This is the first volume to explore the reception of the Pythagorean doctrine of cosmic harmony within a variety of contexts, ranging chronologically from Plato to 18th-century England. This original collection of essays engages with contemporary debates concerning the relationship between music, philosophy, and science, and challenges the view that Renaissance discussions on cosmic harmony are either mere repetitions of ancient music theory or pre-figurations of the 'Scientific Revolution'. Utilizing this interdisciplinary approach, Renaissance Conceptions of Cosmic Harmony offers a new perspective on the reception of an important classical theme in various cultural, sequential and geographical contexts, underlying the continuities and changes between Antiquity, the Middle Ages and the Renaissance. This project will be of particular interest within these emerging disciplines as they continue to explore the ideological significance of the various ways in which we appropriate the past.

This detailed book provides an overview of various classes of computational techniques, including machine learning techniques, commonly used for evaluating kinetic parameters of biological systems. Focusing on three distinct situations, the volume covers the prediction of the kinetics of enzymatic reactions, the prediction of the kinetics of protein-protein or protein-ligand interactions (binding rates, dissociation rates, binding affinities), and the prediction of relatively large set of kinetic rates of reactions usually found in quantitative models of large biological networks. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of expert implementation advice that leads to successful results. Authoritative and practical, Computational Methods for Estimating the Kinetic Parameters of Biological Systems will be of great interest for researchers working through the challenge of identifying the best type of algorithm and who would like to use or develop a computational method for the estimation of kinetic parameters.

Broadening the conversation begun in Making Publics in Early Modern Europe (2009), this book examines how the spatial dynamics of public making changed the shape of early modern society. The publics visited in this volume are voluntary groupings of diverse individuals that could coalesce through the performative uptake of shared cultural forms and practices. The contributors argue that such forms of association were social productions of space as well as collective identities. Chapters explore a range of cultural activities such as theatre performances; travel and migration; practices of persuasion; the embodied experiences of lived space; and the central importance of media and material things in the creation of publics and the production of spaces. They assess a multiplicity of publics that produced and occupied a multiplicity of social spaces where collective identity and voice could be created, discovered, asserted, and exercised. Cultural producers and consumers thus challenged dominant ideas about just who could enter the public arena, greatly expanding both the real and imaginary spaces of public life to include hitherto excluded groups of private people. The consequences of this historical reconfiguration of public space remain relevant, especially for contemporary efforts to meaningfully include the views of ordinary people in public life.

This detailed book explores techniques commonly used for research into drug repurposing, a well-known strategy to find alternative indications for drugs which have already undergone toxicology and pharma-kinetic studies but have failed later stages during the development, via computational methods. Thereby, it addresses the intense challenges of identifying the appropriate type of algorithm and relevant technical information for computational repurposing. Written for the highly successful Methods in Molecular Biology series, the authors of each chapter use their experience in the field to describe the implementation and successful use of a specific repurposing method thus providing lab-ready instruction. Authoritative and practical, Computational Methods for Drug Repurposing serves as an ideal guide to researchers interested in this vital area of drug development.

This is the first volume to explore the reception of the Pythagorean doctrine of cosmic harmony within a variety of contexts, ranging chronologically from Plato to 18th-century England. This original collection of essays engages with contemporary debates concerning the relationship between music, philosophy, and science, and challenges the view that Renaissance discussions on cosmic harmony are either mere repetitions of ancient music theory or pre-figurations of the 'Scientific Revolution'. Utilizing this interdisciplinary approach, Renaissance Conceptions of Cosmic Harmony offers a new perspective on the reception of an important classical theme in various cultural, sequential and geographical contexts, underlying the continuities and changes between Antiquity, the Middle Ages and the Renaissance. This project will be of particular interest within these emerging disciplines as they continue to explore the ideological significance of the various ways in which we appropriate the past.

Broadening the conversation begun in Making Publics in Early Modern Europe (2009), this book examines how the spatial dynamics of public making changed the shape of early modern society. The publics visited in this volume are voluntary groupings of diverse individuals that could coalesce through the performative uptake of shared cultural forms and practices. The contributors argue that such forms of association were social productions of space as well as collective identities. Chapters explore a range of cultural activities such as theatre performances; travel and migration; practices of persuasion; the embodied experiences of lived space; and the central importance of media and material things in the creation of publics and the production of spaces. They assess a multiplicity of publics that produced and occupied a multiplicity of social spaces where collective identity and voice could be created, discovered, asserted, and exercised. Cultural producers and consumers thus challenged dominant ideas about just who could enter the public arena, greatly expanding both the real and imaginary spaces of public life to include hitherto excluded groups of private people. The consequences of this historical reconfiguration of public space remain relevant, especially for contemporary efforts to meaningfully include the views of ordinary people in public life.

The Erotics of Looking: Early Modern Netherlandish Art presents a collection of provocative essays that explore the material qualities of early Dutch art to reveal ways new forms of visual imagery solicit a beholder s involvement. * Explores how descriptive pictures during the early modern Dutch art period operated as social things and were designed to pleasurably engage the eye and prompt discussion and debate * Shows how these works potentially raised ethical and political questions about the interconnectedness of engaging with pictures and the material world * Represents a major contribution to the field of early modern Netherlandish art and to general debates about the status and functions of descriptive art * Features essays addressing a variety of aspects of the field, from the historiography of Dutch art to closely attentive readings of particular works * Crafts an original theoretical framework by applying recent insights about the making of early modern publics and the study of material things to the analysis of Netherlandish art

