Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations.

Innovations in Fermentation and Phytopharmaceutical Technologies discusses recent advancements in the field of different bioprocessing aspects for the development of different reactors, fermented products and phytopharmaceuticals. Written by leading experts in the field, the book presents the basic principles of upstream processing techniques, advanced downstream process technologies, and recycling of by-products during formation/production of various fermented and phytopharmaceutical products. The informative chapters in the book outline an application-oriented path for academicians, researchers and scientists in the field of industrial fermentation technology and phytopharmaceutical production.

Immunomodulatory Effects of Nanomaterials: Assessment and Analysis provides an overview of the modulatory impact of nanomaterials on the immune system, as well as evaluative and analytical methods for assessing effects. Sections cover a range of common nanomaterials for biomedical use and how different properties can elicit varied responses from the immune system. The immunomodulatory effects of these materials are then discussed, with coverage on adverse and/or toxic effects on the immune system, as well as desired modulatory effects to improve efficacy of applied therapeutics. Readers will also learn about the best evaluation methods for immunomodulatory effects of nanomaterials and associated risks. This book is a useful reference for academics and researchers with an interest in immunology, but it is also idea for those working in the fields of materials science, biomedical engineering, pharmaceutical science, immunology and toxicology.

Biomaterials for Angiogenesis and Vasculogenesis covers the application of materials designed to encourage new blood vessel formation. Angiogenesis and vasculogenesis play an important role in tissue engineering and regenerative medicine research by promoting vascular networks inside engineered tissues and thereby increasing tissue healing and regeneration. However, researchers are faced with the challenge of finding suitable materials for improving angiogenesis and vascular formation in assays. This book reviews a broad range of biomaterials for the promotion of blood vessel genesis, from polymers and bioactive glass, to nanomaterial scaffolds and 3D angiogenic constructs. In addition, the book covers a variety of applications for biomaterials in tissue repair and regeneration, including cardiovascular regeneration, liver tissue engineering and much more. It will serve as a detailed reference for researchers in academia and industry, working in the fields of biomedical science and engineering, materials science, regenerative medicine and translational medicine.

Value Addition in Food Products and Processing using Enzyme Technology offers an updated review regarding the potential impact of new enzymes and enzyme technology on the food sector. The book brings together novel sources and technologies regarding enzymes in value added food development, food production, food processing, food preservation, food engineering and food biotechnology. It will be extremely useful for different types of readers, including food scientists, academic and food biotechnologists, but will also be ideal for students studying food-related courses. This book includes concise and up-to-date research information from multiple independent scientific papers from around the world. This is a essential, multidisciplinary text for research and development professionals, research scientists, and academics in food, biotechnology, and agriculture industries. It addresses safety issues and includes the sources, screening, immobilization and application of food-grade enzymes in food.

New Paradigms in Environmental Biomonitoring Using Plants highlights and explores the importance of biomonitoring methodologies and the latest updates in the field. The book presents a holistic approach toward the different aspects of biomonitoring, focusing mainly upon the inclusion of newly emerging concepts of environmental genomics, metabarcoding, and cheminformatics and biomarkers, among other technologies; helping to explore and establish a new outlook for biomonitoring frameworks. This book compiles all aspects of biomonitoring including traditional and modern techniques, using a multidimensional approach without focusing on any specific pollutant. Most biomonitoring programs implemented until now have focused more on traditional methods. This book covers new approaches to biomonitoring that could improve on the currently limited capabilities of existing schemes. The book highlights the possible scope for enriching existing datasets and characterizing biodiversity in situ in a far more complete way than has been possible previously. New Paradigms in Environmental Biomonitoring Using Plants will be important for researchers, academics, postgraduates and undergraduate students in environmental, plant, crop and soil sciences, to provide up-to-date and emerging technologies in biomonitoring for environmental assessment, leading to a new vision of biomonitoring. It will also be helpful for risk assessment professionals and stakeholders involved in planning the future biomonitoring programs.

Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models.

