuses on practical management, sufficient background information is given to enable trainees to care effectively for patients. Essential Paediatric Haematology is an ideal text for haematologists and paediatricians in training and a valuable source of reference for other health care professionals.

In light of recent advances in scientific understanding, this textbook provides a comprehensive yet focused guide to anemia, the most common hematologic malady in medicine. This authoritative, clinical resource covers the scientific basis of the many forms of anemia, while offering a practical approach to prognosis, diagnosis and management. Chapters cover a multitude of topics, ranging from the basic components and physiologic functions, to secondary anemias and transfusion therapy. Modern in approach, this text also looks ahead to new and innovative methodologies. With recommended treatment plans and many case studies, this heavily-illustrated book is essential reading for hematologists and oncologists. In providing a pathophysiologic context, it is also of interest to nurse practitioners, physician assistants and medical students in the field. This book provides access to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover.

Presenting the most up-to-date and authoritative reference on the risks and risk-prevention strategies of blood transfusions, Blood Safety and Surveillance compiles a breadth of information on the reactions, immunological complications, and potential for disease transmission related to blood transfusions in a broad context. Combines numerous resources to become the ideal, multifaceted one-stop handbook! Balancing medical concerns with in-depth scientific research, Blood Safety and Surveillance -describes a host of reactions and potential sources of infection in blood transfusions -considers common and rare transmissible diseases around the world, such as the human immunodeficiency, hepatitis, and human T-lymphotropic viruses -reviews parasitic and tickborne diseases, including a description of the transmission of babesiosis -studies alternatives to allogenic blood -examines cost- and time-effective techniques for reducing transfusion risks -elaborates on the latest red blood cell substitutes -targets preventable errors and accidents related to transfusions and the role of public health agencies in monitoring and regulating procedures -and more! Written by nearly 40 expert contributors and containing almost 2000 literature references, tables, drawings, and photographs, Blood Safety and Surveillance immeasurably improves the arsenal of knowledge of hematologists, infectious disease specialists, blood bank personnel, intensive and critical care physicians, internists, public health officials, health care managers, and medical school students in these disciplines.

This handy reference demonstrates how to use blood, plasma, serum, instrumentation, bone marrow, lymph nodes, and splenic tissue to establish diagnosis, emphasizing practical information to aid in the operation of an efficient hematology laboratory and highlighting up-to-date investigative procedures. Supplies case studies to allow for self-testing in hematopathology and coagulation! Gathering contributions from nearly 40 experts in the field and including more than 1450 references, tables, drawings, micrographs, and photographs, the Handbook of Hematologic Pathology -highlights the need for peripheral blood smear (PBS) review to supplement the quantitative analysis of automated instruments -focuses on the importance of clinical correlation in bone marrow evaluation and interpretation -addresses leukemia and lymphoma -examines clonal stem cell disorders characterized by self-perpetuating and differentiating proliferation -considers common causes of a hypercoagulable state associated with intrinsic circulating plasma factors -details inherited and acquired reactive leukocyte disorders -describes assessing cell lineage and stage of differentiation with monoclonal antibodies -summarizes the results of immunologic and molecular studies of Hodgkin's disease -explores the mechanisms of action, dosage, therapeutic monitoring, and complications associated with anticoagulants -discusses mechanisms of surgical bleeding and laboratory assessment -differentiates between acquired and congenital bleeding disorders and emphasizes laboratory test selection for diagnosis and successful therapy -clarifies the complexity of coagulation instrumentation and offers insight into the recognition of proceduralor instrument errors and interfering medications -outlines blood and blood component therapy options used in the management of bleeding disorders -and more! Presenting brief illustrative examples that elucidate specific clinical problems, the Handbook of Hematologic Pathology is an exceptional reference for clinical and experimental hematologists; pathologists; hematopathologists; medical, surgical, radiation, and research oncologists; immunologists; molecular and cell biologists; and medical school and graduate students in these disciplines.

This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.

