The Poisoners is a history of four devastating chapters in the making of the region, seen through the disturbing use of toxins and accusations of poisoning circulated by soldiers, spies, and politicians in Zimbabwe and South Africa.

Imraan Coovadia’s fascinating new book exposes the secret use of poisons and diseases in the Rhodesian bush war and independent Zimbabwe, and the apparent connection to the 2001 anthrax attacks in the United States; the enquiry into the chemical and biological warfare programme in South Africa known as Project Coast, discovered through the arrest and failed prosecution of Dr Wouter Basson; the use of toxic compounds such as Virodene to treat patients at the height of the Aids epidemic in South Africa, and the insistence of the government that proven therapies like Nevirapine, which could have saved hundreds of thousands of lives, were in fact poisons; and the history of poisoning and accusations of poisoning in the modern history of the African National Congress, from its guerrilla camps in Angola to Jacob Zuma’s suggestion that his fourth wife collaborated with a foreign intelligence agency to have him murdered.

But The Poisoners is not merely a book of history. It is also a meditation, by a most perceptive commentator, on the meaning of race, on the unhappy history of black and white in southern Africa, and on the nature of good and evil.

The history of life is a nearly four billion year old story of transformative change. This change ranges from dramatic macroscopic innovations such as the evolution of wings or eyes, to a myriad of molecular changes that form the basis of macroscopic innovations. We are familiar with many examples of innovations (qualitatively new phenotypes that can provide a critical advantage) but have no systematic understanding of the principles that allow organisms to innovate. This book proposes several such principles as the basis of a theory of innovation, integrating recent knowledge about complex molecular phenotypes with more traditional Darwinian thinking. Central to the book are genotype networks: vast sets of connected genotypes that exist in metabolism and regulatory circuitry, as well as in protein and RNA molecules. The theory can successfully unify innovations that occur at different levels of organization. It captures known features of biological innovation, including the fact that many innovations occur multiple times independently, and that they combine existing parts of a system to new purposes. It also argues that environmental change is important to create biological systems that are both complex and robust, and shows how such robustness can facilitate innovation. Beyond that, the theory can reconcile neutralism and selectionism, as well as explain the role of phenotypic plasticity, gene duplication, recombination, and cryptic variation in innovation. Finally, its principles can be applied to technological innovation, and thus open to human engineering endeavours the powerful principles that have allowed life's spectacular success.

The book "Green Technologies for the Environment" brings together experts in the field of biotechnology, chemistry, chemical engineering, environmental engineering and toxicology from both academia and industry, to discuss green processes for the environment. The topics included finding replacements for crude oil to meet both our energy needs as well as the supply of chemicals for the production of essential products, advances in chemical processing, waste valorization, alternative solvents, and developments in homogeneous and heterogeneous catalysis as well as enzyme-based processes for chemical transformations. Advances in green chemistry concepts will further enhance the field through the design of new chemicals and solvents. In addition, obtaining a better understanding of the mechanistic pathways involved in various reactions is essential toward advances in the field. The goal of the work described in each of the chapters is to address the need for best practices for chemical processes and for the production of chemicals, while promoting sustainability.

Chiral molecules are ubiquitous in nature. Thus, it is not surprising to come across this phenomenon in the world of flavor substances. This book provides an overview on the analytical procedures currently applied to analyze chiral flavor substances at trace levels. It demonstrates several examples for the application of these techniques to determine naturally occurring enantiomeric compositions of chiral key flavor compounds in various natural systems. In addition to the analytical aspects, the contributions focus on the sensory properties of enantiomers and enlarge our knowledge on the correlation between configurations and odor properties and intensities of chiral flavor compounds. The practical importance of the topic is reflected by a discussion of merits and limitations of chiral analysis for the authenticity control of food flavorings. In addition, examples for the use of enzymes and microorganisms to obtain enantiopure flavor substances and thus to meet legal requirements for "natural" labeling are presented. Finally, the book covers aspects recently getting more and more in the focus of flavor science: What are the physiological mechanisms underlying the perception of sensory properties and does chirality matter in that respect?

Climate change is a major challenge facing modern society. The chemistry of air and its influence on the climate system forms the main focus of this book. Vol. 2 of Chemistry of the Climate System takes a problem-based approach to presenting global atmospheric processes, evaluating the effects of changing air compositions as well as possibilities for interference with these processes through the use of chemistry.

