This two-volume set highlights the various innovative and emerging techniques and molecular applications that are currently being used in plant abiotic stress physiology. Volume 1: Responses and Adaptations focuses on the responses and adaptations of plants to stress factors at the cellular and molecular levels and offers a variety of advanced management strategies and technologies. Volume 2: Molecular Advancements introduces a range of state-of-the-art molecular advances for the mitigation of abiotic stress in plants. With contributions from specialists in the field, Volume 1 first discusses the physiology and defense mechanisms of plants and the various kinds of stress, such as from challenging environments, climate change, and nutritional deficiencies. It goes on to discuss trailblazing management techniques that include genetics approaches for improving abiotic stress tolerance in crop plants along with CRISPR/CAS-mediated genome editing technologies. Volume 2 discusses how plants have developed diverse physiological and molecular adjustments to safeguard themselves under challenging conditions and how emerging new technologies can utilize these plant adaptations to enhance plant resistance. These include using plant-environment interactions to develop crop species that are resilient to climate change, applying genomics and phenomics approaches from the study of abiotic stress tolerance and more. Agriculture today faces countless challenges to meet the rising need for sustainable food supplies and guarantees of high-quality nourishment for a quickly increasing population. To ensure sufficient food production, it is necessary to address the difficult environmental circumstances that are causing cellular oxidative stress in plants due to abiotic factors, which play a defining role in shaping yield of crop plants. These two volumes help to meet these challenges by providing a rich source of information on plant abiotic stress physiology and effective management techniques.

This two-volume set highlights the various innovative and emerging techniques and molecular applications that are currently being used in plant abiotic stress physiology. Volume 1: Responses and Adaptations focuses on the responses and adaptations of plants to stress factors at the cellular and molecular levels and offers a variety of advanced management strategies and technologies. Volume 2: Molecular Advancements introduces a range of state-of-the-art molecular advances for the mitigation of abiotic stress in plants. With contributions from specialists in the field, Volume 1 first discusses the physiology and defense mechanisms of plants and the various kinds of stress, such as from challenging environments, climate change, and nutritional deficiencies. It goes on to discuss trailblazing management techniques that include genetics approaches for improving abiotic stress tolerance in crop plants along with CRISPR/CAS-mediated genome editing technologies. Volume 2 discusses how plants have developed diverse physiological and molecular adjustments to safeguard themselves under challenging conditions and how emerging new technologies can utilize these plant adaptations to enhance plant resistance. These include using plant-environment interactions to develop crop species that are resilient to climate change, applying genomics and phenomics approaches from the study of abiotic stress tolerance and more. Agriculture today faces countless challenges to meet the rising need for sustainable food supplies and guarantees of high-quality nourishment for a quickly increasing population. To ensure sufficient food production, it is necessary to address the difficult environmental circumstances that are causing cellular oxidative stress in plants due to abiotic factors, which play a defining role in shaping yield of crop plants. These two volumes help to meet these challenges by providing a rich source of information on plant abiotic stress physiology and effective management techniques.

Nanomedicine, a scientific branch of nanotechnology that operates on the same scale as biology, offers the possibility of influencing the healing process from inside of the body by manipulating the matter at cellular or molecular levels. Throughout this book, current healing approaches based on this revolutionary new technology are summarized from a scientific assessment. The aim of the authors is to give, through select examples, a deep insight to nanotechnology status and the great progress that its rigorous application will bring to human health. The authors' commitment is to broaden the vision of health professionals who will eventually be the future users of this knowledge.

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

- It provides a rigorous mathematical and physical basis to techniques that are often introduced on empirical basis - While the book covers a broad range of techniques, it starts at a basic theoretical level. This gives the book a strong foundation and makes it accessible to students from various backgrounds. - Has a computational focus unlike many competing titles

1. Present more scientific insights that will be helpful for both scientists and healthcare professionals to control, diagnose, and treat COVID-19 2. Useful Scientist, academicians, physicians, aroma therapists, medical practitioners, researchers those are working in development of therapeutics for COVID-19 and other infectious diseases (especially virologists, pathologist, pharmacologist, pulmonologists, ayurvedic practitioners, molecular biologists, essential oil practitioners are consultant/educators), pharmacognosist 3. Demonstrates the role of essential oils and their chemical components in the management of COVID-19

