Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

Circular Bioeconomy: Technologies for Waste Remediation covers information about the strategies and approaches facilitating the integration of technologies for wastewater and solid waste remediation. The book highlights the models developed to valorize wastes to produce biobased products. Various chapters presented in the book put a focus on sustainability approaches as a central theme in order to facilitate industries and policymakers to adopt circular economy goals. Since the principal idea of a circular bioeconomy is to transition from a linear economy, it involves advanced technological and designing breakthroughs to reduce waste with a closed looped system.

Sustainable Energy, Towards a Zero-Carbon Economy Using Chemistry, Electrochemistry and Catalysis provides the reader with a clear outline of some of the strategies, particularly those based on various chemical approaches, that have been put forward with the aim of reducing greenhouse gas emissions in order to achieve "zero carbon" by 2050. The author describes the chemistry of some of the processes involved, paying particular attention to those that involve heterogeneous catalytic steps and electrolysis methods. In cases in which the technology is already established, details are given of the reactor systems used. He discusses novel developments in the areas of transport, the production of essential products using renewable energy and the uses of sustainable biomass.

Biomass Processes and Chemicals is written to assist the reader in understanding the options available for the production of chemicals from biomass. Petroleum-based and natural gas-based chemicals are well-established products that have served industry and consumers for more than one hundred years. However, time is running out and natural gas and petroleum are now being depleted. Thus, the need for alternative technologies to produce chemicals is necessary. Chemicals produced from sources are now coming into place for the establishment of a chemicals-from-biomass industry, hence this book covers these advancements.

Advances in Oil-Water Separation: A Complete Guide for Physical, Chemical, and Biochemical Processes discusses a broad variety of chemical, physical and biochemical processes, including skimming, membrane separation, adsorption, onsite chemical reactions, burning and usage of suitable microbial strains for onsite degradation of oil. It critically reviews all current developments in oil-water separation processes and technologies, identifies gaps and illuminates the scope for future research and development in the field. This book provides researchers, engineers and environmental professionals working in oil recovery and storage with solutions for disposal of waste oil and separation of oil from water in a sustainable, environmentally-friendly way. As the book provides a complete state-of-art overview on oil-water separation technologies, it will also ease literature searches on oil-water separation technologies.

New and Future Developments in Microbial Biotechnology and Bioengineering: Sustainable Agriculture: Advances in Microbe-Based Biostimulants describes advances in microbial mechanisms involved in crop production and stress alleviation. Recent developments in our understanding of the role of microbes in sustainable agriculture and disease management have created a highly potential research area. The plant holobiont has a significant role in stress signaling, nutrient use efficiency, and soil health and fertility for sustainable developments. The mycorrhizosphere, hyphosphere, phyllosphere, rhizosphere and endosphere are critical interfaces for the exchange of signaling and resources between plants and soil environment. This book is an ideal reference source for microbiologists, agrochemists, biotechnologists, biochemists, industrialists, researchers and scientists working on agriculturally important microorganisms and their exploitation in sustainable future applications.

Phytoremediation Technology for the Removal of Heavy Metals and Other Contaminants from Soil and Water focuses on the exploitation of plants and their associated microbes as a tool to degrade/detoxify/stabilize toxic and hazardous contaminants and restore the contaminated site. The book introduces various phytoremediation technologies using an array of plants and their associated microbes for environmental cleanup and sustainable development. The book mainly focuses on the remediation of toxic and hazardous environmental contaminants, their phytoremediation mechanisms and strategies, advances and challenges in the current scenario. This book is intended to appeal to students, researchers, scientists and a wide range of professionals responsible for regulating, monitoring and designing industrial waste facilities. Engineering consultants, industrial waste managers and purchasing department managers, government regulators, and graduate students will also find this book invaluable.

Bioinformatics in Agriculture: Next Generation Sequencing Era is a comprehensive volume presenting an integrated research and development approach to the practical application of genomics to improve agricultural crops. Exploring both the theoretical and applied aspects of computational biology, and focusing on the innovation processes, the book highlights the increased productivity of a translational approach. Presented in four sections and including insights from experts from around the world, the book includes: Section I: Bioinformatics and Next Generation Sequencing Technologies; Section II: Omics Application; Section III: Data mining and Markers Discovery; Section IV: Artificial Intelligence and Agribots. Bioinformatics in Agriculture: Next Generation Sequencing Era explores deep sequencing, NGS, genomic, transcriptome analysis and multiplexing, highlighting practices forreducing time, cost, and effort for the analysis of gene as they are pooled, and sequenced. Readers will gain real-world information on computational biology, genomics, applied data mining, machine learning, and artificial intelligence. This book serves as a complete package for advanced undergraduate students, researchers, and scientists with an interest in bioinformatics.

Hybrid Nanomaterials for Drug Delivery covers a broad range of hybrid nanomaterials and nanocomposites used in drug delivery systems. The book reviews a variety of hybrid nanomaterials and structures, including polymer-lipid, chitosan-based, protein-inorganic, quantum dot hybrids, and more. The strengths, limitations and regulatory aspects of hybrid drug delivery systems are also discussed, allowing readers to make informed decisions when choosing to utilize hybrid nanomaterials. Users will find this to be an exciting and comprehensive look into this emerging area. It will be of particular interest to academics and researchers working in materials science, engineering, biomedical engineering, nanotechnology and pharmaceutical science. Multi nanocarrier-based hybrid systems are an emerging concept in the field of drug delivery that allow researchers to avoid some of the challenges faced when administering drugs, such as low bioavailability, development of drug resistance, toxicities, premature drug release, and therapeutic efficacy.

Bioprospecting of Microbial Diversity: Challenges and Applications in Biochemical Industry, Agriculture and Environment Protection gives a detailed insight into the utilization of microorganisms or microorganism-based bioactive compounds for the development of sustainable approaches, covering recent advances and challenges in the production and recovery of bioactive compounds such as enzymes, biopesticides, biofertilizers, biosensors, therapeutics, nutraceutical and pharmaceutical products. The challenges associated with the different approaches of microbial bioprospecting along with possible solutions to overcome these limitations are addressed. Further, the application of microbe-based products in the area of environmental pollution control and developing greener technologies are discussed. Providing valuable insight into the basics of microbial prospecting, the book covers established knowledge as well as genomic-based technological advancements to offer a better understanding of its application to various industries, promoting the commercialization of microbial-derived bioactive compounds and their application in biochemical industries, agriculture, and environmental protection studies.

A systematic overview of the quickly developing field of bioengineering--with state-of-the-art modeling software! Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering. The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering: Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more Explores stent deployment modeling as well as stent design and optimization techniques Generates different examples of fracture fixation with respect to the advantages in medical practice applications Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well as a support for basic and clinical research. Medical doctors and other clinical professionals will also benefit from this resource and guide to the latest modeling techniques.

Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties and Application systematically introduces basic theories and progress in the research of biomedical ss-Ti alloys achieved by researchers from different fields. It focuses on a high-strength and low elastic modulus biomedical ss-Ti alloy (TLM), etc. designed by the authors. The alloy design methods, microstructural characteristics, mechanical properties, surface treatment methods and biocompatibility of the TLM alloy are discussed in detail, along with a concise description of the medical devices made from this alloy and the application examples. This book will appeal to researchers as well as students from different disciplines, including materials science, biology, medicine and engineering fields.

Biomedical Product and Materials Evaluation: Standards and Ethics provides a much-needed overview of the procedures, issues, standards and ethical issues in the early development of biomedical products. The book covers a range of key biomedical products, from 3D printed organs and blood derived products, to stem calls and decellularized tissue products. Each chapter reviews a single product type, associated materials, biomedical applications, proven development strategies, and potential challenges. The core focus of the book is on the standardization and ethical aspects of biomedical product development, with these elements addressed and discussed in chapters dedicated to product evaluation. This is a useful reference for academics, researchers and industry professionals in R&D groups with an interest in biomaterial research and production, as well as those working in the fields of biomedical engineering, biotechnology and toxicology.

Microbiome Under Changing Climate: Implications and Solutions presents the latest biotechnological interventions for the judicious use of microbes to ensure optimal agricultural yield. Summarizing aspects of vulnerability, adaptation and amelioration of climate impact, this book provides an important resource for understanding microbes, plants and soil in pursuit of sustainable agriculture and improved food security. It emphasizes the interaction between climate and soil microbes and their potential role in promoting advanced sustainable agricultural solutions, focusing on current research designed to use beneficial microbes such as plant growth promoting microorganisms, fungi, endophytic microbes, and more. Changes in climatic conditions influence all factors of the agricultural ecosystem, including adversely impacting yield both in terms of quantity and nutritional quality. In order to develop resilience against climatic changes, it is increasingly important to understand the effect on the native micro-flora, including the distribution of methanogens and methanotrophs, nutrient content and microbial biomass, among others.

Now with a new afterword covering the months-long landmark trials of Elizabeth Holmes and Sunny Balwani. ‘I couldn’t put down this thriller . . . the perfect book to read by the fire this winter.’ Bill Gates Winner of the Financial Times/McKinsey Business Book of the Year Award 2018 The riveting true story of the breathtaking rise and shocking collapse of Theranos, the multibillion-dollar biotech startup founded by Elizabeth Holmes, by the prize-winning journalist who first broke the story and pursued it to the end, despite pressure from its charismatic CEO and threats by her lawyers. In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup ‘unicorn’ promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes’s worth at an estimated $4.7 billion. There was just one problem: the technology didn’t work. In Bad Blood, John Carreyrou tells the riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley. ‘Chilling . . . Reads like a West Coast version of All the President’s Men.’ New York Times Book Review

Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics. Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics. Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems.

Nano-Enabled Agrochemicals in Agriculture presents a targeted overview of the safe implementation of nanotechnologies within agricultural and horticultural settings, with the purpose of achieving enhanced production while maintaining ecological integrity. The growing global request for agricultural crops and products requires high standards of quality and safety, which has stimulated the search for new technologies that preserve their quality and delay their decomposition. Nanotechnology may boost plant production by improving nutrient uptake/use efficiency with nanoformulations of fertilizers and agrochemicals for plant enhancement, detection and treatment of diseases, and host-parasite interactions at the molecular level using nanosensors. It also may improve plant disease diagnostics, removal of contaminants from soil and water, postharvest management of vegetables and flowers, and reclamation of salt-affected soils. Although the markets for nanoproducts and nanoformulations continue to increase, there are also growing concerns regarding the fate and behavior of nanomaterials in environmental systems. Exploring important topics related to nanotechnology and nanomaterials, the book includes the use of nanochemicals in insect pest management, as nanofungicides, nanoherbicides, micronutrient supply, and nanosensors to monitor crop and soil health conditions, from detection of agrochemicals to their slow release of agrochemicals, and their impact on related environs. This book will serve as an excellent resource for a wide range of plant scientists who have concerns about nanomaterial interactions with terrestrial and aquatic plants.

The depletion of fossil fuels is a major issue in energy generation; hence, biomass and renewable energy sources, especially bioenergy, are the solution. The dependence on bioenergy has many benefits to mitigate environmental pollution. It is imperative that the global society adopts these alternative, sustainable energy sources in order to mitigate the constant growth of climate change. Biomass and Bioenergy Solutions for Climate Change Mitigation and Sustainability highlights the challenges of energy conservation and current scenarios of existing fossil fuel uses along with pollution potential of burning fossil fuel. It further promotes the inventory, assessment, and use of biomass, pollution control, and techniques. This book provides the solution for climate change, mitigation, and sustainability. Covering topics such as biofuel policies, economic considerations, and microalgae biofuels, this premier reference source is an essential resource for environmental scientists, environmental engineers, government officials, business leaders, politicians, librarians, students and faculty of higher education, researchers, and academicians.

