The complexity of today's risk decisions is well known. Beyond cost and risk there are many other factors contributing to these decisions, including type of risk (such as human injury or fatality), the economic impact on the local community, profitability, availability of capital, alternatives for reducing or eliminating the risk, costs of implementing alternatives, codes, standards, regulation, and good industry practice. This book presents a large range of decision aids for risk analysts and decision makers in industry so that vital decisions can be made in a more consistent, logical, and rigorous manner. Though primarily aimed at the process industry, this book can be used by anyone who makes similar decisions in other industries, including those in management science.

Valorization of Wastes for Sustainable Development: Waste to Wealth highlights the various valorization of organic and non-organic waste to offer a way forward to a sustainable world. Categorizing the various types of waste valorization for renewable fuel production and other valorizations utilizing organic and non-organic waste, this book offers the reader a comprehensive view of various waste valorizations together with their potential applications. Split into four sections, the book's chapters cover the general scenarios and challenges of current waste management and the valorization of waste specifically for renewable fuels as the alternative energy source to depleting fossil fuels. Other chapters cover waste valorizations categorized into organic and non-organic waste for various applications and the future prospect of waste valorizations with possible plans and strategies for effective global waste management.

New technologies will have an increasing effect on prospects for development and growth in the world economy. Technology and Innovation in the International Economy contains extensive and detailed assessments of two key areas of technological innovation which present both a threat and an opportunity for developing countries: microelectronics and biotechnology.The two major review essays - Jeffrey James on microelectronic technology and Martin Fransman on biotechnology - assess the impact of these new technologies on production, trade, employment and welfare in developing countries. The introduction by Charles Cooper deals with recent advances in the economics of innovation and diffusion of new technologies, and attempts to build a bridge between the study of technology in the industrial sectors of developed countries and the type of technology policy needed in the developing countries. Policymakers, researchers and students will welcome the clarity and breadth of this important volume which contains much original analysis and detailed information on a major issue confronting developing and developed nations alike.

Covering technological aspects as well as the suitability and applicability of various kinds of uses, this handbook shows optimization strategies, techniques and assembly pathways to achieve the combination of complex, even three-dimensional structures with simple manufacturing steps. The authors provide information on markets, commercialization opportunities and aspects of mass or large-scale production as well as design tools, experimental techniques, novel materials, and ideas for future improvements. Not only do they weigh up cost versus quantity, they also consider CMOS and LIGA strategies.
Of interest to physicists, electronics engineers, materials scientists, institutional and industrial libraries as well as graduate students of the relevant disciplines.

This book examines the implications of the net zero transition for food and farming in the UK and how these can be managed to avoid catastrophic climate change in the crucial decades ahead. For the UK to meet its international obligations for reducing greenhouse gas emissions, nothing short of a revolution is required in our use of land, our farming practices and our diet. Taking a historical approach, the book examines the evolution of agriculture and the food system in the UK over the last century and discusses the implications of tackling climate change for food, farming and land use, setting the UK situation in an international context. The chapters analyse the key challenges for this transition, including dietary change and food waste, afforestation and energy crops, and low-emission farming practices. This historical perspective helps develop an understanding of how our food, farming and land use system has evolved to be the way that it is, and draws lessons for how the agri-food system could evolve further to support the transition to net zero and avoid catastrophic climate change. Written in a clear and accessible style, this book will be essential reading to students and scholars of food, agriculture and the environment, as well as policymakers and professionals involved climate change policy and the agriculture and food industry.

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

Highlights the impact of Covid 19 on science, health and health care system Includes evolution, structure, and mode of infection by virus as well as strategies to attack various organs in the body. Describes emergence of various strains of virus Emphasis new techniques to detect and control the virus Discusses vaccine development to control the pandemic

Advanced Nanoformulations: Theranostic Nanosystems, Volume Three examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glycolide, polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials. It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications.

Bioelectronics is emerging as a new area of research where electronics can selectively detect, record, and monitor physiological signals. This is a rapidly expanding area of medical research, that relies heavily on multidisciplinary technology development and cutting-edge research in chemical, biological, engineering, and physical science. This book provides extensive information on the (i) fundamental concepts of bioelectronics, (ii) materials for the developments of bioelectronics such as implantable electronics, self-powered devices, bioelectronic sensors, flexible bioelectronics, etc, and (iii) an overview of the trends and gathering of the latest bioelectronic progress. This book will broaden our knowledge about newer technologies and processes used in bioelectronics.

Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues.
Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.

This set contains the two volumes, Biomolecular Information Processing together with Molecular and Supramolecular Information Processing with contributions from all the major scientists in the field. Edited by a renowned and much cited chemist, the two books cover all the different systems, providing an excellent overview of the latest developments in this rapidly expanding area.
A must-have for all researchers working on this very hot topic.

Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.

Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems.

Describing advanced detectors and their visualization and investigation techniques, this book presents the major applications in nuclear and high-energy physics, astrophysics, medicine and radiation measurements.

Biotechnology and Competitive Advantage investigates the development of biotechnology in Europe and the United States. It examines why Europe has fallen behind in applying biotechnology, when its scientific capabilities are largely comparable to those in the US. In addition it sheds new light on the wider context of the theory of growth of new technologies. This innovative book brings together a wide range of material concerning socio-economic aspects of the development of biotechnology in Europe and the US. Issues discussed include: * European policy for biotechnology, in individual countries and at the European Union level * risk regulation and the ways in which industry, regulators and non-government organizations manage risk regulation and the perception of risk * the formation and roles of biotechnology firms in Europe and the US and their relative capabilities * gene therapy development in Europe and the US * the impact on Europe of overseas biotechnology research by European multinationals. This book argues in favour of developing an integrated research and development system which will strengthen the research and development capabilities of all the actors involved. This book will be of great interest to science policymakers; businesses and academics studying the development of biotechnology and students of economics and business studies throughout Europe and the US.

The new book series "Nanomaterials for the Life Sciences," successor to the highly acclaimed series "Nanotechnology for the Life Sciences," provides an in-depth overview of all nanomaterial types and their uses in the life sciences. Each volume is dedicated to a specific material class and covers fundamentals, synthesis and characterization strategies, structure-property relationships and biomedical applications. The new series brings nanomaterials to the life scientists and life science to the materials scientists so that synergies are seen and developed to the fullest.

Written by international experts of the various facets of this exciting field of research, the ten volumes of this single source of information comprehensively cover the complete range of nanomaterials for medical, biological and cybernetic applications. The series is aimed at scientists of the following disciplines: biology, chemistry, materials science, physics, bioengineering, and medicine, together with cell biology, biomedical engineering, pharmaceutical chemistry, and toxicology, both in academia and fundamental research as well as in pharmaceutical companies.

Volume 3: Mixed Metal nanomaterials
Volume 3 covers the aspects of synthesis, characterization and application of bimetallic and multielemental spherical and anisotropic nanomaterials in the life sciences.

A Times Best Book of 2021 From the very first dog to glowing fish and designer pigs - the human history of remaking nature. Virus-free mosquitoes, resurrected dinosaurs, designer humans - such is the power of the science of tomorrow. But the idea that humans have only recently begun to tinker with the natural world is false. We've been meddling with nature since the last ice age, and we're getting a lot better at it. Drawing on decades of research, Beth Shapiro reveals the surprisingly long history of human intervention in evolution - for good and for ill - and looks ahead to the future, casting aside scaremongering myths about the dangers of interference. New biotechnologies can present us with the chance to improve our own lives, and increase the likelihood that we will continue to live in a rich and biologically diverse world.

This edition of 'Micro Process Engineering' was originally published in the successful series 'Advanced Micro & Nanosystems'. Authors from leading industrial players and research institutions present a concise and didactical introduction to Micro Process Engineering, the combination of microtechnology and process engineering into a most promising and powerful tool for revolutionizing chemical processes and industrial mass production of bulk materials, fine chemicals, pharmaceuticals and many other products. The book takes the readers from the fundamentals of engineering methods, transport processes, and fluid dynamics to device conception, simulation and modelling, control interfaces and issues of modularity and compatibility. Fabrication strategies and techniques are examined next, focused on the fabrication of suitable microcomponents from various materials such as metals, polymers, silicon, ceramics and glass. The book concludes with actual applications and operational aspects of micro process systems, giving broad coverage to industrial efforts in America, Europe and Asia as well as laboratory equipment and education.

