Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.

This book highlights the characteristics, aims, and applications of bionanotechnology as a possible solution for sustainable management and bioremediation of environmental pollutants. It covers remediation of toxic pollutants, removal of emerging contaminants from industrial wastewater, eco-design and modification study of bio-nanoparticles and life-cycle assessment, nano-filtration, bio-nanomaterials based sensors for monitoring air and water pollution, resource recovery from wastewater, and highlights Internet of things-based green nanotechnology. Provides a comprehensive solution of environmental problems in sustainable and cost-effective mode Reviews bionanotechnological applications in nanomaterials design, modification, and treatment of emerging contaminants from industrial wastewater. Covers Eco-design study of bio-nanomaterials, bio-nano filters, and assessment for the treatment of emerging pollutants Includes IoT- based bionanotechnology Explores future research needs on bionanotechnology and scientific challenges in the mitigation of environmental pollutants This book is aimed at researchers, professionals, and graduate students in nanobiotechnology, environmental engineering, biotechnology.

Covers applications of various image processing techniques in thermal imaging applications for diagnosis of different medical conditions Describes the development of a computer diagnostics system (CAD) based on thermographic data Discusses customized deep learning models for accurate diagnosis of various diseases Includes new aspects in rheumatoid arthritis and diabetes research with usage of advanced analytical tools Reviews application of feature fusion algorithms and feature reduction algorithms for accurate classification of images

Concise yet comprehensive resource presenting the foundations of nonlinear optical microscopy Foundations of Nonlinear Optical Microscopy brings together all relevant principles of nonlinear optical (NLO) microscopy, presenting NLO microscopy within a consistent framework to allow for the origin of the signals and the interrelation between different NLO techniques to be understood. The text provides rigorous yet practical derivations, which amount to expressions that can be directly related to measured values of resolution, sensitivity, and imaging contrast. The book also addresses typical questions students ask, and answers them with clear explanations and examples. Readers of this book will develop a solid physical understanding of NLO microscopy, appreciate the advantages and limitations of each technique, and recognize the exciting possibilities that lie ahead. Foundations of Nonlinear Optical Microscopy covers sample topics such as: Light propagation, focusing of light, pulses of light, classical description of light-matter interactions, and quantum mechanical description of light-matter interactions Molecular transitions, selection rules, signal radiation, and detection of light Multi-photon fluorescence and pump-probe microscopy Harmonic generation, sum-frequency generation, and coherent Raman scattering Senior undergraduate and graduate students in chemistry, physics, and biomedical engineering, along with students of electrical engineering and instructors in both of these fields, can use the information within Foundations of Nonlinear Optical Microscopy and the included learning resources to gain a concise yet comprehensive overview of the subject.

Shows the importance of plant tissue culture and transgenic technology on plant biology research and its application to agricultural production Provides insight into what may lie ahead in this rapidly expanding area of plant research and development Contains contributions from major leaders in the field of plant tissue culture and transgenic technology

Develop a healthier connection between worker and work with this practical introduction The United States Bureau of Labor Statistics estimates that 34% of all workdays lost each year are the result of work-related musculoskeletal disorders (WMSDs). These disorders result from a mismatch between a worker, their working conditions, and the task they perform. Improperly designed tasks or equipment, insufficient downtime between shifts or tasks, or even simple sitting position can all produce WMSDs. The key insights into preventing these disorders are produced by ergonomics, the scientific study of human bodies as they relate to objects, systems, and environments, especially work environments. Occupational Ergonomics: A Practical Approach aims to supply an ergonomic toolkit for creating healthier relationships between workers' bodies and their work. Beginning with a set of foundational ergonomic principles, it then details multiple assessment techniques in ways easily adapted to specific workplace situations. This balance of theory and practice has made Occupational Ergonomics an essential reference concerning human beings and the work they do. Readers of the second edition will also find: Up-to-date ergonomic research reflecting the latest clinical and workplace data. Entirely new chapters on Work Physiology, Total Worker Health, Return on Investment, and more. Major revisions to chapters on Elements of an Ergonomic Program, Workstation Design, Work-Related MSDs, How to Conduct an Assessments, and Office Ergonomics Detailed and updated case studies applying ergonomic assessment techniques to common workplace scenarios. Occupational Ergonomics is a must for workplace safety managers, safety coordinators, ergonomics program coordinators, facilities managers, and any professionals concerned with the work environment, and worker health and safety.

