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A New York Times bestseller.
Winner of the Financial Times/McKinsey Business Book of the Year Award.
'Chilling . . . Reads like a West Coast version of All the President’s Men.' New York Times Book Review
The full inside story of the breathtaking rise and shocking collapse of Theranos, the multibillion-dollar biotech startup, by the prize-winning journalist who first broke the story and pursued it to the end, despite pressure from its charismatic CEO and threats by her lawyers.
In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup "unicorn" promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.
In Bad Blood, John Carreyrou tells the riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley.
Now to be adapted into a film, with Jennifer Lawrence to star.
Biomimetics is the idea of creating new technologies abstracted from what we find in biology. Ocean Innovation: Biomimetics Beneath the Waves seeks that technological inspiration from the rich biodiversity of marine organisms. Bringing both a biological and engineering perspective to the biomimetic potential of oceanic organisms, this richly illustrated book investigates questions such as: How can we mimic the sensory systems of sea creatures like sharks, sea turtles, and lobsters to improve our ability to navigate underwater? What can we do to afford humans the opportunity to go unnoticed by marine life? How can we diffuse oxygen from water to enable deep diving without the risk of decompression sickness? Each chapter explores an area where we, as divers and technologists, can benefit from understanding how animals survive in the sea, presenting case studies that demonstrate how natural solutions can be applied to mankind's engineering challenges.
Recent innovations in agriculture and food technologies have brought benefits to many countries, particularly in developing regions, but information about the extent of these has often been sparse. This collection assembles the best papers on the subject to form a comprehensive, global perspective on the impacts of agricultural biotechnology around the world. With an original introduction by the editors and emphasis on the economic, environmental, health and food security aspects of agricultural biotechnology, this book is an invaluable resource for academics, students and researchers alike.
From a journalist and former lab researcher, a penetrating investigation of the explosion in cases of scientific fraud and the factors behind it. In the 1970s, a scientific scandal about painted mice hit the headlines. A cancer researcher was found to have deliberately falsified his experiments by coloring transplanted mouse skin with ink. This widely publicized case of scientific misconduct marked the beginning of an epidemic of fraud that plagues the scientific community today. From manipulated results and made-up data to retouched illustrations and plagiarism, cases of scientific fraud have skyrocketed in the past two decades, especially in the biomedical sciences. Fraud in the Lab examines cases of scientific misconduct around the world and asks why this behavior is so pervasive. Nicolas Chevassus-au-Louis points to large-scale trends that have led to an environment of heightened competition, extreme self-interest, and emphasis on short-term payoffs. Because of the move toward highly specialized research, fewer experts are qualified to verify experimental findings. And the pace of journal publishing has exacerbated the scientific rewards system-publish or perish holds sway more than ever. Even when instances of misconduct are discovered, researchers often face few consequences, and falsified data may continue to circulate after an article has been retracted. Sharp and damning, this expose details the circumstances that have allowed scientific standards to decline. Fraud in the Lab reveals the intense social pressures that lead to fraud, documents the lasting impact it has had on the scientific community, and highlights recent initiatives and proposals to reduce the extent of misconduct in the future.
This title brings together some of the greatest minds deliberating on the workings of the full biotechnology value chain - from the point of basic and applied research right through to the point of commercial production. Central to these deliberations is the search for a comprehensive set of solutions that is aimed at mobilising South Africa's biotechnology resources effectively for social and economic growth.
If you are a biologist and want to get the best out of the powerful methods of modern computational statistics, this is your book. You can visualize and analyze your own data, apply unsupervised and supervised learning, integrate datasets, apply hypothesis testing, and make publication-quality figures using the power of R/Bioconductor and ggplot2. This book will teach you 'cooking from scratch', from raw data to beautiful illuminating output, as you learn to write your own scripts in the R language and to use advanced statistics packages from CRAN and Bioconductor. It covers a broad range of basic and advanced topics important in the analysis of high-throughput biological data, including principal component analysis and multidimensional scaling, clustering, multiple testing, unsupervised and supervised learning, resampling, the pitfalls of experimental design, and power simulations using Monte Carlo, and it even reaches networks, trees, spatial statistics, image data, and microbial ecology. Using a minimum of mathematical notation, it builds understanding from well-chosen examples, simulation, visualization, and above all hands-on interaction with data and code.
