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Modulators of Glutamatergic Signaling as Potential Treatments of Neuropsychiatric Disorders (Hardcover)
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Modulators of Glutamatergic Signaling as Potential Treatments of Neuropsychiatric Disorders (Hardcover)
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Mounting evidence from preclinical and clinical research suggests
that the glutamatergic system is highly involved in the
pathophysiology of major neuropsychiatric disorders. All of these
scientific activities are a necessary first step, which translates
into opportunities in terms of development of new and improved
treatment strategies. Glutamate-based research over the last couple
of decades has provided novel insights into the pathogenesis of
both psychiatric disorders such as treatment resistant depression,
bipolar disorder, schizophrenia, PTSD, ADHD and neurological
disorders including Alzheimer's dementia, migraine, epilepsy, ALS
and neuropathic pain. Recent news developments also indicate
glutamate involvement in neurodevelopmental disorders such as
autism. In addition to the above, recent discoveries that several
novel therapeutic agents like riluzole, memantine, ketamine,
topiramate and lamotrigine possess glutamatergic properties as part
of their mechanism of action, further boosted the interest of drug
development companies and academic research centers to put more
effort into investigating novel therapeutically efficacious
compounds. Moreover, recent large "real life" clinical studies,
such as STAR*D, also looked into disease-associated glutamate
genetics and paved the way for the future creation of first
individualised pharmacogenetic treatments. The overall purpose of
this book is to provide the reader with expert opinions relating to
the most up-to-date information on glutamate's role in
pathophysiology of neuropsychiatric disorders and current and
future glutamatergic treatment strategies. The authors' hope that
this contribution will foster future research activities, which are
all ultimately aiming to improve quality of life in patients with
chronic, psychiatric and neurological disorders, thus enhancing
their contribution to society.
General
Imprint: |
nova science publishers
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Country of origin: |
United States |
Release date: |
December 2015 |
Editors: |
Zoran M. Pavlovic
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Dimensions: |
230 x 155 x 17mm (L x W x T) |
Format: |
Hardcover
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Pages: |
184 |
ISBN-13: |
978-1-63483-493-3 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Psychiatry
|
LSN: |
1-63483-493-3 |
Barcode: |
9781634834933 |
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