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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Precision Medicine in Neurodegenerative Disorders, Volume 193 - Part II (Hardcover)
Loot Price: R5,505
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Precision Medicine in Neurodegenerative Disorders, Volume 193 - Part II (Hardcover)
Series: Handbook of Clinical Neurology
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Precision Medicine in Neurodegenerative Disorders, Part Two, Volume
193 deals with the "How" in the reconfiguration of our approach to
slow the progression of those suffering from diseases of
accelerated brain aging. This second Handbook of Clinical Neurology
volume offers a rethinking of the animal models on which therapies
are tested; outlines the progress and expected changes in
biological subtyping efforts using lysosomal, endosomal,
mitochondrial, immune dysregulation, and inflammatory mechanisms of
disease pathophysiology; and the growing role of microbiome in
shaping disease and as a future target of therapeutic efforts. The
volume separates the potentially disease-modifying neurorescue and
neurorestoration, (e.g., gene therapy and cell replacement therapy)
from true precision medicine -matching the biology of those
affected with the mechanism of the intervention of interest.
Specific chapters are dedicated to the promise and challenges of
extracellular vesicles for both diagnosis and treatment, the
growing application of digital measures and other evaluations of
clinical response, the nuts and bolts of novel adaptive clinical
trial designs, and the regulatory changes needed to facilitate drug
development for disease-modification purposes.
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