3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their industrial applications. Sections cover 4D Printing Smart Multi-responsive Structure, Cells for Bioprinting, 4D Printing Biomaterials, 3D/4D printing functional biomedical devices, 3D Printing for Cardiac and Heart Regeneration, Integrating 3D printing with Ultrasound for Musculoskeletal Regeneration, 3D Printing for Liver Regeneration, 3D Printing for Cancer Studies, 4D Printing Soft Bio-robots, Clinical Translation and Future Directions. The book's team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application. The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs. This book provides an overview of these technologies and their integration.

Lactic Acid Bacteria in Food Biotechnology: Innovations and Functional Aspects describes the latest advancements in LAB applications in the development of functional foods and fermented foods, biotechnological products using LAB, i.e., bio chemicals (organic acids, bacteriocins, etc.), bioactive and functional biomolecules, comparative genomics of probiotic LAB, and genetically modified LAB in food industry. Bridging the gap between LAB-mediated fermented foods and bioactive compounds, vis-a-vis molecular aspects, this book enables the transition from research to application. The book details applications of LAB in fermented/functional foods including cereals, vegetables, fish, meat cheese, other dairy products, and much more. Other sections cover their biochemistry and biotechnology aspects, bio preservation by bio molecules produced by LAB, bioactive metabolites and biosurfactants, including their value in health and wellness and exploring the genomics of LAB from food to health. Finally, the book addresses genetically modified lactic acid bacteria in food and beverages.

Musculoskeletal Tissue Engineering introduces the fundamental concepts and translational applications of musculoskeletal tissue engineering, in combination with emerging technologies and materials. Sections discuss Tissues and Technologies, covering a range of musculoskeletal tissues, including bone, cartilage, ligament and more. Each chapter in this section details core tissue engineering principles specific to each tissue type. Next, a Technologies section looks at the range of biomaterials used in musculoskeletal tissue engineering, focusing on biocompatibility of materials and interactions at the material-tissue interface. Other chapters cover nanotechnology, 3D printing, gene therapy, tissue chips, and more. This book offers an advanced reference text for researchers in biomedical engineering, materials science and regenerative medicine.

Microneedles explores the design, fabrication and use of microneedles for drug and vaccine delivery. This book discusses the contemporary status of the field, describing several areas in detail, including the distinct types of microneedles (dissolving, solid, coted, hollow and hydrogel-forming). The anatomy of the eye is also described to facilitate an understanding of microneedle-assisted ocular drug delivery. Finally, the book provides a detailed discussion of microneedle use in the field of diagnostics, with a chapter dedicated to the mathematical modeling of microneedle-mediated drug delivery. As microneedles can be used by research scientists in academia and in industry, this book will be ideal for regulatory scientists and graduate students who find the topic relevant to their area of study.

Agricultural Nanobiotechnology: Biogenic Nanoparticles, Nanofertilizers and Nanoscale Biocontrol Agents presents the most up-to-date advances in nanotechnology to improve the agriculture and food industry with novel nanotools for the controlling of rapid disease diagnostic and enhancement of the capacity of plants to absorb nutrients and resist environmental challenges. Highlighting the emerging nanofertilizers, nanopesticides and nanoherbicides that are being widely explored in order to overcome the limitations of conventional agricultural supplements, the book provides important insights to enable smart, knowledge-driven selection of nanoscale agricultural biomaterials, coupled with suitable delivery approaches and formulations will lead to promising agricultural innovation using nanotechnology. Agricultural Nanobiotechnology: Biogenic Nanoparticles, Nanofertilizers and Nanoscale Biocontrol Agents explores emerging innovations in nanobiotechnology for agriculture, food, and natural resources to address the challenges of food security, sustainability, susceptibility, human health, and healthy life. The book is ideal for the multidisciplinary scientists whose goal is to see the use of nanomaterials in agriculture to reduce the amount of spread chemicals, minimize nutrient losses in fertilization and to generate increased yield through pest and nutrient management.

Hybrid Nanomaterials for Drug Delivery covers a broad range of hybrid nanomaterials and nanocomposites used in drug delivery systems. The book reviews a variety of hybrid nanomaterials and structures, including polymer-lipid, chitosan-based, protein-inorganic, quantum dot hybrids, and more. The strengths, limitations and regulatory aspects of hybrid drug delivery systems are also discussed, allowing readers to make informed decisions when choosing to utilize hybrid nanomaterials. Users will find this to be an exciting and comprehensive look into this emerging area. It will be of particular interest to academics and researchers working in materials science, engineering, biomedical engineering, nanotechnology and pharmaceutical science. Multi nanocarrier-based hybrid systems are an emerging concept in the field of drug delivery that allow researchers to avoid some of the challenges faced when administering drugs, such as low bioavailability, development of drug resistance, toxicities, premature drug release, and therapeutic efficacy.

