Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book's expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation

Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fifth edition of the Handbook of Biochemistry and Molecular Biology gathers a wealth of information not easily obtained, including information not found on the web. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. An entirely new section on Chemical Biology and Drug Design gathers data on amino acid antagonists, click chemistry, plus glossaries for computational drug design and medicinal chemistry. Each table is exhaustively referenced, giving the user a quick entry point into the primary literature. New tables for this edition: Chromatographic methods and solvents Protein spectroscopy Partial volumes of amino acids Matrix Metalloproteinases Gene Editing Click Chemistry

The field of industrial microbiology involves a thorough knowledge of the microbial physiology behind the processes in the large-scale, profit-oriented production of microbe-related goods which are the subject of the field. In recent times a paradigm shift has occurred, and a molecular understanding of the various processes by which plants, animals and microorganisms are manipulated is now central to industrial microbiology. Thus the various applications of industrial microbiology are covered broadly, with emphasis on the physiological and genomic principles behind these applications. Relevance of the new elements such as bioinformatics, genomics, proteomics, site-directed mutation and metabolic engineering, which have necessitated the paradigm shift in industrial microbiology are discussed.

Metal-air batteries (MABs) have attracted attention because of their high specific energy, low cost, and safety features. This book discusses science and technology including material selection, synthesis, characterization, and their applications in MABs. It comprehensively describes various composite bifunctional electrocatalysts, corrosion/oxidation of carbon-containing air cathode catalysts, and how improvements can be achieved in the catalytic activities of oxygen reduction reaction and oxygen evolution reaction and their durability/stability. This book also analyzes, compares, and discusses composite bifunctional electrocatalysts in the applications of MABs, matching the fast information of commercial MABs in requirements. Aimed at researchers and industry professionals, this comprehensive work provides readers with an appreciation for what bifunctional composite electrocatalysts are capable of, how this field has grown in the past decades, and how bifunctional composite electrocatalysts can significantly improve the performance of MABs. It also offers suggestions for future research directions to overcome technical challenges and further facilitate research and development in this important area.

This new volume, Promising Drug Molecules of Natural Origin, explores potential beneficial drug substances derived from nature. It presents the general principles, characteristics, evaluation techniques, and applications involved in drug molecules from natural sources, such as plants and marine life. With chapters from renowned experts from around the world, the chapters in this volume address the challenges of standardization of herbal medicines, methods of characterization of natural medicines and phyto-constituents, and quality control methods for herbal medicines. Several chapters in the book focus on the evolution of phyto-constituents in cancer therapeutics, while others deal with applications for other diseases, such as diabetes and neuroinflammatory disorders. The volume also specifically reviews heterocyclic drugs from plants. This volume will be a valuable resource for faculty and advanced students in pharmaceutics as well as researchers, scientists, and industry professionals in medicine and drug development.

Although designed for undergraduates with an interest in molecular biology, biotechnology, and bioengineering, this book-Techniques in Genetic Engineering-IS NOT: a laboratory manual; nor is it a textbook on molecular biology or biochemistry. There is some basic information in the appendices about core concepts such as DNA, RNA, protein, genes, and genomes; however, in general it is assumed that the reader has a background on these key issues. Techniques in Genetic Engineering briefly introduces some common genetic engineering techniques and focuses on how to approach different real-life problems using a combination of these key issues. Although not an exhaustive review of these techniques, basic information includes core concepts such as DNA, RNA, protein, genes, and genomes. It is assumed that the reader has background on these key issues. The book provides sufficient background and future perspectives for the readers to develop their own experimental strategies and innovations. This easy-to-follow book presents not only the theoretical background of molecular techniques, but also provides case study examples, with some sample solutions. The book covers basic molecular cloning procedures; genetic modification of cells, including stem cells; as well as multicellular organisms, using problem-based case study examples.

Quantum physics provides the concepts and their mathematical formalization that lend themselves to describe important properties of biological networks topology, such as vulnerability to external stress and their dynamic response to changing physiological conditions. A theory of networks enhanced with mathematical concepts and tools of quantum physics opens a new area of biological physics, the one of systems biological physics.

This book provides a link between different disciplines of nanophysics, biophotonics, nanobiomaterials & applications of nanobiophotonics in biomedical research and engineering. The fundamentals of light, matter, nanobiomaterials & nanophysics are discussed together, and relevant applications in biomedical engineering as well as other related factors influencing the interaction process are explicated. Theoretical and experimental research is combined, emphasizing the influence of crucial common factors on applications.

