Histochemistry and cytochemistry are important fields for studying the inner workings of cells and tissues of the body. While visualization techniques have been in use for many years, new methods of detection developed recently help researchers and practitioners better understand cell activity. Histochemical and Cytochemical Methods of Visualization describes the essential techniques that can be used for histochemical investigations in both light and transmission electron microscopy. The book begins by discussing techniques in light microscopy. It reviews classical methods of visualization, histochemical and histoenzymatic methods, and methods used to visualize cell proliferation and apoptosis. Next, the book examines the cytochemical methods used in electron microscopy with traditional techniques, as well as more specialized methods. The final section provides an overview of image analysis and describes how image processing methods can be used to extract vital information. A 16-page insert supplies color illustrations to enhance the text. Techniques will continue to adapt to the latest technological innovations, allowing more and more precise quantification of images. These developments are essential to the biological as well as the medical sciences. This manual is a critical resource for novice and experienced researchers, technicians, and students who need to visualize what happens in the cell, the molecules expressed, the main enzymatic activities, and the repercussions of the molecular activities upon the structure of the cells in the body.

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism's physiology and survival.

Drawing on contributions from more than thirty scholars and experts in the field, this book examines the role of business as an enabler, as an inhibitor, and ultimately as a co-actor in global sustainability transformations expected over the next few decades. The Role of Business in Global Sustainability Transformations employs several theoretical perspectives and provides abundant examples and cases to discuss a variety of emerging concepts, phenomena, and trends shaping business sustainability. Weaving through the chapters, the editors present core tensions and sources of inertia towards transformative change, and acknowledge that envisioning multiple solutions and pathways are possible and desirable. They advocate for the need to align visions, actions and time horizons between policy, society and business in addressing the interlinked socio-ecological challenges that our society currently faces. This book will be an important resource for scholars and professionals working in the field of sustainability and sustainable business, and a vital educational text for students interested in this discipline.

When marketing managers and financial managers join forces within any business, the result can often be poor communication on financial criteria and goals. The risk of this situation occurring is inevitably present when those with different professional backgrounds and roles are working in accordance with their own norms. In his seminal 1956 paper on general systems theory, the economist Kenneth Boulding referred to the phenomenon of "specialised ears and generalised deafness", which can be seen to exist when marketing managers are financially illiterate or when financial managers lack the necessary insights to design, implement and operate accounting systems which are useful to marketing managers in carrying out their roles. It is increasingly difficult to attach credence to the idea of marketing managers who lack financial skills, or financial managers who fail to relate to the context in which marketing managers operate. Understanding the marketing/accounting interface is therefore important in generating emergent properties from the interaction of marketers and accountants whereby the whole is greater than the sum of the parts. The chapters in this volume seek to address this challenge. This book was originally published as a special issue of the Journal of Marketing Management.

Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.

1. Discusses implications of COVID on education, environment, and lifestyle 2. Elucidates life-style transformation strategy to counter COVID 3. Focuses on transformative strategy to overcome COVID impact

This important book traces the history of genetics and genomics policy in Britain. Detailing the scientific, political, and economic factors that have informed policy and the development of new health services, the book highlights the particular importance of the field of Public Health Genomics. Although focused primarily on events in Britain, the book reveals a number of globally applicable lessons. The authors explain how and why Public Health Genomics developed and the ways in which genetics and genomics have come to have a central place in many important health debates. Consideration of their ethical, social, and legal implications and ensuring that new services that are equitable, appropriate, and well-targeted will be central to effective health planning and policymaking in future. The book features: Interviews with leading individuals who were intimately involved in the development of genetics and genomics policy and Public Health Genomics Insights from experts who participated in a pair of 'witness seminars' Historical analysis exploiting a wide range of primary sources Written in a clear and accessible style, this book will be of interest to those involved in the research and practice of genetics, genomics, bioethics, and population health, but also to NHS staff, policymakers, politicians, and the public. It will also be valuable supplementary reading for students of the History of Medicine and Health, Public Health, and Biomedical Sciences.

