Evolutionary biology has increasingly relied upon tools developed in molecular biology that allow for the structure and function of macromolecules to be used as data for exploring the patterns and processes of evolutionary change. Integrated Molecular Evolution, Second Edition is a textbook intended to expansively and comprehensive review evolutionary studies now routinely using molecular data. This new edition has been thoroughly updated and expanded, and provides a basic summary of evolutionary biology as well as a review of current phylogenetics and phylogenomics. Reflecting a burgeoning pedagogical landscape, this new edition includes nearly double the number of chapters, including a new section on molecular and bioinformatic methods. Dedicated chapters were added on: Evolution of the genetic code Mendelian genetics and population genetics Natural selection Horizontal gene transfers Animal development and plant development Cancer Extraction of biological molecules Analytical methods Sequencing methods and sequencing analyses Omics Phylogenetics and phylogenetic networks Protein trafficking Human genomics More than 400 illustrations appear in this edition, doubling the number included in the first edition, and over 100 of these diagrams are now in color. The second edition combines and integrates extensive summaries of genetics and evolutionary biology in a manner that is accessible for students at either the graduate or undergraduate level. It also provides both the basic foundations of molecular evolution, such as the structure and function of DNA, RNA and proteins, as well as more advanced chapters reviewing analytical techniques for obtaining sequences, and interpreting and archiving molecular and genomic data.

The objective of this book is to present a critical review and evaluation of the so-called conventional methods currently being used for bacterial identification, as well as to discuss the new approaches for the detection and identification of bacteria. Morphological, biochemical, and serological methods of detection and identification of bacteria in clinical specimens are emphasised, and current methods of characterization and enumeration of bacteria in air, water, milk, and other food materials are also described.

This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers

This special volume titled The Cardiovascular Glycocalyx in Health and Disease has the goal of giving an updated perspective of the glycocalyx function through the cardiovascular system and its integration in whole system physiology. This volume will address roles of the glycocalyx at the membrane and cellular level and its implications to overall cardiovascular function and disease progression. Further, pharmacological targeting of the glycocalyx will be addressed as an important mechanism for diagnosis and therapeutic interventions.

First Published in 1985, this book offers a full insight into the differences and similarities between varying diseases. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of medicine and other practitioners in their respective fields.

Dramatic progress in molecular biology and genetic engineering has recently produced an unparalleled wealth of information on the mechanisms of plant and pathogen interactions at the cellular and molecular levels. Completely revised and expanded, Fungal Pathogenesis in Plants and Crops: Molecular Biology and Host Defense Mechanisms, Second Edition offers fresh insight into the interplay of signaling systems in plant and pathogen interactions. The book delineates the battle between plant and fungal pathogen and the complex signaling systems involved. See what's new in the Second Edition: -Chapter on the role of disease resistance genes in signal perception and emission -Chapter on cell death signaling in disease susceptibility and resistance -Revised material on phytoalexins, toxins, and signal perception and transduction in fungal pathogenesis -17 additional families of pathogenesis-related proteins and antifungal proteins The book describes the weapons used by fungal pathogens to evade or suppress the host defense mechanisms. It covers each fungal infection process from initial contact and penetration to the subsequent invasion and symptom development. The author explains complex signaling systems in the plant-pathogen interface with flow charts and provides drawings elucidating the biosynthetic pathway of secondary metabolites. He includes figures that highlight cutting-edge breakthroughs in molecular science and tables documenting important findings in the field of molecular plant pathology. These features and more make this book not only the most up to date resource in the field, but also the most important.

Rice is probably the most important food crop in the world, feeding half its population. Rice Improvement in the Genomics Era examines the findings in the current studies of rice improvement, using the modern genomic tools available in today's agriculture to better enable food security and human welfare. This comprehensive text describes in detail the latest tools of genomics and the application of biotechnology to improve this crucial food crop that is the most important staple of developing countries. Top respected experts in rice science and genomics offer the latest in cutting-edge science and research based on genome sequencing, gene technology, and molecular biology. Rice Improvement in the Genomics Era provides a wide range of information essential to any professional concerned with food safety, security, and sustainability. This valuable source comprehensively and accurately describes rice science from the basics of modern genomics on up to the application of biotechnology. This text is extensively referenced, and includes photographs, tables, graphs, and figures to clearly present information. Topics discussed include: * rice genome sequencing project and its impact * gene expression using microarray system * haploid breeding * hybrid rice technology * Bt and disease resistance * abiotic stress tolerance * ensuring rice quality * genetically improved nutrition in rice * human milk proteins in rice grains * food safety of transgenic crops * and much more! Rice Improvement in the Genomics Era is an informative resource for educators, students, rice scientists, rice breeders, plant biotechnologists, researchers, and policymakers in agricultural sciences, rice improvement, and biotechnology. This source is a crucial addition to agricultural institutions, libraries, and teaching organizations.

Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including: Human T-cell leukemia virus type 1 (HTLV-1) Hepatitis C virus (HCV) Epstein-Barr virus (EBV) Human papilloma virus (HPV) Human herpes virus 8 (HHV-8)/Kaposi's sarcoma-associated herpes virus (KSHV) Human immunodeficiency virus (HIV/AIDS) Oncolytic viruses This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies.

Control of Cell Cycle & Cell Proliferation, Volume 135 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances, with this new volume presenting chapters on a variety of timely topics, including Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest, Viral infection on through Cell Cycle Regulation, Analyzing drug resistant mutation in CDK4 gene and identification of potential inhibitors through structure based virtual screening approach, Controlling cell proliferation by targeting CDK6 using drug repurposing approach, Cdk Regulators: Growth Arrest or Apoptosis? Scenarios in normal and cancerous cells, Targeting cell cycle signaling pathways for cancer therapy, and much more. Other sections focus on The role of the nucleolus in regulating cell cycle, Chromatin regulators in DNA replication and genome stability maintenance during S-phase, Role of macrophage in cancer cell progression and targeted immunotherapies, Anti-cancer drug molecules targeting cancer cell cycle and proliferation, Cellular signals integrate cell cycle and metabolic control in cancer, Therapeutic targeting and proliferation of HSCs by small molecules and biologicals, Mechanism of cell cycle regulation and cell proliferation during human viral infection, and Cyclin-dependent kinases: Role, regulation, and therapeutic targets in cancer.

John Betteridge, Professor of Medicine at the Middlesex Hospital in London is one of the world's leading lipidologists and diabetologists.

Professor Betteridge has bought together a definitive collection of 35 study cases written by opinion leaders in the field of lipid management. Each case is a highly informative study based on each contributor's own personal experiences within the discipline of l ipids. 'Case Studies in Lipid Management' presents topics of current interest ranging from diet to the latest pharmaceutical therapies.

It will provide a practically and useful resource for common clinical situations and is an essential text for practitioners in the field and those in related professions.

In the English edition of his landmark book Endosymbiosis of Animals with Plant Microorganisms (1965), Professor Paul Buchner, probably the most prominent founder of systematic symbiosis research, wrote: "I too soon fell victim to the spell of this subject, and from 1911 on devoted myself to it." Almost half a century later, a growing number of entomologists are recognizing the impact that arthropod-bacteria symbiosis has on virtually all aspects of the biology of both host and symbiont. The discussion of this subject tends to be system based, with primary emphasis on the insect host. However, recent screening studies have revealed that the diversity of bacteria associated with arthropods may not be as wide as initially expected, and some genera are constantly being found in hosts that belong to distantly related taxa. Manipulative Tenants: Bacteria Associated with Arthropods introduces the fascinating world of bacteria-arthropod associations with an emphasis on the bacterial partner. Written by an interdisciplinary team of international contributors, this book provides an overview of the diversity of bacterial symbionts identified to date as frequent partners of terrestrial arthropods. It discusses primary (obligatory) symbionts as well as the most abundant secondary (facultative) symbionts currently known. Summarizing the most up-to-date information available on each symbiont, the book presents a synopsis of the field from the bacterial angle. Chapters examine Proteobacteria, including Sodalis and Wigglesworthia in tsetse flies and Stammerula and other symbiotic bacteria in fruit flies, as well as Bacteroidetes such as Blattabacterium and Cardinium. The book also identifies questions that emerge from the study of these systems. This comprehensive reference introduces the topic of bacteria-arthropod associations to researchers who are not familiar with it, enlarges the scope of knowledge of those who are, and provides a textbook for students in microbiology and other branches of biology. Key selling features: Combines entomologists' and microbiologists' perspectives to create a full picture of complex systems Discusses dramatic differences in structure and behavior between some symbiotic bacteria and autonomous bacteria Examines the influence of symbiotic bacteria on the evolution of their hosts Includes diagrams, tables, graphs, pictures, and extensive references Emphasizes potential applications of symbiotic bacteria for solving agricultural and medical problems

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.

This reference supplies a comprehensive and current overview of every aspect of gastrointestinal microbiota. Expertly written chapters cover conventional and molecular techniques for the study of differing microbial populations, as well as the analysis of microbial activity and interaction with host bodies. Illustrative and up-to-date, this source showcases how fluctuations in our diet, environment, and pharmaceutical intake affect microbial composition and behavior.

