Fundamentals of Robotics presents the basic concepts of robots to engineering and technology students and to practicing engineers who want to grasp the fundamentals in the growing field of robotics.

Foreseeing and planning for all of the possibilities and pitfalls involved in bringing a biotechnology innovation from inception to widespread therapeutic use takes strong managerial skills and a solid grounding in biopharmaceutical research and development procedures. Unfortunately there has been a dearth of resources for this aspect of the field. Until now. Focusing on the management of healthcare-related biotech, from conception through the product's regulatory approval and entire life cycle, Healthcare Biotechnology: A Practical Guide provides a practical, applicable resource to assist all health-care related biotech professionals in their day-to-day activities from the lab to the boardroom. Divided into six sections, the book begins with current systems and recent progress and controversy, major players and products, and a comparison with the pharmaceutical industry. It covers intellectual property protection and management, the innovation cycle, patent application, commercialization, and competition. Coverage includes funding, partnering, cash-intensive activities, financing alternatives, and the complexities of alliance implementation and management. It highlights research, development, and biomanufacturing; and examines clinical trial design and regulations; "fast-track" approvals; and patient recruitment as well as production platforms and processes, costs, strategies, and timelines. It investigates marketing including planning, promotion, pricing, supply chain management, and bio-brand lifecycle management. It concludes with tips on running the business, offering diverse biobusiness models and reasonable expectations from inception through maturity and decline. An indispensible guide, this book offers more than 40 figures, 220 tables, and 180 references as well as a list of abbreviations and a business plan outline. Each chapter contains 10 questions to reinforce the material covered and 10 exercises

Uses the FPT to Solve the Quantification Problem in MRS An invaluable tool in non-invasive clinical oncology diagnostics Addressing the critical need in clinical oncology for robust and stable signal processing in magnetic resonance spectroscopy (MRS), Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications explores cutting-edge theory-based innovations for obtaining reliable quantitative information from MR signals for cancer diagnostics. By defining the natural framework of signal processing using the well-established theory of quantum physics, the book illustrates how advances in signal processing can optimize MRS. The authors employ the fast Pade transform (FPT) as the unique polynomial quotient for the spectral analysis of MR time signals. They prove that residual spectra are necessary but not sufficient criteria to estimate the error invoked in quantification. Instead, they provide a more comprehensive strategy that monitors constancy of spectral parameters as one of the most reliable signatures of stability and robustness of quantification. The authors also use Froissart doublets to unequivocally distinguish between genuine and spurious resonances in both noise-free and noise-corrupted time signals, enabling the exact reconstruction of all the genuine spectral parameters. They show how the FPT resolves and quantifies tightly overlapped resonances that are abundantly seen in MR spectra generated using data from encoded time signals from the brain, breast, ovary, and prostate. Written by a mathematical physicist and a clinical scientist, this book captures the multidisciplinary nature of biomedicine. It examines the remarkable ability of the FPT to unambiguously quantify isolated, tightly overlapped, and nearly confluent resonances.

This two volume set discusses the functions, metabolism and composition, biochemistry, illuminate materials, of fish and shellfish. It explores the utilization of byproducts from marine sources and explains the implications in the development and application of marine biochemistry. The two volume set discusses various approaches for extracting fish and shellfish, and the exploration and exploitation of Biochemistry of sea flora and fauna. The two volume set also examines essential elements and trace minerals that nurture various hormones produced in the human endocrine system that can regulate the metabolism and thereby provide safe and healthy options to treating diseases.

From the laboratory to full-scale commercial production, this reference provides a clear and in-depth analysis of bioreactor design and operation and encompasses critical aspects of the biocatalytic manufacturing process. It clarifies principles in reaction and biochemical engineering, synthetic and biotransformation chemistry, and biocell and enzyme kinetics for successful applications of biocatalysis and bioprocess technologies in the food, chiral drug, vitamin, pharmaceutical, and animal feed industries. Studying reactions from small to supramolecules, this reference provides an abundant supply of end-of-chapter problems to sharpen understanding of key concepts presented in the text.