Melioidosis is an endemic tropical disease and is fast becoming an emerging global concern. Its clinical mimicry with several other common diseases has made its diagnosis and treatment difficult. This book identifies a gap in the literature and represents the management and diagnosis of this fatal but curable disease. It provides detailed coverage of its history, epidemiology, the latency of the agent, pathogenesis, manifestations, clinical clues for detection, microbiological diagnosis, treatment, prevention, and environmental aspects. This book is for clinicians, infectious disease specialists, microbiologists, and public health professionals, in countries where melioidosis is endemic. Key Features: * Provides practical guidance on clinical diagnosis, management, and prevention of melioidosis. * Features high quality radiological and clinical photographs for clinicians and professionals. * Explores the latest techniques and advancements in laboratory diagnosis.

The replacement of fossil-derived compounds by bio-based fuels and chemicals is crucial for the implementation of a sustainable bioeconomy. In this context, microorganisms are key players for biofuels' production from renewable sources. Biotechnological biofuel production processes require conversion microorganisms capable of both efficiently assimilating renewable low-cost carbon sources and diverting their metabolisms towards the specific biofuel. Exploring the wide diversity of microorganisms available on Earth will surely aid to make the production of green fuels a reality. This book gives a wide overview of different microbial-based processes for green fuels production. The book also includes techno-economic analysis and highlights strategic, commercial and environmental interests in promoting green fuels. All these facts make this book very valuable not only for the scientific community but also for biofuel companies and policy makers.

This handbook provides an in-depth review of information across the developmental spectrum of gene and cell therapy products. From introductory information to state-of-the-art technologies and concepts, the book provides insights into upstream processes such as vector design and construction, purification, formulation and fill/finish as well as delivery options. Planning steps for compliance with current good manufacturing practice (CGMP) to readiness for chemistry, manufacturing, and controls (CMC) are also discussed.This book wraps up with examples of successes and pitfalls addressed by experts who have navigated the multiple challenges that are part of any innovative endeavor. Features Intended as a one-stop resource for availability of state-of-the-art information related to cell and gene therapy products for researchers, scientists, management and other academic and research institutions. Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing. Discusses siRNA, mRNA, and plasmid manufacturing. Describes the importance of supplier-sponsor synergies on the path to commercialization. Diverse audience with a large number of individuals in the core technologies and supportive practices.

Author Prof Jim Lynch is widely known and very experienced, well-connected with wide international networks, and globally distinguished. He was awarded the UNESCO Prize in Microbiology and Einstein Medal and Distinguished Scientist of the US Department of Agriculture. His OUP textbook Soil Microbiology was a bestseller. Taps directly into the topical area of the COVID-19 pandemic and One Health. Affordable and accessible to a wide interdisciplinary audience.

Encyclopedia of Biological Chemistry, Six Volume Set has always been characterized by its unique and comprehensive content. Since publication of the 2nd edition, many important discoveries have been made leading to novel concepts in several areas of biochemistry, and new technologies have advanced our understanding of key processes of life. All of these advances are included in the new and expanded third edition. With its 6 volumes, this is the most up-to-date and complete resource on biochemistry and molecular biology, provided through contributions by leading experts in the field.

This book focuses on the design methodologies of various quantum circuits, DNA circuits, DNA-quantum circuits and quantum-DNA circuits. It considers the merits and challenges of multivalued logic circuits in quantum, DNA, quantum-DNA and DNA-quantum computing. Multiple-Valued Computing in Quantum Molecular Biology: Arithmetic and Combinational Circuits is Volume 1 of a two-volume set. From fundamentals to advanced levels, this book discusses different multiple-valued logic DNA-quantum and quantum-DNA circuits. The text consists of four parts. Part I introduces multiple-valued quantum computing and DNA computing. It contains the basic understanding of multiple-valued quantum computing, multiple-valued DNA computing, multiple-valued quantum-DNA computing and multiple-valued DNA-quantum computing. Part II examines heat calculation, speed calculation, heat transfer, data conversion and data management in multi-valued quantum, DNA, quantum-DNA and DNA-quantum computing. Part III discusses multiple-valued logic operations in quantum and DNA computing such as ternary AND, NAND, OR, NOR, XOR, XNOR and multiple-valued arithmetic operations such as adder, multiplier, divider and more. Quantum-DNA and DNA-quantum multiple-valued arithmetic operations are also explained in this section. Part IV explains multiple-valued quantum and DNA combinational circuits such as multiple-valued DNA-quantum and quantum-DNA multiplexer, demultiplexer, encoder and decoder. This book will be of great help to researchers and students in quantum computing, DNA computing, quantum-DNA computing and DNA-quantum computing researchers.

