Production of Top 12 Biochemicals Selected by USDOE from Renewable Resources: Status and Innovation covers all important technological aspects of the production of biochemicals from renewable feedstock. All the important technological aspects of biomass conversion for example biomass pretreatment, enzymatic hydrolysis for cellulosic sugars production followed by the fermentation into chemicals and downstream recovery of the products is reviewed. Recent technological advancements in suitable microorganism development, bioprocess engineering for biomass conversion for cellulosic sugars production and various fermentation strategies and downstream recovery of these top 12 products is presented. Each bio-chemical selected by US Department of Energy i.e. ethanol, xylitol/sorbitol, furans (5-HMF, 2,5-FDCA,), glycerol & its derivatives, hydrocarbons) isoprene, iso-butadienes and others), lactic acid, succinic acid, 3-hydroxy propionic acid, levulinic acid and biohydrogen/biogas is included in a single book chapter. In addition to the technical aspects of these 12 biochemicals, general technological challenges dealing with lignocellulose refining, perspectives and solutions are elaborated in the book. Also, life cycle analysis, techno-economic viability, and sustainability index of biofuels/biochemicals are comprehensively reviewed in the book.

Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics. Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics. Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems.

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

Long-Acting Drug Delivery Systems: Pharmaceutical, Clinical, and Regulatory Aspects offers a comprehensive overview of the technical, clinical, regulatory and industrial perspectives on these drug delivery systems. The book follows a sequential order, beginning with the current technical state-of-the-field and moving on to more clinical, industrial and regulatory topics. Opening chapters describe the current needs and potential applications of implantable and long-acting therapeutic approaches. The book goes on to describe established and novel long-acting systems, with a focus on the materials used to prepare these systems and their biocompatibility. Importantly, applied topics such as scale-up manufacturing, products under clinical trials and regulatory aspects are covered, offering the reader a holistic view of this rapidly growing field.

Cognitive Models for Sustainable Environment reviews the fundamental concepts of gathering, processing and analyzing data from batch processes, along with a review of intelligent and cognitive tools that can be used. The book is centered on evolving novel intelligent/cognitive models and algorithms to develop sustainable solutions for the mitigation of environmental pollution. It unveils intelligent and cognitive models to address issues related to the effective monitoring of environmental pollution and sustainable environmental design. As such, the book focuses on the overall well-being of the global environment for better sustenance and livelihood. The book covers novel cognitive models for effective environmental pollution data management at par with the standards laid down by the World Health Organization. Every chapter is supported by real-life case studies, illustrative examples and video demonstrations that enlighten readers.

Modern Practical Healthcare Issues in Biomedical Instrumentation describes the designs, applications and principles of several medical devices used in hospitals and at home. The book presents practical devices that can potentially be used for healthcare purposes. Sections cover the use of biosensors to monitor the physiological properties of the human body, focusing on devices used to evaluate, measure and manipulate the biological system, and highlighting practical devices that can potentially be used for healthcare purposes. It is an excellent resource for undergraduate, graduate and post-graduate students of biomedical engineering.

Improvements in Bio-Based Building Blocks Production Through Process Intensification and Sustainability Concepts discusses new information on the production and cost of bio-based building blocks. From a technical point-of-view, almost all industrial materials made from fossil resources can be substituted using bio-based counterparts. However, the cost of bio-based production in many cases exceeds the cost of petrochemical production. In addition, new products must be proven to perform at least as good as their petrochemical equivalents, have a lower environmental impact, meet consumer demand for environmentally-friendly products, factor in population growth, and account for limited supplies of non-renewables. This book outlines the application of process intensification techniques which allow for the generation of clean, efficient and economical processes for bio-based chemical blocks production.

Biomass, Biochemicals, Biofuel: Climate Change Mitigation: Sequestration of Green House Gases is designed to not only give basic knowledge on the topics presented, but also to enlighten on conventional and advanced technologies, socioeconomic aspects, techno-economic feasibility, models and modeling tools, and detailed LCA approaches in the sequestration of GHGs for biofuel and biomaterials, including biopolymer production. These innovative technologies and novel prospective directly find applications in day-to-day practices. The book is a useful guide to politicians, researchers, teachers and waste management practitioners. It offers a treasure of knowledge to guide readers on the importance of GHGs sequestration in important areas. The issue of climate change is gaining much more attention by researchers, public, politicians and others. Climate change is one of the most complex issues the world is facing today. It has implications across society, including in science, technology, economics, society, politics, and moral and ethical dilemmas.

New and Future Developments in Microbial Biotechnology and Bioengineering: Sustainable Agriculture: Revitalization through Organic Products provides a comprehensive overview of different organic products which work as plant biostimulants, i.e., protein hydrolysates, chitosan, microbial derived exopolysaccharides, pectin, nanoparticles, etc. In addition, detailed insights in their mechanisms for plant growth promotion and stress alleviation are covered. This volume further discusses the extraction and formulation of organic products for use in sustainable agriculture. The application of microbial derived secondary metabolites in crop protection is also extensively covered. This book will be ideal for agrochemists, biotechnologists, biochemists, industrialists, researchers and scientists working on organic farming.

Nanotechnology in Medicine and Biology brings together a multidisciplinary team of experts from the fields of materials science, nanotechnology, medicine and biomedical engineering to introduce new nanoscale biomaterials and their applications, diagnosis and treatment of disorders of the human body. The book presents the fundamentals for understanding the design, properties and selection of nanobiomaterials as well as their real-world applications in medicine. Each chapter addresses current regulations, manufacturing processes, and translation issues of nanobiomaterials for key applications. A discussion of current protocols and their benefits and disadvantages is also included. This book provides comprehensive background and knowledge in the field of nanobiomaterials that is suitable for academics, scientists and clinicians.

Value Addition in Food Products and Processing using Enzyme Technology offers an updated review regarding the potential impact of new enzymes and enzyme technology on the food sector. The book brings together novel sources and technologies regarding enzymes in value added food development, food production, food processing, food preservation, food engineering and food biotechnology. It will be extremely useful for different types of readers, including food scientists, academic and food biotechnologists, but will also be ideal for students studying food-related courses. This book includes concise and up-to-date research information from multiple independent scientific papers from around the world. This is a essential, multidisciplinary text for research and development professionals, research scientists, and academics in food, biotechnology, and agriculture industries. It addresses safety issues and includes the sources, screening, immobilization and application of food-grade enzymes in food.

Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties and Application systematically introduces basic theories and progress in the research of biomedical ss-Ti alloys achieved by researchers from different fields. It focuses on a high-strength and low elastic modulus biomedical ss-Ti alloy (TLM), etc. designed by the authors. The alloy design methods, microstructural characteristics, mechanical properties, surface treatment methods and biocompatibility of the TLM alloy are discussed in detail, along with a concise description of the medical devices made from this alloy and the application examples. This book will appeal to researchers as well as students from different disciplines, including materials science, biology, medicine and engineering fields.

Abiotic Stress and Legumes: Tolerance and Management is the first book to focus on the ability of legume plants to adapt effectively to environmental challenges. Using the -omic approach, this book takes a targeted approach to understanding the methods and means of ensuring survival and maximizing the productivity of the legume plant by improving tolerance to environmental /abiotic stress factors including drought, temperature change, and other challenges. The book presents a comprehensive overview of the progress that has been made in identifying means of managing abiotic stress effects, specifically in legumes, including the development of several varieties which exhibit tolerance through high yield using transcriptomic, proteomic, metabolomic and ionomic approaches. Further, exogenous application of various stimulants such as plant hormones, nutrients, sugars, and polyamines has emerged as an alternative strategy to improve productivity under these environmental challenges. Abiotic Stress and Legumes: Tolerance and Management examines these emerging strategies and serves as an important resource for researchers, academicians and scientists, enhancing their knowledge and aiding further research.

Microbial Extremozymes: Novel Sources and Industrial Applications is a unique resource of practical research information on the latest novel sources and technologies regarding extremozymes in bioremediation, waste management, valorization of industrial by-products, biotransformation of natural polymers, nutrition, food safety and diagnosis of disease. The book's broad knowledge and varying applications are useful to the food industry, dairy industry, fruit and vegetable processing, and baking and beverages industries, as well as the pharmaceutical and biomedical industries. This is a concise, all-encompassing resource for a range of scientists needing knowledge of extremozymes to enhance and research. Furthermore, it provides an updated knowledge of microbial enzymes isolated from extreme environments (temperatures, etc.) and their biotechnological applications. It will be useful to researchers, scientists and students in enzyme research. In addition, users from the dairy and baking industries will benefit from the presented content.

Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology. Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems.

A-Z of Biorefinery: A Comprehensive View provides a comprehensive book that highlights and illustrates important topics relating to biorefineries, including associated theory, current and future research trends, available techniques and future challenges. This book will benefit a wide range of audiences, including students, engineers, scientists, practitioners, and those who are keen to explore more on biorefinery. Sections cover the availability of current technologies, constraints, market trends, recent system developments, and the concepts that enable modern biorefineries to utilize all kinds of biomass. This book is an essential resource for students, scientists, engineers and practitioners working in industry and academia.

This book provides a comprehensive overview of different agriculturally important microorganisms and their role as plant biostimulants. Arbuscular Mycorrhizal Fungi, Trichoderma, Cyanobacteria, Endophytes, and Plant growth promoting rhizobacteria have the potential to promote plant growth, disease management, nutrient acquisition, stress alleviation, and soil health management. Presenting an all-inclusive collection of information, this book will be important for students, academicians, researchers working in the field of sustainable agriculture, microbial technology, and biochemical engineers. It will also be of use for policymakers in the area of food security and sustainable agriculture.

Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology.

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert" immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.