The analysis of blood, bone marrow and tissue fluid specimens requires a multi-faceted approach with the integration of scientific data from a number of disciplines. No single discipline can operate in isolation or errors will occur. Flow cytometry is in a privileged position in that it can provide rapid analysis of specimens and it is often the first definitive investigation to produce results and help formulate a working diagnosis. This companion text to Practical Flow Cytometry in Haematology Diagnosis contains 100 worked examples drawn from real clinical cases presenting to the authors institution. Cases are illustrated with peripheral blood and bone marrow cytology, tissue pathology and cytogenetic and molecular data, which are integrated to generate, where appropriate, a diagnosis based on the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The spectrum of clinical cases includes adult and paediatric patients, and both neoplastic and reactive disorders. The cases appear in no particular order to challenge the reader to make their own diagnosis. The reader will review May Grunwald Giemsa (MGG)-stained films of peripheral blood and bone marrow aspirates presented alongside flow cytometric data and haematoxylin and eosin (H&E)-stained bone marrow and other tissue biopsy sections. Immunohistochemistry is used to further clarify the tissue lineage and cell differentiation. Cytogenetic studies using metaphase preparations are used to identify translocations and chromosome gains and losses whilst interphase fluorescence in situ hybridisation (FISH) studies and polymerase chain reaction (PCR) are used to identify gene fusions, gene rearrangements and deletions. Each case concludes with a discussion of the features that are important to making a diagnosis. The cases are also listed according to disease classification in the appendix so that the text can also be used as a reference. Practical Flow Cytometry in Haematology: 100 Worked Examples: * Provides a practical, example-based resource for flow cytometry * Demonstrates how flow cytometry results should be interpreted and applied to optimize patient care * Includes both malignant and benign conditions * Can be used in conjunction with Practical Flow Cytometry in Haematology Diagnosis, by the same author team (ISBN 9780470671207) Practical Flow Cytometry in Haematology: 100 Worked Examples is ideal for practicing haematologists and histopathologists with an interest in haematopathology, but particularly directed at trainee haematologists and scientists preparing for FRCPath and related examinations.

This fourth edition presents an updated and expanded text and illustrations to reflect continued morphologic, immunophenotypic, and especially molecular advances in the field of neoplastic hematology, mostly due to the rapidly expanding application of next-generation sequencing. Those advances not only allow a more reliable diagnosis of the majority of tumors and identification of early changes such as monoclonal B-cell lymphocytosis or clonal hematopoiesis of indeterminate potential (CHIP), but also in many cases identify mutations or phenotypic changes in tumors that can be targeted by mutation-specific or antigen-specific drugs. This edition incorporates the updated WHO classification of hematopoietic tumors and new immunophenotypic and molecular markers to provide a thorough pathologic overview of hematologic neoplasms while focusing on flow cytometric features. Special emphasis has been put on hematological neoplasms with crucial clinical significance such as acute promyelocytic leukemia, other acute leukemias, and difficult areas in flow cytometry. Flow cytometric features in AML, MDS, CMML, CLL and measurable residual disease were significantly expanded. There are many new comparative tables, illustrations, and diagrams of algorithmic approaches.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition. Integrates basic science into individual cancer chapters for more efficient reference Features quarterly updates that include late-breaking developments in oncology such as new drugs and clinical trials, as well as new case studies and interactive algorithms Offers balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist Provides updated content on immunotherapy and genetics throughout Includes important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues Now available in a convenient single volume, or a seven-multivolume option for portability and ease of use Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Everything you need to know about red cell disorders, from basic science to clinical application When red blood cells do not have enough hemoglobin, oxygen cannot reach all parts of the body-as a result, organs start to malfunction and may lead to a host of issues including deformities, enlarged spleen, heart problems and other diseases. There are myriad red cell disorders, such as iron deficiency anemia, pernicious anemia, aplastic anemia, autoimmune hemolytic anemia, sickle cell, thalassemia and other hemoglobinopathies. Williams Hematology: The Red Cells and its Diseases provides clinicians with a practical diagnostic and treatment framework for identifying and successfully managing acute, congenital, and chronic red blood cell disorders. Presented in an accessible template format, the book includes classifications, etiology and pathogenesis, clinical and laboratory features, differential diagnosis, treatment, management, and supportive care. This comprehensive, yet concise resource covers: * Structure and physiology of the red cell * Classification of red cell diseases * Diseases of red cell production * Anemias resulting principally from inherited disorders * Anemia as a result of exogenous factors * Polyclonal erythrocytosis * Red cell transfusion

Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.

Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. * Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions * Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program * Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral * Benefits from expert contributions from an international authorship

Hemostatis and Desmopressin: Molecular Mechanisms of Cellular Responses to DDAVP; S. Hashemi, et al. Pharmacology and Pharmacodynamics of Desmopressin: Toxicity of Desmopressin and Related Peptides; L.B. Kinter, et al. Desmopressin in Renal Disease: Control of Bleeding in Uremic Patients; Y. Sultan. Desmopressin and Platelets: Desmopressin in the Treatment of Congenital and Acquired Defects of Platelet Function; M. Cattaneo, P.M. Mannucci. Desmopressin and Surgery: Desmopressin, von Willenbrand Factor, and Surgery; M. Weinstein. Desmopressin and Blood Donation: Effects of Desmopressin on Normal Donors in Plasma Exchange Donations; R.J. Sassetti, B.C. McLeod. Clinical Applications of Desmopressin in Hemophilia and von Willenbrand's Disease: Intravenous and Subcutaneous Desmopressin; M. Kohler, G. Mariani. SideEffects and Adverse Reactions of Desmopressin: DDAVP and Tachyphylaxis in Healthy Subjects; V. Vicente, et al. Recapitulation: General Recapitulation and Search for a Consensus; P.M. Mannucci, et al. 33 additional articles. Index.