Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 deals with the "How" in the reconfiguration of our approach to slow the progression of those suffering from diseases of accelerated brain aging. This second Handbook of Clinical Neurology volume offers a rethinking of the animal models on which therapies are tested; outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology; and the growing role of microbiome in shaping disease and as a future target of therapeutic efforts. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision medicine -matching the biology of those affected with the mechanism of the intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes.

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 deals with the "Why" in the approach to slow the progression of those suffering from diseases of accelerated brain aging. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine. This first Handbook of Clinical Neurology volume is intended to provide a scholarly background on the framework, basic science, and conceptual pitfalls related to disease-modifying efforts in Parkinson, Alzheimer, and other neurodegenerative disorders. Among the topics covered are the different models of precision medicine, the lumping-versus-splitting tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases. Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration.

Parkinson's disease is no longer considered only a motor disorder. It has become evident that the pathological changes are broad, the progression seems to follow a pattern suggesting transynaptic transmission via templation of proteins in a prion-like fashion, and that these pathological changes usually antedate the motor symptoms by decades. This book emphasizes treatment options for Parkinson's disease, critically assessing pharmacologic and surgical interventions for all aspects of the disease. Evidence from randomized controlled clinical trials is highlighted to develop practical recommendations for clinical practice. Lessons learnt from clinical trials - and controversies and future challenges - are all addressed. Readers will find the necessary clinical and scientific foundations for the understanding of the disease, the underpinnings of the pathological processes, the identification of disease biomarkers, and the basis for solid therapeutics. Chapters are authored by an international team of specialists who bring their expertise to improving the management of this disease.

With easy-to-read, high-yield coverage of essential information in neurology, Concise Neurology: A Focused Review is a practical, everyday reference for busy practitioners, fellows, residents, and students who need a rapid overview of a complex subject. The second edition has been almost entirely rewritten to stay current with recent developments in the field but retains its quick-reference format: an intuitively designed one- or two-page presentation of each topic to facilitate rapid review. Virtually every topic of interest is covered, including the core concepts in diagnosis and treatment for each syndrome or disease. Material is presented in order of clinical relevance, maintaining a thematic unity across related pages for the most effective, efficient review. An engaging writing style offers many pearls and personal explanations from the authors that clarify difficult concepts. Every page offers a quick yet thoughtful summary of key points, making it particularly useful for busy residents, fellows, and practitioners. Enrich Your Ebook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

Visual observation of patients is crucial in the diagnosis of movement disorders. Such observation can be subject to many pitfalls. The powerful lessons in this case-based book will help the reader appreciate diagnoses missed or wrongly attributed, movements difficult to characterize, tests inappropriately ordered or interpreted, and treatments incorrectly chosen or dosed. The wisdom of hindsight thus generated becomes an invaluable and enduring lesson. Organized in nine chapters according to the categories of errors and oversights, each case conveys a specific set of clinical pearls on diagnostic or therapeutic issues. The text is written in a coaching style, buttressed by the strong pedagogic wisdom of the authors. The 'hard questions' after each case are meant to steer the discussion straight into the pitfalls - and how they could have been avoided. Video segments on the accompanying CD-ROM are important complementary data, critical to a field so intimately dependent on phenomenological clues.