Provides insight to extremophiles. Unveils the mysticism of extreme environments. Explores applications of extremophiles in biorefineries. Throws light on the advancement of industrially important extremozymes. Explores applications in biofilms and microbial corrosion.

This book provides a review of innovative and novel biotechnological techniques that can be implemented to assess, analyze, and mitigate harmful pollutants and wastes that result from agricultural and industrial operations. It helps to meet the much-needed demand for improvement of low-cost technologies that tackle pollution problems scientifically for the safeguard of the environment, focusing on bioremediation solutions that also create useful and renewable forms of energy. The biotechnological interventions discussed in the volume include approaches involving genomics, proteomics, transcriptomics, metabolomics, and fluxomics. In addition, biological agents such as microalgae, bacteria, fungi, and bacteriophage, which can also prove to be helpful in the elimination of wastes, are explored. Topics in Environmental Biotechnology: Sustainable Remediation of Contamination in Different Environs include the associated consequences and hazards from agricultural and industrial waste and a variety of bioremediation measures, including the use of bioaugmentation, biosensors, challenges of biofuel production, and more. The book is directed to researchers, scientists, industrialists, farmers, agricultural waste management authorities, as well as to faculty and students, and aims to help implement these novel technologies for environmental stability.

Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases. This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines. Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.

makes the case that through biological and, especially, cultural evolution the human diet can gravitate away from farmed meat and dairy products and to create a vegan economy. calls for legislative leaders, policy makers, and educators to shift away from animal farming and inform people about the advantages of a vegan culture argues that we have to start thinking collectively about smarter ways of growing and processing plant foods, not farming animals as food to generate good consequences for health, the environment, and, therefore, animals. essential reading for all interested in veganism, whether for ethical, environmental or health and nutrition reasons, and those studying the human diet from a range of disciplines, including cultural evolution, food ecology, animal ethics and evolutionary studies.

Covers recent progress on green catalysts derived from biomass Explores biomass conversion to different resources Introduces utilization of bio-waste in environmental aspects Discusses biomass applications in different types of energy Proposes microbial waste biomass as a resource of renewable energy

Emphasizes recent advances in biotechnological techniques that could ameliorate the high level global food insecurity through fermentation technologies applicable to traditional African indigenous and underutilized novel foods, algal biotechnology and value-added bio-products. Provides detailed information on how to harness indigenous bio-resources including microalgae for food and nutrition security, climate change adaptation, industrial enzyme production, environmental remediation, and health care delivery Introduces new frontiers in the area of large scale enzyme production using fermentation biotechnologies and their applications in the food and beverage industries Discusses current biotechnologies applicable in the food, beverage and bioproduct industries

Emphasizes recent advances in biotechnologies that will help in tackling emerging global health challenges Provides detailed information on how to harness indigenous bio-resources including microorganisms and plants for health care delivery Introduces new frontiers in the area of molecular diagnostics and DNA forensic science and bioinformatics with case studies, recent advances in medical insect biotechnology, molecular genetics of pest towards the exploitation of arthropod midgut components to develop interventions against infectious diseases Reviews bioactive molecules derived from commonly used and underutilized medicinal plants that could be used to develop novel drugs for improved healthcare delivery Discuss current approaches in medical and biopharmaceutical biotechnology, deployment of inexpensive genomics-based vector surveillance for effective disease outbreak prediction and control of mosquito-borne viruses

This book covers the very important principle of nanobiotechnology as applied in the petroleum industry and how it can be used for Oil recovery Microbial enhanced oil recovery Petroleum refinery, such as, for example, desulfurization, denitrogenation, demetallization, biotransformation, and bio-upgrading Bioremediation of oil polluted soil and water Mitigation of microbial corrosion and bio-fouling Toxicity of nano-materials and its obstacles upon application Nanobiotechnology in petroleum industry and the 17 goals of sustainable development.

Emphasizes recent advances in biotechnology that could ameliorate the high level global food insecurity through the deployment of the technology in Nigeria. Provides detailed information on how to domesticate biotechnology and boost training of the biotechnology workforce in the universities and research institutes Introduces new frontiers in the area of organizing informal biotechnology capacity building courses and professional certification Reviews biosafety and bioethical guidelines that could enhance adoption of biotechnology in alignment with national priorities and research agenda Discuss current biotechnology policy advocacy, enlightenment and public engagement with stakeholders and Policy makers

First published in 1982 . This report examines the application of classical and molecular genetic technologies to micro-organisms, plants, and animals. This book is one of the first comprehensive documents on emerging genetic technologies and their implications for society. The authors discuss the opportunities and problems involved, describe current techniques, and attempt to project some of the economic, environmental, and institutional impacts of those techniques. The issues they raise go beyond those of technology, utility, and economic feasibility. As we gain the ability to manipulate life, we must face basic questions of just what life means and how far we can reasonably-and safely-allow ourselves to go.

