Animal Cell Technology will provide an insight into biological and engineering concepts related to mammalian and insect cell technology, as well as provide an overview of the applications of animal cell technology. The interest in this area of science has grown significantly in recent years so this book will be suitable for undergraduates who wish to learn from the basics upwards, and for postgraduates and scientists in the expanding biopharmaceutical industry who wish to build upon their existing knowledge base. The authors of the chapters are leaders of internationally-recognized animal cell culture research and have extensive experience in the areas covered in their respective chapters.

From quantum theory to statistical mechanics, the methodologies of physics are often used to explain some of life's most complex biological problems. Exploring this challenging yet fascinating area of study, Molecular and Cellular Biophysics covers both molecular and cellular structures as well as the biophysical processes that occur in these structures. Designed for advanced undergraduate and beginning graduate students in biophysics courses, this textbook features a quantitative approach that avoids being too abstract in its presentation. Logically organized from small-scale (molecular) to large-scale (cellular) systems, the text first defines life, discussing the scientific controversies between mechanists and vitalists, the characteristics of living things, and the evolution of life. It then delves into molecular structures, including nucleic acids, DNA, RNA, interatomic interactions, and hydrogen bonds. After looking at these smaller systems, the author probes the larger cellular structures. He examines the cytoplasm, the cytoskeleton, chromosomes, mitochondria, motor proteins, and more. The book concludes with discussions on biophysical processes, including oxidative phosphorylation, diffusion, bioenergetics, conformational transitions in proteins, vesicle transport, subcellular structure formation, and cell division.

Stem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation-including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.

Vertebrates possess lineage-specific characteristics. These include paired anterior sense organs and a robust, modular head skeleton built of cellular cartilage and bone. All of these structures are derived, at least partly, from an embryonic tissue unique vertebrates - the neural crest. The evolutionary history of the neural crest, and neural crest cells, has been difficult to reconstruct. This volume will use a comparative approach to survey the development of the neural crest in vertebrates, and neural crest-like cells, across the metazoa. This information will be used to reveal neural crest evolution and identify the genomic, genetic, and gene-regulatory changes that drove them. Key selling features: Summarizes the data regarding neural crest cells and nerural crest derivatives Uses a broad-based comparative approach Suggests hypothesis that the origin of neural crest cells involved the novel co-activation of ancient metazoan gene programs in neural border cells Illustrates how the emergences of neural crest made possible the diversification of vertebrate heads

MCB: CAR T Cells: Development, Characterization and Applications, Volume 167 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including High-efficiency of genetic modification using CRISPR/Cpf1 system for engineered CAR T-cell therapy, Determination of the Biodistribution of Chimeric Antigen Receptor-Modified T Cells against CD19 in NSG Mice, Generation of CAR-T cells using lentiviral vectors, Generation of CAR T-cells using ?-retroviral vector, Flow cytometry detection and quantification of CAR T cells into solid tumors, Evaluation of CAR-T Cell Cytotoxicity: Real-Time Impedance-Based Analysis, and much more.

Muscle cells, including cardiomyocytes, contain a specialized smooth endoplasmic reticulum (ER), sarcoplasmic reticulum (SR) calcium ions (Ca2+) release and reuptake by the sarcoplasmic reticulum trigger the contraction and relaxation of the myofibrils, respectively. This book examines the control and modulation of the SR and how this may vary among skeletal and cardiac muscle without bypassing the smooth muscle. It presents new and exciting work in this area and identifies promising new research directions. Furthermore, it considers the advances in this relatively unexplored field, offering new insights into the role of SR communication with other organelles and the new concepts about ER stress. Generally, this scientific book brings together contributions from key workersboth in basic and clinical sciences whose studies range from physiological to pathological and molecular to whole animal. In this book, the authors provide insights into the evolution of SR design and function.

This volume looks at the liver's epithelial cells-hepatocytes and cholangiocytes-and their progenitors. This book is divided into five parts: isolation of progenitor cells; characterization of liver progenitors in vivo; generation of hepatocytes, cholangiocytes, and their progenitors; reconstitution of liver tissue structures; and liver injury models. The chapters in this book cover topics such as expansion of bipotential liver stem/progenitor cells (LPCs) from fetal and neonatal liver; identifying progenitor cells involved in liver regeneration in vivo; methods for generating hepatocytes and cholangiocytes from multiple cellular sources; 3D tissue structures ex vivo; and resolving hepatic fibrosis by bone marrow transplantation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Hepatic Stem Cells: Methods and Protocols is a valuable resource to help researchers understand the current theories used to study hepatic stem/progenitor cells, and aid them in performing experiments related to liver biology and pathophysiology.

The first and only source to offer a detailed and authoritative review of every aspect of nasal and sinus disorders in children, this reference provides an impressive collection of reviews on topics ranging from disease mechanisms and immunodefense to diagnosis, medical management, and surgical strategy.

This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic target.

Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences.

Advances in Biomembranes and Lipid Self-Assembly, Volume 34, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for the study of cell membranes, lipid model membranes and lipid self-assemblies, from the micro- to the nanoscale. As planar lipid bilayers are widely studied due to their ubiquity in nature, this book presents research on their application in the formulation of biomimetic model membranes, and in the design of artificial dispersion of liposomes. Chapters cover Physical properties of SOPC lipid membranes containing cholesterol by molecular dynamics simulation, Exciting membrane fluctuations - more than thermal stimulation, Fluctuations shaping bio-membrane adhesion, and more.