Tissue Engineering Using Ceramics and Polymers, Third Edition is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction, repair and organ regeneration. With its distinguished editors and international team of contributors, this book reviews the latest research and advances in this thriving area and how they can be used to develop treatments for disease states. New sections cover nanobiomaterials, drug delivery, advanced imaging and MRI for tissue engineering, and characterization of vascularized scaffolds. Technology and research in the field of tissue engineering has drastically increased within the last few years to the extent that almost every tissue and organ of the human body could potentially be regenerated with the aid of biomaterials.

Biomaterials in Endodontics offers an up-to-date overview of endodontic biomaterials and their applications in regenerative medicine and tissue engineering. This book details the key biomaterials used in clinical endodontics and the benefits and challenges of using these materials, from root canal obturation materials to alloys for endodontic files and hand instruments. Chapters also offer a unique insight into the regenerative applications of endodontic biomaterials, such as the use of stem cells and growth factors for bone regeneration. Biomaterials in Endodontics is a useful resource for researchers working in biomedical engineering, regenerative medicine, and materials science with an interest in dentistry and bone regeneration. This book is also a helpful guide for endodontists, dentists, dental scientists, and clinicians with an interest in biomaterials for endodontics.

Innovation Strategies for the Food Industry: Tools for Implementation, Second Edition explores how process technologies and innovations are implemented in the food industry, by i.e., detecting problems and providing answers to questions of modern applications. As in all science sectors, Internet and big data have brought a renaissance of changes in the way academics and researchers communicate and collaborate, and in the way that the food industry develops. The new edition covers emerging skills of food technologists and the integration of food science and technology knowledge into the food chain. This handbook is ideal for all relevant actors in the food sector (professors, researchers, students and professionals) as well as for anyone dealing with food science and technology, new products development and food industry.

Handbook of Microbial Nanotechnology is a collection of the most recent scientific advancements in the fundamental application of microbial nanotechnology across various sectors. This comprehensive handbook highlights the vast subject areas of microbial nanotechnology and its potential applications in food, pharmacology, water, environmental remediation, etc. This book will serve as an excellent reference handbook for researchers and students in the food sciences, materials sciences, biotechnology, microbiology and in the pharmaceutical fields. Microbial nanotechnology is taking part in creating development and innovation in various sectors. Despite the participation of microbial nanotechnology in modern development, there are some hindrances. The lack of information, the possibility of adverse impacts on the environment, human health, safety and sustainability are still a challenge. This handbook addresses these challenges.

Nano-Enabled Agrochemicals in Agriculture presents a targeted overview of the safe implementation of nanotechnologies within agricultural and horticultural settings, with the purpose of achieving enhanced production while maintaining ecological integrity. The growing global request for agricultural crops and products requires high standards of quality and safety, which has stimulated the search for new technologies that preserve their quality and delay their decomposition. Nanotechnology may boost plant production by improving nutrient uptake/use efficiency with nanoformulations of fertilizers and agrochemicals for plant enhancement, detection and treatment of diseases, and host-parasite interactions at the molecular level using nanosensors. It also may improve plant disease diagnostics, removal of contaminants from soil and water, postharvest management of vegetables and flowers, and reclamation of salt-affected soils. Although the markets for nanoproducts and nanoformulations continue to increase, there are also growing concerns regarding the fate and behavior of nanomaterials in environmental systems. Exploring important topics related to nanotechnology and nanomaterials, the book includes the use of nanochemicals in insect pest management, as nanofungicides, nanoherbicides, micronutrient supply, and nanosensors to monitor crop and soil health conditions, from detection of agrochemicals to their slow release of agrochemicals, and their impact on related environs. This book will serve as an excellent resource for a wide range of plant scientists who have concerns about nanomaterial interactions with terrestrial and aquatic plants.

Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics. Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics. Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems.

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.