Polymer Coatings: Technologies and Applications provides a comprehensive account of the recent developments in polymer coatings encompassing novel methods, techniques, and a broad spectrum of applications. The chapters explore the key aspects of polymer coatings while highlighting fundamental research, different types of polymer coatings, and technology advances. This book also integrates the various aspects of these materials from synthesis to application. Current status, trends, future directions, and opportunities are also discussed. FEATURES Examines the basics to the most recent advances in all areas of polymer coatings Serves as a one-stop reference Discusses polymer-coated nanocrystals and coatings based on nanocomposites Describes morphology, spectroscopic analysis, adhesion, and rheology of polymer coatings Explores conducting, stimuli-responsive, self-healing, hydrophobic and hydrophilic, antifouling, and antibacterial polymer coatings Covers modeling and simulation With contributions from the top international researchers from industry, academia, government, and private research institutions, both new and experienced readers will benefit from this applications-oriented book. Sanjay Mavinkere Rangappa is a research scientist at the Natural Composites Research Group Lab, Academic Enhancement Department, King Mongkut's University of Technology North Bangkok, Thailand. Jyotishkumar Parameswaranpillai is a research professor at the Center of Innovation in Design and Engineering for Manufacturing, King Mongkut's University of Technology North Bangkok, Thailand. Suchart Siengchin is a professor at and president of King Mongkut's University of Technology North Bangkok, Thailand.

In this sophisticated examination of the EU regulatory framework for GMOs, Naveen Thayyil identifies a worrying shortfall between the commitment to public participation and its implementation-a deficit that results in a failure fully to engage the public in debates that represent their concerns (whether about what is 'safe' or what is 'right'). For anyone who senses that our technological futures are too important to be left to the 'experts', this is a book to be read.' - Roger Brownsword, King's College London, UKThis thoughtful book explores how EU law treats serious disagreements about the development and use of a radically new technology like genetic modification. Relevant EU laws are examined to analyze the room available, or possible, for public participation in the EU regulation of GMOs. Since linkages between law, technology and public contestations could have a crucial dimension in the shaping of democratic societies, the space that EU law provides for publics (outside of the scientific experts who shape the regulation of GMOs) becomes significant. By examining the employment of the precautionary principle and (advice from) public bioethics committees in GMO regulation, this book examines the policy claim that public participation as a regulatory mechanism represents and mediates public contestations about the use and regulation of GMOs. Biotechnology Regulation and GMOs will be of great interest to researchers, academics, students, policy advisors, decision-makers and other professionals involved in the fields of law, biotechnology, innovation systems, science and technology policy, as well as development. Federal regulators and industry representatives will also find much to interest them in this detailed study. Contents: 1. Introduction 2. The EU Legal Framework for GMO Regulation 3. Risk, Science and Society 4. Precaution, Public Participation and Technocratic Responses 5. Participation in Safety and Public Morals Regulation Ambit in Global Rules 6. Public Contestations and Pursuit of Public Values Index

The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.

Nanomedicine, a scientific branch of nanotechnology that operates on the same scale as biology, offers the possibility of influencing the healing process from inside of the body by manipulating the matter at cellular or molecular levels. Throughout this book, current healing approaches based on this revolutionary new technology are summarized from a scientific assessment. The aim of the authors is to give, through select examples, a deep insight to nanotechnology status and the great progress that its rigorous application will bring to human health. The authors' commitment is to broaden the vision of health professionals who will eventually be the future users of this knowledge.

The first and only book on Spray-freeze-drying" which is a relatively recent drying technique, that provides the signature advantages of spray-drying and freeze-drying, while overcoming the limitations of both. Provides examples and case studies of nuances and intricacies associated with each stage of the spray-freeze-drying process Contains 200+ illustrations and tabulations Highlights the applications of spray-freeze-drying in the production of food products including soluble coffee, dairy powders, probiotics, and flavors.

Biodesign in the Age of Artificial Intelligence: Deep Green investigates the potential of nature based technology for shaping the evolution of contemporary architecture and design. It takes on the now pervasive topic of design intelligence, extending its definition to encompass both biological and digital realms. As in their first title, Systemic Architecture: Operating Manual for the Self Organizing City, the authors engage the topic through the specific lens of their innovative design practice, ecoLogicStudio and their research at the University of Innsbruck and at the Bartlett, UCL. Part One of the book, entitled PhotoSynthetica (TM), illustrates design solutions that engage the urban microbiome and seek to achieve an immediate impact, while Part Two, entitled Deep Green, includes synthetic landscapes and operates within a much larger spatio-temporal frame, going beyond human perception and life span to envision design as a geographical and geological force. In the age of catastrophic climate change, such perceptual expansion helps to clarify that change cannot simply be stopped or rolled back. We must instead establish more positive dynamics of change within the living world. To this end, this book proposes to engage with design and architecture as an extended cognitive interface, a sentient being that is co-evolutionary and symbiotic with the living planet, contributing to its beauty and to our continued enjoyment of it.

A New York Times bestseller.

Winner of the Financial Times/McKinsey Business Book of the Year Award.