The Guide to AIDS is succinct review of HIV/AIDS from a human-interest perspective. Chapters focus on some of the common patterns and prevention of HIV transmission and debunks misconceptions about HIV and AIDS. Brief descriptions the human immune system and epidemiology of HIV are included. The cultural component of disease, treatment and living with AIDS is central to much of this guide intended to synthesize, explain and de-mystify HIV and AIDS. key selling featurws: Provides a simplified brief review of HIV and the disease it causes - AIDS Debunks myths associated with HIV transmision such as through mosquito bites Identifies simple and low cost ways to prevent the transmission and spread of HIV Illustrates the crucial role that culture plays in the prevention of HIV spread and AIDS treatment Puts a human face on the problem of diagnosing and living with AIDS

With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses a few environmentally pertinent, toxic divalent cations, including mercury, cadmium, and arsenic. This authoritative resource reviews the physiological mechanisms underlying the handling of essential and toxic metal ions, including metal ion homeostasis, metals and enzyme activity, metals and transcriptional regulation, and metal ion transport. It also analyzes other functions designed to avoid metal-induced toxicity and mediate the metal enhancement of cellular function. The role of metal ions and their effect on mammalian cells and organs are only beginning to be truly defined. Cellular and Molecular Biology of Metals arms metals toxicologists and cellular and molecular biologists with the necessary knowledge they need to take the research effort to the next level. Key selling features: Presents the most recent advances in the cell and molecular biology of metal ions Provides a complete exploration of transport mechanisms Addresses homeostatic metals as well as several environmentally relevant toxic divalent cations Features contributions from experts in their respective fields

Sharply focused, up-to-date information on microbial biofertilizers--including emerging options such as "Piriformospora indica" and "Matsutake" The Handbook of Microbial Biofertilizers provides in-depth coverage of all major microbial biofertilizers (rhizobia, arbuscular mycorrhizal fungi, and cyanobacteriaas well as new and emerging growth promoters (endophytes). It examines the role of microbes in growth promotion, bioprotectors, and bioremidiators, and presents protocols and practical strategies for using microbes in sustainable agriculture. An abundance of helpful charts, tables, and figures make complex information easy to access and understand.In this first-of-its-kind volume, contributors from 11 countries and several continents address important issues surrounding microbial biofertilizers, including: the rhizobium-host-arbuscular mycorrhizal" tripartite relationship mycorrhiza as a disease suppresser and stress reducer mycorrhiza helping bacteria the impact of functional groups of soil microorganisms on nutrient turnover PBPRs as biofertilizers and biopesticides the potential of wild-legume rhizobia for use as a biofertilizers the expanding role of blue-green algae in sustainable agriculture the role of microbial fertilizers in sustainable plant production new and emerging endophytes the commercial potential of biofertilizersIn this young century, the use of biofertilizers is already growing rapidly. It has been recognized that these environment-friendly bioprotectors, growth boosters, and remediators are essential for soil/plant health. The Handbook of Microbial Biofertilizers is designed to fit the expanding information needs of current and future biotechnologists, microbiologists, botanists, agronomists, environmentalists, and others whose work involves sustained agriculture.

Unique in its focus on this particular field of cardiovascular science, Molecular Mechanisms of Cardiac Hypertrophy and Failure reviews current knowledge of the mechanisms contributing to heart failure.Bringing together an internationally renowned team of contributors, the text provides expert reviews on the latest advances in molecular and cell biology, biochemistry and pharmacology. scientists in academia and industry, the book has particular emphasis on the following key areas: - cardiac hypertrophy - contractile depression - arrhythmogenesis - genetics - the clinical implications of the research in these areas. interest to clinical cardiologists, vascular medicine specialists, hematologists, and internists, as well as members of the cardiovascular research community and pharmaceutical and biotechnology industries.

Chromatin immunoprecipitation sequencing (ChIP-seq), which maps the genome-wide localization patterns of transcription factors and epigenetic marks, is among the most widely used methods in molecular biology. Practical Guide to ChIP-seq Data Analysis will guide readers through the steps of ChIP-seq analysis: from quality control, through peak calling, to downstream analyses. It will help experimental biologists to design their ChIP-seq experiments with the analysis in mind, and to perform the basic analysis steps themselves. It also aims to support bioinformaticians to understand how the data is generated, what the sources of biases are, and which methods are appropriate for different analyses.

