This volume is an English translation of Overton's monograph on
structure-activity relationships regarding anaesthetic action and
toxicity. This book has been cited widely by scientists studying
the correlation of biological activity with partition coefficients
and the mechanism of anaesthesia. Although the original monograph
was published in 1901, it should still be of value to modern
toxicologists, particularly those involved in the development of
quantitative structure-toxicity relationships and the predictive
limitations of such models. Introductory chapters by Lipnick,
Miller and Winter emphasize the importance of this text. This book
should be of interest to anaesthetists, pharmacologists,
toxicologists, medical and organic chemists and pharmaceutical
historians.
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