Provides a contemporary view of the impact of climate change on cultivation of various fruit species. Offers modern approaches for mitigating the adverse impact of climate change on fruits cultivation. Describes case studies, empirical experiments and observations emphasizing the research progress of understanding and combating the impact of climate change on fruits production. Illustrates presented concepts with relevant figures and tabulated data.

Biohydrogen is a promising gaseous biofuel that has prospective applications in combined heat and power, for fuel cells, or as a precursor for chemicals production. Hydrogen can also be converted to liquid hydrocarbon fuels and value-added chemicals through catalytic thermochemical or through biocatalytic biological pathways. This book covers some the important recent advances in the production and utilization of biohydrogen and its solutions for clean fuel, waste management, waste valorization, reduced greenhouse gas emissions, and climate change mitigation. Biohydrogen: Developments and Prospects first covers the basic principles, benefits, and challenges concerning both the biological and thermochemical routes for biohydrogen production and then goes on to address topics such as biomass conversion to hydrogen through gasification with a focus on the process parameters, catalytic reforming technologies for hydrogen production concerning various feedstocks; the co-conversion of plastic wastes and biomass into biohydrogen through co-gasification technology; the effect of process parameters on syngas yields through co-gasification; fermentative hydrogen production technologies; the molecular mechanism of hydrogen production and enhancing the yield in hydrogen production by genetic and metabolic engineering; hydrogen production routes through microbial electrolysis; and much more. Key features: Helps to provide the most up-to-date information addressing solutions for clean fuel, waste management, waste valorization, reduced greenhouse gas emissions, and climate change mitigation Offers in-depth knowledge about recent developments on thermochemical methanation technologies and bioreactor and bioprocess design in anaerobic digestion technologies Discusses biotechnological interventions for metabolic engineering of microorganisms towards biohydrogen production Looks at gasification technologies and catalytic reforming technologies for hydrogen production Addressing both the fundamentals as well as advanced new technological research on biohydrogen production by focusing on recent global research with emphasis on the technological, environmental, socioeconomic, and techno-economic aspects, this volume will be a valuable resource for faculty and advanced students, chemical and biochemical engineers, bioprocess technologists, biochemists, environmental scientists and researchers as well as theoretical and applied statisticians and policymakers in this area.

The replacement of fossil-derived compounds by bio-based fuels and chemicals is crucial for the implementation of a sustainable bioeconomy. In this context, microorganisms are key players for biofuels' production from renewable sources. Biotechnological biofuel production processes require conversion microorganisms capable of both efficiently assimilating renewable low-cost carbon sources and diverting their metabolisms towards the specific biofuel. Exploring the wide diversity of microorganisms available on Earth will surely aid to make the production of green fuels a reality. This book gives a wide overview of different microbial-based processes for green fuels production. The book also includes techno-economic analysis and highlights strategic, commercial and environmental interests in promoting green fuels. All these facts make this book very valuable not only for the scientific community but also for biofuel companies and policy makers.

Microfluidic biochips have gained prominence due to their versatile applications to biochemistry and health-care domains such as point-of-care clinical diagnosis of tropical and cardiovascular diseases, cancer, diabetes, toxicity analysis, and for the mitigation of the global HIV crisis, among others. Microfluidic Lab-on-Chips (LoCs) offer a convenient platform for emulating various fluidic operations in an automated fashion. However, because of the inherent uncertainty of fluidic operations, the outcome of biochemical experiments performed on-chip can be erroneous even if the chip is tested a priori and deemed to be defect-free. This book focuses on the issues encountered in reliable sample preparation with digital microfluidic biochips (DMFBs), particularly in an error-prone environment. It presents state-of-the-art error management techniques and underlying algorithmic challenges along with their comparative discussions. Describes a comprehensive framework for designing a robust and error-tolerant biomedical system which will help in migrating from cumbersome medical laboratory tasks to small-sized LOC-based systems Presents a comparative study on current error-tolerant strategies for robust sample preparation using DMFBs and reports on efficient algorithms for error-tolerant sample dilution using these devices Illustrates how algorithmic engineering, cyber-physical tools, and software techniques are helpful in implementing fault tolerance Covers the challenges associated with design automation for biochemical sample preparation Teaches how to implement biochemical protocols using software-controlled microfluidic biochips Interdisciplinary in its coverage, this reference is written for practitioners and researchers in biochemical, biomedical, electrical, computer, and mechanical engineering, especially those involved in LOC or bio-MEMS design.