Discusses various design aspects of multiple-valued logic DNA-quantum and quantum-DNA sequential circuits, memory devices, programmable logic devices and nano-processors Presents how multiple-valued quantum, DNA, quantum-DNA and DNA-quantum nano processors are designed with algorithms Examines the architecture and design procedure of memory devices such as Random Access Memory (RAM), Read Only Memory (ROM) Reviews the designs and algorithms of Multiple-valued quantum, DNA, quantum-DNA and DNA-quantum nano processors.

Microbial biofilms have both positive and negative effects. This book considers new ways of controlling environmental microbial biofilm such as using phages, nanotechnology, and newly discovered microbial enzymes. A team of contributors shares current, relevant and original research to add weight and recognition to the book. Also, each chapter provides enlightening and relevant tabular information, charts, and illustrations. The book is, therefore, informative, precise, useful and easily digested by users.

This new volume offers comprehensive coverage of bacterial biosurfactants, the competitive new area of research that has exciting potential application in agriculture and petroleum exploration. The book helps readers to understand the synthesis of biosurfactants by some specific bacteria, their culture, and extraction toward use in bioremediation and enhanced crude oil recovery. The volume covers the gamut of topics in bacterial biosurfactants in nanostructure, including their comparison to synthetic surfactants, their interaction with microorganisms, and their biochemistry, characterization, genetics of production, bioremedial effects, and more. The volume also explores the myriad uses of bacterial biosurfactants, including in laundry detergents, cosmetics, food production, petroleum, agriculture, medicine and therapeutics, environment, metallurgy, etc. Attention to biosurfactants has been gradually increasing in recent years due to the possibility of their production through fermentation technology and their potential applications in environmental protection. Despite their numerous advantages over synthetic chemical surfactants, biosurfactants have been unable to compete with chemically synthesized surfactants due to high production costs in relation to the inefficient bioprocessing techniques, poor strain productivity, and use of costly substrates. This volume helps to identify the factors that need to be addressed to reduce the cost of production of biosurfactants.

Emerging microbial and viral infections are a serious challenge to health, safety, and economics around the world. Antimicrobial and antiviral technologies are needed to disrupt the progression and replication of bacteria and viruses and to counter their rapidly evolving resistance. This book discusses recent developments in materials science and engineering in combating infectious diseases and explores advances in antimicrobial and antiviral materials, including polymers, metals, and ceramics and their applications in the fight against pathogens. Features * Covers progress in biomimetic antimicrobial and antiviral materials and antimicrobial/antiviral bulk materials and coatings * Describes modern methods for disinfection of biomedical materials against microbial and viral infection resistance, especially for depressing novel coronavirus (COVID-19) * Details methods to improve material properties to have a longer service life in combating infection * Emphasizes chemical, physical, mechanical, tribological, and antimicrobial/antiviral properties * Offers current and future applications of emerging antimicrobial/antiviral technologies This book will be of interest to materials researchers and industry professionals focusing on antimicrobial and antiviral applications.

Arts, heritage, non-profit and social marketing today comprise key components of the contemporary marketing management scene. Governments, charities and voluntary sector organisations throughout the world are increasingly involved in the development of marketing campaigns, and more and more of these organisations are likely to be at the cutting edge of the application of the very latest marketing methods. Research in the arts, heritage, non-profit and social marketing fields is intellectually rigorous, relevant for user communities, and has a great deal to offer to marketing theory as well as to promotional practice. This book presents a collection of stimulating articles that report some of the freshest and most innovative research and thinking in the authors' specialist domains. Collectively the chapters offer a balance of empirical and conceptual research in arts, heritage, non-profit and social marketing. They explore new ideas, challenge pre-existing orthodoxies, develop knowledge, and demonstrate the epistemological importance of current research in these critical areas. This book was originally published as a special issue of the Journal of Marketing Management.