Biomass, Biofuels, Biochemicals: Circular Bioeconomy: Technologies for Biofuels and Biochemicals provides comprehensive information on strategies and approaches that facilitate the integration of technologies for the production of bio-based fuels, chemicals and other value-added products from wastes with waste biorefinery concepts and green strategies. The book also covers lifecycle assessment and techno-economic analyses of integrated biorefineries within a circular bioeconomy framework. As there has been continual research on new designs in production and consumerist approaches as we move towards sustainable development by scientists of various disciplines, law makers, environmental activists and industrialists, this book provides the latest details. Resources consumption and environment degradation necessitates a transition of our linear economy towards sustainable social and technical systems. As fossil resources are only projected to fulfill the needs of the population for the next couple of centuries, new tactics and standards must be created to ensure future success.

Value Addition in Food Products and Processing using Enzyme Technology offers an updated review regarding the potential impact of new enzymes and enzyme technology on the food sector. The book brings together novel sources and technologies regarding enzymes in value added food development, food production, food processing, food preservation, food engineering and food biotechnology. It will be extremely useful for different types of readers, including food scientists, academic and food biotechnologists, but will also be ideal for students studying food-related courses. This book includes concise and up-to-date research information from multiple independent scientific papers from around the world. This is a essential, multidisciplinary text for research and development professionals, research scientists, and academics in food, biotechnology, and agriculture industries. It addresses safety issues and includes the sources, screening, immobilization and application of food-grade enzymes in food.

3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their industrial applications. Sections cover 4D Printing Smart Multi-responsive Structure, Cells for Bioprinting, 4D Printing Biomaterials, 3D/4D printing functional biomedical devices, 3D Printing for Cardiac and Heart Regeneration, Integrating 3D printing with Ultrasound for Musculoskeletal Regeneration, 3D Printing for Liver Regeneration, 3D Printing for Cancer Studies, 4D Printing Soft Bio-robots, Clinical Translation and Future Directions. The book's team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application. The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs. This book provides an overview of these technologies and their integration.

Applied Biomedical Engineering Using Artificial Intelligence and Cognitive Models focuses on the relationship between three different multidisciplinary branches of engineering: Biomedical Engineering, Cognitive Science and Computer Science through Artificial Intelligence models. These models will be used to study how the nervous system and musculoskeletal system obey movement orders from the brain, as well as the mental processes of the information during cognition when injuries and neurologic diseases are present in the human body. The interaction between these three areas are studied in this book with the objective of obtaining AI models on injuries and neurologic diseases of the human body, studying diseases of the brain, spine and the nerves that connect them with the musculoskeletal system. There are more than 600 diseases of the nervous system, including brain tumors, epilepsy, Parkinson's disease, stroke, and many others. These diseases affect the human cognitive system that sends orders from the central nervous system (CNS) through the peripheral nervous systems (PNS) to do tasks using the musculoskeletal system. These actions can be detected by many Bioinstruments (Biomedical Instruments) and cognitive device data, allowing us to apply AI using Machine Learning-Deep Learning-Cognitive Computing models through algorithms to analyze, detect, classify, and forecast the process of various illnesses, diseases, and injuries of the human body. Applied Biomedical Engineering Using Artificial Intelligence and Cognitive Models provides readers with the study of injuries, illness, and neurological diseases of the human body through Artificial Intelligence using Machine Learning (ML), Deep Learning (DL) and Cognitive Computing (CC) models based on algorithms developed with MATLAB (R) and IBM Watson (R).

Current Developments in Biotechnology and Bioengineering: Technologies for Production of Nutraceuticals and Functional Food Products covers a wide range of topics related to the the microbial process for the production of high- value nutraceuticals and fermented functional foods. This reference includes the bioactive compounds derived from the foods substrate, including bioactive peptides, transformed polyphenols, oligosaccharides, prebiotics, and functional lipids. Scientific information related to the recombinant microorganisms and their role in the production of nutraceutical and functional foods are also included. The translational aspects of microbial bioprocess technologies are illustrated, by emphasizing the current requirements and future perspectives of industrial and food biotechnology. Edited by a group of experienced Eeditors and contributors, Technologies for Production of Nutraceuticals and Functional Food Productsthe book gives scientists and engineers the translational aspects of microbial processes for the development of functional foods and high- value nutraceuticals with future perspectives.