Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models.

Microneedles explores the design, fabrication and use of microneedles for drug and vaccine delivery. This book discusses the contemporary status of the field, describing several areas in detail, including the distinct types of microneedles (dissolving, solid, coted, hollow and hydrogel-forming). The anatomy of the eye is also described to facilitate an understanding of microneedle-assisted ocular drug delivery. Finally, the book provides a detailed discussion of microneedle use in the field of diagnostics, with a chapter dedicated to the mathematical modeling of microneedle-mediated drug delivery. As microneedles can be used by research scientists in academia and in industry, this book will be ideal for regulatory scientists and graduate students who find the topic relevant to their area of study.

Musculoskeletal Tissue Engineering introduces the fundamental concepts and translational applications of musculoskeletal tissue engineering, in combination with emerging technologies and materials. Sections discuss Tissues and Technologies, covering a range of musculoskeletal tissues, including bone, cartilage, ligament and more. Each chapter in this section details core tissue engineering principles specific to each tissue type. Next, a Technologies section looks at the range of biomaterials used in musculoskeletal tissue engineering, focusing on biocompatibility of materials and interactions at the material-tissue interface. Other chapters cover nanotechnology, 3D printing, gene therapy, tissue chips, and more. This book offers an advanced reference text for researchers in biomedical engineering, materials science and regenerative medicine.

Advances in Applied Microbiology, Volume 117 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology.

Tissue Engineering Using Ceramics and Polymers, Third Edition is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction, repair and organ regeneration. With its distinguished editors and international team of contributors, this book reviews the latest research and advances in this thriving area and how they can be used to develop treatments for disease states. New sections cover nanobiomaterials, drug delivery, advanced imaging and MRI for tissue engineering, and characterization of vascularized scaffolds. Technology and research in the field of tissue engineering has drastically increased within the last few years to the extent that almost every tissue and organ of the human body could potentially be regenerated with the aid of biomaterials.

Biomaterials in Endodontics offers an up-to-date overview of endodontic biomaterials and their applications in regenerative medicine and tissue engineering. This book details the key biomaterials used in clinical endodontics and the benefits and challenges of using these materials, from root canal obturation materials to alloys for endodontic files and hand instruments. Chapters also offer a unique insight into the regenerative applications of endodontic biomaterials, such as the use of stem cells and growth factors for bone regeneration. Biomaterials in Endodontics is a useful resource for researchers working in biomedical engineering, regenerative medicine, and materials science with an interest in dentistry and bone regeneration. This book is also a helpful guide for endodontists, dentists, dental scientists, and clinicians with an interest in biomaterials for endodontics.

Innovation Strategies for the Food Industry: Tools for Implementation, Second Edition explores how process technologies and innovations are implemented in the food industry, by i.e., detecting problems and providing answers to questions of modern applications. As in all science sectors, Internet and big data have brought a renaissance of changes in the way academics and researchers communicate and collaborate, and in the way that the food industry develops. The new edition covers emerging skills of food technologists and the integration of food science and technology knowledge into the food chain. This handbook is ideal for all relevant actors in the food sector (professors, researchers, students and professionals) as well as for anyone dealing with food science and technology, new products development and food industry.

Long-Acting Drug Delivery Systems: Pharmaceutical, Clinical, and Regulatory Aspects offers a comprehensive overview of the technical, clinical, regulatory and industrial perspectives on these drug delivery systems. The book follows a sequential order, beginning with the current technical state-of-the-field and moving on to more clinical, industrial and regulatory topics. Opening chapters describe the current needs and potential applications of implantable and long-acting therapeutic approaches. The book goes on to describe established and novel long-acting systems, with a focus on the materials used to prepare these systems and their biocompatibility. Importantly, applied topics such as scale-up manufacturing, products under clinical trials and regulatory aspects are covered, offering the reader a holistic view of this rapidly growing field.

