ANCA-Associated Vasculitides - Immunological and Clinical Aspects (Hardcover, 1993 ed.)

WEGENER'S GRANULOMATOSIS & ANCA-ASSOCIATED DISEASES: THE STORY CONTINUES The disease now designated as Wegener's granulomatosis (WG) was first described in 1931 by Heinz Klinger, who considered it to be a special form of polyarteritis nodosa. Klinger's friend, Friedrich Wegener, expanded on the first observations and interpreted the pathological and clinical fmdings to represent a distinct disease entity (Wegener, 1939). He described this entity as a "peculiar rhinogenous granulomatosis with a unique participation of the arterial system and the kidneys". Later, Godman and Churg (1954) established the classical diagnostic criteria (the "WG triad"): granuloma, vasculitis, and glomerulonephritis. In 1958 Walton pointed out the poor prognosis of WG based on a small number of published cases (mean survival time: 5 months). In 1966 Carrington and Liebow reported "limited forms" of WG with a defmitely more favorable prognosis. Since then positive results have been reported with cyclophosphamide therapy. In addition, a retrospective study of combined low-dose cyclophosphamide and prednisolone in 85 WG patients over a period of 21 years found a similarly encouraging outcome. The*latter experience led to the current "standard" treatment protocol (FAUCI et al. , 1973 and 1983). More recently, strong evidence has emerged that some of the morbidity and mortality ofWG - and other types of systemic vasculitis - may be a consequence of this treatment (Hoffman et al. , 1992).

General

Imprint:	Kluwer Academic / Plenum Publishers
Country of origin:	United States
Series:	Advances in Experimental Medicine and Biology, 336
Release date:	2001
First published:	1993
Editors:	Wolfgang L. Gross
Dimensions:	234 x 156 x 33mm (L x W x T)
Format:	Hardcover
Pages:	552
Edition:	1993 ed.
ISBN-13:	978-0-306-44573-6
Categories:	Books > Medicine > Clinical & internal medicine > Haematology Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal pathology & diseases
LSN:	0-306-44573-5
Barcode:	9780306445736

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