The book provides background knowledge on the molecular biology of plants and a comprehensive description of plant biotechnology. It is in three parts. Part A deals with an overview of Plant Molecular Biology. Part B is concerned with Plant Tissue Culture. Part C is about Plant Genetic Engineering and Biotechnological Applications. Several transgenic applications dealt with in detail are in areas of engineering plants for stress tolerance, metabolic engineering of plants, transplastomic technology, crop protection, and antisense technology in plants. One of the highlights of this book is that it presents the concepts of both plant molecular biology and plant biotechnology.

This groundbreaking book is the first comparative analysis of the relative strengths of global bioregions. Growth Cultures investigates the rapidly growing phenomena of biotechnology and sets this study within a knowledge economy context. Philip Cooke proposes a new knowledge-focused theoretical framework, 'the New Global Bioeconomy', against which to test empirical characteristics of biotechnology. In this timely volume, Cooke unifies concepts from the sociology of science, economic sociology and evolutionary economic geography to focus on the problems and prospects for policy agencies worldwide trying to build 'biotechnology clusters'. He develops a superior policy approach of thinking in terms of platforms that integrate proximities and pipelines, which will be of significant interest for the scientific and technological communities as well as economic development policy communities. Growth Cultures will make fascinating reading for students, policy makers and researchers across management and business studies, innovation and knowledge studies, sociology, science and technology policy, applied economics, development studies and regional science.

Comprehensive Foodomics, Three Volume Set offers a definitive collection of over 150 articles that provide researchers with innovative answers to crucial questions relating to food quality, safety and its vital and complex links to our health. Topics covered include transcriptomics, proteomics, metabolomics, genomics, green foodomics, epigenetics and noncoding RNA, food safety, food bioactivity and health, food quality and traceability, data treatment and systems biology. Logically structured into 10 focused sections, each article is authored by world leading scientists who cover the whole breadth of Omics and related technologies, including the latest advances and applications. By bringing all this information together in an easily navigable reference, food scientists and nutritionists in both academia and industry will find it the perfect, modern day compendium for frequent reference. List of sections and Section Editors: Genomics - Olivia McAuliffe, Dept of Food Biosciences, Moorepark, Fermoy, Co. Cork, Ireland Epigenetics & Noncoding RNA - Juan Cui, Department of Computer Science & Engineering, University of Nebraska-Lincoln, Lincoln, NE Transcriptomics - Robert Henry, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Australia Proteomics - Jens Brockmeyer, Institute of Biochemistry and Technical Biochemistry, University Stuttgart, Germany Metabolomics - Philippe Schmitt-Kopplin, Research Unit Analytical BioGeoChemistry, Neuherberg, Germany Omics data treatment, System Biology and Foodomics - Carlos Leon Canseco, Visiting Professor, Biomedical Engineering, Universidad Carlos III de Madrid Green Foodomics - Elena Ibanez, Foodomics Lab, CIAL, CSIC, Madrid, Spain Food safety and Foodomics - Djuro Josic, Professor Medicine (Research) Warren Alpert Medical School, Brown University, Providence, RI, USA & Sandra Kraljevic Pavelic, University of Rijeka, Department of Biotechnology, Rijeka, Croatia Food Quality, Traceability and Foodomics - Daniel Cozzolino, Centre for Nutrition and Food Sciences, The University of Queensland, Queensland, Australia Food Bioactivity, Health and Foodomics - Miguel Herrero, Department of Bioactivity and Food Analysis, Foodomics Lab, CIAL, CSIC, Madrid, Spain