'D-Amino Acids in Chemistry, Life Sciences and Biotechnology' presents a collection of state of the art contributions from leading scientists in D-amino acid research, a field that has significant implications in relation to health care, research in age-related and neuronal diseases, pharmaceutical chemistry and food science.
The increasing importance of D-amino acids and the need for a forum to exchange ideas and hypothesis led to the foundation of the 'D-Amino Acid Research Society' in Japan, followed by the First International Conference on D-Amino Acid Research in 2009. The majority of the contributions published in D-Amino Acids in Chemistry, Life Sciences and Biotechnology result from this event and reflect the long-standing interest of the Guest Editors and their co-workers and collaborators in the field of D-amino acid research.

The riveting true story of John and Aileen Crowley's race to find a cure for Pompe disease that inspired the movie Extraordinary Measures

With three beautiful children, a new house, and financial security, John and Aileen Crowley were on top of the world--until their two youngest children, fifteen-month-old Megan and five-month-old Patrick, were diagnosed with Pompe disease and given only months to live. Refusing to accept a death sentence, John quit his financial consultant job and invested his life savings in a biotechnology start-up to research the disease and find a cure. Battling scientific setbacks, conflict of interest accusations, and business troubles, John and Aileen would be tested to their limits as they valiantly fought, and succeeded, in finding revolutionary new treatment for the disease--offering hope to Megan, Patrick, and the many children and families affected by Pompe disease around the world.

The inspiration for the captivating film Extraordinary Measures, starring Brendan Fraser and Harrison Ford, The Cure is a remarkable true story of cutting-edge science, business acumen and daring, and one family's indomitable spirit.

IN "THE ANTIDOTE," Barry Werth draws upon unprecedented inside reporting spanning more than two decades to provide a groundbreaking closeup of the upstart pharmaceutical company Vertex and the ferocious but indispensable world of Big Pharma that it inhabits.
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Werth described the company's tumultuous early days during the AIDS crisis in "The Billion-Dollar Molecule," a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325 billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It's riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's twentyfive- year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, "The Antidote" is a powerful inside look at one of the most intriguing and important business stories of recent decades.

The depletion of fossil fuels is a major issue in energy generation; hence, biomass and renewable energy sources, especially bioenergy, are the solution. The dependence on bioenergy has many benefits to mitigate environmental pollution. It is imperative that the global society adopts these alternative, sustainable energy sources in order to mitigate the constant growth of climate change. Biomass and Bioenergy Solutions for Climate Change Mitigation and Sustainability highlights the challenges of energy conservation and current scenarios of existing fossil fuel uses along with pollution potential of burning fossil fuel. It further promotes the inventory, assessment, and use of biomass, pollution control, and techniques. This book provides the solution for climate change, mitigation, and sustainability. Covering topics such as biofuel policies, economic considerations, and microalgae biofuels, this premier reference source is an essential resource for environmental scientists, environmental engineers, government officials, business leaders, politicians, librarians, students and faculty of higher education, researchers, and academicians.

Now with a new afterword covering the months-long landmark trials of Elizabeth Holmes and Sunny Balwani. ‘I couldn’t put down this thriller . . . the perfect book to read by the fire this winter.’ Bill Gates Winner of the Financial Times/McKinsey Business Book of the Year Award 2018 The riveting true story of the breathtaking rise and shocking collapse of Theranos, the multibillion-dollar biotech startup founded by Elizabeth Holmes, by the prize-winning journalist who first broke the story and pursued it to the end, despite pressure from its charismatic CEO and threats by her lawyers. In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup ‘unicorn’ promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.7 billion. There was just one problem: the technology didn’t work. In Bad Blood, John Carreyrou tells the riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley. ‘Chilling . . . Reads like a West Coast version of All the President’s Men.’ New York Times Book Review

A systematic overview of the quickly developing field of bioengineering--with state-of-the-art modeling software! Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering. The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering: Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more Explores stent deployment modeling as well as stent design and optimization techniques Generates different examples of fracture fixation with respect to the advantages in medical practice applications Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well as a support for basic and clinical research. Medical doctors and other clinical professionals will also benefit from this resource and guide to the latest modeling techniques.

Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology.