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Immunomodulatory Biomaterials - Regulating the Immune Response with Biomaterials to Affect Clinical Outcome (Paperback)
Loot Price: R4,700
Discovery Miles 47 000
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Immunomodulatory Biomaterials - Regulating the Immune Response with Biomaterials to Affect Clinical Outcome (Paperback)
Series: Woodhead Publishing Series in Biomaterials
Expected to ship within 12 - 17 working days
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Biomaterials have existed for millennia as mechanical replacement
structures following disease or injury. Biomaterial design has
changed markedly from structural support with an "inert" immune
profile as the primary objective to designs that elicit an
integrative local tissue response and a pro-repair immune cell
phenotype. Immunomodulatory Biomaterials: Regulating the Immune
Response with Biomaterials to Affect Clinical Outcome offers a
single, comprehensive reference on biomaterials for modulation of
the host response, for materials scientists, tissue engineers and
those working in regenerative medicine. This book details methods,
materials and strategies designed to regulate the host immune
response following surgical implantation and thus facilitate
specific local cell infiltration and tissue deposition. There has
been a dramatic transformation in our understanding of the role of
the immune system, both innate and adaptive; these changes include
recognition of the plasticity of immune cells, especially
macrophages, cross-talk between the immune system and stem cells,
and the necessity for in situ transition between inflammatory and
regulatory immune cell phenotypes. The exploitation of these
findings and the design and manufacture of new biomaterials is
occurring at an astounding pace. There is currently no book
directed at the interdisciplinary principles guiding the design,
manufacture, testing, and clinical translation of biomaterials that
proactively regulate the host tissue immune response. The challenge
for academia, industry, and regulatory agencies to encourage
innovation while assuring safety and maximizing efficacy has never
been greater. Given the highly interdisciplinary requirements for
the design, manufacture and use of immunomodulatory biomaterials,
this book will prove a useful single resource across disciplines.
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