"Algae are mysterious and fascinating organisms that hold great potential for discovery and biotechnology." -Dr. Thierry Tonon, Department of Biology, University of York "Science is a beautiful gift to humanity; we should not distort it." -A.P.J. Abdul Kalam In this book, we emphasize the importance of algal biotechnology as a sustainable platform to replace the conventional fossil-based economy. With this focus, Volume 2 summarizes the up-to-date literature and knowledge and discusses the advances in algal cultivation, genetic improvement, wastewater treatment, resource recovery, commercial operation, and technoeconomic analysis of algal biotechnology. FEATURES Discusses in detail recent developments in algae cultivation and biomass harvesting Provides an overview of genetic engineering and algal-bacteria consortia to improve productivity Presents applications of algae in the area of wastewater treatment and resource recovery Provides case studies and technoeconomic analysis to understand the algal biorefinery Shashi Kant Bhatia, PhD, is an Associate Professor in the Department of Biological Engineering, Konkuk University, Seoul, South Korea. Sanjeet Mehariya, PhD, is a Postdoctoral Researcher at the Department of Chemistry, Umea University, Umea, Sweden. Obulisamy Parthiba Karthikeyan, PhD, is a Research Scientist and Lecturer (Adjunct) in the Department of Civil and Environmental Engineering, South Dakota School of Mines and Technology, Rapid City, South Dakota, USA.

What existential threats does humanity face? And how can we secure our future? 'The Precipice is a powerful book . . . Ord's love for humanity and hope for its future is infectious' Spectator 'Ord's analysis of the science is exemplary . . . Thrillingly written' Sunday Times We live during the most important era of human history. In the twentieth century, we developed the means to destroy ourselves - without developing the moral framework to ensure we won't. This is the Precipice, and how we respond to it will be the most crucial decision of our time. Oxford moral philosopher Toby Ord explores the risks to humanity's future, from the familiar man-made threats of climate change and nuclear war, to the potentially greater, more unfamiliar threats from engineered pandemics and advanced artificial intelligence. With clear and rigorous thinking, Ord calculates the various risk levels, and shows how our own time fits within the larger story of human history. We can say with certainty that the novel coronavirus does not pose such a risk. But could the next pandemic? And what can we do, in our present moment, to face the risks head on? A major work that brings together the disciplines of physics, biology, earth and computer science, history, anthropology, statistics, international relations, political science and moral philosophy, The Precipice is a call for a new understanding of our age: a major reorientation in the way we see the world, our history, and the role we play in it.

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development.

- Presents A rational holistic approach to use terrestrial biomass as a raw material - Comprises New techniques for converting waste biomass in added value materials - Describes The Methanol/ sulphuric acid system in cellulose saccharification - Reviews Fusion biomass straw in carbon fiber by acid impregnation techniques

Describe new developments in non-opsin-based optogenetic tools Introduce cutting-edge methods for precise modulation of cell signaling Highlight applications of optogenetic regulation of cellular functions Cover contributions from an international team of leading experts

Because of many misconceptions, the biological drug manufacturing industry does not fully utilize disposable components, despite their wide availability. These misconceptions include concerns for the quality of materials, running costs, scalability, the level of automation possible, and the training of staff needed to include these components in existing bioprocessing systems. Not fully realizing the long-term benefits, many manufacturers are unwilling to discard investments made in fixed equipment and traditional stainless steel systems. Regulatory and environmental concerns, however, will eventually compel manufacturers to adopt disposable systems. Making a strong case for disposables, Disposable Bioprocessing Systems demonstrates the true potential of these systems. Written by a researcher and professor with hands-on experience in designing, establishing, and validating biological manufacturing facilities worldwide, and creating model facilities using maximum disposable technology, this book is the first comprehensive introduction to understanding disposable systems. It gives an overview of the current state of the disposable bioprocessing industry, resolves all controversial issues, and guides readers in choosing disposable components that meet their needs. An important chapter on safety addresses facts and myths about the use of plastics and elastomers-including the issue of leaching-and how to ensure regulatory compliance. Helping readers understand their choices, the book describes the equipment and systems available to prepare the starting materials for the manufacturing of biological drugs-from disposable containers to filters. The author also discusses costs, regulations, and concerns about waste disposal, and shares his predictions for the future of the disposable bioprocessing industry. A practical manual for those interested in the transition to disposable systems, this book will also interest students of bioprocessing. It offers a timely view of disposable bioprocessing technology as a "game changer" that will facilitate developing new drugs and conducting research in the emerging field of stem cells and gene therapy.

