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A New York Times bestseller.
Winner of the Financial Times/McKinsey Business Book of the Year Award.
'Chilling . . . Reads like a West Coast version of All the President’s Men.' New York Times Book Review
The full inside story of the breathtaking rise and shocking collapse of Theranos, the multibillion-dollar biotech startup, by the prize-winning journalist who first broke the story and pursued it to the end, despite pressure from its charismatic CEO and threats by her lawyers.
In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup "unicorn" promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.
In Bad Blood, John Carreyrou tells the riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley.
Now to be adapted into a film, with Jennifer Lawrence to star.
A valuable introduction to the appreciation of corrosion and the techniques for control.
If you are a biologist and want to get the best out of the powerful methods of modern computational statistics, this is your book. You can visualize and analyze your own data, apply unsupervised and supervised learning, integrate datasets, apply hypothesis testing, and make publication-quality figures using the power of R/Bioconductor and ggplot2. This book will teach you 'cooking from scratch', from raw data to beautiful illuminating output, as you learn to write your own scripts in the R language and to use advanced statistics packages from CRAN and Bioconductor. It covers a broad range of basic and advanced topics important in the analysis of high-throughput biological data, including principal component analysis and multidimensional scaling, clustering, multiple testing, unsupervised and supervised learning, resampling, the pitfalls of experimental design, and power simulations using Monte Carlo, and it even reaches networks, trees, spatial statistics, image data, and microbial ecology. Using a minimum of mathematical notation, it builds understanding from well-chosen examples, simulation, visualization, and above all hands-on interaction with data and code.
Biomimetics is the idea of creating new technologies abstracted from what we find in biology. Ocean Innovation: Biomimetics Beneath the Waves seeks that technological inspiration from the rich biodiversity of marine organisms. Bringing both a biological and engineering perspective to the biomimetic potential of oceanic organisms, this richly illustrated book investigates questions such as: How can we mimic the sensory systems of sea creatures like sharks, sea turtles, and lobsters to improve our ability to navigate underwater? What can we do to afford humans the opportunity to go unnoticed by marine life? How can we diffuse oxygen from water to enable deep diving without the risk of decompression sickness? Each chapter explores an area where we, as divers and technologists, can benefit from understanding how animals survive in the sea, presenting case studies that demonstrate how natural solutions can be applied to mankind's engineering challenges.
Written by a highly regarded author with industrial and academic experience, this new edition of an established bestselling book provides practical guidance for students, researchers, and those in chemical engineering. The book includes a new section on sustainable energy, with sections on carbon capture and sequestration, as a result of increasing environmental awareness; and a companion website that includes problems, worked solutions, and Excel spreadsheets to enable students to carry out complex calculations.
This title brings together some of the greatest minds deliberating on the workings of the full biotechnology value chain - from the point of basic and applied research right through to the point of commercial production. Central to these deliberations is the search for a comprehensive set of solutions that is aimed at mobilising South Africa's biotechnology resources effectively for social and economic growth.
This volume gives a survey of the state of the art in the traditional fields of industrial mycology as well as of selected novel applications of fungi. The first section deals with the use of fungi in the production and processing of bread, cheese, beer and wine, traditional Asian fermentation products and edible mushrooms. The second section is devoted to the production of fungal metabolites and enzymes representing value-added products. In addition to antibiotics, alkaloids organic acids, vitamins and industrial enzymes, which have successfully been in use for decades, it is also dedicated to fungal metabolites, such as insecticidal and nematicidal compounds, immunosurppressants and flavors with promising biotechnological potential. In the next section, the recent developments in fungal biotransformation of small molecules, the bioconversion of lignocelluloses as well as the use of fungi in metal recovery are presented. The final part introduces some innovative new trends in the field of applied mycology: the preparation of fungal bioherbicides, recent genomic approaches for the identification of biopolymer degrading enzymes, current developments in using oxidative enzymes from fungi as well as new attempts to transfer fungal remediation technologies into practice. Content Level Research
This work describes the essential steps in the development of biocatalytic processes from concept to completion. This integrated text combines the fundamentals of biocatalysis with technological experience and in-depth commercial case studies. The book starts with an introductory look at this history and present scope of biocatalysis, followed by overviews of: applications of specific enzymes; bioprocess case studies; biocatalyst selection and production; enzyme performance - activity and stability; non-conventional media - aqueous/organic biphasic, organic, gaseous media; immobilization; protein engineering and metabolic engineering; process concepts; bioreactor selection and design; patents; and commercial and financial aspects. Written by industrial and academic experts, this world is intended for the bookshelf of anyone teaching biocatalysis or working in the chemical, food, manufacturing of pharmaceutical industries who is seeking to exploit the potential of biocatalysts.
