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Find out where our world is headed with this dazzling first-hand account of inventing the future from the #1 New York Times bestselling author of What Should I Do With My Life? and the founder of science accelerator IndieBio. Decoding the World is a buddy adventure about the quest to live meaningfully in a world with such uncertainty. It starts with Po Bronson coming to IndieBio. Arvind Gupta created IndieBio as a laboratory for early biotech startups trying to solve major world problems. Glaciers melting. Dying bees. Infertility. Cancer. Ocean plastic. Pandemics. Arvind is the fearless one, a radical experimentalist. Po is the studious detective, patiently synthesizing clues others have missed. Their styles mix and create a quadratic speedup of creativity. Yin and Yang crystallized. As they travel around the world, finding scientists to join their cause, the authors bring their firsthand experience to the great mysteries that haunt our future. Natural resource depletion. Job-taking robots. China's global influence. Arvind feels he needs to leave IndieBio to help startups do more than just get started. But as his departure draws near, he struggles to leave the sanctum he created. While Po has to prove he can keep the "indie" in IndieBio after Arvind is gone. After looking through their lens, you'll never see the world the same.
A valuable introduction to the appreciation of corrosion and the techniques for control.
Connecting theory with real-life applications, this is the first ever textbook to equip students with a comprehensive knowledge of all the key concepts in bionanotechnology. By bridging the interdisciplinary gap from which bionanotechnology emerged, it provides a systematic introduction to the subject, accessible to students from a wide variety of backgrounds. Topics range from nanomaterial preparation, properties and biofunctionalisation, and analytical methods used in bionanotechnology, to bioinspired and DNA nanotechnology, and applications in biosensing, medicine and tissue engineering. Throughout the book, features such as 'Back to basics' and 'Research report' boxes enable students to build a strong theoretical knowledge and to link this to practical applications and up-to-date research. With over 200 detailed, full-colour illustrations and more than 100 end-of-chapter problems, this is an essential guide to bionanotechnology for any student studying this exciting, fast-developing and interdisciplinary field.
This detailed book aims to provide readers with critical information to accomplish the synthesis of nanosystems for the purpose of supramolecular entities complexing with drugs, targeted drug delivery system characterization, as well as the study of the physical-chemical interactions that govern the stability and properties of these systems. Beginning with a collection of chapters on drug delivery platforms such as cyclodextrins, micelles, liposomes, polymeric, nanotubes, and more, the volume continues with coverage of the study of nanotechnology systems using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and electrochemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols serves as an ideal guide for researchers working toward drug delivery mechanisms that can tailor their physical chemical properties and enhance their efficacy, while retaining their structures intact.
Biomimetics is the idea of creating new technologies abstracted from what we find in biology. Ocean Innovation: Biomimetics Beneath the Waves seeks that technological inspiration from the rich biodiversity of marine organisms. Bringing both a biological and engineering perspective to the biomimetic potential of oceanic organisms, this richly illustrated book investigates questions such as: How can we mimic the sensory systems of sea creatures like sharks, sea turtles, and lobsters to improve our ability to navigate underwater? What can we do to afford humans the opportunity to go unnoticed by marine life? How can we diffuse oxygen from water to enable deep diving without the risk of decompression sickness? Each chapter explores an area where we, as divers and technologists, can benefit from understanding how animals survive in the sea, presenting case studies that demonstrate how natural solutions can be applied to mankind's engineering challenges.
If you are a biologist and want to get the best out of the powerful methods of modern computational statistics, this is your book. You can visualize and analyze your own data, apply unsupervised and supervised learning, integrate datasets, apply hypothesis testing, and make publication-quality figures using the power of R/Bioconductor and ggplot2. This book will teach you 'cooking from scratch', from raw data to beautiful illuminating output, as you learn to write your own scripts in the R language and to use advanced statistics packages from CRAN and Bioconductor. It covers a broad range of basic and advanced topics important in the analysis of high-throughput biological data, including principal component analysis and multidimensional scaling, clustering, multiple testing, unsupervised and supervised learning, resampling, the pitfalls of experimental design, and power simulations using Monte Carlo, and it even reaches networks, trees, spatial statistics, image data, and microbial ecology. Using a minimum of mathematical notation, it builds understanding from well-chosen examples, simulation, visualization, and above all hands-on interaction with data and code.