Covers comprehensive overview of the neurological diseases associated with neurochemical imbalances. Provides a brief account of neurotransmission, as either a study or high-yield revision aid

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

This book comprehensively explores the early evolution of life and the Archean environment. Topics include the differences between prokaryotes and eukaryotes, variations in metabolisms, concepts of ecosystems and biogeochemical cycles (nitrogen, sulfur, phosphorous), Archean geology and environments, and the widely accepted early evolutionary history of life. The text addresses controversies regarding early life and its environment, particularly the unusual microfossil assemblages from the 3.4 Ga Strelley Pool Formation and the 3.0 Ga Farrel Quartzite of Western Australia. Readers will get a fuller picture of the Archean world, and an appreciation of many still unresolved questions. Key Features Illustrated with figures visualizing ecosystems, biogeochemical cycles etc which are indispensable for understanding the Archean Earth. Includes tables arranging key words, definitions, and interpretations. Documents the Archean environment with photographic evidence and detailed descriptions the rocks, minerals and microfossils. Summarizes the latest field research. Details exciting unresolved questions for future study.

Chromatin immunoprecipitation sequencing (ChIP-seq), which maps the genome-wide localization patterns of transcription factors and epigenetic marks, is among the most widely used methods in molecular biology. Practical Guide to ChIP-seq Data Analysis will guide readers through the steps of ChIP-seq analysis: from quality control, through peak calling, to downstream analyses. It will help experimental biologists to design their ChIP-seq experiments with the analysis in mind, and to perform the basic analysis steps themselves. It also aims to support bioinformaticians to understand how the data is generated, what the sources of biases are, and which methods are appropriate for different analyses.

Nanomaterials in the Battle Against Pathogens and Disease Vectors presents an overview of the use of nanotechnology to mitigate pathogens of concern, and is the first book to discuss applications of nanotechnology in the fight against all three major domains of disease-causing pathogens. Bacteria, viruses, and parasites constitute the list of emerging and re-emerging pathogens of high priority. Nanotechnology has proven to be a groundbreaking success in the elimination, targeted toxicity, precise immunogenicity, diagnosis, and imaging of these major pathogens and disease vectors. This text discusses basic concepts and advanced applications for bacteria, viruses, and parasites. It describes the use of metallic and non-metallic nanoparticles and nanotoxicity, as well as presents future applications of nanotechnology in biological applications. This work is ideal for engineers and scientists across the interdisciplinary fields of materials science, biomedical engineering, biotechnology, and others concerned with mitigating the risk and effect of pathogens.

Phytochemicals from Medicinal Plants: Scope, Applications and Potential Health Claims explores the importance of medicinal plants and their potential benefits for human health. This book looks at bioactive compounds from medicinal plants, the health benefits of bioactive compounds, the applications of plant-based products in the food and pharmaceutical industries. The first section discusses available sources of bioactive compounds from medicinal plants, biochemistry, structural composition, potential biological activities, and how bioactive molecules are isolated from medicinal plants. The authors examine the applications of bioactive molecules from a health perspective, looking at the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany/and medicinal properties, and also present a novel dietary approach for disease management. The book goes on to examine the plant-based products are used and can be used in various sectors of the food and pharmaceutical industries.

Microbes are the most abundant organisms in the biosphere and regulate many critical elemental and biogeochemical phenomena. Because microbes are the key players in the carbon cycle and in related biological reactions, microbial ecology is a vital research area for understanding the contribution of the biosphere in global warming and the response of the natural environment to climate variations. The beneficial uses of microbes have enabled constructive and cost-effective responses that have not been possible through physical or chemical methods. This new volume reviews the multifaceted interactions among microbes, ecosystems, and their pivotal role in maintaining a more balanced environment, in order to help facilitate living organisms coexisting with the natural environment. With extensive references, tables, and illustrations, this book provides valuable information on microbial utilization for environmental sustainability and provides fascinating insights into microbial diversity. Key features include: Looks at enhancing plant production through growth-promoting arbuscular mycorrhizae, endophytic bacteria, and microbiome networks Considers microbial degradation and environmental management of e-wastes and azo dyes Explores soil-plant microbe interactions in metal-contaminated soils Examines radiation-resistant thermophiles for engineered bioremediation Describes potential indigenous/effective microbes for wastewater treatment processes Presents research on earthworms and microbes for organic farming

This informative volume provides new insights with scientific evidence on the uses of medicinal plants in the treatment of certain diseases. It reviews various therapies with herbal phytoconstituents for certain types of disorders, modes of action, and pharmacological screening. It focuses on potential benefits of herbal extracts and bioactive compounds for human health care, provides a comparative phytoconstituent analysis of selected medicinal plants using GCMS/FTIR techniques, and discusses the role of herbal medicines in female genital infections. It goes on to look at the health-boosting properties of cabbage and the functional properties of milk yam (Ipomoea digitata L.).