Cognitive Models for Sustainable Environment reviews the fundamental concepts of gathering, processing and analyzing data from batch processes, along with a review of intelligent and cognitive tools that can be used. The book is centered on evolving novel intelligent/cognitive models and algorithms to develop sustainable solutions for the mitigation of environmental pollution. It unveils intelligent and cognitive models to address issues related to the effective monitoring of environmental pollution and sustainable environmental design. As such, the book focuses on the overall well-being of the global environment for better sustenance and livelihood. The book covers novel cognitive models for effective environmental pollution data management at par with the standards laid down by the World Health Organization. Every chapter is supported by real-life case studies, illustrative examples and video demonstrations that enlighten readers.

Modern Practical Healthcare Issues in Biomedical Instrumentation describes the designs, applications and principles of several medical devices used in hospitals and at home. The book presents practical devices that can potentially be used for healthcare purposes. Sections cover the use of biosensors to monitor the physiological properties of the human body, focusing on devices used to evaluate, measure and manipulate the biological system, and highlighting practical devices that can potentially be used for healthcare purposes. It is an excellent resource for undergraduate, graduate and post-graduate students of biomedical engineering.

Smart Agrochemicals for Sustainable Agriculture proposes products that fulfill the need for chemicals that provide a sustainable delivery system for nutrients necessary to maximize the production of agricultural animals and plants while producing the smallest possible environmental footprint. This book addresses all aspects related to the production process, including chemical formulas, stability of formulations, and the application of the effect of its utilization. Over the past decade, biobased chemicals have received significant attention as candidate resource materials in fertilizers and agrochemicals production due to their renewability. Substitution of conventional raw materials with biobased requires a new approach towards the development of technology. On the other hand, the use of biobased chemicals, such as biostimulants, bioregulators and biofertilizers offers a new palette of products that are natural, thus their application does not pose an impact on the environment (residues) or cultivated plants.

Microbial Biodegradation and Bioremediation: Techniques and Case Studies for Environmental Pollution, Second Edition describes the successful application of microbes and their derivatives for bioremediation of potentially toxic and relatively novel compounds in the environment. Our natural biodiversity and environment is in danger due to the release of continuously emerging potential pollutants by anthropogenic activities. Though many attempts have been made to eradicate and remediate these noxious elements, thousands of xenobiotics of relatively new entities emerge every day, thus worsening the situation. Primitive microorganisms are highly adaptable to toxic environments, and can reduce the load of toxic elements by their successful transformation and remediation. This completely updated new edition presents many new technologies and techniques and includes theoretical context and case studies in every chapter. Microbial Biodegradation and Bioremediation: Techniques and Case Studies for Environmental Pollution, Second Edition serves as a single-source reference and encompasses all categories of pollutants and their applications in a convenient, comprehensive format for researchers in environmental science and engineering, pollution, environmental microbiology, and biotechnology.

Nanotechnology in Medicine and Biology brings together a multidisciplinary team of experts from the fields of materials science, nanotechnology, medicine and biomedical engineering to introduce new nanoscale biomaterials and their applications, diagnosis and treatment of disorders of the human body. The book presents the fundamentals for understanding the design, properties and selection of nanobiomaterials as well as their real-world applications in medicine. Each chapter addresses current regulations, manufacturing processes, and translation issues of nanobiomaterials for key applications. A discussion of current protocols and their benefits and disadvantages is also included. This book provides comprehensive background and knowledge in the field of nanobiomaterials that is suitable for academics, scientists and clinicians.

Microbial Extremozymes: Novel Sources and Industrial Applications is a unique resource of practical research information on the latest novel sources and technologies regarding extremozymes in bioremediation, waste management, valorization of industrial by-products, biotransformation of natural polymers, nutrition, food safety and diagnosis of disease. The book's broad knowledge and varying applications are useful to the food industry, dairy industry, fruit and vegetable processing, and baking and beverages industries, as well as the pharmaceutical and biomedical industries. This is a concise, all-encompassing resource for a range of scientists needing knowledge of extremozymes to enhance and research. Furthermore, it provides an updated knowledge of microbial enzymes isolated from extreme environments (temperatures, etc.) and their biotechnological applications. It will be useful to researchers, scientists and students in enzyme research. In addition, users from the dairy and baking industries will benefit from the presented content.

Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology. Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems.

Abiotic Stress and Legumes: Tolerance and Management is the first book to focus on the ability of legume plants to adapt effectively to environmental challenges. Using the -omic approach, this book takes a targeted approach to understanding the methods and means of ensuring survival and maximizing the productivity of the legume plant by improving tolerance to environmental /abiotic stress factors including drought, temperature change, and other challenges. The book presents a comprehensive overview of the progress that has been made in identifying means of managing abiotic stress effects, specifically in legumes, including the development of several varieties which exhibit tolerance through high yield using transcriptomic, proteomic, metabolomic and ionomic approaches. Further, exogenous application of various stimulants such as plant hormones, nutrients, sugars, and polyamines has emerged as an alternative strategy to improve productivity under these environmental challenges. Abiotic Stress and Legumes: Tolerance and Management examines these emerging strategies and serves as an important resource for researchers, academicians and scientists, enhancing their knowledge and aiding further research.

Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies.

Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists.

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert" immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.

Bioleaching of chalcopyrite is always a challenge and research hotspot. The low copper extraction and dissolution kinetics restricted the industrial application of chalcopyrite bioleaching. To solve this problem, the dissolution process and passivation mechanism of chalcopyrite in bioleaching should be first studied, then the rate-limiting steps should be analysed explicitly, and finally the intensifying method can be put forward. Many scholars have made efforts to investigate the dissolution mechanism of chalcopyrite in bioleaching. However, there is no congruence of opinion as yet. Biohydrometallurgy of Chalcopyrite summarizes and discusses the reported research findings. In addition, this book publishes the related results found by the authors' research. Then, the dissolution mechanism of chalcopyrite in bioleaching is interpreted. Finally, the process intensification techniques of chalcopyrite bioleaching are provided and discussed. Hence, this book provides useful reference and guidance in both laboratory research and industrial production.

Nanotechnology in Conservative Dentistry provides a detailed review of the use of nanotechnology in conservative dentistry, from diagnosis and restorative materials, through to tissue engineering and regeneration. This book covers fundamental topics in the field of conservative dentistry, including caries therapy, dentin reconstruction, pulp protection and more; each chapter reviews and discusses how nanotechnology can be implemented as a novel approach to traditional conservative dentistry techniques, exploring the many uses and advantages of this fast-growing technology. Various nanobiomaterials and technologies are covered, as well as assessment of the biocompatibility and toxicological risks of utilizing nanotechnology in dentistry. Nanotechnology in Conservative Dentistry will help dentists and materials science academics alike, understand the potential of nanotechnology in dentistry, building on and going beyond traditional concepts and techniques in this field.

Bioinspired and Biomimetic Materials for Drug Delivery delves into the potential of bioinspired materials in drug delivery, detailing each material type and its latest developments. In the last decade, biomimetic and bioinspired materials and technology has garnered increased attention in drug delivery research. Various material types including polymer, small molecular, protein, peptide, cholesterol, polysaccharide, nano-crystal and hybrid materials are widely considered in drug delivery research. However, biomimetic and bioinspired materials and technology have shown promising results for use in therapeutics, due to their high biocompatibility and reduced immunogenicity. Such materials include dopamine, extracellular exosome, bile acids, ionic liquids, and red blood cell. This book covers each of these materials in detail, reviewing their potential and usage in drug delivery. As such, this book will be a great source of information for biomaterials scientists, biomedical engineers and those working in pharmaceutical research.

Green Biocomposites for Biomedical Engineering: Design, Properties, and Applications combines emergent research outcomes with fundamental theoretical concepts relevant to processing, properties and applications of advanced green composites in the field of biomedical engineering. The book outlines the design elements and characterization of biocomposites, highlighting each class of biocomposite separately. A broad range of biomedical applications for biocomposites is then covered, with a final section discussing the ethics and safety regulations associated with manufacturing and the use of biocomposites. With contributions from eminent editors and recognized authors around the world, this book is a vital reference for researchers in biomedical engineering, materials science and environmental science, both in industry and academia.