Gets right to the point with step-by-step guidance on solving physics problems. Covers all topics in standard general physics courses in the same sequence. Keeps learning about physics fun and engaging through the story of dinosaurs being tested on their knowledge for a final challenge (deflecting an asteroid headed to Earth!). Enables the reader to quickly flip through and locate steps needed for a particular problem. Includes tons of easy to follow diagrams and worked solutions.

Examining the chemical modification of biological polymers and the emerging applications of this technology, Chemical Modification of Biological Polymers reflects the change in emphasis in this subsection of biotechnology from the study of protein structure and function toward applications in therapeutics and diagnostics.

Highlights

• The basic organic chemistry of the modification proteins, nucleic acids, oligosaccharides, polysaccharides, and their applications
• New analytical technologies used to characterize the chemical modification of biological polymers
• Identification of in vivo, non-enzymatic chemical modification of biological polymers
• Specific chemical modifications to generate biopharmaceutical products

This book covers the basics on the organic chemistry underlying the chemical modification of biopolymers, including updates on the use of various chemical reagents. It describes the current status of chemical modification of biological polymers and emerging applications of this technology in biotechnology. These technologies are important for the manufacture of conjugate proteins used in drug delivery, for the preparation of nucleic acid microarrays, and for the preparation of hydrogels and other materials used in tissue engineering.

When marketing managers and financial managers join forces within any business, the result can often be poor communication on financial criteria and goals. The risk of this situation occurring is inevitably present when those with different professional backgrounds and roles are working in accordance with their own norms. In his seminal 1956 paper on general systems theory, the economist Kenneth Boulding referred to the phenomenon of "specialised ears and generalised deafness", which can be seen to exist when marketing managers are financially illiterate or when financial managers lack the necessary insights to design, implement and operate accounting systems which are useful to marketing managers in carrying out their roles. It is increasingly difficult to attach credence to the idea of marketing managers who lack financial skills, or financial managers who fail to relate to the context in which marketing managers operate. Understanding the marketing/accounting interface is therefore important in generating emergent properties from the interaction of marketers and accountants whereby the whole is greater than the sum of the parts. The chapters in this volume seek to address this challenge. This book was originally published as a special issue of the Journal of Marketing Management.

Developmental biology is seemingly well understood, with development widely accepted as being a series of programmed changes through which an egg turns into an adult organism, or a seed matures into a plant. However, the picture is much more complex than that: is it all genetically controlled or does environment have an influence? Is the final adult stage the target of development and everything else just a build-up to that point? Are developmental strategies the same in plants as in animals? How do we consider development in single-celled organisms? In this concise, engaging volume, Alessandro Minelli, a leading developmental biologist, addresses these key questions. Using familiar examples and easy-to-follow arguments, he offers fresh alternatives to a number of preconceptions and stereotypes, awakening the reader to the disparity of developmental phenomena across all main branches of the tree of life.

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways.

Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection. Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluation Evaluates various candidate rotavirus and norovirus vaccines Discusses human gut microbiota transplanted Gn pig models Documents the role of probiotics and rice bran as prophylactics and vaccine adjuvants

Named #1 of 15 Best New Biotechnology Books to Read in 2021 by BookAuthority. This volume explores and explains the vast uses and benefits of algae as food, feed, and fuel. It covers the most advanced applications of algae in the food and feed industries and for environmental sustainability. With chapters written by experts and which were extensively reviewed by many well-known subject experts and professionals, Phycobiotechnology: Biodiversity and Biotechnology of Algae and Algal Products for Food, Feed, and Fuel provides an abundance of valuable information. Algae are a genetically diverse group of organisms with a wide range of physiological and biochemical characteristics that have unique capabilities in the fields of agriculture, pharmaceuticals, industry, and environment. Algae hold the potential to become the planet's next major source of energy and a vital part of the solution for climate change and dependence on fossil fuels. Many varieties of algae are also known to be an abundant source of vitamins, minerals, and other nutrients that can boost the human immune system.