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Microbiology for Minerals, Metals, Materials and the Environment links chemical, metallurgical, and other metal inherent systems with microbes, and analyzes the interdependence between them. Specifically intended to underscore the importance of microbes in environmental remediation in the mining industries, this text offers a basic and conceptual understanding of the role of microbes, and provides an extensive exploration of microbiology and metals. Each chapter is written by experts from research, industry and academia. The authors expand on the whole scale of microbiology applications relevant to minerals, metal, material, and environment. They elicit the applications of microbes for metal extraction (including mechanisms and methods) from primary ores/minerals and mining wastes, biomining and related concepts of microbial diversity and various operations, and molecular biology of microbes involved in such systems (extremophiles). They also address in detail biohydrometallurgy, biomineralisation, bioleaching, biobeneficiation, biosynthesis, and bioremediation and other related areas. This book: Includes bacterial leaching, hybrid leaching, and biosynthesis related to different metals Covers recent developments in alternative procedures with the use of extremophiles and leaching bacteria Explains the imperative importance of bacteria in minerals and metals sector Addresses microbial interventions for waste cleanup and upgradation of minerals Compares existing processes with the new ones to elicit their importance Provides case studies on all respective topics by eminent researchers A resource for researchers, graduate students, and industry professionals involved in chemical/mining/metallurgical engineering/environmental science/microbiology, Microbiology for Minerals, Metals, Materials and the Environment skillfully explains the symbiotic relationship between microbiology and minerals-metals-materials, and utilizes experts from across the globe.

Systems-Level Modelling of Microbial Communities: Theory and Practice introduces various aspects of modelling microbial communities and presents a detailed overview of the computational methods which have been developed in this area. This book is aimed at researchers in the field of computational/systems biology as well as biologists/experimentalists studying microbial communities, who are keen on embracing the concepts of computational modelling. The primary focus of this book is on methods for modelling interactions between micro-organisms in a community, with special emphasis on constraint-based and network-based modelling techniques. A brief overview of population- and agent-based modelling is also presented. Lastly, it covers the experimental methods to understand microbial communities, and provides an outlook on how the field may evolve in the coming years.

Easily Get Started with Biological Experiments Introduction to Experimental Biophysics - A Laboratory Guide presents wet lab methods for courses in biophysics or molecular biology. A companion to the author's highly praised An Introduction to Experimental Biophysics: Biological Methods for Physical Scientists, this manual offers a flexible course plan that permits completion of the labs in either a full term or intensive summer course. Tested in a pedagogical setting, the experiments follow a logical progression beginning with a DNA construct. The book starts with the basics of molecular cloning: amplifying and purifying plasmid, plasmid mapping, and using restriction enzymes. Later experiments deal with more advanced, emerging techniques, such as the synthesis and characterization of quantum dots and gold nanoparticles, protein crystallization, and spectroscopic techniques. This accessible guide will help both students and instructors in molecular biology, biophysics, and biomedical engineering. Students will understand how to use a variety of techniques in biological experiments while instructors will get practical guidance on preparing the experiments.

Micro-organisms play a major role in the geochemistry of the planet, forming the basic stage in the food chain, and thus sustaining the existence of higher evolutionary life. The continuing interaction between these living organisms and the environment, combined with their exploitation by man are shaping the material world today.Over the last few years our understanding has increased considerably due to the development of new technology and the emergence of new paradigms which have enabled the microbiologist to view the microbial world, and its significance to life, with new eyes. Combining the basics of science with the most up-to-date new material, and incorporating high quality photographs and graphics, this book is valuable as both a textbook and reference guide for students and professionals.

Molecular Embryology explains in simple terms the molecular interactions that transform an egg to a complex embryo that in the end gives rise to a fully-formed animal. In doing so, the book covers one hundred and fifty years of experiments that have led to our present understanding of these molecular interactions. As the text progresses, the reader will gain a sense of the developmental similarities and differences between organisms. Students studying developmental biology and embryology will find this book an extremely useful introduction to the subject and will also appeal to anyone with an interest in the most recent advances in this largely undiscovered territory.

Key features: High quality full color photographs and descriptive texts on the location and removal of the organs from the mouse Instructive methods and clear visuals for trimming and orienting the organs for paraffin histology to obtain the best possible sections for analysis Full color photomicrographs of the resulting section for each organ stained with hematoxylin and eosin demonstrating important features and landmarks for the histologist to ensure the optimal area for analysis is achieved All in one, easy to use guide organized by individual organs of the laboratory mouse Spiralbound for easy reference in the lab This "one-stop" guide offers an essential resource for any academic, research or development operation where mouse necropsy and/or histology are performed. Connecting the reader 'from the mouse to the microscope', it provides a detailed guide for locating, trimming, orientating and embedding of the most frequently investigated tissues collected in the laboratory mouse. It shows where the organs reside in the mouse, how to trim and embed them as well as the resulting optimal sections. This guide brings together the wealth of scattered information into one high-quality text, the emphasis is on providing knowledge that will help histologists and scientists get better results in any downstream assays where ideal sections are needed.