From the dawn of life itself, every being that has ever lived owes its existence to the cell.

The discovery of this vital form led to a transformation in medicine but also in our understanding of ourselves - not as bodies or machines but as ecosystems. It has also given us the power to treat a vast array of mortal maladies...and even to create new kinds of human altogether.

Rich with stories of scientists, doctors and the patients whose lives may be saved by their work, The Song of the Cell is a stunning ode to the building blocks of life and the cutting-edge science harnessing their power for the better.

This book summarizes the most recent data on the molecular and cellular mechanisms which determine the unique properties of nerve cells - their ability to differentiate, establish connections to each other, and to form the nervous system with its immense capability for receiving, analysing, and storing information about our external and internal world. The key role of calcium ions in this process is particularly explored, along with nervous system function in aging and neural pathology. The author, based at a high-profile research unit in the Ukraine, is able to draw on significant new research which has not been widely published. Plasticity in nerve cell function will be of interest to researchers and research students in the fields of neurophysiology, cellular physiology, biophysics, and neurochemistry in particular. It will also be of relevance to researchers and medical doctors interested in neuropathology and aging.

Available for the first time with Macmillan's new online learning tool, Achieve, Molecular Cell Biology remains the most authoritative and cutting-edge resource available for the cell biology course. The author team, consisting of world-class researchers and teachers, incorporates medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. Emphasis on experimental techniques that drive advances in biomedical sciences and introduce students to cutting edge research teach students the skills they need for their careers. Achieve, Macmillan's new online learning platform, supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. Featuring new digital resources to engage students and help them to master cell biology concepts, the pairing of a powerful new platform with outstanding biology content provides an unrivaled learning experience.

Advances in Biomembranes and Lipid Self-Assembly, Volume 36 serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Regulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, presents interesting chapters on topics such as Transcriptional regulatory mechanisms and signaling networks in Viral Infections, Identification of potential key genes associated with pathogenesis and prognosis of endometrial cancer based on Integrated Bioinformatics Approaches, Differential regulation of genes in stage IB pancreatic cancer associated with increased risk of metastasis, AMPK-related LKB1-downstream targets, A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer, Protein phosphatases and their targets: Critical determinants of signaling pathway in plants, and more. Other sections cover Calcium decoders and their targets: The holy alliance that regulate cellular responses, Importin alpha family NAAT/IBB domain: functions of a multi-faceted long chameleon sequence, Aurora Kinase A and related downstream molecules: A Potential Network for Cancer Therapy, Emerging Role of Heat Shock Proteins in Cardiovascular Diseases, Function, Structure, Evolution, Regulation and Drug Target Relevance of Arylalkylamine N-acetyltransferase, and Analysis of signaling cascades from myeloma cells treated with pristimerin.

Adoptive Cell Transfer, Volume 370 in the International Review of Cell and Molecular Biology series highlights advances in the field, with this new volume presenting interesting chapters written by an international board of authors who expound on topics such as the Impact of tumor microenvironment on Adoptive Cell Transfer activity, Dendritic Cell Transfer, CAR-T Cell dysfunction and exhaustion, NK Cell-based cancer immunotherapy, Enabling CAR-T cells for solid tumors: rage against the suppressive tumor microenvironment, Improving Adoptive T-Cell therapy with cytokines administration, and What will (and should) be improved in Immunotherapy with CAR?

Ion Transport and Membrane Interactions in Vascular Health and Disease, Volume 90 in the Current Topics in Membranes series, highlights advances in the field, with this new volume including chapters on an Introduction to Ion transport and membrane interactions in vascular health and disease, Endothelial cell microdomains of Ca2+ and metabolism, Cytoplasmic nanojunctions between smooth muscle organelles control specific Ca2+ signaling, TRPML channels in coronary vascular phenotypic modulation and calcification, Local voltage-gated Ca2+ channel regulation of vascular smooth muscle in diabetes, Biphasic changes in smooth muscle Ca2+ transporters during the progression of coronary atherosclerosis, Role of K+ channels in atherosclerosis, and more.

Forcourses in cell biology. Connectingfundamental concepts across the world of the cell Known for its strong biochemistry coverage and clear, easy-to-followexplanations and figures, Becker's World of the Cell provides abeautifully illustrated, up-to-date introduction to cell biology concepts,processes, and applications. Informed by years of classroom experience in thecell biology course, the text features accessible and authoritativedescriptions of all major principles, as well as unique scientific insightsinto visualization and applications of cell and molecular biology. With the 10thEdition, the authors guide students to make connections throughout cellbiology, and provide questions that encourage students to practice interpretingand analyzing data. Embedded features in Pearson eText add interactivity,walking students through key figures with narrated explanations. Personalizelearning with Mastering Biology with Pearson eText Mastering (R) empowers youto personalize learning and reach every student. This flexible digital platformcombines trusted content with customizable features so you can teach yourcourse your way. And with digital tools and assessments, students become activeparticipants in their learning, leading to better results. PearsoneText is an easy-to-use digital textbook available within Mastering that letsstudents read, highlight, take notes, and review key vocabulary all in oneplace. If you're not using Mastering, students can purchase Pearson eText ontheir own or you can assign it as a course to schedule readings, view studentusage analytics, and share your own notes with students.

Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis. The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of (10) tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer. The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy. The mission of the 'Alliance' is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis. This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI's efforts to diagnose early-stage cancer and provide curative anti-cancer therapies. The main goals of these research efforts are: 1. To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis 2. To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer 3. To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer This volume consists of (9) chapters, one from each funded laboratory, that reviews new methods and mechanisms highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets.

Strategies to Mitigate the Toxicity of Cancer Therapeutics, Volume 155 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters, each of which is written by an international board of authors.

Role of TRPV4 Channels in Different Organ Systems, Volume 89, the latest release in the Current Topics in Membranes series, provides an in-depth description of the role of TRPV4 ion channels in different organ systems under healthy and disease conditions. Research over the last two decades shows crucial physiological and pathological roles for TRPV4 channels. In this volume, we present chapters focusing on TRPV4 channels in the vasculature, lungs, heart, kidney, bladder, skin, musculoskeletal system, eye, and immune cells. Understanding the behavior of TRPV4 channels in various organ systems will provide a big picture on their physiological roles and therapeutic targeting.

Advances in Biomembranes and Lipid Self-Assembly, Volume 34, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for the study of cell membranes, lipid model membranes and lipid self-assemblies, from the micro- to the nanoscale. As planar lipid bilayers are widely studied due to their ubiquity in nature, this book presents research on their application in the formulation of biomimetic model membranes, and in the design of artificial dispersion of liposomes. Chapters cover Physical properties of SOPC lipid membranes containing cholesterol by molecular dynamics simulation, Exciting membrane fluctuations - more than thermal stimulation, Fluctuations shaping bio-membrane adhesion, and more.

Advances in Genetics serial, Volume 110 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, all written by an international board of authors.

Advances in Genetics, Volume 109 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Epigenetic regulation of angiogenesis in tumor progression, RecBCD and Chi hotspots as determinants of self vs. non-self: A re-evaluation, Horizontal gene transfer to plants from Agrobacterium and related bacterial species, and more.

This special volume titled The Cardiovascular Glycocalyx in Health and Disease has the goal of giving an updated perspective of the glycocalyx function through the cardiovascular system and its integration in whole system physiology. This volume will address roles of the glycocalyx at the membrane and cellular level and its implications to overall cardiovascular function and disease progression. Further, pharmacological targeting of the glycocalyx will be addressed as an important mechanism for diagnosis and therapeutic interventions.

Body fluid regulation is pivotal to human health and is served by extensive clinical and pre-clinical science. By combining modern advances with previous findings in the field, this book presents a comprehensive treatment of major experiments, theories, and new advances in the field of body fluid regulation, thirst, and drinking. It features the main integrative brain mechanisms for fluid regulation, the development of such systems, fluid balance during heat and exercise, aging and clinical disorders, and comparative aspects of fluid regulation. The volume focuses on mammalian thirst or drinking behaviour alongside relevant aspects of the physiology of fluid balance. The principal fluid compartments and their regulation by both intakes and losses are highlighted, using both human and animal studies to illustrate the main concepts.

Viral Vectors in Cancer Immunotherapy, Volume 379 in the International Review of Cell and Molecular Biology presents the latest on cancer immunotherapy and how it has transformed cancer treatment through advances in immune checkpoint inhibitors and adoptive cell therapy. Chapters in this new release include Past, present and future of viral vectors in cancer immunotherapy, Alphaviruses in cancer immunotherapy, Adenoviral-based cancer gene therapy, Armored modified vaccinia Ankara in cancer immunotherapy, Strategies of Semliki Forest virus in immuno-oncology, Maraba virus in cancer immunotherapy, Oncolytic viruses in hematological malignancies, Oncolytic virus for cancer therapies: Overview and future directions, and more. The use of genetically modified viruses allows the expression of pro-inflammatory molecules, while the immune system receives danger signals from the viruses themselves. In some cases, the virus can also induce tumor cell death. This book will review advances in virus-based cancer immunotherapy in both solid tumors and hematologic malignancies.

This popular science book systematically introduces major scientific and technological achievements in the field of cells and stem cells, and the conveniences they bring to human life. It covers plant cloning, animal cloning, human cloning, biological missiles, biological drugs, immunocytotherapy, stem cell therapy, stem cell bank, 4D printing, 5D printing, CAR-T technology, and other frontier fields, which reflect the latest progresses and development trends of life sciences. The book is both interesting and rich in information, revealing the magic and mystery of life sciences.

This popular science book systematically introduces major scientific and technological achievements in the field of cells and stem cells, and the conveniences they bring to human life. It covers plant cloning, animal cloning, human cloning, biological missiles, biological drugs, immunocytotherapy, stem cell therapy, stem cell bank, 4D printing, 5D printing, CAR-T technology, and other frontier fields, which reflect the latest progresses and development trends of life sciences. The book is both interesting and rich in information, revealing the magic and mystery of life sciences.

Advances in Applied Microbiology, Volume 118 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topics of microbiology.