Stresses the Potential Applications of Biosurfactants in Various Industries Environmental concerns and a demand for sustainable chemical production have become important issues in recent years. As a result, microbial biosurfactant-producing systems are gaining momentum as potential replacements for chemical surfactants. Biosurfactants: Production and Utilization-Processes, Technologies, and Economics explores the production, utilization, and industrial/economic use of biosurfactants in modern biotechnology. This book represents comprehensive material developed by contemporary experts in the field. Focusing on research and developments within the last 20 years, it highlights relevant changes in the industry. It provides a detailed account of the current applications of biosurfactants, considers the potential for further environmental, biological, and industrial applications, and concentrates on surfactants and organisms with possibilities for future use. Emphasizes Process Scale-Up and Commercialization Factoring in the industrial application of biosurfactant production based on renewable resources, the book determines how biosurfactants can enhance or replace the properties of chemically synthesized surface-active agents. It discusses moving beyond the laboratory scale of research and development and on to the industrial scale of commercial interest. The book consists of 17 chapters and features expert authors discussing topics that include: Understanding the regulatory processes controlling the production of biosurfactants Strategies for feasible commercial biosurfactant production Examples of cost analysis based on published information The viability of industrial applications in food, cosmetics, and pharmaceuticals Patents for future trends Biosurfactants: Production and Utilization-Processes, Technologies, and Economics contains special sections devoted to the overview and evaluation of specific patents relating to biosurfactants, and methods for production of biosurfactants on a laboratory and industrial/commercial scale. It also presents novel and proven applications for biosurfactants from a number of biotechnology laboratories and research facilities around the world. In addition, it introduces the reader to a variety of real-world industry techniques readily applicable for practical use.

Provides information about the different surfactants. Describes constraints in production and novel production strategies. Includes application oriented aspects of biosurfactants in various fields such as agriculture, Environmental, Pharmaceutical, and Food industry. Authored by experts in the field of biosurfactants.

Basic curiosity-driven biomedical science has delivered many of today's most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read, which will delight undergraduate and graduate students, as well as scientific researchers, it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin, and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science, and a fascinating look through the history of modern biomedical research, this book highlights with stirring examples why basic biomedical research is so important, and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today's classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers, including researchers as well as those with advanced degrees. Related Titles Staddon, J. Scientific Method: How Science Works, Fails to Work, and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell, J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie, F. Scientific Research as a Career (ISBN 978-1-4398-6965-9)

Provides the current state of the art of genome editing technologies used in basic and applied research. Bring the latest advances in CRISPR/Cas9 technologies for treating genetic diseases. Provides future prospects and directions for clinical research.

Basic curiosity-driven biomedical science has delivered many of today's most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read, which will delight undergraduate and graduate students, as well as scientific researchers, it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin, and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science, and a fascinating look through the history of modern biomedical research, this book highlights with stirring examples why basic biomedical research is so important, and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today's classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers, including researchers as well as those with advanced degrees. Related Titles Staddon, J. Scientific Method: How Science Works, Fails to Work, and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell, J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie, F. Scientific Research as a Career (ISBN 978-1-4398-6965-9)

Explores how antiviral nanomaterials can be used in developing targeted drug delivery practices and enable pharmaceutical industries to reformulate available drugs on market Covers immunization, imaging, and drug delivery and features various case studies on managing viral diseases Addresses synthesis protocols and recent developments by performing physicochemistry on virion substrate, hybrid viral networks, and multilayered arrays thus enabling R&D experts to study and successfully instigate cutting-edge technologies unique to viruses Discusses current and near future applications of antiviral nanomaterials and their activity in drug delivery systems Describes the role of nanotechnology in prevention, detection, and treatment of COVID-19 Investigates the role of antiviral nanodrugs play in human and animal body systems and in major viral disease types.