From disease marker identification to accelerated drug development, Protein Arrays, Biochips, and Proteomics offers a detailed overview of current and emerging trends in the field of array-based proteomics. This reference focuses on innovations in protein microarrays and biochips, mass spectrometry, high-throughput protein expression, protein-protein interactions, structural proteomics, and the proteomic marketplace for comprehensive understanding of past, present, and future proteomic research. Offering an abundance of figures and charts, the book compiles a wide variety of technologies and applications ranging from functionalized chip surfaces to strategies for protein expression.

Radioembolization is a widely used treatment for non-resectable primary and secondary liver cancer. This handbook addresses the radiation biology, physics, nuclear medicine, and imaging for radioembolization using Yttrium-90 (90Y) microspheres, in addition to discussing aspects related to interventional radiology. The contents reflect on and off-label treatment indications, dose-response relationships, treatment-planning, therapy optimization, radiation safety, imaging follow-up and many other facets of this therapy necessary for both novice and advanced users alike.

Fate and transport models are critical components in the determination of the exposure to and risk from hazardous contaminants. Analytical models are preferable because they are generally more accessible, more reliable, and require fewer computational resources. Surprisingly, until today, only a limited number of analytical models have been accessible in the literature. Now, there is Diffusion Models of Environmental Transport, which provides more than 40 analytical models of diffusion and advective-diffusion in one, two, and three layer systems, subject to a wide range of boundary and initial conditions. This text illustrates applications to contaminant transport in sediments and soils, including porewater and vapor transport, and also provides Mathcad spreadsheets to aid in the use of these models. The authors supply complete details of the solutions to the models for those who wish for a deeper understanding. For others, who do not have the time or the need, the solutions themselves are ready to be picked up and used. Reible and Choy use their 20-plus years of cumulative experience to create a thorough exploration of fate and transport models. This comprehensive text furnishes an invaluable reference for students and environmental professionals.

Contributors from European and US universities and corporations review recent developments in the integration of downstream processing and bioconversion, describing their experience with many separation technologies, including some still in the experimental stage. The topics include the construction

Biosensors are analytical devices that combine a biologically sensitive element with a physical or chemical transducer to selectively and quantitatively detect the presence of specific compounds. Balancing basics, principles, and case studies, Biosensors: Microelectrochemical Devices covers the theory and applications of one class of biosensor-microelectrochemical devices. The book clearly explains microelectronic techniques used to produce these cheap, fast reacting, and disposable sensors with the aid of helpful diagrams and tables. Researchers and postgraduates active in the field of chemical sensors, analytical chemistry, or microelectronics will find this an invaluable reference.

The fast-growing sugarcane plant is a major source of sugar (sucrose) in tropical and sub-tropical regions. The high productivity of the plant also makes it a key target for use as an energy crop. The fiber of the plant is used to generate electricity and produce ethanol as a fuel. Sugarcane is a hybrid of two species, each of which is genetically complex. The high level of genetic complexity in sugarcane creates challenges in the application of both conventional and molecular breeding to the genetic improvement of sugarcane as a sugar and energy crop. This book describes technologies that support the continued use and improvement of sugarcane as source of food and energy. Recent technology developments indicate the potential to greatly increase our understanding of the sugarcane plant by application of emerging genomic technologies. This should result in an increased rate of improvement of sugarcane for human uses.

Covers the Fundamentals of Chiral Separation, Available Chiral Selectors, and Numerous Applications of Chiral Separation by Capillary Electrophoresis Since the 1980s, modern analytical tools have enabled capillary electrophoresis to become a standard part of the chemist's toolkit. With contributions from international experts, Chiral Separations by Capillary Electrophoresis provides a general overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. The book discusses the most important as well as several new chiral selectors used in capillary electrophoresis. It reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. The book also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available. Capillary electrophoresis has proven to be an effective tool for chiral separation. This book explains how this technique can be used in the separation of molecules, offering insight into both existing and emerging applications.

