Mesenchymal Stromal Cells: Translational Pathways to Clinical Adoption provides the latest information on the necessary steps for successful production of stem cells for a clinical trial. Written by professionals with hands-on experience in bringing MSC therapies to the clinic, and building on the biology and mechanisms of action, this unique book covers the development and production of clinical-grade products that are suitable for use in humans. From design of a cell production facility, to obtaining regulatory approval and reimbursement issues, it is a useful guide for researchers and administrators across biomedical research.

Monitoring and Evaluation of Biomaterials and Their Performance In Vivo provides essential information for scientists and researchers who need to assess and evaluate performance, monitor biological responses, gauge efficacy, and observe changes over time. Crucially, it also enables the optimization of design for future biomaterials and implants. This book presents readers with comprehensive coverage of the topic of in vivo monitoring of medical implants and biomaterials.

Biomaterials and medical devices must be rigorously tested in the laboratory before they can be implanted. Testing requires the right analytical techniques. Characterization of biomaterials reviews the latest methods for analyzing the structure, properties and behaviour of biomaterials. Beginning with an introduction to microscopy techniques for analyzing the phase nature and morphology of biomaterials, Characterization of biomaterials goes on to discuss scattering techniques for structural analysis, quantitative assays for measuring cell adhesion, motility and differentiation, and the evaluation of cell infiltration and tissue formation using bioreactors. Further topics considered include studying molecular-scale protein-surface interactions in biomaterials, analysis of the cellular genome and abnormalities, and the use of microarrays to measure cellular changes induced by biomaterials. Finally, the book concludes by outlining standards and methods for assessing the safety and biocompatibility of biomaterials. With its distinguished editors and international team of expert contributors, Characterization of biomaterials is an authoritative reference tool for all those involved in the development, production and application of biomaterials.

Biofilms and Implantable Medical Devices: Infection and Control explores the increasing use of permanent and semi-permanent implants and indwelling medical devices. As an understanding of the growth and impact of biofilm formation on these medical devices and biomaterials is vital for protecting the health of the human host, this book provides readers with a comprehensive treatise on biofilms and their relationship with medical devices, also reporting on infections and associated strategies for prevention.

Current Developments in Biotechnology and Bioengineering: Human and Animal Health Applications provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, presenting data-based scientific knowledge and information on medical biotechnological interventions for human and animal health. Drawing on the key development areas in this field, the book reviews biotechnological advances and applications in immunotechnology, vaccines and vaccinology, combinatorial libraries, gene and cell therapy, tissue engineering, and parasite and infectious disease diagnostics. This title outlines why biotechnological techniques in these areas are useful in a clinical context and considers their potential uses, limitations, and the ethical considerations surrounding their use.

Current Developments in Biotechnology and Bioengineering: Crop Modification, Nutrition, and Food Production provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, presenting data-based scientific knowledge on agribiotechnology and describing world agriculture and the role biotechnology can play in ensuring food security over the next fifty years. The book discusses the effects of climate change in agriculture and the resultant emergence of new crops, including drought tolerant and more nutritious plants. In addition, the book discusses insect and virus resistance in plants and outlines plant metabolic engineering for agriculture, genetically engineered plants, and microbial diseases.

Current Developments in Biotechnology and Bioengineering: Production, Isolation and Purification of Industrial Products provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, focusing on industrial biotechnology and bioengineering practices for the production of industrial products, such as enzymes, organic acids, biopolymers, and biosurfactants, and the processes for isolating and purifying them from a production medium. During the last few years, the tools of molecular biology and genetic and metabolic engineering have rendered tremendous improvements in the production of industrial products by fermentation. Structured by industrial product classifications, this book provides an overview of the current practice, status, and future potential for the production of these agents, along with reviews of the industrial scenario relating to their production.

Current Developments in Biotechnology and Bioengineering: Solid Waste Management provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, reviewing the latest innovative developments in environmental biotechnology and bioengineering as they pertain to solid wastes, also revealing current research priority areas in solid waste treatment and management. The fate of solid wastes can be divided into three major areas, recycling, energy recovery, and safe disposal. From this foundation, the book covers such key areas as biotechnological production of value added products from solid waste, bioenergy production from various organic solid wastes, and biotechnological solutions for safe, environmentally-friendly treatment and disposal. The state of the art situation, potential advantages, and limitations are discussed, along with proposed strategies on how to overcome limitations.

Current Developments in Biotechnology and Bioengineering: Biological Treatment of Industrial Effluents provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends in data-based scientific knowledge and advanced information on the role and application of environmental biotechnology and engineering in the treatment of industrial effluents. These treatment processes have been broadly classified under aerobic and anaerobic processes which determines the scope and level of pollutant removal. Chapters in this volume review the most recent developments and perspectives at different environmental cleanup operation scales.