General compendium of HDAC inhibitors with deep emphasis on toxicity issues of synthetic HDAC inhibitors Various groups of natural HDAC inhibitors, their representatives and premier sources Cyclic tetrapeptides of natural origin and their importance as cancer chemotherapeutic agents Hydroxamates and depsipeptides from natural sources and their promising role in cancer therapy Natural Flavonoids, their HDAC inhibitory tendency and marvellous anticancer activity Non-flavonoid natural HDAC inhibitors and their pleasing cytotoxic effects towards cancer models Combined therapy involving natural flavonoids with other anticancer molecules for synergistic and additive benefits against cancer models Non-flavonoid HDAC inhibitors and conventional drugs in collaborative mode against aggressive malignancies Nanotechnology based delivery of natural HDAC inhibitors for greater therapeutic efficacy over traditional combinatorial therapy

"Algae are mysterious and fascinating organisms that hold great potential for discovery and biotechnology." -Dr. Thierry Tonon, Department of Biology, University of York "Science is a beautiful gift to humanity; we should not distort it." -A.P.J. Abdul Kalam In this book, we emphasise the importance of algal biotechnology as a sustainable platform to replace the conventional fossil-based economy. With this focus, Volume 2 summarizes up-to-date literature knowledge and discusses the advances in algal cultivation, genetic improvement, wastewater treatment, resource recovery, commercial operation, and technoeconomic analysis of algal biotechnology. FEATURES Discusses in detail recent developments in algae cultivation and biomass harvesting Provides an overview of genetic engineering and algal-bacteria consortia to improve productivity Presents applications of algae in the area of wastewater treatment and resource recovery Provides case studies and technoeconomic analysis to understand the algal biorefinery Shashi Kant Bhatia, PhD, is an Associate Professor in the Department of Biological Engineering, Konkuk University, Seoul, South Korea. Sanjeet Mehariya, PhD, is a Postdoctoral Researcher in the Department of Chemistry, Umea University, Umea, Sweden. Obulisamy Parthiba Karthikeyan, PhD, is a Research Scientist and Lecturer (Adjunct) in the Department of Civil and Environmental Engineering, South Dakota School of Mines and Technology, Rapid City, South Dakota, USA.

The scope of opportunities in chemical and biomolecular engineering has grown tremendously in recent years. Careers in Chemical and Biomolecular Engineering conveys the breadth and depth of today's chemical and biomolecular engineering practice, and describes the intellectually enriching, socially conscious and financially lucrative opportunities available for such graduates in an ever-widening array of industries and applications. This book aims to help students interested in studying chemical engineering and biomolecular engineering to understand the many potential career pathways that are available in these dynamic fields - and is an indispensable resource for the parents, teachers, advisors and guidance counselors who support them, In addition to 10 chapters that discuss the roles such graduates play in many diverse industries, this book also features 25 Profile articles that share in-depth, first-person insight from industry-leading chemical and biomolecular engineers. These technical professionals discuss their work and educational experiences (in terms of both triumphs and challenges), and share wisdom and recommendations for students pursuing these two dynamic engineering disciplines.

Directs the attention to the smart digital healthcare system in this COVID-19 pandemic. Simulates novel investigations and how they will be beneficial in understanding the pandemic. Presents the latest ideas developed for data scientists, doctors, engineers, and economists. Analyses the various issues related to computing, AI apps, big data analytic techniques, and predictive scientific skill gaps. Explains some interesting and diverse types of challenges and data-driven healthcare applications.

This book provides a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. This authors examine microfluidics based diagnosis in the biomedical field as an upcoming field with extensive applications. It provides a unique approach and comprehensive technology overview for diagnosis management towards early stages of various bioanalytes via cancer diagnostics diabetes, alzheimer disease, toxicity in food products, brain and retinal diseases, cardiovascular diseases, and bacterial infections etc. Thus, this book would encompass a combinatorial approach of medical science, engineering and biomedical technology. The authors provide a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. Moreover, this book contains detailed description on the diagnosis of novel techniques. This book would serve as a guide for students, scientists, researchers, and microfluidics based point of care technologies via smart diagnostics and to plan future research in this valuable field.