'Chilling . . . Reads like a West Coast version of All the President’s Men.' New York Times Book Review

The full inside story of the breathtaking rise and shocking collapse of Theranos, the multibillion-dollar biotech startup, by the prize-winning journalist who first broke the story and pursued it to the end, despite pressure from its charismatic CEO and threats by her lawyers.

In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup "unicorn" promised to revolutionize the medical industry with a machine that would make blood testing significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at more than $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.

In Bad Blood, John Carreyrou tells the riveting story of the biggest corporate fraud since Enron, a tale of ambition and hubris set amid the bold promises of Silicon Valley.

Now to be adapted into a film, with Jennifer Lawrence to star.

An integrated approach to provide information about all aspects of cancer biology, diagnosis and therapy. Covers both conventional and emerging tools/ techniques applicable in cancer screening and diagnosis. Covers the mechanisms of conventional and emerging anticancer drugs and therapies. Provides insights about personalized medicine based approach in cancer diagnosis and therapy.

This volume provides detailed technical protocols on current biomedical technologies and examples of their applications and capabilities. Chapters focus on molecular and cellular analytical methods, experimental new drug delivery approaches, guided surgery, implants and tissue engineering. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Biomedical Engineering Technologies, Volume 2 provides technical details in descriptions of major technologies by experts in the field.

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Multiple myeloma is a form of bone cancer. Specifically, it is a cancer of the plasma cells found in bone marrow (bone soft tissue). Normal plasma cells are an important part of the immune system. Mathematical models for multiple myeloma based on ordinary and partial differential equations (ODE/PDEs) are presented in this book, starting with a basic ODE model in Chapter 1, and concluding with a detailed ODE/PDE model in Chapter 4 that gives the spatiotemporal distribution of four dependent variable components in the bone marrow and peripheral blood: (1) protein produced by multiple myeloma cells, termed the M protein, (2) cytotoxic T lymphocytes (CTLs), (3) natural killer (NK) cells, and (4) regulatory T cells (Tregs). The computer-based implementation of the example models is presented through routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers using the R routines that are available through a download. The PDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences.

The handbook provides an understanding of consolidated processing and biorefinery systems for the production of bio-based chemicals and value-added bioproducts from renewable sources. The chapters look at a variety of bioenergy technological advances and improvements in the energy and materials sectors that aim to lower our dependence of fossil fuels and consequently reduce greenhouse gas (GHG) emissions. The volume looks at a selection of processes for the production of energy and biomaterials, including the Fischer-Tropsch process, gasification, pyrolysis, combustion, fermentation from renewable sources (such as, plants, animals and their byproducts), and others. Applications that are explored include transportation fuels, biodiesel production, wastewater treatment, edible packaging, bioplastics, physical rehabilitation, tissue engineering, biomedical applications, thermal insulation, industrial value compounds, and more. All of the topics covered in this publication address consolidated processes that play a pivotal role in the production of bioenergy and biomaterials because these processes require fewer unitary operations needed in the process, leading to a more direct method of production. This type of production system contributes to decreasing negative effects on the environment, lowering costs, saving energy and time, and improving profitability and efficiency. This volume will be valuable for the industrial sector, for researchers and scientists, as well as for faculty and advanced students.

This book critiques the decision-making process in Article 53(a) of the European Patent Convention. To date, such decisions have been taken at high levels of expertise without much public involvement. The book eschews traditional solutions, such as those found within legislative, judicial and patent office realms and instead develops a radical blueprint for how these decisions can be put to the public. By examining wide-scale models of participatory democracy and deliberation, this book fills a significant gap in the literature. It will be invaluable for patent lawyers, academics, practitioners and intellectual property and patent officials.

Nanomaterials in the Battle Against Pathogens and Disease Vectors presents an overview of the use of nanotechnology to mitigate pathogens of concern, and is the first book to discuss applications of nanotechnology in the fight against all three major domains of disease-causing pathogens. Bacteria, viruses, and parasites constitute the list of emerging and re-emerging pathogens of high priority. Nanotechnology has proven to be a groundbreaking success in the elimination, targeted toxicity, precise immunogenicity, diagnosis, and imaging of these major pathogens and disease vectors. This text discusses basic concepts and advanced applications for bacteria, viruses, and parasites. It describes the use of metallic and non-metallic nanoparticles and nanotoxicity, as well as presents future applications of nanotechnology in biological applications. This work is ideal for engineers and scientists across the interdisciplinary fields of materials science, biomedical engineering, biotechnology, and others concerned with mitigating the risk and effect of pathogens.

This new volume provides an abundance of information on new biomedical applications being used today. The book covers a wide range of concepts and technologies, discussing such modern technological methods as the Internet of Things, e-pills, biomedical sensors, support vector machines, wireless devices, image and signal processing in e-health, and machine learning. It also includes a discussion on software implementation for the devices used in biomedical applications. The different types of antennas, including antennas using RF energy harvesting for biomedical applications, are covered as well.