This book focuses on chemical syntheses and processes for biofuel production mediated by microwave energy. This is the first contribution in this area serving as a resource and guidance manual for understanding the principles, mechanisms, design, and applications of microwaves in biofuel process chemistry. Green chemistry of microwave-mediated biofuel reactions and thermodynamic potentials for the process biochemistry are the focus of this book. Microwave generation, wave propagation, process design, development and configurations, and biofuel applications are discussed in detail.

Biologically active natural products and their substructures have long been valuable starting points for medicinal chemistry and drug discovery. This new volume explores biologically active natural products and their use in microbial technologies and as phyto-pharmaceuticals in drug development. It presents detailed scientific principles and recent research on applications of nanotechnology in diagnostics and drug delivery. Topics include pharmacotherapeutically active proteins and peptides; the biotechnological potential of hydrogen-oxidizing bacteria; synthesis and production; synthetic colorants, pigments, dyes, and lakes; and more. The use of various plants is discussed in several chapters, including Artemisia, Asteraceae, Abutilon indicum, Prosopis juliflora, Acacia arabica, Aloe barbadensis, Tabermontana divaricate Linn., among others. With the information presented in Biologically Active Natural Products: Microbial Technologies and Phyto-Pharmaceuticals in Drug Development, scientists, faculty, and graduate students will gain a unique insight into nanotechnology and natural pharmaceuticals today with practical implementation in various industrial sectors.

Starch is the most widespread and abundant reserve carbohydrate in plants and is unique in that it can be used for the production of food, materials in bio-based products, and energy. Starch in the Bioeconomy covers the structure, biosynthesis, biodegradation, properties, and applications of starch in the context of the bioeconomy. The book Describes the present state of cognition of the starch granule Discusses physicochemical aspects and digestibility Considers physical, chemical, and biochemical processes to yield a variety of starch substrates Examines starch-based products including bioethanol, plastics, and composites and their use in various sectors including food, materials and energy Covers the valorization of starch as a pillar of the bioeconomy The book is aimed at researchers and industry professionals focused on the development of starch science, technology, and economics. Built on a reliable and well-documented base of information, the book presents the paths that remain to be taken to decipher this still mysterious resource that has contributed so much to the rise of humanity.

The major issues relating to environmental sustainability such as a heavy dependency on fossil fuels, increased greenhouse gas emissions, pollution, global warming and climate change have prompted many efforts around the globe to seek alternative energy sources that have negligible environmental impacts and societal benefits. There is an immense interest in biofuels research throughout the world owing to its massive potential to address environmental concerns. Biofuels have the capacity to supplement current and future energy demands through being blended with fossil fuels or even replacing them completely as drop-in fuels in automobiles as well as for heating and the power industries. Waste biomass, primarily lignocellulosic biomass (e.g. agricultural crop residues, forestry biomass and energy crops) and microalgae can act as some inexpensive renewable bioresources for the production of biofuels and biochemicals. The prime focus of Bioprocessing of Biofuels is to shed light on this significant process, especially through microbial conversion technologies to recover and transform the inedible polysaccharides into hydrocarbon biofuels and bioenergy. The book offers introductory coverage of the most crucial topics as follows: A systematic overview of the state-of-the-art in the production and utilization of biofuels Categorical bioprospecting of bioresources for biofuel production Biomass pretreatment and enzymatic saccharification Bioconversion of waste biomass and algae to liquid and gaseous biofuels New developments in microbial fuel-cell technologies Bioprocessing of Biofuels unites topics related to the cutting-edge applications of bioresources and green technologies to reinvigorate biorefineries, positioning them within a competitive energy market. Written to be instantly applicable, this volume offers a reference book for undergraduate and graduate students, scientific investigators and research scholars around the globe working in the areas relating to energy and fuels.

This volume on applied pharmaceutical science and microbiology looks at the latest research on the applications of natural products for drug uses. It focuses on understanding how to apply the principles of novel green chemistry methods in the vital area of pharmaceuticals and covers the important aspects of green microbial technology in the pharmaceutical industry. Chapters include studies on the applications of natural products used in folk and regional medicines, such as for digestive problems, dermatological infections, respiratory diseases, vessel diseases, diarrhea and dysentery, ringworms, boils, fevers (antipyretic), skin and blood diseases, mouth sores, channel discharges, and even cancer. The volume also looks at medical benefit of microbial fermentation for the conservation of nutrients.