Protein engineering has proved to be one of the more fruitful
technological approaches in biotechnology, being both very powerful
and able to generate valuable intellectual property. This book aims
to present examples in which the application of protein engineering
has successfully solved problems arising in industrial
biotechnology. There is a section on its use to enhance
purification of recombinant proteins. The use of protein
engineering to modify the activity or the stability of industrial
enzymes from lipases to proteases, from carboxypeptidases to
glucanases and glucosidases, and from pectin modifying enzymes to
enzymes able to degrade recalcitrant compounds is extensively
covered. It is shown how areas as diverse as agrofood technology,
fine chemistry, detergents, bioremediation and biosensors receive
significant contributions from protein and solvent engineering.
Bridging the gap between laboratory observations and industrial practices, this work presents detailed information on recombinant micro-organisms and their applications in industry and agriculture. All recombinant microbes, bacteria, yeasts and fungi are covered.
Presents an interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. This title offers a biological perspective of large-scale animal cell culture. It examines diverse processing strategies and process management.
Uniquely focusing on dynamic modeling, this volume incorporates metabolic regulation as a survival mechanism for cells, by driving metabolism through optimal investment of its resources for control of enzyme synthesis and activity. Consequently, the models have a proven record of describing various uptake patterns of mixed carbon substrates that have become significant in modern applications of biomass for the production of bioenergy. The models accurately describe dynamic behavior of microbes in nutrient environments with mixtures of complementary substrates, such as carbon and nitrogen. Modeling of large metabolic networks (including prospects for extension to genome scale) is enabled by lumped hybrid cybernetic models with an unparalleled capacity to predict dynamic behavior of knockout strains. This is an invaluable, must-have reference for bio-researchers and practicing engineers.
The basic concept of this book is to examine the use of innovative methods augmenting traditional plant breeding towards the development of new crop varieties under different environmental conditions to achieve sustainable food production. This book consists of two volumes: Volume 1 subtitled Breeding, Biotechnology and Molecular Tools and Volume 2 subtitled Agronomic, Abiotic and Biotic Stress Traits. This is Volume 1 which consists of 21 chapters covering domestication and germplasm utilization, conventional breeding techniques and the role of biotechnology. In addition to various biotechnological applications in plant breeding, it includes functional genomics, mutations and methods of detection, and molecular markers. In vitro techniques and their applications in plant breeding are discussed with an emphasis on embryo rescue, somatic cell hybridization and somaclonal variation. Other chapters cover haploid breeding, transgenics, cryogenics and bioinformatics.
Now presented in large format, the new Schmid is the ideal primer in biotechnology. The two-page layout with one page being a full color figure and the opposite page being explanatory text is the ideal combination between rapid visual-based learning with in depth information.
This Springer Handbook provides, for the first time, a complete and consistent overview over the methods, applications, and products in the field of marine biotechnology. A large portion of the surface of the earth (ca. 70%) is covered by the oceans. More than 80% of the living organisms on the earth are found in aquatic ecosystems. The aquatic systems thus constitute a rich reservoir for various chemical materials and (bio-)chemical processes. Edited by a renowned expert with a longstanding experience, and including over 60 contributions from leading international scientists, the Springer Handbook of Marine Biotechnology is a major authoritative desk reference for everyone interested or working in the field of marine biotechnology and bioprocessing - from undergraduate and graduate students, over scientists and teachers, to professionals. Marine biotechnology is concerned with the study of biochemical materials and processes from marine sources, that play a vital role in the isolation of novel drugs, and to bring them to industrial and pharmaceutical development. Today, a multitude of bioprocess techniques is employed to isolate and produce marine natural compounds, novel biomaterials, or proteins and enzymes from marine organisms, and to bring them to applications as pharmaceuticals, cosmeceuticals or nutraceuticals, or for the production of bioenergy from marine sources. All these topics are addressed by the Springer Handbook of Marine Biotechnology. The book is divided into ten parts. Each part is consistently organized, so that the handbook provides a sound introduction to marine biotechnology - from historical backgrounds and the fundamentals, over the description of the methods and technology, to their applications - but it can also be used as a reference work. Key topics include: - Marine flora and fauna - Tools and methods in marine biotechnology - Marine genomics - Marine microbiology - Bioenergy and biofuels - Marine bioproducts in industrial applications - Marine bioproducts in medical and pharmaceutical applications - and many more...
Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co-author Jun-ichi Horiuchi, who is one of the leading experts in the field. The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self-study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions. An excellent, comprehensive introduction to the principles of biochemical engineering.