Warum brauchen wir Schlaf? Wie entsteht Durst? Oder ein Herzinfarkt? In der Physiologie lernen Sie alles über die Funktionen des menschlichen Körpers. Die 32. Auflage der Physiologie des Menschen wurde komplett überarbeitet, der Stoff ist nun in 84 übersichtliche Kapitel gegliedert. Gleich die erste Seite eines Kapitels bietet einen hervorragenden Überblick über den Lernstoff: In einer Box wird kurz und knapp erklärt, worum es im Kapitel geht. Danach kommen die visuellen Lerner auf ihre Kosten: eine zusammenfassende Abbildung bringt das Wesentliche auf den Punkt. Beim Lernen und Wiederholen unterstützen Sie außerdem: Grüne Zwischenüberschriften – fassen die einzelnen Abschnitte in einem Satz zusammen, ideal zum Wiederholen! Rote Merksätze – machen auf besonders wichtige Inhalte aufmerksam Zusammenfassungen zu allen Abschnitten Fast 200 Klinikboxen – machen die klinischen Bezüge deutlich Über 1000 Abbildungen für das visuelle Lernen Interessante Hintergrundinformationen als Kleingedrucktes Nicht nur für die Vorklinik, auch im klinischen Abschnitt sind die physiologischen Zusammenhänge Grundlage, um Krankheiten und ihre Entstehung zu verstehen. Machen Sie den Brandes/Lang/Schmidt zu Ihrem Begleiter durch das gesamte Studium!

New Methods and Sensors for Membrane and Cell Volume Research, Volume 88 provides an overview of novel experimental approaches to study both the cell membrane and the under-membrane space - the cytosol, which have lately began drawing renewed attention. The book's overall emphasis is on fluorescent and FRET-based sensors, however, other optical (such as variants of transmission microscopy) and non-optical methods (neutron scattering and mass spectrometry) also have dedicated chapters. This volume provides a rare review of experimental approaches to study intracellular phase transitions, as well as anion channels, membrane tension and dynamics, and other topics of intense current interest.

Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.

In the past three decades, considerable progress has been made in the mathematical analysis, modeling, and simulation of the fluid dynamics of liquid capsules and biological cells. In this book, leaders in the field explore topics related to the modeling and numerical simulation of capsule fluid dynamics and cell biomechanics. Providing an outstanding overview of the subject, the authors include results from their own ongoing research.

The book covers the fundamentals of cell and membrane mechanics, modeling hydrodynamics under various flow conditions, and drop and bubble dynamics associated with temperature variations and surfactant transport. The clear exposition and stand-alone format provided by Modeling and Simulation of Capsules and Biological Cells puts state-of-the-art information in a single source that will undoubtedly motivate further work in this developing field.

Self-contained presentation (everything necessary provided in introductory chapters) Focused story line (journey through the cell nucleus) Balance between precise mathematics and physical intuition Up-to-date with the newest scientific developments Over 190 colored figures specially designed for this book A large number of exercises, including extensive computational problems

Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology.

Based on the proceedings of a Symposium held during the 2002 World Congress of the Oxygen Club of California, 2002.

This volume explores protocols for identifying mutant mice and characterizing parts of their anatomical, functional, cellular, and molecular phenotypes. The chapters in this book look at anatomical and functional phenotyping using quantitative imaging, isolation of specific embryonic cell types for cell culture, analysis of gene expression, and how to define chromatin structure. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Mouse Embryogenesis: Methods and Protocols is a valuable resource for experimentalists interested in discovering new aspects of embryogenesis control, organ function, and the origin of disease.

Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part A, Volume 365 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release include MPN a continuum of different disease entities, Bone marrow microenvironment of MPN, Extramedullary hemopoiesis in MPN, The JAK2 mutation, Calreticulin mutations in myeloproliferative neoplasms, and Cytogenetic abnormalities and non-driver mutations in MPN. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology.

Endothelial Signaling, Mechanotransduction, Vascular Biology and Atherosclerosis, Volume 87, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.

Contents:
1. Introduction-metabolism 2. Enzyme-catalysed Reactions 3. Overview of Signal Transduction 4. Glycolysis 5. Citric Acid Cycle 6. Fatty Acid Oxidation 7. Amino Acid Metabolism 8. Glycogen 9. Gluconcogenesis 10. Synthesis of Triglycerides 11. Cholesterol 12. Metabolic Interrelationships of Tissue.

Forcourses in cell biology. Connectingfundamental concepts across the world of the cell Known for its strong biochemistry coverage and clear, easy-to-followexplanations and figures, Becker's World of the Cell provides abeautifully illustrated, up-to-date introduction to cell biology concepts,processes, and applications. Informed by years of classroom experience in thecell biology course, the text features accessible and authoritativedescriptions of all major principles, as well as unique scientific insightsinto visualization and applications of cell and molecular biology. With the 10thEdition, the authors guide students to make connections throughout cellbiology, and provide questions that encourage students to practice interpretingand analyzing data. Embedded features in Pearson eText add interactivity,walking students through key figures with narrated explanations. Personalizelearning with Mastering Biology with Pearson eText Mastering (R) empowers youto personalize learning and reach every student. This flexible digital platformcombines trusted content with customizable features so you can teach yourcourse your way. And with digital tools and assessments, students become activeparticipants in their learning, leading to better results. PearsoneText is an easy-to-use digital textbook available within Mastering that letsstudents read, highlight, take notes, and review key vocabulary all in oneplace. If you're not using Mastering, students can purchase Pearson eText ontheir own or you can assign it as a course to schedule readings, view studentusage analytics, and share your own notes with students.