Molecular Detection of Animal Viral Pathogens presents expert summaries on state-of-the-art diagnostic approaches for major animal viral pathogens, with a particular emphasis on identification and differentiation at the molecular level. Written by specialists in related research areas, each chapter provides a concise overview of an individual virus or group concerning its Classification Morphology Genome organization Epidemiology Clinical features Diagnosis Sample collection and preparation procedures Molecular detection protocols Each chapter also discusses future prospects or further research requirements for streamlining the identification and epidemiological tracking of the virus concerned. With broad coverage presented in a concise format, Molecular Detection of Animal Viral Pathogens is an essential reference for both beginning and experienced laboratory scientists as well as students of virology. It also offers an indispensable guide applicable to medical, veterinary, and industrial settings that are dependent on speedy turnarounds, extreme sensitivity, and exquisite specificity of virological testing for decision making and disease prevention.

This book 'Extremophiles: Wastewater and Algal Biorefinery' explores the potential of extremophiles/extremotolerant organisms in wastewater treatment, biorefining of algal biomass and in the treatment of industrial waste effluent. The book provides a holistic overview about the current status of extremophiles in waste water treatment and various industrial processes. The chapters comprehensively cover the scientific and research findings on various industrial applications of extremophiles such as biofuels, extremozymes, electricity generation, biofilms, microbial corrosion and waste water treatment etc. This book is an integrated source of literature for the scientists, engineers, academicians, and students working in the area of extremophiles, microbial technology and biorefinery.

Systems-Level Modelling of Microbial Communities: Theory and Practice introduces various aspects of modelling microbial communities and presents a detailed overview of the computational methods which have been developed in this area. This book is aimed at researchers in the field of computational/systems biology as well as biologists/experimentalists studying microbial communities, who are keen on embracing the concepts of computational modelling. The primary focus of this book is on methods for modelling interactions between micro-organisms in a community, with special emphasis on constraint-based and network-based modelling techniques. A brief overview of population- and agent-based modelling is also presented. Lastly, it covers the experimental methods to understand microbial communities, and provides an outlook on how the field may evolve in the coming years.

Evolution is the single unifying principle of biology and core to everything in the life sciences. More than a century of work by scientists from across the biological spectrum has produced a detailed history of life across the phyla and explained the mechanisms by which new species form. This textbook covers both this history and the mechanisms of speciation; it also aims to provide students with the background needed to read the research literature on evolution. Students will therefore learn about cladistics, molecular phylogenies, the molecular-genetical basis of evolutionary change including the important role of protein networks, symbionts and holobionts, together with the core principles of developmental biology. The book also includes introductory appendices that provide background knowledge on, for example, the diversity of life today, fossils, the geology of Earth and the history of evolutionary thought. Key Features Summarizes the origins of life and the evolution of the eukaryotic cell and of Urbilateria, the last common ancestor of invertebrates and vertebrates. Reviews the history of life across the phyla based on the fossil record and computational phylogenetics. Explains evo-devo and the generation of anatomical novelties. Illustrates the roles of small populations, genetic drift, mutation and selection in speciation. Documents human evolution using the fossil record and evidence of dispersal across the world leading to the emergence of modern humans.

Considering the ever-increasing global population and finite arable land, technology and sustainable agricultural practices are required to improve crop yield. This book examines the interaction between plants and microbes and considers the use of advanced techniques such as genetic engineering, revolutionary gene editing technologies, and their applications to understand how plants and microbes help or harm each other at the molecular level. Understanding plant-microbe interactions and related gene editing technologies will provide new possibilities for sustainable agriculture. The book will be extremely useful for researchers working in the fields of plant science, molecular plant biology, plant-microbe interactions, plant engineering technology, agricultural microbiology, and related fields. It will be useful for upper-level students and instructors specifically in the field of biotechnology, microbiology, biochemistry, and agricultural science. Features: Examines the most advanced approaches for genetic engineering of agriculture (CRISPR, TALAN, ZFN, etc.). Discusses the microbiological control of various plant diseases. Explores future perspectives for research in microbiological plant science. Plant-Microbial Interactions and Smart Agricultural Biotechnology will serve as a useful source of cutting-edge information for researchers and innovative professionals, as well as upper-level undergraduate and graduate students taking related agriculture and environmental science courses.