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Books > Professional & Technical > Biochemical engineering > Biotechnology > Genetic engineering
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Therapeutic Antibody Engineering - Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry (Hardcover, New)
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Therapeutic Antibody Engineering - Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry (Hardcover, New)
Series: Woodhead Publishing Series in Biomedicine
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The field of antibody engineering has become a vital and integral
part of making new, improved next generation therapeutic monoclonal
antibodies, of which there are currently more than 300 in clinical
trials across several therapeutic areas. Therapeutic antibody
engineering examines all aspects of engineering monoclonal
antibodies and analyses the effect that various genetic engineering
approaches will have on future candidates. Chapters in the first
part of the book provide an introduction to monoclonal antibodies,
their discovery and development and the fundamental technologies
used in their production. Following chapters cover a number of
specific issues relating to different aspects of antibody
engineering, including variable chain engineering, targets and
mechanisms of action, classes of antibody and the use of antibody
fragments, among many other topics. The last part of the book
examines development issues, the interaction of human IgGs with
non-human systems, and cell line development, before a conclusion
looking at future issues affecting the field of therapeutic
antibody engineering.
Goes beyond the standard engineering issues covered by most books
and delves into structure-function relationshipsIntegration of
knowledge across all areas of antibody engineering, development,
and marketingDiscusses how current and future genetic engineering
of cell lines will pave the way for much higher productivity
General
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