The aim of preparation of current book is to provide the state-of-the-art knowledge about anaerobes and anaerobic process to undergraduate, graduate and PhD students. During the preparation of book we tried to incorporate contents from very basic like cultivation, handling, preservation and various important process related to anaerobes like biomethanation, anaerobic methanotrophy, solid waste management, anaerobic biohydrogen and biobutanol production, anaerobic nitrogen treatment, anaerobic solid waste management. In addition considering the importance of anaerobes in human health and disease we tried to dedicate a complete section like anaerobic probiotic, anaerobes and human gut microbiology and anaerobes and human infection. Finally we tried to incorporate a chapter on role of anaerobes in animal rumen and food digestion. We believe that current book will serve its aim to satisfy the hunger of knowledge about anaerobes and anaerobic process for the UG, PG and PhD students of Microbiology, Biotechnology, Environmental Science and Biochemistry background. Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka. This title is co-published with New India Publishing Agency.

This unique book covers the molecular aspects of plant stress and the various industrial applications. Chapters cover many important topics in the biology of plant stress, including morphological and physiological changes of plants due to accumulation of pollutants; the types of stress for enhanced biofuel production from plant biomass; plant adaptation due to different types of environmental stresses; potential applications of microRNAs to improve abiotic stress tolerance in plants; plant resistance to viruses and the molecular aspects; photosynthesis under stress conditions; plant responses to weeds, pests, pathogens, and agrichemical stress conditions; and plant responses under the stress of drought. Key features: * Describes the different types of plant stress * Details the current and possible applications of plant stress biology * Presents several case studies that include applications of plant stress * Explores plant stress biology for applications in biofuel science Plant Stress Biology: Progress and Prospects of Genetic Engineering will be useful for researchers in diverse fields as well as for plant biologists, environmental biologists, faculty, and students. The book will also be helpful for further advancement of research in the area of plant stress biology.

First published in 1996, liposomes have become an important model in fundamental biomembrane research, including biophysical, biochemical, and cell biological studies of membranes and cell function. They are thoroughly studied in several applications, such as drug delivery systems in medical applications and as controlled release systems, microencapsulating media, signal carriers, support matrices, and solubilizers in other applications. While medical applications have been extensively reviewed in recent literature, there is a need for easily accessible information on applications for liposomes beyond pharmacology and medicine. The Handbook of Nonmedical Applications of Liposomes fills this void.This unique new handbook series presents recent developments in the use of liposomes in many scientific disciplines, from studies on the origin of life, protein function, and vesicle shapes, to applications in cosmetics, diagnostics, ecology, bioreclamation, and the food industry. In these volumes many of the top experts contribute extensive reviews of their work.

This new volume discusses new and well-known electrochemical energy harvesting, conversion, and storage techniques. It provides significant insight into the current progress being made in this field and suggests plausible solutions to the future energy crisis along with approaches to mitigate environmental degradation caused by energy generation, production, and storage. Topics in Electrochemical Energy Conversion and Storage Systems for Future Sustainability: Technological Advancements address photoelectrochemical catalysis by ZnO, hydrogen oxidation reaction for fuel cell application, and miniaturized energy storage devices in the form of micro-supercapacitors. The volume looks at the underlying mechanisms and acquired first-hand information on how to overcome some of the critical bottlenecks to achieve long-term and reliable energy solutions. The detailed synthesis processes that have been tried and tested over time through rigorous attempts of many researchers can help in selecting the most effective and economical ways to achieve maximum output and efficiency, without going through time-consuming and complex steps. The theoretical analyses and computational results corroborate the experimental findings for better and reliable energy solutions.

Introduces new and advanced methods of model discovery for time-series data using artificial intelligence. Implements topological approaches to distill "machine-intuitive" models from complex dynamics data. Introduces a new paradigm for a parsimonious model of a dynamical system without resorting to differential equations. Heralds a new era in data-driven science and engineering based on the operational concept of "computational intuition".

