This book describes the basic features of virus replication, and points out how these features lead into the diverse biologies and genetics of the various viruses.

Basics of proteins and proteomics techniques In-depth understanding of mass-spectrometry and quantitative proteomics An overview of interactomics and its application for translational research. Advancement in the field of proteomics and challenges in clinical applications.

1. Blend of classical human genetics with molecular and genome-based applications 2. Techniques applied for the diagnosis of the genetic disorders 3. Diagnostics of 19 genetic disorders including symptoms, etiology, diagnosis, and treatment. 4. Role of gene therapy in the amelioration of disorders 5. Type studies describing the role of diagnostics in conserving the human health.

Microbe-Assisted Phytoremediation of Environmental Pollutants: Recent Advances and Challenges provides comprehensive information on the principles and practical knowledge of microbe-assisted phytoremediation of organic and inorganic pollutants for environmental safety. This book describes the physiological, biochemical, microbiological, and molecular basis of microbe-assisted phytoremediation and contains many relevant topics to fill the gaps in developing an understanding of microbe-assisted phytoremediation of environmental pollutants. The book provides state-of-the-art knowledge on fundamental, practical, and purposeful utilization of plant-associated bacteria (plant growth-promoting rhizobacteria [PGPR] and endophytes) and arbuscular mycorrhizal fungi for plant-growth promotion and enhanced phytoremediation of environmental pollutants in the contaminated matrix. Features: Provides a state-of-the-art overview of microbe-assisted phytoremediation Emphasizes the roles of PGPR, endophytes, and mycorrhizal fungi in assisted phytoremediation Elucidates biochemical and molecular mechanisms of microbe-assisted phytoremediation Details field studies and success stories of microbe-assisted phytoremediation Explores advances, challenges, and future directions in microbe-assisted phytoremediation The book serves as a valuable resource for researchers, ecotoxicologists, environmental scientists and engineers, environmental microbiologists and biotechnologists, environmental health and risk scientists, environmental science managers and administrators, remediation practitioners, environmental policymakers, and students at the postgraduate and doctoral levels in the relevant fields who wish to work on microbe-assisted phytoremediation of pollutants for environmental safety and sustainability.

Biotechnology is a multidisciplinary field encompassing microbiology, bichemistry, genetics, molecular biology, chemistry, immunology, cell and tissue culture physiology. This book describes the recent developments in these areas. Current research topics such as Quorum sensing, Integrons, Phytomining are discussed, which would serve as an excellent reference work for both academicians and researchers in the field.

A Unified Microscopic Approach to Analyzing Complex Processes in Molecular Motors Motor Proteins and Molecular Motors explores the mechanisms of cellular functioning associated with several specific enzymatic molecules called motor proteins. Motor proteins, also known as molecular motors, play important roles in living systems by supporting cellular transport and force generation via the transformation of chemical energy into mechanical work. The book presents established results, theoretical methods, and experimental observations related to biological molecular motors. It uses fundamental physical-chemical concepts and methods to develop a systematic theoretical framework for understanding motor protein dynamics. The author introduces the main ideas using simple arguments that avoid heavy mathematical derivations in favor of more intuitive physical understanding. Although the book assumes some rudimentary knowledge of cell biology, calculus, and basic ideas from chemistry and physics, it gives explanations and derivations for most results. Accessible to students and researchers in a wide range of scientific fields, this book provides a unified molecular picture for analyzing motor proteins. It connects major experimental facts on molecular motors to principal theoretical concepts consistent with the fundamental laws of chemistry and physics.

The development of biofilms and their role in public health - particularly drinking water - is often overlooked. Ideal for anyone interested in water related issues, Microbiological Aspects of Biofilms and Drinking Water presents an overview of the public health effects associated with drinking water. It highlights the microbiological aspects relating to the development of biofilms. The first four chapters focus on the state of the water supply. The authors review methods for studying the epidemiological spread of waterborne infections and those used in surveillance and control of pathogenic microbes. He includes the methods used for the detection of pathogens of public health importance in drinking water. In the subsequent chapters the authors pay close attention to biofilm development within drinking water systems, underlining the public health threat. They cover the microbes important to public health and include the methods used to detect biofilms. In conclusion they review the methods involved in biofilm control - both conventional and biocidal treatments. Overall, Microbiological Aspects of Biofilms and Drinking Water provides a snapshot of public health and the water supply. It covers the future of drinking water and its associated health hazards and provides a deeper understanding of biofilms and how they provide a safe haven for pathogens and water related diseases.

The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.

Describes the state-of-the-art techniques and the application of omics tools in wastewater treatment reactors (WWTRs) Includes both the theoretical and practical knowledge on the fundamental roles of microorganisms in WWTRs Discusses environmental microbial community proteomics Covers relating function and community structure of complex microbial systems using neural networks Reviews the economics of wastewater treatment and the development of suitable alternatives in terms of performance and cost effectiveness

The third edition of Environmental Microbiology for Engineers explores the role that microorganisms play in the engineered protection and enhancement of an environment. Offering a perfect balance of microbiological knowledge and environmental biotechnology principles, it provides a practical understanding of microorganisms and their functions in the environment and in environmental engineering systems. The book also presents a quantitative description of applied microbiological processes and their engineering design. This updated edition includes all new information on construction biotechnology, biogeotechnical engineering, construction biomaterials, environmental engineering of life-support closed ecosystems, defense biotechnologies, and biosafety in civil and environmental engineering. Features: Classroom tested in universities as a primary course text for civil and environmental engineering students Includes quizzes, problems, and solutions for better understanding of the material Covers essential topics such as the diversity and functions of microorganisms in the environment and environmental engineering systems, the structure and functions of microbial ecosystems, applied microbial genetics and molecular biology, environmental bioengineering, and more Offers combined coverage of microbiology and biotechnology adapted for students in advanced civil and environmental engineering courses Environmental Microbiology for Engineers provides a practical understanding of microorganisms in civil engineering processes and their functions in environmental engineering systems. It is intended for upper-level undergraduate, graduate, and post-graduate students of civil and environmental engineering. It is also useful for practicing environmental engineers working in the areas of wastewater, solid waste treatment, soil remediation, and ground improvement.

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

1. Discusses the effects of environmental stresses on nitrogen metabolism 2. Useful for people doing research in plant physiologists, plant biochemists, geneticists, molecular biologists, agronomists, environmental researchers 3. Details the significant advances that have been made in understanding the physiological, biochemical, and molecular aspects of nitrogen metabolism and its regulation in plants

One of the oldest scientific traditions, plant breeding began in Neolithic times with methods as simple as saving the seeds of desirable plants and sowing them later. It was not until the re-encounter with Mendel's discoveries thousands of years later, the genetic basis of breeding was understood. Developments following have provided further insight into how genes acting alone or in concert with other genes and the environment, result in a particular phenotype. From Abaxial to Zymogram, the third edition of Dictionary of Plant Breeding contains clear and useful definitions of the terms associated with plant breeding and related scientific/technological disciplines. It defines jargon; provides helpful tables, examples, and breeding schemes; and includes a list of crop plants with salient details. Packed with data and organized to make that data easy to access, this revised and expanded reference provides comprehensive coverage of the latest discoveries in cytogenetics, molecular genetics, marker-assisted selection, experimental gene transfer, CRISPR technology, seed sciences, crop physiology, and genetically modified crops. Features: Provides a comprehensive list of technical terms used in plant breeding Explores the historical development of crop improvement Discusses applications of molecular genetics and biotechnology Includes numerous figures, drawings, tables, and schemes supplementing the glossary A complex subject, plant breeding draws from many scientific and technological disciplines, often making it difficult to know the precise meanings of many terms and to accurately interpret specific concepts. As in the previous editions, this dictionary unifies concepts by including the specific terms of plant breeding and terms that are adjusted from other disciplines. Drawing on Rolf Schlegel's 50 years of experience, the book provides an encyclopedic list of commonly used technical terms that reflect the latest developments in the field.

Provides clear summaries of Fluorescence in situ hybridization technologies and others. Comprehensively covers established and emerging methods. Chapters from an international team of leading researchers. Useful for students, researchers and clinicians.

This new edition of a foundational text presents a contemporary review of cladistics, as applied to biological classification. It provides a comprehensive account of the past fifty years of discussion on the relationship between classification, phylogeny and evolution. It covers cladistics in the era of molecular data, detailing new advances and ideas that have emerged over the last twenty-five years. Written in an accessible style by internationally renowned authors in the field, readers are straightforwardly guided through fundamental principles and terminology. Simple worked examples and easy-to-understand diagrams also help readers navigate complex problems that have perplexed scientists for centuries. This practical guide is an essential addition for advanced undergraduates, postgraduates and researchers in taxonomy, systematics, comparative biology, evolutionary biology and molecular biology.

Written by leaders in their fields, Calcium Oxalate in Biological Systems comprehensively discusses current information about the importance of this compound in animals, plants, fungi, and microorganisms. Both in vivo and in vitro methods of crystallization as well as crystallization systems are discussed. Researchers who pioneered the field contribute their invaluable knowledge for the first time about oxalate bacteria and their importance. This is an essential reference for both plant and animal scientists concerned with human and animal kidney disease.

1) General description of the Genetic Polymorphism and its various types 2) Discuss the role of Genetic Polymorphisms in modulating risk of various human diseases 3) Discuss various molecular techniques used for detecting GPs 4) Discuss the role of SNPs in modulating the susceptibility of human diseases 5) Genetic basis for individual variations in response to therapeutics

Microbes are the most abundant organisms in the biosphere and regulate many critical elemental and biogeochemical phenomena. Because microbes are the key players in the carbon cycle and in related biological reactions, microbial ecology is a vital research area for understanding the contribution of the biosphere in global warming and the response of the natural environment to climate variations. The beneficial uses of microbes have enabled constructive and cost-effective responses that have not been possible through physical or chemical methods. This new volume reviews the multifaceted interactions among microbes, ecosystems, and their pivotal role in maintaining a more balanced environment, in order to help facilitate living organisms coexisting with the natural environment. With extensive references, tables, and illustrations, this book provides valuable information on microbial utilization for environmental sustainability and provides fascinating insights into microbial diversity. Key features include: Looks at enhancing plant production through growth-promoting arbuscular mycorrhizae, endophytic bacteria, and microbiome networks Considers microbial degradation and environmental management of e-wastes and azo dyes Explores soil-plant microbe interactions in metal-contaminated soils Examines radiation-resistant thermophiles for engineered bioremediation Describes potential indigenous/effective microbes for wastewater treatment processes Presents research on earthworms and microbes for organic farming

Plant volatiles-compounds emitted from plant organs to interact with the surrounding environment-play essential roles in attracting pollinators and defending against herbivores and pathogenes, plant-plant signaling, and abiotic stress responses. Biology of Plant Volatiles, with contributions from leading international groups of distinguished scientists in the field, explores the major aspects of plant scent biology. Responding to new developments in the detection of the complex compound structures of volatiles, this book details the composition and biosynthesis of plant volatiles and their mode of emission. It explains the function and significance of volatiles for plants as well as insects and microbes whose interactions with plants are affected by these compounds. The content also explores the biotechnological and commercial potential for the manipulation of plant volatiles. Features: Combines widely scattered literature in a single volume for the first time, covering all important aspects of plant volatiles, from their chemical structures to their biosynthesis to their roles in the interactions of plants with their biotic and abiotic environment Takes an interdisciplinary approach, providing multilevel analysis from chemistry and genes to enzymology, cell biology, organismal biology and ecology Includes up-to-date methodologies in plant scent biology research, from molecular biology and enzymology to functional genomics This book will be a touchstone for future research on the many applications of plant volatiles and is aimed at plant biologists, entomologists, evolutionary biologists and researchers in the horticulture and perfume industries.

In the 1960s, Sydney Brenner proposed to use the nematode worm Caenorhabditis elegans to discover the control mechanisms of animal development and to reveal how a small number of neurons generate different behaviours, giving birth to a vibrant community that uses this animal model for their studies. Brenner was aided in his aim by John Sulston, who mapped the C. elegans cell lineages - from a single cell to the multicellular adult - which transformed the field of developmental biology. As a tribute to these two men, this book captures the perspectives of some of the early pioneers of the worm community, from Martin Chalfie, Robert Waterston and Donald Moerman to Catherine Rankin, Antony Stretton and John White. It also includes contributions from subsequent generations of the community, who explore the development and function of the C. elegans nervous system. This book features how this animal has become one of the best models for elucidating the biology of different sensory modalities and their complex behavioural outputs, or how this animal's survival strategies have contributed to our understanding of ageing and neurodegeneration. Thus, this volume documents the development of the C. elegans neuroscience field, from infancy to maturity. The chapters in this book were originally published as a special issue of the Journal of Neurogenetics.

The discovery of enzymes as biocatalysts has led to various biotechnological developments. The capability of enzymes to catalyse various chemical reactions both in vivo and in vitro has led them to applications in various industries, such as food, feed, pharmaceutical, diagnostics, detergent, textile, paper, leather, and fine chemical industries. Microbial Fermentation and Enzyme Technology mainly focuses on production and application of enzymes in various industries. Further, it also discusses recent developments in enzyme engineering particularly those involved in creating and improving product formations through enzyme and fermentation technology. Salient features: Includes current research and developments in the area of microbial aspects in different fields like food, chemicals, pharmaceutical, bioprocess, etc. Discusses various enzymes that are used in refinement of environmental pollutions and its application in different industrial sectors Focuses on production and application of enzymes in various industries Highlights recent developments in enzyme engineering with respect to its application in textile, pharmaceutical, nanobiotechnology, bioremediation and many other related fields.

There is a renewed interest in the fundamentals of energy metabolism, yet most people base their understanding on the views of generalists expressed in elementary textbooks. New techniques that enable analysis of thousands of metabolites provide useful data, but do not themselves substitute for an understanding of the fundamentals of metabolism. While classical ideas of metabolism are also valuable, some earlier ideas have not withstood further investigation. This book presents a personal philosophy but rests on what is broadly accepted by metabolic biochemists over the past few decades.

Environmental protection and sustainability are major concerns in today's world, and a reduction in CO2 emission and the implementation of clean energy are inevitable challenges for scientists and engineers today. The development of electrochemical devices, such as fuel cells, Li-ion batteries, and artificial photosynthesis, is vital for solving environmental problems. A practical device requires designing of materials and operational systems; however, a multidisciplinary subject covering microscopic physics and chemistry as well as macroscopic device properties is absent. In this situation, multiscale simulations play an important role. This book compiles and details cutting-edge research and development of atomistic, nanoscale, microscale, and macroscale computational modeling for various electrochemical devices, including hydrogen storage, Li-ion batteries, fuel cells, and artificial photocatalysis. The authors have been involved in the development of energy materials and devices for many years. In each chapter, after reviewing the calculation methods commonly used in the field, the authors focus on a specific computational approach that is applied to a realistic problem crucial for device improvement. They introduce the simulation technique not only as an analysis tool to explain experimental results but also as a design tool in the scale of interest. At the end of each chapter, a future perspective is added as a guide for the extension of research. Therefore, this book is suitable as a textbook or a reference on multiscale simulations and will appeal to anyone interested in learning practical simulations and applying them to problems in the development of frontier and futuristic electrochemical devices.

The over-riding premise for biotechnology in this book is bringing novel products to market to substantially advance patient care and disease mitigation. Biotechnology, over its relatively brief existence of 40 years, has experienced a mercurial growth. The vast educational need for biotechnology information in this rapidly burgeoning field is a basic rationale here. However a more prominent underpinning is that, bringing biotech products to market for patient care involves success in the following four areas of engagement simultaneously - scientific advances for healthcare technologies, novel and varied products for untreated diseases, regulatory authorities, and biotech companies. Features Comprehensive coverage of biotechnology science topics used in development and manufacturing Addresses all the scientific technologies within biotechnology responsible for products on the market and the pipeline Presents business issues such as marketing and sales of the products, as well as companies engaged, and how biotech business has evolved

This book explains current strategies for mapping genomes of higher organisms and explores applications of gene mapping to agriculturally important species of plants and animals. It also explores the experimental techniques used for genetic and physical mapping of genes.