Worldwide energy and food crises are spotlighting the importance of bio-based products - an area many are calling on for solutions to these shortages. Biocatalysis and Agricultural Biotechnology encapsulates the cutting-edge advances in the field with contributions from more than 50 international experts comprising sectors of academia, industry, and government research institutes, a virtual Who's Who among biocatalysis scientists. Created Under the Editorial Guidance of Leading Biotechnology Experts With the aid of numerous graphs and illustrations, this authoritative reference documents such important advances as: Cloning and characterization of Kennedy pathway acyltransferases Engineering of plants for industrial uses New approaches from acquired tolerance to the biotic and abiotic stress of economically important crops This comprehensive text also explores a variety of bio-based industrial products, including: The modification of enzyme character through gene manipulation The biocatalytic synthesis of chiral intermediates for drug development The use of Omega-3 phospholipid nano capsules as effective forms for transporting immune response modifiers Providing in-depth reviews of this ancient field and its modern-day advances, Biocatalysis and Agricultural Biotechnology is an invaluable lab reference for teachers, graduate students, and industrial scientists conducting research in the biosciences.

Featuring in-depth discussions on tensile and compressive properties, shear properties, strength, hardness, environmental effects, and creep crack growth, "Mechanical Properties of Engineered Materials" considers computation of principal stresses and strains, mechanical testing, plasticity in ceramics, metals, intermetallics, and polymers, materials selection for thermal shock resistance, the analysis of failure mechanisms such as fatigue, fracture, and creep, and fatigue life prediction. It is a top-shelf reference for professionals and students in materials, chemical, mechanical, corrosion, industrial, civil, and maintenance engineering; and surface chemistry.

Industrial Waste Treatment Process Engineering is a step-by-step implementation manual in three volumes, detailing the selection and design of industrial liquid and solid waste treatment systems. It consolidates all the process engineering principles required to evaluate a wide range of industrial facilities, starting with pollution prevention and source control and ending with end-of-pipe treatment technologies. Industrial Waste Treatment Process Engineering guides experienced engineers through the various steps of industrial liquid and solid waste treatment. The structure of the text allows a wider application to various levels of experience. By beginning each chapter with a simplified explanation of applicable theory, expanding to practical design discussions, and finishing with system Flowsheets and Case Study detail calculations, readers can "enter or leave" a section according to their specific needs. As a result, this set serves as a primer for students engaged in environmental engineering studies AND a comprehensive single-source reference for experienced engineers. Industrial Waste Treatment Process Engineering includes design principles applicable to municipal systems with significant industrial influents. The information presented in these volumes is basic to conventional treatment procedures, while allowing evaluation and implementation of specialized and emerging treatment technologies. What makes Industrial Waste Treatment Process Engineering unique is the level of process engineering detail. The facility evaluation section includes a step-by-step review of each major and support manufacturing operation, identifying probable contaminant discharges, practical prevention measures, and point source control procedures. This theoretical plant review is followed by procedures to conduct a site specific pollution control program. The unit operation chapters contain all the details needed to complete a treatment process design. Industrial Waste Treatment Process Engineering will interest environmental engineers, chemical process engineers working in environmental engineering, civil engineers with environmental specialties, as well as graduate students in environmental engineering, corporate environmental engineers, plant engineers, and industry and university technical libraries. These books supplement existing texts detailing the regulatory, legal, and permit preparation requirements imposed on manufacturing facilities. Additionally, Industrial Waste Treatment Process Engineering is designed for engineers preparing environmental appropriations for corporate funding and developing systems for plant facilities sensitive to operating costs.

As we enter a new millennium, the environmental issues faced by both developing and industrialised nations are as pressing as ever. Environmental biotechnologies are increasingly being viewed as a major weapon against environmental damage. Cleaner production is part of this strategy and yet there is still widespread ignorance about this emerging technology. Environmental Biotechnology and Cleaner Bioprocesses provides this information at various levels, from introductory to advanced. The first section covers the development of cleaner bioprocesses within the framework of sustainable development. Aspects of environmental policy for small and medium businesses are then discussed using case studies to illustrate principles. The second section covers the recycling and treatment of organic waste, including the use of aquatic plants and microalgae for wastewater treatment and recovery of nutrients. Section three covers bioremediation technologies and finally, section four is dedicated to emerging cleaner bioprocesses and environmentally sound products. All chapters have been written and edited by leading authorities in the field. Students and professionals interested in environmental biotechnology and cleaner production will find the background information and detail they require in this one convenient source.

