He's ingenious, he's phobic, he's obsessive-compulsive. Emmy and Golden Globe Award winner Tony Shalhoub is a riot in Monk, the show that critics are praising as fresh, exciting and utterly original.

Monk's hilarious, offbeat antics have made him unfit for duty but he's back as a police consultant to help out on their most baffling cases. The brilliant but neurotic Monk is now fighting crime as well as his abnormal fears of germs, cars, heights, crowds and virtually everything else known to man in the best detective show to come along in decades.

Nothing on TV generated more fun than this and now you can enjoy the entire first season of Monk on DVD.

Ben Lewin writes and directs this Academy Award-nominated drama about the sexual awakening of a life-long polio sufferer. John Hawkes stars as Mark O'Brien, a writer in his late thirties who has spent his life lying horizontally in an iron lung since a debilitating childhood bout of polio. A poet and a romantic, Mark has lived a life devoid of sexual intimacy. When he is given the job of writing an article about the sex lives of the disabled, he arranges - with the support of his local priest, Father Brendan (William H. Macy) - to employ the services of sexual surrogate Cheryl (Helen Hunt). Their 'sessions' take Mark on an unexpected journey of discovery and self-awareness.

Buddy comedy starring Ethan Embry and Michael Gladis. Kevin and Bruce (Embry and Gladis) run their own private security firm in a sleepy suburban town where crime is low and new contracts scarce. In order to ramp up business, the two men decide to use their home security knowledge to their advantage and rob their neighbours' homes to make them aware that they are not entirely safe. Initially, their plan comes through for them, and they enjoy a rush of new customers desperate for their help. But when a local drug lord (Cary Elwes)'s money goes missing and a police officer (Ving Rhames) begins investigating the rise in robberies, it seems like Kevin and Bruce might be in deeper than they'd hoped...

This book explores Systems Biology as the understanding of biological network behaviors, and in particular their dynamic aspects, which requires the utilization of mathematical modeling tightly linked to experiment. A variety of approaches are discussed here: the identification and validation of networks, the creation of appropriate datasets, the development of tools for data acquisition and software development, and the use of modeling and simulation software in close concert with experiment.

Systems biology is defined for the purpose of this study as the understanding of biological network behaviors, and in particular their dynamic aspects, which requires the utilization of mathematical modeling tightly linked to experiment. This involves a variety of approaches, such as the identification and validation of networks, the creation of appropriate datasets, the development of tools for data acquisition and software development, and the use of modeling and simulation software in close linkage with experiment. All of these are discussed in this volume. Of course, the definition becomes ambiguous at the margins, but at the core is the focus on networks, which makes it clear that the goal is to understand the operation of the systems, rather than the component parts. It was concluded that the U.S. is currently ahead of the rest of the world in systems biology, largely because of earlier investment by funding organizations and research institutions.

A married couple's relationship is tested when they find themselves serving as attorneys on opposite sides of the same headline-making case. The fireworks displayed in the courtroom follow Adam and Amanda Bonner home, creating a wildly witty portrait of love and work. This story look its inspiration from a real court case. Based on the original 1949 "battle of the sexes" film starring Katherine Hepburn and Spencer Tracy, directed by George Cukor.

The milieu is the art world, and Pulitzer Prize-winning playwright Donald Margulies takes us on a rocky backward and forward journey through the career, values, and loves of a now-famous painter. It's about the art scene, the loss of love, and the price of assimilation--both ethnic and intellectual--in an America where authenticity often has little to do with an artist's, or anyone's rise to the top.

Computational methods are playing an ever increasing role in cell biology.This volume of Methods in Cell Biology focuses on Computational Methods in Cell Biology and consists of two parts: (1) data extraction and analysis to distill models and mechanisms, and (2) developing and simulating models to make predictions and testable hypotheses.
Focuses on computational methods in cell biologySplit into 2 parts--data extraction and analysis to distill models and mechanisms, and developing and simulating models to make predictions and testable hypothesesEmphasizes the intimate and necessary connection with interpreting experimental data and proposing the next hypothesis and experiment "