The present book volume presents a holistic view of the aspects of nanobiomaterials incl. their stellar merits and limitations, applications in diverse fields, their futuristic promise in the fields of biomedical science and drug delivery. The federal & regulatory issues on the usage of nanobiomaterials have been assigned due consideration.
Keep pace with the rapid developments in bioremediation field investigations
The focus of this book is to introduce up-to-date information on applications and practical use of RNA for agriculture, biotechnology and medicine. It provides unique ideas, tools, and methods in detail from a variety of scientific and technical disciplines. RNA science has progressed enormously in recent decades, and vast amounts of information on RNA functions and their regulatory mechanisms are becoming available. Such a progress opened the door to an age of practical application of RNA in many fields including agriculture, plant science, medical science, brewing and fermentation technology, and material production. This book inspires its readership and contributes to not only expansion in application of RNA but also to basic research.
Nature offers abundant renewable resources that can be used to partially replace fossil fuels and commodity chemicals but issues of cost, technology readiness levels, and compatibility with existing distribution networks remain huge challenges. Cellulosic ethanol and biodiesel are the most immediately obvious target fuels, with hydrogen, methane and butanol as other potentially viable products. This book continues to bridge the technology gap and focus on critical aspects of lignocellulosic biomolecules and the respective mechanisms regulating their bioconversion to liquid fuels into energy and value-added products of industrial significance. This book is a collection of reviews elucidating several broad-ranging areas of progress and challenges in the utilization of sustainable resources of renewable energy, especially in biofuels. This book comes just at a time when government and industries are accelerating their efforts in the exploration of alternative energy resources, with expectations of the establishment of long-term sustainable alternatives to petroleum-based liquid fuels. Apart from liquid fuel this book also emphasizes the use of sustainable resources for value-added products, which may help in revitalizing the biotechnology industry at a broader scale. This book also provides a comprehensive review of basic literature and advance research methodologies to graduate students studying environmental microbiology, chemical engineering, bio-economy and microbial biotechnology.
This book provides an overview on the basics in insect molecular biology and presents the most recent developments in several fields such as insect genomics and proteomics, insect pathology and applications of insect derived compounds in modern research. The book aims to provide a common platform for the molecular entomologist to stimulate further research in insect molecular biology and biotechnology. Insects are one of the most versatile groups of the animal kingdom. Due to their large population sizes and adaptability since long they attract researchers' interest as efficient resource for agricultural and biotechnological purposes. Several economically important insects such as Silkworms, Honey Bee, Lac and Drosophila or Termites were established as invertebrate model organisms. Starting with the era of genetic engineering, a broad range of molecular and genetic tools have been developed to study the molecular biology of these insects in detail and thus opened up a new horizon for multidisciplinary research. Nowadays, insect derived products are widely used in biomedical and biotechnology industries. The book targets researchers from both academia and industry, professors and graduate students working in molecular biology, biotechnology and entomology.
This textbook discusses the new relationship between artificial, synthetic material and living matter, and presents defined examples of approaches aiming for the creation of artificial cells. It also offers insights into the world of synthetic biology from its origins to the present day, showing what is currently possible in this discipline. Furthermore, it examines the ethical concerns and potential threats posed by this new field. The textbook is based on a lecture of the same title, held for master's students at the University of Natural Resources and Life Sciences (BOKU), Vienna, and is primarily intended for students of synthetic biology, biotechnology and bioengineering. It is also of interest to research scientists from other disciplines wishing to learn more about the state of the art of synthetic biology and its future.
This book presents biotechnological advances and approaches to improving the nutritional value of agri-foods. The respective chapters explore how biotechnology is being used to enhance food production, nutritional quality, food safety and food packaging, and to address postharvest issues. Written and prepared by eminent scientists working in the field of food biotechnology, the book offers authentic, reliable and detailed information on technological advances, fundamental principles, and the applications of recent innovations. Accordingly, it offers a valuable guide for researchers, as well as undergraduate and graduate students in the fields of biotechnology, agriculture and food technology.
The collection of chapters in this proceedings volume brings together research from academic and industry scientists and clinical development experts who are focused on contemporary and emerging aspects of improving treatments employing biosurfaces. Interactions between biomaterial implants, devices, cell therapies, and whole organ transplants frequently trigger activation of body defense systems and responses that negatively affect the clinical outcome. Optimal tissue integration and modulation of foreign body reactions is therefore essential for preserving anticipated functions and avoiding adverse effects. Topics covered include mechanistic and applied research within the fields of extracorporeal devices, soft and hard tissue implants, tissue and biomaterial-targeting, therapeutic modulation of foreign body reactions, cell encapsulations, as well as cell and whole organ transplantation.
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