Combining elements of biochemistry, molecular biology, and immunology, artificial DNA can be employed in a number of scientific disciplines. Some of the varied applications include site-specific mutagenesis, hybridization, amplification, protein engineering, anti-sense technology, DNA vaccines, protein vaccines, recombinant antibodies, screening for genetic and pathogenic diseases, development of materials with new biochemical and structural properties, and many more. Artificial DNA: Methods and Applications introduces the concept of artificial DNA that has been rationally designed and explains how it may be exploited in order to develop products that will achieve your intended purpose. The first part of the book covers methods of oligonucleotide synthesis and direct applications of synthetic DNA. The second part describes methods of gene assembly from synthetic oligonucleotides and applications of synthetic genes. The authors also discuss the different trends and future developments within each application area . With state-of-the art research, the contributing authors describe how to engineer proteins using rational and semi-rational design to exhibit the desired traits and detail the various amplification reactions and hybridization techniques for modeling evolution and for use in basic research. The only text devoted to this subject, Artificial DNA offers a comprehensive review that allows you to understand the strategy, design, and applications of synthetic oligonucleotides.

This book explores how policies targeting public research institutions, such as universities, contribute to the appropriation of biotechnology through national innovation systems. Around the world, biotechnology has become a driving force for dramatic change in systems and policies intended to spur innovation. The leading contributors expertly construct a detailed picture of policy approaches that support biotechnology and how such approaches work under different economic and social conditions. They also provide an insight into the role of universities in this process. Researchers, academics, students, policy advisors, decision makers and other professionals involved in the fields of biotechnology, innovation systems, higher education and development will find this book an invaluable resource. Contributors: A. Adamsone-Fiskovica, S.G. Antunes de Souza, I. Bortagaray, T.N. Ca, J.E. Cassiolato, L.V. Chuong, A.M. da Graca Mondjana, B.D. Diyamett, B. Goeransson, B. Gregersen, J. Kristapsons, R. Lindner, A. Lulle, P. Macucule, N.P. Mai, E. Mneney, L.F. Montalvo Arriete, B.L.M. Mwamila, L. Neves, J. Nunez Jover, C.M. Palsson, I. Perez Ones, T.T. Phuong, M.S. Rapini, T. Reiss, C.M. Ribeiro, G. Sagieva, U. Schmoch, J. Sutz, E. Tjunina, L. Van Chuong, H. Wang, Z. Yuan, G.F. Zucoloto

Nanotechnology can be used to address challenges faced by the food and bioprocessing industries for developing and implementing improved or novel systems that can produce safer, nutritious, healthier, sustainable, and environmental-friendly food products. This book overviews the most recent advances made on the field of nanoscience and nanotechnology that significantly influenced the food industry. Advances in Processing Technologies for Bio-Based Nanosystems in Food provides a multidisciplinary review of the complex mechanisms involved in the research, development, production and legislation of food containing nanostructures systems. Features: Presents the most recent advances made in the field of nanoscience and nanotechnology as applied to the food industry Discusses innovative approaches and processing technologies Shows how nanotechnology can be used to produce safer, nutritious, healthier, sustainable and environmental-friendly food products Covers the complex mechanisms involved in the research, development, production and legislation of food containing nanostructures Selected examples of nanotechnology applications in food industry are shown, focusing on advanced aspects of food packaging, processing and preservation; followed by one contribution that presents the potential commercialization and the main challenges for scale-up. Comprised of 15 chapters, this book provides much-needed and up-to-date information on the use of emergent technologies in bio-based nanosystems for foods, and serves as an ideal reference for scientists, regulators, industrialists, and consumers that conduct research and development in the food processing industry.