Medicinal Plants, Volume 6 of the Genetic Resources, Chromosome Engineering, and Crop Improvement series summarizes landmark research and describes medicinal plants as nature's pharmacy. Highlights Examines the use of molecular technology for maintaining authenticity and quality of plant-based products Details reports on individual medicinal plants including their history, origin, genetic resources, cytogenetics, and varietal improvement through conventional and modern methods, and their use in pharmaceutical, cosmeceutical, nutrition, and food industries Explains how to protect plants with medicinal properties from deforestation, urbanization, overgrazing, pollution, overharvesting, and biopiracy Brings together information on germplasm resources of medicinal plants, their history, taxonomy and biogeography, ecology and biodiversity, genetics and breeding, exploitation, and utilization in the medicine and food industries Written by leading international experts and an innovative panel of scientists, Medicinal Plants offers the most comprehensive and up-to-date information on medicinal plant genetic resources and their increasing importance in pharmaceutical and cosmeceutical industries, medicine, and nutrition around the world. Includes eight-page color insert more than 25 full color figures.

Examining the chemical modification of biological polymers and the emerging applications of this technology, Chemical Modification of Biological Polymers reflects the change in emphasis in this subsection of biotechnology from the study of protein structure and function toward applications in therapeutics and diagnostics.

Highlights

• The basic organic chemistry of the modification proteins, nucleic acids, oligosaccharides, polysaccharides, and their applications
• New analytical technologies used to characterize the chemical modification of biological polymers
• Identification of in vivo, non-enzymatic chemical modification of biological polymers
• Specific chemical modifications to generate biopharmaceutical products

This book covers the basics on the organic chemistry underlying the chemical modification of biopolymers, including updates on the use of various chemical reagents. It describes the current status of chemical modification of biological polymers and emerging applications of this technology in biotechnology. These technologies are important for the manufacture of conjugate proteins used in drug delivery, for the preparation of nucleic acid microarrays, and for the preparation of hydrogels and other materials used in tissue engineering.

"Science is fun " Is the motto of this fun-filled book by Prof Reinhard Renneberg. Do you know that in Japan, washing machines have no "cooking program" thanks to enzyme detergents? How to make German-style beer from rice? How do you make real snow with dead frost-bacteria? Is using bio-ethanol as a car fuel going against our environment? How can you clone your neighbor's beautiful cat? How to eliminate breast cancer genes before a baby girl is born? Can the financial crisis be solved by breeding better stock market traders? How to measure the fitness of students? The questions are endless.
Cartoonists Manfred Bofinger (Germany) and Ming Fai Chow (Hong Kong) here together with Prof Renneberg, created a fireworks of stories with funny cartoons, which are easily digestable for the layman reader but at the same time will interest even the specialists. Through this collection of inspirational short stories, you will get a complete picture of the latest advances in modern biotechnology with no technical jargons, no equations and no animals harmed

This volume focuses on how waste biomass can be transformed into useful biomaterials, food and feed, fuel, and chemicals by using various processes such as chemical, physical, thermal, biological, and biotechnological procedures. Biomass from biowastes, such as agriculture crop residues, wood processing residues, forest residues, food waste, industrial waste, and municipal solid waste, have emerged as potential substrates for bioenergy production. This volume explores the key features of biotechnology for waste biomass utilization, presenting scientific and technical literature on sustainable waste biomass management as well as for biomass conversion for biofuels, chemicals, and other new commercial products. It discusses a variety of novel biotechnical applications and interventions, including microbial fermentation and anaerobic digestion, biotechnological modes of xylooligosaccharides production, multifaceted utilization of microalgal biomass, vermiculture and vermicomposting, and more. Key features: Provides the most recent information about waste biomass utilization for the production of biofuels and biochemicals Shows a wide range of novel technologies in the field of biotechnology towards waste biomass utilization Focuses on the utilization of microbial resources for waste biomass conversion into value-added products Explores methods for food wastes and crop wastes conversion into biofuels and biochemicals Provides the scientific information describing various examples and case studies which aid gaining knowledge to researchers and academicians With chapters from eminent researchers who have significant global experience in the field of waste biomass management, this volume delivers a wealth of valuable information for researchers involved in bioenergy utilization. It will also be an essential source for academicians, researchers, economists, policymakers, and policy analysts.

This book provides information essential to students taking courses/modules in biotechnology as part of environmental sciences, environmental management, and environmental biology programs. It is also suitable for those studying water, waste management, and pollution abatement. Topics discussed include biodiversity, renewable energy, bioremediation technology, recombinant DNA technology, genetic engineering, solid waste management, composting, vermicomposting, biofertilizer, chemical pesticides, biological control of pests, and genetically modified organisms. The book also discusses bioethics and risk assessment, intellectual property rights, environmental cleanup technologies, and environmental nanotechnology.