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Books > Medicine > Clinical & internal medicine > Haematology
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Heme Oxygenase in Biology and Medicine (Hardcover, 2002 ed.)
Loot Price: R5,301
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Heme Oxygenase in Biology and Medicine (Hardcover, 2002 ed.)
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Heme oxygenase is rapidly taking its place as the centerpiece of
multiple inter acting metabolic systems. Only 25 years ago heme
oxygenase and its metabolic prod ucts appeared to be merely a
simple metabolic system-one substrate, heme; one enzyme, heme
oxygenase; and one set of products, iron to be recycled, and
bilirubin and carbon monoxide to be disposed. From a group of about
25 people in 1974, as judged by attendance at various Gordon
conferences, heme oxygenase has, in the year 2000, attracted
working scientists-and clinicians I might add-by the hundreds and
has produced referenced publications by the thousands. It is
well-deserved attention. Heme oxygenase system is now similar to
the metabolic networks surrounding glucose in those complex maps of
glycolytic and non-glycolytic metabolic pathways, which we had to
memorize as students. The relevance of heme oxygenase to regulatory
biology was recognized many years ago, but the work conducted over
the past five years has created a new wave of emphasis focusing on
genetic manipulation to alter heme oxygenase gene expression, the
regulatory actions of heme oxygenase products including carbon
monoxide, and the significance of changes in the heme oxygenase
system. The physiological and pathological relevance of heme
oxygenase in the brain, heart, liver, bone marrow, organ
transplant, lung and kidney, opens many areas of investigation in
various dis ciplines. Advances in the pharmacology of bilirubin and
its ability as an antioxidant have provided a new avenue in
clinical research.
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