Bioleaching of chalcopyrite is always a challenge and research hotspot. The low copper extraction and dissolution kinetics restricted the industrial application of chalcopyrite bioleaching. To solve this problem, the dissolution process and passivation mechanism of chalcopyrite in bioleaching should be first studied, then the rate-limiting steps should be analysed explicitly, and finally the intensifying method can be put forward. Many scholars have made efforts to investigate the dissolution mechanism of chalcopyrite in bioleaching. However, there is no congruence of opinion as yet. Biohydrometallurgy of Chalcopyrite summarizes and discusses the reported research findings. In addition, this book publishes the related results found by the authors' research. Then, the dissolution mechanism of chalcopyrite in bioleaching is interpreted. Finally, the process intensification techniques of chalcopyrite bioleaching are provided and discussed. Hence, this book provides useful reference and guidance in both laboratory research and industrial production.

Colloidal Foundations of Nanoscience, Second Edition explores the theory and concepts of colloid chemistry and its applications to nanoscience and nanotechnology. The book provides the essential conceptual and methodological tools to approach nano-research issues. The authors' expertise in colloid science will contribute to the understanding of basic issues involved in research. Each chapter covers a classical subject of colloid science in simple and straightforward terms, addressing its relevance to nanoscience before introducing case studies. Sections cover colloids rheology, electrokinetics, nanoparticle tracking analysis (NTA), bio-layer interferometry, and the treatment of inter-particle interactions and colloidal stability.

Development in Waste Water Treatment Research and Processes: Innovative Microbe-Based Applications for Removal of Chemicals and Metals in Wastewater Treatment Plants focuses on the exploitation of various biological treatment technologies and their use to treat toxic and hazardous contaminants present in industrial effluent and restore the contaminated sites, a topic which lacks discussion in existing titles on the global market. This book encompasses advanced technologies and updated information as well as future directions for young researchers and scientists who are working in the field of wastewater treatment or effluent treatment plants and biodegradation of environmental contaminants for environmental safety and sustainable development.

Tissue Engineering Using Ceramics and Polymers, Third Edition is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction, repair and organ regeneration. With its distinguished editors and international team of contributors, this book reviews the latest research and advances in this thriving area and how they can be used to develop treatments for disease states. New sections cover nanobiomaterials, drug delivery, advanced imaging and MRI for tissue engineering, and characterization of vascularized scaffolds. Technology and research in the field of tissue engineering has drastically increased within the last few years to the extent that almost every tissue and organ of the human body could potentially be regenerated with the aid of biomaterials.

Applied Biomedical Engineering Using Artificial Intelligence and Cognitive Models focuses on the relationship between three different multidisciplinary branches of engineering: Biomedical Engineering, Cognitive Science and Computer Science through Artificial Intelligence models. These models will be used to study how the nervous system and musculoskeletal system obey movement orders from the brain, as well as the mental processes of the information during cognition when injuries and neurologic diseases are present in the human body. The interaction between these three areas are studied in this book with the objective of obtaining AI models on injuries and neurologic diseases of the human body, studying diseases of the brain, spine and the nerves that connect them with the musculoskeletal system. There are more than 600 diseases of the nervous system, including brain tumors, epilepsy, Parkinson's disease, stroke, and many others. These diseases affect the human cognitive system that sends orders from the central nervous system (CNS) through the peripheral nervous systems (PNS) to do tasks using the musculoskeletal system. These actions can be detected by many Bioinstruments (Biomedical Instruments) and cognitive device data, allowing us to apply AI using Machine Learning-Deep Learning-Cognitive Computing models through algorithms to analyze, detect, classify, and forecast the process of various illnesses, diseases, and injuries of the human body. Applied Biomedical Engineering Using Artificial Intelligence and Cognitive Models provides readers with the study of injuries, illness, and neurological diseases of the human body through Artificial Intelligence using Machine Learning (ML), Deep Learning (DL) and Cognitive Computing (CC) models based on algorithms developed with MATLAB (R) and IBM Watson (R).

Microbial Biodegradation and Bioremediation: Techniques and Case Studies for Environmental Pollution, Second Edition describes the successful application of microbes and their derivatives for bioremediation of potentially toxic and relatively novel compounds in the environment. Our natural biodiversity and environment is in danger due to the release of continuously emerging potential pollutants by anthropogenic activities. Though many attempts have been made to eradicate and remediate these noxious elements, thousands of xenobiotics of relatively new entities emerge every day, thus worsening the situation. Primitive microorganisms are highly adaptable to toxic environments, and can reduce the load of toxic elements by their successful transformation and remediation. This completely updated new edition presents many new technologies and techniques and includes theoretical context and case studies in every chapter. Microbial Biodegradation and Bioremediation: Techniques and Case Studies for Environmental Pollution, Second Edition serves as a single-source reference and encompasses all categories of pollutants and their applications in a convenient, comprehensive format for researchers in environmental science and engineering, pollution, environmental microbiology, and biotechnology.