This book opens a window onto a fascinating and understudied aspect of the visual, material, intellectual, and cultural history of seventeenth-century Amsterdam: the role played by its inns and taverns, specifically the doolhoven. Doolhoven were a type of labyrinth unique to early modern Amsterdam. Offering guest lodgings, these licensed public houses also housed remarkable displays of artwork in their gardens and galleries. The main attractions were inventive displays of moving mechanical figures (automata) and a famed set of waxwork portraits of the rulers of Protestant Europe. Publicized as the most innovative artworks on display in Amsterdam, the doolhoven exhibits presented the mercantile city as a global center of artistic and technological advancement. This evocative tour through the doolhoven pub gardens—where drinking, entertainment, and the acquisition of knowledge mingled in encounters with lively displays of animated artifacts—shows that the exhibits had a forceful and transformative impact on visitors, one that moved them toward Protestant reform. Deeply researched and decidedly original, The Moving Statues of Seventeenth-Century Amsterdam uncovers a wealth of information about these nearly forgotten public pleasure parks, situating them within popular culture, religious controversies, global trade relations, and intellectual debates of the seventeenth century. It will appeal in particular to scholars in art history and early modern studies.

This detailed book provides an overview of various classes of computational techniques, including machine learning techniques, commonly used for evaluating kinetic parameters of biological systems. Focusing on three distinct situations, the volume covers the prediction of the kinetics of enzymatic reactions, the prediction of the kinetics of protein-protein or protein-ligand interactions (binding rates, dissociation rates, binding affinities), and the prediction of relatively large set of kinetic rates of reactions usually found in quantitative models of large biological networks. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of expert implementation advice that leads to successful results. Authoritative and practical, Computational Methods for Estimating the Kinetic Parameters of Biological Systems will be of great interest for researchers working through the challenge of identifying the best type of algorithm and who would like to use or develop a computational method for the estimation of kinetic parameters.

Marsilio Ficino (1433–1499), the Florentine scholar-philosopher-magus, was largely responsible for the Renaissance revival of Plato. Ficino’s commentaries on Plato remained the standard guide to the Greek philosopher’s works for centuries. Vanhaelen’s new translation of Ficino’s vast commentary on the Parmenides makes this monument of Renaissance metaphysics accessible to the modern student of philosophy. The volume contains the first critical edition of the Latin text, an ample introduction, and extensive notes.

This book opens a window onto a fascinating and understudied aspect of the visual, material, intellectual, and cultural history of seventeenth-century Amsterdam: the role played by its inns and taverns, specifically the doolhoven. Doolhoven were a type of labyrinth unique to early modern Amsterdam. Offering guest lodgings, these licensed public houses also housed remarkable displays of artwork in their gardens and galleries. The main attractions were inventive displays of moving mechanical figures (automata) and a famed set of waxwork portraits of the rulers of Protestant Europe. Publicized as the most innovative artworks on display in Amsterdam, the doolhoven exhibits presented the mercantile city as a global center of artistic and technological advancement. This evocative tour through the doolhoven pub gardens-where drinking, entertainment, and the acquisition of knowledge mingled in encounters with lively displays of animated artifacts-shows that the exhibits had a forceful and transformative impact on visitors, one that moved them toward Protestant reform. Deeply researched and decidedly original, The Moving Statues of Seventeenth-Century Amsterdam uncovers a wealth of information about these nearly forgotten public pleasure parks, situating them within popular culture, religious controversies, global trade relations, and intellectual debates of the seventeenth century. It will appeal in particular to scholars in art history and early modern studies.

In describing the seventeenth-century Dutch Republic, Johan Huizinga said, "Paintings could be found everywhere . . . everywhere except in churches." Although pictures were ubiquitous in the Dutch world, the official religion expressed a fundamental distrust of visual imagery. Indeed, Calvinism and visual culture were both central modes of self-understanding in Dutch society. Investigating this paradox, The Wake of Iconoclasm takes as its main subject the numerous paintings of austere Calvinist church interiors that proliferated in the seventeenth century. Painstakingly crafted and highly naturalistic images of interiors, these peculiar paintings show spaces that were purged of visual imagery during and after the iconoclast riots of the sixteenth century. In essence, they depict the interface of the histories of art and religion. Angela Vanhaelen argues that the main function of this imagery was to stimulate debate about the transformed role of art in relation to the religious and political upheavals of the Reformation and the Dutch Revolt. Paintings of the emptied churches allowed their beholders to grapple with the significant public influence of Calvinism--especially its suppression of past cultural traditions and the new conditions of possibility it created for the visual arts.

Taking into account the destructive powers of globalization, Making Worlds considers the interconnectedness of the world in the early modern period. This collection examines the interdisciplinary phenomenon of making worlds, with essays from scholars of history, literary studies, theatre and performance, art history, and anthropology. The volume advances questions about the history of globalization by focusing on how the expansion of global transit offered possibilities for interactions that included the testing of local identities through inventive experimentation with new and various forms of culture. Case studies show how the imposition of European economic, religious, political, and military models on other parts of the world unleashed unprecedented forces of invention as institutionalized powers came up against the creativity of peoples, cultural practices, materials, and techniques of making. In doing so, Making Worlds offers an important rethinking of how early globalization inconsistently generated ongoing dynamics of making, unmaking, and remaking worlds.

Marsilio Ficino (1433-1499), the Florentine scholar-philosopher-magus, was largely responsible for the Renaissance revival of Plato. Ficino's commentaries on Plato remained the standard guide to the Greek philosopher's works for centuries. Vanhaelen's new translation of Ficino's vast commentary on the Parmenides makes this monument of Renaissance metaphysics accessible to the modern student of philosophy. The volume contains the first critical edition of the Latin text, an ample introduction, and extensive notes.