The third volume of the Handbook of Polyhydroxyalkanoates (PHA) focusses on the production of functionalized PHA bio-polyesters, the post-synthetic modification of PHA, processing and additive manufacturing of PHA, development and properties of PHA-based (bio)composites and blends, the market potential of PHA and follow-up materials, different bulk- and niche applications of PHA, and the fate and use of spent PHA items. Divided into fourteen chapters, it describes functionalized PHA and PHA modification, processing and their application including degradation of spent PHA-based products and fate of these bio-polyesters during compositing and other disposal strategies. Aimed at graduate students and professionals in Polymer science, chemical engineering and bioprocessing, it: Covers current state of the art in the development of chemically modifiable PHA including mult-istep modifications of isolated biopolyesters, short syntheses of monomer feedstocks and so forth. Describes design of functionalized PHA-based polymeric materials by chemical modification . Illustrates preparation of bioactive oligomers derived from microbial PHA and synthetic analogues of natural PHA oligomers. Discusses processing and thermomechanical properties of PHA. Reviews advantages of PHA against other bio-based and conventional polymers with current applications and potential uses of PHA-based polymers highlighting innovative products.

This edited book focuses on the role and use of VR for healthcare professions in both health and rehabilitation settings. It is also offers future trends of other emerging technology within medicine and allied health professions. This text draws on expertise of leading medical practitioners and researchers who utilise such VR technologies in their practices to enhance patient/service user outcomes. Research and practical evidence is presented with a strong applied emphasis to further enhance the use VR technologies within the community, the hospital and in education environment(s). The book may also be used to influence policymakers on how healthcare delivery is offered.

This practical manual provides basic theoretical knowledge about fermentative processes, biochemical laboratory techniques, and an arsenal of practical tricks, recipes, do's, and don'ts for the biogas plant manager. It explains why some popular tests and techniques are unreliable, how to optimize the feedstock's cost and the energy self-consumption of the digester, and how to analyze experimental error propagation and judge whether a marketing claim or a test result from the literature is correct. All examples are taken from the author's experience as consultant in managing biogas plants in Italy and Spain. It features a glossary of technical jargon and useful reference tables and formulae. By following the procedures described in this manual, anybody can learn in short time how to become a "bacteria farmer."

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings's College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Drying of Biomass, Biosolids, and Coal: For Efficient Energy Supply and Environmental Benefits provides insight into advanced technologies and knowledge of the drying of biomass, biosolids, and coal in terms of improved efficiency, economics, and environmental impact. It comprehensively covers all the important aspects of drying for a variety of biomass, biosolids and coal resources. This book covers the drying of biomass, bio-solids and coal while also providing integration of the drying process with the energy system. Important issues in the commercial drying operations are tackled, including energy and exergy efficiencies, environmental impact, and potential safety concerns. It also assesses the performance of energy production plants in integration with biomass/coal drying to provide information for plant optimization. It offers in-depth analysis and data for process understanding and design, and analyzes the drying process's effect on economics and the environment. This book is aimed at drying professionals and researchers, chemical engineers, industrial engineers, and manufacturing engineers. It will also be of use to anyone who is interested in the utilization of biomass, organic solid wastes, algae and low-rank coals for energy.

Magnesium is one of the most abundant minerals in seawater. Extracting magnesium from seawater could reduce cost of this mineral, resulting in positive implications for industries that use it. This book addresses mineral process engineering with emphasis on magnesium and provides practicing engineers and students with comprehensive knowledge on magnesium and how it is extracted from seawater and magnesium ores. It takes a chemical engineering approach as separation of magnesium from seawater involves the application of the powerful science of chemistry and transport phenomena principles. This monograph discusses magnesium resources and occurrence, includes an exploration study on deriving magnesium and mineral salts from seawater, and features coverage of magnesium chloride. It also covers commercial methods for magnesium production as an end product, current and prospective applications in the energy domain, and offers an account of the use of magnesium to store hydrogen in the form of magnesium hydride.

The development of biologically based processes for the treatment of hazardous inorganic and organic wastes is a multi-disciplinary effort requiring the consideration of a number of biological, chemical, and physical parameters, as well as the effective teaming of biologists, chemists, engineers, and regulatory agencies. This new text/reference bridges the disciplines in a unique way, allowing an exchange of fundamental information to take place. The book begins with a description of the biological transformations of inorganic and organic compounds and a review of strategies that may be used for the treatment of hazardous wastes. It continues with a discussion of the physiological and engineering factors that must be considered for successful process development and concludes with a discussion of the regulations that have influenced biological waste treatment and environmental remediation.