The development of suitable assays, the integration of appropriate
technology, and the effective management of the essential
infrastructure are all critical to the success of any high-
throughput screening (HTS) endeavor. However, few scientists have
the multidisciplinary experience needed to control all aspects of
an HTS drug discovery project. A Practical Guide to Assay
Development and High-Throughput Screening in Drug Discovery
integrates the experience of diverse experts who offer fundamental
and practical guidance across numerous situations. The book first
discusses assay developments for important target classes such as
protein kinases and phosphatases, proteases, nuclear receptors, G
protein-coupled receptors, ion channels, and heat shock proteins.
It next examines assay developments for cell viability, apoptosis,
and infectious diseases. The contributors explore the application
of emerging technologies and systems, including image-based high
content screening, RNA interference, and primary cells. Finally,
they discuss the essential components of the integrated HTS
process, such as screening automation, compound library management,
the screening of natural products from botanical sources, and
screening informatics. Designed to motivate researchers to bring
further advances to the field, this volume provides practical
guidance on how to initiate, validate, optimize, and manage a
bioassay intended to screen large collections of compounds. Drawing
on the knowledge from experts actively involved in assay
development and HTS, this is a resource that is both comprehensive
and focused.
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