Ben Lewin writes and directs this Academy Award-nominated drama about the sexual awakening of a life-long polio sufferer. John Hawkes stars as Mark O'Brien, a writer in his late thirties who has spent his life lying horizontally in an iron lung since a debilitating childhood bout of polio. A poet and a romantic, Mark has lived a life devoid of sexual intimacy. When he is given the job of writing an article about the sex lives of the disabled, he arranges - with the support of his local priest, Father Brendan (William H. Macy) - to employ the services of sexual surrogate Cheryl (Helen Hunt). Their 'sessions' take Mark on an unexpected journey of discovery and self-awareness.

Adrian Monk is San Francisco's most brilliant detective but is unable to serve on the police force because of his crippling neuroses and obsessive-compulsive disorder.

However he continues his investigations independently often solving cases before the actual police are able to do so and always seeking clues to the unsolved murder of his wife.

This seventh entry in the 'Halloween' series is also the first since 'Halloween 2' to feature Laurie Strode (Jamie Lee Curtis), the sister and victim of psychopath Michael Myers. Apparently killed in a car crash, Laurie in fact faked her death so that she could adopt a new identity. She is now Keri Tate, headmistress of a private school in California, and mother of a teenage son, John. Unfortunately, Halloween 1998 - the twentieth anniversary of Michael's original attack - sees the slasher decide that the time is now right to get back in touch with his family.

An Introduction to Systems Bioengineering
Takes a Clear and Systematic Engineering Approach to Systems Biology

Focusing on genetic regulatory networks, Engineering Genetic Circuits presents the modeling, analysis, and design methods for systems biology. It discusses how to examine experimental data to learn about mathematical models, develop efficient abstraction and simulation methods to analyze these models, and use analytical methods to guide the design of new circuits.

After reviewing the basic molecular biology and biochemistry principles needed to understand genetic circuits, the book describes modern experimental techniques and methods for discovering genetic circuit models from the data generated by experiments. The next four chapters present state-of-the-art methods for analyzing these genetic circuit models. The final chapter explores how researchers are beginning to use analytical methods to design synthetic genetic circuits.

This text clearly shows how the success of systems biology depends on collaborations between engineers and biologists. From biomolecular observations to mathematical models to circuit design, it provides essential information on genetic circuits and engineering techniques that can be used to study biological systems.

Buddy comedy starring Ethan Embry and Michael Gladis. Kevin and Bruce (Embry and Gladis) run their own private security firm in a sleepy suburban town where crime is low and new contracts scarce. In order to ramp up business, the two men decide to use their home security knowledge to their advantage and rob their neighbours' homes to make them aware that they are not entirely safe. Initially, their plan comes through for them, and they enjoy a rush of new customers desperate for their help. But when a local drug lord (Cary Elwes)'s money goes missing and a police officer (Ving Rhames) begins investigating the rise in robberies, it seems like Kevin and Bruce might be in deeper than they'd hoped...

All 26 episodes from the third season of the US hospital drama created by David E. Kelley. Set in a Chicago charity hospital, the show follows a pair of skilled surgeons, Jeffrey Geiger (Mandy Patinkin) and Aaron Shutt (Adam Arkin), as they attempt to balance the demands of their personal lives with caring for their patients. The episodes are: 'Out of Africa', 'Back to the Future', 'Papa's Got a Brand New Bag', 'Liver Let Die', 'Liar, Liar', 'Higher Powers', 'A Time to Kill', 'A Day in the Life', 'Divided Loyalty', 'V-Fibbing', 'Mummy Dearest', 'Split Decisions', 'Verdicts', 'The Day of the Rope', 'Take My Wife, Please', 'Missed Conception', 'Mother, May I?', 'Growing Pains', The Son Also Rises', 'Second Chances', 'Positive I.D.s', 'Leggo My Ego', 'Colonel of Truth', 'Lamb to the Slaughter', 'Love on the Rocks' and 'Hope Against Hope'.

This book explores Systems Biology as the understanding of biological network behaviors, and in particular their dynamic aspects, which requires the utilization of mathematical modeling tightly linked to experiment. A variety of approaches are discussed here: the identification and validation of networks, the creation of appropriate datasets, the development of tools for data acquisition and software development, and the use of modeling and simulation software in close concert with experiment.

Computational methods are playing an ever increasing role in cell biology.This volume of Methods in Cell Biology focuses on Computational Methods in Cell Biology and consists of two parts: (1) data extraction and analysis to distill models and mechanisms, and (2) developing and simulating models to make predictions and testable hypotheses.
Focuses on computational methods in cell biologySplit into 2 parts--data extraction and analysis to distill models and mechanisms, and developing and simulating models to make predictions and testable hypothesesEmphasizes the intimate and necessary connection with interpreting experimental data and proposing the next hypothesis and experiment "

Hollywood producer Bobby Gould has spent a career reaping what others sow, until he's forced to choose between his friend's sure hit and a beautiful girl's art house project. During an evening of seduction and manipulation, Bobby discovers that the power he exerts is more elusive than it seems. Pulitzer Prize winner David Mamet pulls the tinsel off the town in this hilarious dissection of the movie business.

A married couple's relationship is tested when they find themselves serving as attorneys on opposite sides of the same headline-making case. The fireworks displayed in the courtroom follow Adam and Amanda Bonner home, creating a wildly witty portrait of love and work. This story look its inspiration from a real court case. Based on the original 1949 "battle of the sexes" film starring Katherine Hepburn and Spencer Tracy, directed by George Cukor.

The milieu is the art world, and Pulitzer Prize-winning playwright Donald Margulies takes us on a rocky backward and forward journey through the career, values, and loves of a now-famous painter. It's about the art scene, the loss of love, and the price of assimilation--both ethnic and intellectual--in an America where authenticity often has little to do with an artist's, or anyone's rise to the top.

A coming-of-age, coming-out cocktail with a twist of terror. Thirteen-year-old Franklin Robertson is trying to survive adolescence. His parents don't understand him, his brother torments him, he has no friends, and he's more interested in the high school quarterback than any girl. The one bright spot in his life is the glow of the black-and-white TV in his parents' basement. Here, he worships at the altar of the Saturday Night Horror Movie, hosted by the eerie Dr. Cerberus. Before long, Franklin is convinced that only by going on the show will his life be redeemed - by Dr. Cerberus himself

A L.A. Theatre Works full cast performance starring Simon Helberg as Franklin Robertson, Jamison Jones as Doctor Cerberus, Steven Culp as Lawrence Robertson, Pamela J. Gray as Lydia Robertson and Jarrett Sleeper as Rodney Robertson, with original music by Steven Cahill.

Systems biology is defined for the purpose of this study as the understanding of biological network behaviors, and in particular their dynamic aspects, which requires the utilization of mathematical modeling tightly linked to experiment. This involves a variety of approaches, such as the identification and validation of networks, the creation of appropriate datasets, the development of tools for data acquisition and software development, and the use of modeling and simulation software in close linkage with experiment. All of these are discussed in this volume. Of course, the definition becomes ambiguous at the margins, but at the core is the focus on networks, which makes it clear that the goal is to understand the operation of the systems, rather than the component parts. It was concluded that the U.S. is currently ahead of the rest of the world in systems biology, largely because of earlier investment by funding organizations and research institutions.