This title brings together some of the greatest minds deliberating on the workings of the full biotechnology value chain - from the point of basic and applied research right through to the point of commercial production. Central to these deliberations is the search for a comprehensive set of solutions that is aimed at mobilising South Africa's biotechnology resources effectively for social and economic growth.
With contributions from nearly 130 internationally renowned experts in the field, this reference details advances in transgenic plant construction and explores the social, political, and legal aspects of genetic plant manipulation. It provides analyzes of the history, genetics, physiology, and cultivation of over 30 species of transgenic seeds, fruits, and vegetables. Stressing the impact of genetic engineering strategies on the nutritional and functional benefit of foods as well as on consumer health and the global market economy, the book covers methods of gene marking, transferring, and tagging public perceptions to the selective breeding, hybridization, and recombinant DNA manipulation of food.
Written by a highly regarded author with industrial and academic experience, this new edition of an established bestselling book provides practical guidance for students, researchers, and those in chemical engineering. The book includes a new section on sustainable energy, with sections on carbon capture and sequestration, as a result of increasing environmental awareness; and a companion website that includes problems, worked solutions, and Excel spreadsheets to enable students to carry out complex calculations.
Bridging the gap between laboratory observations and industrial practices, this work presents detailed information on recombinant micro-organisms and their applications in industry and agriculture. All recombinant microbes, bacteria, yeasts and fungi are covered.
A New York Times bestseller.
Winner of the Financial Times/McKinsey Business Book of the Year Award.
'Chilling . . . Reads like a West Coast version of All the President’s Men.' New York Times Book Review
The full inside story of the breathtaking rise and shocking collapse of Theranos, the multibillion-dollar biotech startup, by the prize-winning journalist who first broke the story and pursued it to the end, despite pressure from its charismatic CEO and threats by her lawyers.
In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup "unicorn" promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.
In Bad Blood, John Carreyrou tells the riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley.
Now to be adapted into a film, with Jennifer Lawrence to star.
Presents an interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. This title offers a biological perspective of large-scale animal cell culture. It examines diverse processing strategies and process management.
This one-stop resource is ideal for understanding the extent to which toxic chemicals are used in American industry and agriculture-impacting public health and the environment through everything from industrial solvents to children's toys. Every year, about four billion pounds of toxic chemicals are generated and released by U.S. industries. Do these chemicals pose a potential health threat to American families, including vulnerable groups like children and the elderly? Is their manufacture and use adequately regulated to protect both human and environmental health? Is the Chemical Safety for the 21st Century Act, signed in June 2016 by former President Obama with bipartisan support, truly the first major overhaul of toxic chemical regulation in forty years to put human health first, as its supporters asserted? Or is it a fatally flawed bill that does the bidding of industry by undermining strong state environmental and public health laws, as some detractors claim? This two-volume set will address all of those questions. Moreover, it will present and examine arguments marshaled by business interests, community leaders, scientists, activists, and lawmakers alike. It will thus provide users with the information they need to accurately assess the impacts-pro and con-that industrial chemicals are having in shaping the world in which we work, eat, drink, breathe, and play. Approximately 300 encyclopedia entries on toxic chemicals in the United States, including product/commercial uses, laws and regulations governing their use, environmental and human health risks, types of contamination, and notable events and individuals Chronology of major events in the development and regulation of toxic chemicals in the United States Authoritative and objective analysis of the risks and benefits of chemicals in modern society Perspectives of chemical industry and related businesses, environmental and public health advocacy organizations, and lawmakers from across the political spectrum
Uniquely focusing on dynamic modeling, this volume incorporates metabolic regulation as a survival mechanism for cells, by driving metabolism through optimal investment of its resources for control of enzyme synthesis and activity. Consequently, the models have a proven record of describing various uptake patterns of mixed carbon substrates that have become significant in modern applications of biomass for the production of bioenergy. The models accurately describe dynamic behavior of microbes in nutrient environments with mixtures of complementary substrates, such as carbon and nitrogen. Modeling of large metabolic networks (including prospects for extension to genome scale) is enabled by lumped hybrid cybernetic models with an unparalleled capacity to predict dynamic behavior of knockout strains. This is an invaluable, must-have reference for bio-researchers and practicing engineers.
