Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology.

Biotechnology in Healthcare, Technologies and Innovations, Volume One presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Sections cover 3D printing, tissue engineering, synthetic biology, nano-biotechnology, omics, precision medicine, gene therapy, vaccine development, predictive healthcare, entrepreneurship, financing, business models, product development and marketing in the sector. This is a valuable source for biotechnologists, bioinformaticians, clinicians and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare.

Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists.

Applied Biomedical Engineering Using Artificial Intelligence and Cognitive Models focuses on the relationship between three different multidisciplinary branches of engineering: Biomedical Engineering, Cognitive Science and Computer Science through Artificial Intelligence models. These models will be used to study how the nervous system and musculoskeletal system obey movement orders from the brain, as well as the mental processes of the information during cognition when injuries and neurologic diseases are present in the human body. The interaction between these three areas are studied in this book with the objective of obtaining AI models on injuries and neurologic diseases of the human body, studying diseases of the brain, spine and the nerves that connect them with the musculoskeletal system. There are more than 600 diseases of the nervous system, including brain tumors, epilepsy, Parkinson's disease, stroke, and many others. These diseases affect the human cognitive system that sends orders from the central nervous system (CNS) through the peripheral nervous systems (PNS) to do tasks using the musculoskeletal system. These actions can be detected by many Bioinstruments (Biomedical Instruments) and cognitive device data, allowing us to apply AI using Machine Learning-Deep Learning-Cognitive Computing models through algorithms to analyze, detect, classify, and forecast the process of various illnesses, diseases, and injuries of the human body. Applied Biomedical Engineering Using Artificial Intelligence and Cognitive Models provides readers with the study of injuries, illness, and neurological diseases of the human body through Artificial Intelligence using Machine Learning (ML), Deep Learning (DL) and Cognitive Computing (CC) models based on algorithms developed with MATLAB (R) and IBM Watson (R).

Microbial Biodegradation and Bioremediation: Techniques and Case Studies for Environmental Pollution, Second Edition describes the successful application of microbes and their derivatives for bioremediation of potentially toxic and relatively novel compounds in the environment. Our natural biodiversity and environment is in danger due to the release of continuously emerging potential pollutants by anthropogenic activities. Though many attempts have been made to eradicate and remediate these noxious elements, thousands of xenobiotics of relatively new entities emerge every day, thus worsening the situation. Primitive microorganisms are highly adaptable to toxic environments, and can reduce the load of toxic elements by their successful transformation and remediation. This completely updated new edition presents many new technologies and techniques and includes theoretical context and case studies in every chapter. Microbial Biodegradation and Bioremediation: Techniques and Case Studies for Environmental Pollution, Second Edition serves as a single-source reference and encompasses all categories of pollutants and their applications in a convenient, comprehensive format for researchers in environmental science and engineering, pollution, environmental microbiology, and biotechnology.

Smart Agrochemicals for Sustainable Agriculture proposes products that fulfill the need for chemicals that provide a sustainable delivery system for nutrients necessary to maximize the production of agricultural animals and plants while producing the smallest possible environmental footprint. This book addresses all aspects related to the production process, including chemical formulas, stability of formulations, and the application of the effect of its utilization. Over the past decade, biobased chemicals have received significant attention as candidate resource materials in fertilizers and agrochemicals production due to their renewability. Substitution of conventional raw materials with biobased requires a new approach towards the development of technology. On the other hand, the use of biobased chemicals, such as biostimulants, bioregulators and biofertilizers offers a new palette of products that are natural, thus their application does not pose an impact on the environment (residues) or cultivated plants.

Long-Acting Drug Delivery Systems: Pharmaceutical, Clinical, and Regulatory Aspects offers a comprehensive overview of the technical, clinical, regulatory and industrial perspectives on these drug delivery systems. The book follows a sequential order, beginning with the current technical state-of-the-field and moving on to more clinical, industrial and regulatory topics. Opening chapters describe the current needs and potential applications of implantable and long-acting therapeutic approaches. The book goes on to describe established and novel long-acting systems, with a focus on the materials used to prepare these systems and their biocompatibility. Importantly, applied topics such as scale-up manufacturing, products under clinical trials and regulatory aspects are covered, offering the reader a holistic view of this rapidly growing field.

Green Biocomposites for Biomedical Engineering: Design, Properties, and Applications combines emergent research outcomes with fundamental theoretical concepts relevant to processing, properties and applications of advanced green composites in the field of biomedical engineering. The book outlines the design elements and characterization of biocomposites, highlighting each class of biocomposite separately. A broad range of biomedical applications for biocomposites is then covered, with a final section discussing the ethics and safety regulations associated with manufacturing and the use of biocomposites. With contributions from eminent editors and recognized authors around the world, this book is a vital reference for researchers in biomedical engineering, materials science and environmental science, both in industry and academia.

Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists.

Plant and Algal Hydrogels for Drug Delivery and Regenerative Medicine offers a materials-focused and systematic overview of biopolymeric hydrogels utilized for biomedical applications. The book details the synthesis and characterization of plant and algal-based hydrogels, with each chapter addressing a separate polysaccharide hydrogel type. Specific applications in drug delivery and regenerative medicine are also discussed, highlighting the efficacy, biocompatibility, benefits and challenges for each polysaccharide hydrogel subtype. There is increasing demand for biomaterials which reduce/prevent the host response, inflammation and rejection, hence this book provides a timely resource. Biopolymeric hydrogels have skyrocketed because of their necessity in in vivo applications. They create an environment similar to living tissue, which is both biocompatible and biodegradable. Plant and algal polysaccharides in particular are well-equipped with functional groups that are easily modified for beneficial results.

Abiotic Stress and Legumes: Tolerance and Management is the first book to focus on the ability of legume plants to adapt effectively to environmental challenges. Using the -omic approach, this book takes a targeted approach to understanding the methods and means of ensuring survival and maximizing the productivity of the legume plant by improving tolerance to environmental /abiotic stress factors including drought, temperature change, and other challenges. The book presents a comprehensive overview of the progress that has been made in identifying means of managing abiotic stress effects, specifically in legumes, including the development of several varieties which exhibit tolerance through high yield using transcriptomic, proteomic, metabolomic and ionomic approaches. Further, exogenous application of various stimulants such as plant hormones, nutrients, sugars, and polyamines has emerged as an alternative strategy to improve productivity under these environmental challenges. Abiotic Stress and Legumes: Tolerance and Management examines these emerging strategies and serves as an important resource for researchers, academicians and scientists, enhancing their knowledge and aiding further research.

Optical Fiber Biosensors: Device Platforms, Biorecognition, Applications provides a comprehensive overview of the field of fiber optic sensors using an interdisciplinary approach that covers the fabrication of sensing devices and optical hardware, the functionalization to perform selective biorecognition, and the main applications of biosensors, with a present and a future outlook. Chapters discuss the principles of light propagation and the sensing devices suitable to perform biosensing with optical fibers, the process to functionalize the previous devices to selective biosensing, and applications in cells, small molecules, biomarkers and protein sensing, with a birds eye view on the most important results. This book provides a coherent picture of fiber optic biosensors, from the start (the device) to the end (the application), explaining in simple terms what is the whole process for development of a biosensor. The book also contains practical material (e.g. commercial instruments, fabrication instructions, medical standards for biocompatibility) that cannot be easily found elsewhere, and this is very useful for researchers to plan their development and build their labs.

Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties and Application systematically introduces basic theories and progress in the research of biomedical ss-Ti alloys achieved by researchers from different fields. It focuses on a high-strength and low elastic modulus biomedical ss-Ti alloy (TLM), etc. designed by the authors. The alloy design methods, microstructural characteristics, mechanical properties, surface treatment methods and biocompatibility of the TLM alloy are discussed in detail, along with a concise description of the medical devices made from this alloy and the application examples. This book will appeal to researchers as well as students from different disciplines, including materials science, biology, medicine and engineering fields.

Biomedical Applications of Electrospinning and Electrospraying describes the principles and laboratory set up for electrospinning and electrospraying, addressing a range of biomedical applications. Sections cover novel combinational approaches, such as electrospinning/spraying and 3D printing. Electrospinning has evolved from being a technique to prepare random networks of textile fibers to a technique to fabricate highly ordered patterns of biomedical materials of defined scale. The technological advancements in recent years with regard to the way the jet is facilitated, how the jet path is controlled, and how the fibers are collected have provided invaluable insights into controlled fabrication of a material of choice. Additionally, the electrospray technique has also evolved from being a technique to prepare food formulations to a technique to prepare cell encapsulated beads for transplantation in clinics. Several innovations in this line, such as those leading to core-shell materials have tremendously changed the way the technique is used. Thus, a combinational approach using electrospinning, electrospraying and 3D printing has emerged.

Advances in Applied Microbiology, Volume 116 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology, with this release focusing on the lipid production by oleaginous yeasts.