A leading bioethicist offers critical insights into the scientific, ethical, and political implications of human genome editing. Designer babies, once found only in science fiction, have become a reality. We are entering a new era of human evolution with the advent of a technology called CRISPR, which allows scientists to modify our genes. Although CRISPR shows great promise for therapeutic use, it raises thorny ethical, legal, political, and societal concerns because it can be used to make permanent changes to future generations. What if changes intended for the good turn out to have unforeseen negative effects? What if the divide between the haves and have-nots widens as a result? Who decides whether we genetically modify human beings and, if so, how? Francoise Baylis insists that we must all have a role in determining our future as a species. The scientists who develop and use genome-editing tools should not be the only ones making decisions about future uses of the technology. Such decisions must be the fruit of a broad societal consensus. Baylis argues that it is in our collective interest to assess and steer the development and implementation of biomedical technologies. Members of the public with different interests and diverse perspectives must be among the decision makers; only in this way can we ensure that societal concerns are taken into account and that responsible decisions are made. We must be engaged and informed, think critically, and raise our voices as we create our future together. Sharp, rousing, timely, and thought-provoking, Altered Inheritance is essential reading. The future of humanity is in our hands.
The basic concept of this book is to examine the use of innovative methods augmenting traditional plant breeding towards the development of new crop varieties under different environmental conditions to achieve sustainable food production. This book consists of two volumes: Volume 1 subtitled Breeding, Biotechnology and Molecular Tools and Volume 2 subtitled Agronomic, Abiotic and Biotic Stress Traits. This is Volume 1 which consists of 21 chapters covering domestication and germplasm utilization, conventional breeding techniques and the role of biotechnology. In addition to various biotechnological applications in plant breeding, it includes functional genomics, mutations and methods of detection, and molecular markers. In vitro techniques and their applications in plant breeding are discussed with an emphasis on embryo rescue, somatic cell hybridization and somaclonal variation. Other chapters cover haploid breeding, transgenics, cryogenics and bioinformatics.
Keep pace with the rapid developments in bioremediation field investigations
From breakfast toast to evening wine, yeast is the microscopic thing that we cannot live without. We knew what yeast did as an invisible brewer and baker long before we had a clue about the existence of microorganisms. Ten thousand years ago, our ancestors abandoned bush meat and wild fruit in favor of farming animals and cultivating grain. Leaving the forests and grasslands, our desire for beer and wine produced by the fungus was a major stimulus for agricultural settlement. It takes a village to run a brewery or tend a vineyard. We domesticated wild yeast and yeast domesticated us. With the inevitable escape of the fungus from beer vats into bread dough, our marriage with yeast was secured by an appetite for fresh loaves of leavened bread. Over the millennia, we have adapted the technologies of brewing, winemaking, and baking and have come to rely on yeast more and more. Yeast produces corn ethanol and other biofuels and has become the genetically-modified darling of the pharmaceutical business as a source of human insulin and a range of life-saving medicines. These practical uses of yeast have been made possible by advances in our understanding of its biology, and the power of genetic engineering has been used to modify the fungus to do just about anything we wish. We know more about yeast than any other organism built from complex cells like our own. To understand yeast is to understand life. In this book Nicholas P. Money offers a celebration of our favorite microorganism.
A century ago, discoveries in physics came together with engineering to produce an array of astonishing new technologies: radios, telephones, televisions, aircraft, radar, nuclear power, computers, the Internet and a host of still- evolving digital tools. These technologies so radically reshaped our world that we can no longer conceive of life without them. Today we are on the cusp of a new convergence, with discoveries in biology coming together with engineering to produce another array of almost inconceivable technologies. These next-generation products have the potential to be every bit as revolutionary as the twentieth century's digital wonders: Virusbuilt batteries. Protein-based water filters. Cancer- detecting nanoparticles. Mind- reading bionic limbs. Computer-engineered crops. These few examples illustrate the promise of the technology story of the twenty-first century to overcome some of the greatest humanitarian, medical and environmental challenges of our time.
This edited volume focuses on the latest and most impactful advancements of multimedia data globally available for environmental and earth biodiversity. The data reflects the status, behavior, change as well as human interests and concerns which are increasingly crucial for understanding environmental issues and phenomena. This volume addresses the need for the development of advanced methods, techniques and tools for collecting, managing, analyzing, understanding and modeling environmental & biodiversity data, including the automated or collaborative species identification, the species distribution modeling and their environment, such as the air quality or the bio-acoustic monitoring. Researchers and practitioners in multimedia and environmental topics will find the chapters essential to their continued studies.
Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer--while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician's performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.
How new biomedical technologies-from prenatal testing to gene-editing techniques-require us to imagine who counts as human and what it means to belong. From next-generation prenatal tests, to virtual children, to the genome-editing tool CRISPR-Cas9, new biotechnologies grant us unprecedented power to predict and shape future people. That power implies a question about belonging: which people, which variations, will we welcome? How will we square new biotech advances with the real but fragile gains for people with disabilities-especially when their voices are all but absent from the conversation? This book explores that conversation, the troubled territory where biotechnology and disability meet. In it, George Estreich-an award-winning poet and memoirist, and the father of a young woman with Down syndrome-delves into popular representations of cutting-edge biotech: websites advertising next-generation prenatal tests, feature articles on "three-parent IVF," a scientist's memoir of constructing a semisynthetic cell, and more. As Estreich shows, each new application of biotechnology is accompanied by a persuasive story, one that minimizes downsides and promises enormous benefits. In this story, people with disabilities are both invisible and essential: a key promise of new technologies is that disability will be repaired or prevented. In chapters that blend personal narrative and scholarship, Estreich restores disability to our narratives of technology. He also considers broader themes: the place of people with disabilities in a world built for the able; the echoes of eugenic history in the genomic present; and the equation of intellect and human value. Examining the stories we tell ourselves, the fables already creating our futures, Estreich argues that, given biotech that can select and shape who we are, we need to imagine, as broadly as possible, what it means to belong.
Biotechnology and genetic engineering are the key technologies of
the 21st century. They allow the findings in cell biology and
genetics, biochemistry and microbiology, biochemical engineering
and bioinformatics to be applied to health care, agriculture, food
production, environmental protection and alternative production
methods for chemicals.
** THE PERFECT STOCKING FILLER FOR YOUR FAVOURITE SCIENCE NERD. ** Part of the ALL-NEW LADYBIRD EXPERT SERIES. ____________ Who discovered genetics? How does gene inheritance work? Is DNA common to all living things? We inherit CODES from our parents. And these codes are written in the molecule DNA. This DNA means that we RESEMBLE each other, namely our families. This raises so many questions such as how does DNA influence evolution? How was it discovered? And what does it mean for the future of the human race? Discover the answers and more inside Adam Rutherford's Ladybird Expert - Genetics, the thrilling and accessible account that explains race and genetics, whether it is our DNA or the environment that influences us most, what are our chances of being related to royalty, genetic engineering and much more . . .
This candid narrative by Nobel laureate, Arthur Kornberg, chronicles the saga of a small biotech start-up, the key players, the painstaking development of the perfect product, and the forces affecting its resulting success or failure. Kornberg's razor-sharp wit and provocative opinions make this book a compelling page turner, whether he is decrying the current fashion in scientific funding or delving into the hotly contested PCR patent trial.
This book was written for graduate and medical students, as well as
clinicians and postdoctoral researchers. It describes the theory of
alternative pre-mRNA splicing in
This complete series of 10 volumes provides an excellent, in-depth overview of all nanoscale technologies and fabrication methods in materials engineering towards the life sciences. Each volume is dedicated to a specific topic that is covered in detail by experts from that particular field, reviewing existing technologies as well as current developments and the directions they are taking. The result is a cross-disciplinary, major reference work, bringing together the pertinent knowledge that was hitherto widely spread among many different sources.
Now presented in large format, the new Schmid is the ideal primer in biotechnology. The two-page layout with one page being a full color figure and the opposite page being explanatory text is the ideal combination between rapid visual-based learning with in depth information.
This volume gives a survey of the state of the art in the traditional fields of industrial mycology as well as of selected novel applications of fungi. The first section deals with the use of fungi in the production and processing of bread, cheese, beer and wine, traditional Asian fermentation products and edible mushrooms. The second section is devoted to the production of fungal metabolites and enzymes representing value-added products. In addition to antibiotics, alkaloids organic acids, vitamins and industrial enzymes, which have successfully been in use for decades, it is also dedicated to fungal metabolites, such as insecticidal and nematicidal compounds, immunosurppressants and flavors with promising biotechnological potential. In the next section, the recent developments in fungal biotransformation of small molecules, the bioconversion of lignocelluloses as well as the use of fungi in metal recovery are presented. The final part introduces some innovative new trends in the field of applied mycology: the preparation of fungal bioherbicides, recent genomic approaches for the identification of biopolymer degrading enzymes, current developments in using oxidative enzymes from fungi as well as new attempts to transfer fungal remediation technologies into practice. Content Level Research
This is the only book to focus on industrial and environmental
applications of synthetic biology, covering 17 of the most
promising uses in the areas of biofuel, bioremediation and
biomaterials. The contributions are written by experts from
academia, non-profit organizations and industry, outlining not only
the scientific basics but also the economic, environmental and
ethical impact of the new technologies.
Due to the rapid advances over the past few years in the field of
rapid prototyping, the crucial information for researchers in the
field is scattered throughout numerous journals and thus not
readily available. This carefully compiled collection of selected
articles from the top Wiley-Blackwell journals on the topic of
rapid prototyping provides the fundamentals necessary to comprehend
current rapid prototyping technologies while also developing new
Filling an obvious gap in the scientific literature, this
practice-oriented reference is the first to tie together the
working knowledge of large
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