A comprehensive source of information about modern drying technologies that uniquely focus on the processing of pharmaceuticals and biologicals Drying technologies are an indispensable production step in the pharmaceutical industry and the knowledge of drying technologies and applications is absolutely essential for current drug product development. This book focuses on the application of various drying technologies to the processing of pharmaceuticals and biologicals. It offers a complete overview of innovative as well as standard drying technologies, and addresses the issues of why drying is required and what the critical considerations are for implementing this process operation during drug product development. Drying Technologies for Biotechnology and Pharmaceutical Applications discusses the state-of-the-art of established drying technologies like freeze- and spray- drying and highlights limitations that need to be overcome to achieve the future state of pharmaceutical manufacturing. The book also describes promising next generation drying technologies, which are currently used in fields outside of pharmaceuticals, and how they can be implemented and adapted for future use in the pharmaceutical industry. In addition, it deals with the generation of synergistic effects (e.g. by applying process analytical technology) and provides an outlook toward future developments. -Presents a full technical overview of well established standard drying methods alongside various other drying technologies, possible improvements, limitations, synergies, and future directions -Outlines different drying technologies from an application-oriented point of view and with consideration of real world challenges in the field of drug product development -Edited by renowned experts from the pharmaceutical industry and assembled by leading experts from industry and academia Drying Technologies for Biotechnology and Pharmaceutical Applications is an important book for pharma engineers, process engineers, chemical engineers, and others who work in related industries.
This second edition book provides complete coverage of the computational approaches currently used in Synthetic Biology. New chapters detail computational methods and algorithms for the design of bio-components, insight on CAD programs, analysis techniques, and distributed systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Computational Methods in Synthetic Biology, Second Edition aims to feature a broad overview of the research areas that can be met in the area of in silico Synthetic Biology.
A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working - not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.
Now presented in large format, the new Schmid is the ideal primer in biotechnology. The two-page layout with one page being a full color figure and the opposite page being explanatory text is the ideal combination between rapid visual-based learning with in depth information.
The present book volume presents a holistic view of the aspects of nanobiomaterials incl. their stellar merits and limitations, applications in diverse fields, their futuristic promise in the fields of biomedical science and drug delivery. The federal & regulatory issues on the usage of nanobiomaterials have been assigned due consideration.
Rapid advances in the life sciences means that there is now a far more detailed understanding of biological systems on the cellular, molecular and genetic levels. Sited at the intersection between the life sciences, the engineering sciences and the design sciences, innovations in the biomaterials industry are expected to garner increasing attention and play a key role in future development. This book examines the biomaterials innovations taking place in corporations and in academic research settings today. Biomaterials Innovation offers a comprehensive overview of life science innovation and presents empirical research in the field of biomaterials innovation. Alexander Styhre examines innovation management practices in the field of biomaterials development and explains institutional changes in the biomaterials industry. The demand for accomplishing biocompatibility between the human body and the materials developed is highlighted, as is the relationship between financial markets and biomaterials companies. Finally, the author discusses the therapeutic, regulatory and managerial implications of biomaterials innovation. Biomaterials Innovation will be required reading for any researcher, policy-maker or student interested in innovation management, the life sciences and the development of health care therapies.
Keep pace with the rapid developments in bioremediation field investigations
This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.
The book focuses on novel particulate technologies for the purpose of drug delivery to humans. Nowadays, macro and nano-scale particles are being investigated for targeted delivery of small and large biological macromolecules. The targeting of drugs can minimize the dosage regimen and reduces dose related potential toxicity of drug molecules, which in turn lead to increased potential compliance. Various types of organic, inorganic and polymer particles are currently being investigated. These are attracting the attention of the research workers in the field of drug delivery science and technology. This book covers polymersomes, inorganic- organic composites, gold nanoparticles biopolymer and synthetic polymer particles etc.All aspects of drug delivery in relation to each technology have been described including these advances, Easy to read and understand the content of each chapter Rich in up-to-date information regarding their application.
Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co-author Jun-ichi Horiuchi, who is one of the leading experts in the field. The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self-study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions. An excellent, comprehensive introduction to the principles of biochemical engineering.
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