Bioleaching of chalcopyrite is always a challenge and research hotspot. The low copper extraction and dissolution kinetics restricted the industrial application of chalcopyrite bioleaching. To solve this problem, the dissolution process and passivation mechanism of chalcopyrite in bioleaching should be first studied, then the rate-limiting steps should be analysed explicitly, and finally the intensifying method can be put forward. Many scholars have made efforts to investigate the dissolution mechanism of chalcopyrite in bioleaching. However, there is no congruence of opinion as yet. Biohydrometallurgy of Chalcopyrite summarizes and discusses the reported research findings. In addition, this book publishes the related results found by the authors' research. Then, the dissolution mechanism of chalcopyrite in bioleaching is interpreted. Finally, the process intensification techniques of chalcopyrite bioleaching are provided and discussed. Hence, this book provides useful reference and guidance in both laboratory research and industrial production.

Modern Practical Healthcare Issues in Biomedical Instrumentation describes the designs, applications and principles of several medical devices used in hospitals and at home. The book presents practical devices that can potentially be used for healthcare purposes. Sections cover the use of biosensors to monitor the physiological properties of the human body, focusing on devices used to evaluate, measure and manipulate the biological system, and highlighting practical devices that can potentially be used for healthcare purposes. It is an excellent resource for undergraduate, graduate and post-graduate students of biomedical engineering.

Microbial Extremozymes: Novel Sources and Industrial Applications is a unique resource of practical research information on the latest novel sources and technologies regarding extremozymes in bioremediation, waste management, valorization of industrial by-products, biotransformation of natural polymers, nutrition, food safety and diagnosis of disease. The book's broad knowledge and varying applications are useful to the food industry, dairy industry, fruit and vegetable processing, and baking and beverages industries, as well as the pharmaceutical and biomedical industries. This is a concise, all-encompassing resource for a range of scientists needing knowledge of extremozymes to enhance and research. Furthermore, it provides an updated knowledge of microbial enzymes isolated from extreme environments (temperatures, etc.) and their biotechnological applications. It will be useful to researchers, scientists and students in enzyme research. In addition, users from the dairy and baking industries will benefit from the presented content.

Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.

Wild Germplasm for Genetic Improvement in Crop Plants addresses the need for an integrated reference on a wide variety of crop plants, facilitating comparison and contrast, as well as providing relevant relationships for future research and development. The book presents the genetic and natural history value of wild relatives, covers what wild relatives exist, explores the existing knowledge regarding specific relatives and the research surrounding them and identifies knowledge gaps. As understanding the role of crop wild relatives in plant breeding expands the genetic pool for abiotic and biotic stress resistance, this is an ideal reference on this important topic.

Polysaccharide-Based Nanocomposites for Gene Delivery and Tissue Engineering presents quantitative background on new polysaccharide nanocomposites in a clear and logical way, highlighting the most exciting applications in gene delivery and tissue engineering and their progress. The book focuses on the different types of polysaccharide nanocomposites for gene delivery and tissue engineering and covers polysaccharide hydrogels for tissue engineering and polysaccharide magnetic nanocomposites for gene delivery. Chapters cover various nanocomposites presented in twenty-one separate chapters. This book will be of great interest to all those researching the development and applications of polysaccharide-based nanocomposites for modeling. As polysaccharide-based nanocomposites promise cutting-edge applications in gene delivery and tissue engineering, with their development at the forefront of modern medicine, this book is a welcome title on this exciting science.

Autonomous Robot-Aided Optical Manipulation for Biological Cells gives a systematically and almost self-contained description of the many facets of modeling, sensing, and control techniques or experimentally exploring emerging trends in optical manipulation of biological cell in micro/nanorobotics systems. To achieve biomedical applications, reliability design, modeling, and precision control are vitally important for the development of engineering systems. With the advances in modeling, sensing, and control techniques, it is opportunistic to exploit them for the benefit of reliability design, actuation, and precision control of micro/nanomanipulation systems to expanding the applications of robot at the micro and nano scales, especially in biomedical engineering. This book presents new techniques in reliability modeling and advanced control of robot-aided optical manipulation of biological cells systems. The book will be beneficial to the researchers within robotics, mechatronics, biomedical engineering, and automatic control society, including both academic and industrial parts.

Nanotechnology in Conservative Dentistry provides a detailed review of the use of nanotechnology in conservative dentistry, from diagnosis and restorative materials, through to tissue engineering and regeneration. This book covers fundamental topics in the field of conservative dentistry, including caries therapy, dentin reconstruction, pulp protection and more; each chapter reviews and discusses how nanotechnology can be implemented as a novel approach to traditional conservative dentistry techniques, exploring the many uses and advantages of this fast-growing technology. Various nanobiomaterials and technologies are covered, as well as assessment of the biocompatibility and toxicological risks of utilizing nanotechnology in dentistry. Nanotechnology in Conservative Dentistry will help dentists and materials science academics alike, understand the potential of nanotechnology in dentistry, building on and going beyond traditional concepts and techniques in this field.

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert" immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.