Current Developments in Biotechnology and Bioengineering: Food and Beverages Industry provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends compiled from the latest ideas across the entire arena of biotechnology and bioengineering. This volume reviews current developments in the application of food biotechnology and engineering for food and beverage production. As there have been significant advances in the areas of food fermentation, processing, and beverage production, this title highlights the advances in specific transformation processes, including those used for alcoholic beverage and fermented food production. Taking a food process and engineering point-of-view, the book also aims to select important bioengineering principles, highlighting how they can be quantitatively applied in the food and beverages industry.

Current Developments in Biotechnology and Bioengineering: Functional Genomics and Metabolic Engineering provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends in the field, compiling the latest ideas from across the entire arena of biotechnology and bioengineering. This volume provides data-based scientific knowledge and state-of-art information on functional genomics and metabolic engineering. It covers the core subjects of functional genomics, such as epigenomics, metagenomics, genomics of extremophiles, genomics studies in nutrient transport, genomics of miRNA, and genomics of pathogenesis. An overview of metabolic engineering theories and approaches is supported with specific important examples of secondary metabolites, including Streptomyces, pentose utilization in E. coli, bacterial ethanol fermentation, yeast mediated benzaldehyde biotransformation, carotenoid production, acetic acid production by E. coli, and NADH regeneration.

Current Developments in Biotechnology and Bioengineering: Foundations of Biotechnology and Bioengineering is a package of nine books that compile the latest ideas from across the entire arena of biotechnology and bioengineering. This volume focuses on the underlying principles of biochemistry, microbiology, fermentation technology, and chemical engineering as interdisciplinary themes, constructing the foundation of biotechnology and bioengineering.

Platform Chemical Biorefinery: Future Green Chemistry provides information on three different aspects of platform chemical biorefinery. The book first presents a basic introduction to the industry beneficial for university students, then provides engineering details of existing or potential platform chemical biorefinery processes helpful to technical staff of biorefineries. Finally, the book presents a critical review of the entire platform chemical biorefinery process, including extensive global biorefinery practices and their potential environmental and market-related consequences. Platform chemicals are building blocks of different valuable chemicals. The book evaluates the possibility of renewable feedstock-based platform chemical production and the fundamental challenges associated with this objective. Thus, the book is a useful reference for both academic readers and industry technical workers. The book guides the research community working in the field of platform chemical biorefinery to develop new pathways and technologies in combination with their market value and desirability.

Cardiovascular disease is one of the leading causes of death in the world today. Thanks to major advances in circulatory biomaterials and medical devices over the past few decades, many complications of this prevalent disease can be managed with great success for prolonged periods. Biomaterials and devices for the circulatory system reviews the latest developments in this important field and how they can be used to improve the success and safety in this industry. Part one discusses physiological responses to biomaterials with chapters on tissue response, blood interface and biocompatibility. Part two then reviews clinical applications including developments in valve technology, percutaneous valve replacement, bypass technologies and cardiovascular stents. Part three covers future developments in the field with topics such as nanomedicine, cardiac restoration therapy, biosensor technology in the treatment of cardiovascular disease and vascular tissue engineering. With its distinguished editors and international team of contributors Biomaterials and devices for the circulatory system is a vital reference for those concerned with bioengineering, medical devices and clinicians within this critical field.

Biotechnology has impacted the textiles industry through the development of more efficient and environmentally friendly manufacturing processes, as well as enabling the design of improved textile materials. This book will provide a thorough overview of current and future focuses of biotechnology in the fibre and textile industry. Part one of the book opens with a review of technologies involved in textile biotechnology. Chapters explore the design and engineering of novel enzymes for textile applications and developments in processes and equipment for enzymatic textile treatments. Part two investigates the modification of particular fibres through the use of biotechnology. Key topics include the treatment of wool and silk fibres and the enzymatic treatment versus conventional processing of cotton. With expert contributions from leaders in their fields, Advances in textile biotechnology is a comprehensive guide for those in the textile and fibre industry, as well as experts in the biology, chemical and environmental engineering industries.

Adverse Effects of Engineered Nanoparticles: A Disease-Oriented Approach provides a systematic evaluation of representative engineered nanomaterial (ENM) of high volume production and of high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies and the general public need to know about nanosafety. This book, written by leading international experts in nanotoxicology and nanmoedicine, gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers and patients. The beneficial applications, both diagnostic and therapeutic, of ENM are also highlighted. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, and the clinical and pathological consequences of such exposure in the human population.