Viruses do not behave as other microbes; their life cycles require infecting healthy cells, commandeering their cellular apparatus, replicating and then killing the host cell. Methods for virus detection and identification have been developed only in the past few decades. These recently developed methods include molecular, physical, and proteomic techniques. All these approaches (Electron Microscopy, Molecular, Direct Counting, and Mass Spectrometry Proteomics) to detection and identification are reviewed in this succinct volume. It is written in approachable language with enough detail for trained professionals to follow and want to recommend to others. Key Features Covers common detection methods Reviews the history of detection from antiquity to the present Documents the strengths and weaknesses of various detection methods Describes how to detect newly discovered viruses Recommends specific applications for clinical, hospital, environmental, and public health uses

Increase in antibiotic resistance has forced researchers to develop new drugs against microorganisms. Lipopeptides are produced as secondary metabolites by some microorganisms. Computer-aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates provides the identification of novel ligands for different antimicrobial lipopeptides. Along with identification, it also provides some of the in silico drug design processes, namely homology modelling, molecular docking, QSAR studies, drug ADMET studies and pharmacophore studies to check the ligand-lipopeptide interaction. Some lipopeptides have shown anti-cancerous properties too, and this book discusses the required templates to design new drugs using computational techniques. Key Features: Focuses on the use lipopeptides as new antimicrobial compounds Presents the basics of in silico modelling for design and development of new drug molecules, and is therefore of interest to beginners in the field Provides a step-by-step process for identification of drug molecules and testing its efficacy in silico Couples with courses on patents and intellectual property rights

Genetic engineering suggests new avenues for constructing useful products, but it also poses hazards to the health of the environment and the public. Delineating those hazards is complicated, difficult, and important at every level of risk assessment and risk management decision-making. Risk assessment and risk management may be further complicated by the need to discover more detailed information than is usually available. Genetically Engineered Organisms: Assessing Environmental and Human Health Effects gives credence to good science and to the notion that we do not have to argue about the ecological and human health effects of genetic engineering. Instead, it supports the position that we can undertake the painstaking science necessary to identify and understand those effects. Written by researchers who have done cutting edge research in disciplines such as botany, entomology, plant pathology, and other agricultural and environmental sciences, this book elaborates critical research on pollen movement, spread of transgenes in natural communities, fitness effects, resistance development, and unpredicted impacts on target and non-target organisms. These topics are explored in contexts ranging from Bt corn events and viral resistant oats to transgenic salmon and altered malarial vectors. Many chapters address theoretical and informational gaps that research presents to questions of biosafety, and some offer historical insights into factors that may affect risk assessment and risk management decision-making at the community, national, and international levels.

The overarching aim of Finance, Innovation and Geography: Harnessing Knowledge Dynamics in German Biotechnology is to explore linkages between geographies of finance and relational geographies of innovation. This is achieved by questioning how investment activities affect the unfolding of innovations and in turn are affected by it. This book focuses on biotechnology innovation processes from the perspective of relational economic geography. It reconstructs the unfolding in time and space of eight innovations in German biotechnology. Each one is represented in a qualitative case study. The analysis focuses on the relational work of building, transforming, ending and replacing of collaborative relationships and organizational arrangements surrounding emergent innovations including investment relations and relational work by investors. In this way, the contribution of investors to unfolding innovations is studied with sensitivity to context and situated interactions. The geography of these dynamics is conceptualized by drawing on the recent literature on relational proximity and distance as well as ideas of materiality and space. This book provides a unique perspective, and shows that innovation paths are strongly interwoven with local and temporary opportunities as well as crises, and that investment is embedded in these dynamics. This is essential reading for students and academics of both economics and innovation.

Introductory text for students of genetics is general and the students of agronomy as the book gives numerous agronomic applications.

We have previously described the syntheses of both magnetic and nonmagnetic polymeric microspheres, and we have reported their application in removal of neuroblastoma cells from normal cells in bone marrow, in the separation of red blood cells, and the separation of human B and T lymphocytes. In the present study, we describe a series of hydrophilic microspheres consisting of (1) poly-HEMA and (2) a copolymer sequence of HEMA-acrolein microspheres.